A novel approach to characterize phenotypic variation in GSD IV: Reconceptualizing the clinical continuum by Bridget T. Kiely, Rebecca L. Koch, Leticia Flores, Danielle Burner, Samantha Kaplan, Priya S. Kishnani

“…A novel phenotypic scoring approach was applied to characterize the extent of hepatic, neuromuscular, and cardiac involvement in each eligible patient.Results: 146 patients met all inclusion criteria. …”
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Unexpected complications of novel deep brain stimulation treatments: ethical issues and clinical recommendations by Savulescu, J, Maslen, H, Cheeran, B, Pugh, J, Boccard, S, Green, A, FitzGerald, J, Aziz, T

“…Examining these unexpected complications in light of medical ethical principles, we argue that serious complications of novel DBS treatments do not necessarily make it unethical to offer the intervention to eligible patients. …”

A novel score to predict progression in anterior circulation single subcortical infarction patients by Jing Lin, Shiying Ruan, Weipeng Sun, Liangbin Dong, Shumeng Li, Qin Huang, Xiaocheng Mao, Jinchong Zhang, Keji Zou, Hudie Zhang, Pengcheng Huang, Pu Fang, Xiaobing Li, Yuhua Fan, Daojun Hong

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Comparative effectiveness of aspirin for symptomatic venous thromboembolism prophylaxis in patients undergoing total joint arthroplasty, a cohort study by Verinder Sidhu, Helen Badge, Timothy Churches, Justine Maree Naylor, Sam Adie, Ian A Harris

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Novel molecular hepatocellular carcinoma subtypes and RiskScore utilizing apoptosis-related genes by Menggang Zhang, Shuijun Zhang, Wenzhi Guo, Yuting He

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Circulating MicroRNAs as Novel Potential Diagnostic Biomarkers for Osteosarcoma: A Systematic Review by Thaís Borges Gally, Milena Magalhães Aleluia, Grasiely Faccin Borges, Carla Martins Kaneto

“…The identification of novel biomarkers would be helpful, and recently, circulating microRNAs (miRNAs) have been pointed to as possible non-invasive biomarkers. …”
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Novel methodology to quantify dehydration in head and neck cancer radiotherapy using DIXON MRI by Sophie Duncan, Amy Walker, Shivani Kumar, Kylie Dundas, Katherine Bell, Andrew Wallis, Yolanda Surjan, Farhannah Aly, Mark Lee

“…Conclusion This study developed a novel method for measuring changes in water fraction volumes over time, using T2‐weighted DIXON MRIs. …”
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Novel staging for gastric neuroendocrine neoplasms by incorporating the WHO grading into the TNM staging system by Rihong Zhang, Yu Guo, Youliang Wang, Li Hu, Cheng Fang, Yujie Yang, Xianqi Yang, Luohai Chen, Jie Chen, Wei Wang, Xiaowei Sun

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Efficient oil-water separation by novel biodegradable all cellulose composite filter paper by Chizhou Wang, Shaodi Wu, Ning Zhang, Zhaoli Jiang, Xianglin Hou, Long Huang, Tiansheng Deng

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The therapeutic effect of a novel parenteral formulation of dihydroxyacetone in aluminum phosphide-intoxicated patients by Hossein Niknahad, Reza Heidari, Ali Jangjou, Vahidreza Asghari, Fatemeh M. Niknahad, Fazel Goudarzi, Nasim Tavakoli, Mitra Rahimi, Amir Mohammad Niknahad, Marziye Rashedinia

“…Interpretation and conclusions: These data suggest that parenteral DHA is a novel and effective antidote against AlP poisoning to be used as an adjuvant in addition to routine supportive treatment. …”
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A Novel Access Control Method Via Smart Contracts for Internet-Based Service Provisioning by Fariba Ghaffari, Emmanuel Bertin, Noel Crespi, Shanay Behrad, Julien Hatin

“…Blockchain is an enabling technology that provides unprecedented opportunities to novel distributed access control methods for new business models. …”
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In Search of Novel Degradation-Resistant Monomers for Adhesive Dentistry: A Systematic Review and Meta-Analysis by Vlasta Mocharko, Paulo Mascarenhas, Ana Mano Azul, António H. S. Delgado

“…Of the 177 potentially eligible studies, a total of 7 studies were included. …”
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Development and Validation of a Novel Method for Converting the Japan Coma Scale to Glasgow Coma Scale by Mikio Nakajima, Yohei Okada, Tomohiro Sonoo, Tadahiro Goto

“…Results: We identified 8,194 eligible patients. The development cohort included 7,373 patients and the validation cohort included 821 patients. …”
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A novel experience-based internet intervention for smoking cessation: feasibility randomised controlled trial by Powell, J, Newhouse, N, Martin, A, Jawad, S, Yu, L, Davoudianfar, M, Locock, L, Ziebland, S

“…The aim of this study was to determine the feasibility of a randomised trial assessing the effects of a novel, experience-based website as a smoking cessation intervention. …”

The Bronchiectasis Exacerbation Diary: a novel patient-reported outcome for non-cystic fibrosis bronchiectasis by Vivian H. Shih, Maria Jison, Erik Bark, Meredith Venerus, Oren Meyers, James D. Chalmers

“…The BED was revised and finalised based upon patient feedback. The final BED is a novel, eight-item patient-reported outcome (PRO) instrument for monitoring key exacerbation symptoms on a daily basis with content validity established through comprehensive qualitative research and direct patient insight. …”
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Clinical features and novel technologies for prehospital detection of intracerebral haemorrhage: a scoping review protocol by David Jenkins, Adrian Robert Parry-Jones, Mohammed Almubayyidh, Ibrahim Alghamdi

“…In combination with clinical features, novel technologies may improve diagnosis further. …”
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28561 Optimization of Heart Failure Treatment Using a Novel Application Programming Interface (API) by Anthony Mack, David Cordwin, Michael Dorsch

“…OBJECTIVES/GOALS: To evaluate the accuracy and clinical applicability of a novel web-based application programming interface in the optimization of care for patients being treated for heart failure with reduced ejection fraction (HFrEF). …”
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Assessing trainee critical thinking skills using a novel interactive online learning tool by Barbara A. Jantausch, James E. Bost, Priti Bhansali, Yosefa Hefter, Isabella Greenberg, Ellen Goldman

“…Comparison between pre and post-test scores across subgroups were performed using paired t-tests or one-way ANOVA.Results Between 4 April 2017 to 14 July 2019, 62 of 75 (82%) eligible subjects completed both the pre and the post-test. …”
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Thoracic fluid content: a novel parameter for predicting failed weaning from mechanical ventilation by Shymaa Fathy, Ahmed M. Hasanin, Mohamed Raafat, Maha M. A. Mostafa, Ahmed M. Fetouh, Mohamed Elsayed, Esraa M. Badr, Hanan M. Kamal, Ahmed Z. Fouad

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In Vitro Testing and Clinical Handling of a Novel Implant Positioning Technology for Proximal Humeral Plating by Markus Windolf, Dominik Knierzinger, Stefaan Nijs, An Sermon, Michael Blauth, Robert Geoff Richards, Jan Buschbaum

“…Retrospective X-ray analysis on six eligible patients revealed differences in the calculated screw lengths of ≤2 mm before and after screw insertion for five patients. …”
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