Repositioning of Cefuroxime as novel selective inhibitor of the thyroid hormone activating enzyme type 2 deiodinase by Serena Sagliocchi, Melania Murolo, Annunziata Gaetana Cicatiello, Caterina Miro, Annarita Nappi, Emery Di Cicco, Sepehr Torabinejad, Evelina La Civita, Veronica Romano, Daniela Terracciano, Mariano Stornaiuolo, Monica Dentice

“…Here, we describe the cephalosporin Cefuroxime as a novel D2 specific inhibitor. In both in vivo and in vitro settings, Cefuroxime acts as a selective inhibitor of D2 activity, without altering the enzymatic activity of D1 and D3. …”
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A novel CT-emphysema index/FEV1 approach of phenotyping COPD to predict mortality by Loh LC, Ong CK, Koo HJ, Lee SM, Lee JS, Oh YM, Seo JB, Lee SD

“…Li-Cher Loh,1 Choo-Khoon Ong,1 Hyun-Jung Koo,2 Sang Min Lee,2 Jae-Seung Lee,3 Yeon-Mok Oh,3 Joon-Beom Seo,2 Sang-Do Lee3 1Department of Medicine, RCSI & UCD Malaysia Campus, Penang, Malaysia; 2Department of Radiology, Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; 3Department of Pulmonary and Critical Care Medicine, and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea Background: COPD-associated mortality was examined using a novel approach of phenotyping COPD based on computed tomography (CT)-emphysema index from quantitative CT (QCT) and post-bronchodilator (BD) forced expiratory volume in 1 second (FEV1) in a local Malaysian cohort.Patients and methods: Prospectively collected data of 112 eligible COPD subjects (mean age, 67 years; male, 93%; mean post-BD FEV1, 45.7%) was available for mortality analysis. …”
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Identifying novel subgroups in heart failure patients with unsupervised machine learning: A scoping review by Jin Sun, Hua Guo, Wenjun Wang, Wenjun Wang, Xiao Wang, Xiao Wang, Junyu Ding, Kunlun He, Kunlun He, Xizhou Guan

“…Many studies reported a variety of novel subgroups in heart failure patients, with unsupervised machine learning methods. …”
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Novel Adaption of the SARC-F Score to Classify Pediatric Hemato-Oncology Patients with Functional Sarcopenia by Emma J. Verwaaijen, Patrick van der Torre, Josef Vormoor, Rob Pieters, Marta Fiocco, Annelies Hartman, Marry M. van den Heuvel-Eibrink

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Assessment and Prognosis in CSA-AKI Using Novel Kidney Injury Biomarkers: A Prospective Observational Study by Jakub Udzik, Aleksandra Waszczyk, Krzysztof Safranow, Andrzej Biskupski, Krzysztof Majer, Sebastian Kwiatkowski, Ewa Kwiatkowska

“…The TNF-α, MMP-9, IL-18, TIMP-1 and MMP-9/TIMP-1 ratio in the early postoperative period correlated with long-term kidney function impairment; Conclusions: Novel kidney injury biomarkers are an eligible tool for early diagnosis of CSA-AKI. …”
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A Novel Technique of Urethroplasty Could Reduce Urethra-Related Complications in Phalloplasty With Urethral Lengthening by Hong Gao, MD, Dan Wu, MD, Xiangjing Kong, MD, Lie Zhu, MD, Xiang Jie, MD, Wenjun Zhang, MD, Zheyuan Hu, MD, Xiaohai Zhu, MD

“…Introduction: Urethral lengthening in phalloplasty could bring many postoperative complications, such as urethra fistula and stricture, which greatly affects the patient's mental health and quality of life. Aim: To describe a novel technique of vaginal mucosal graft for prelamination urethra (VMGPU) combined with modified urethral anastomosis (MUA) for the reconstruction of a neourethra. …”
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Prognostic Effect of a Novel Simply Calculated Nutritional Index in Acute Decompensated Heart Failure by Sayaki Ishiwata, Shoichiro Yatsu, Takatoshi Kasai, Akihiro Sato, Hiroki Matsumoto, Jun Shitara, Megumi Shimizu, Azusa Murata, Takao Kato, Shoko Suda, Shinichiro Doi, Masaru Hiki, Yuya Matsue, Ryo Naito, Hiroshi Iwata, Atsutoshi Takagi, Hiroyuki Daida

“…The TCB index (triglycerides × total cholesterol × body weight), a novel simply calculated nutritional index based on serum triglycerides (TGs), serum total cholesterol (TC), and body weight (BW), was recently reported to be a useful prognostic indicator in patients with coronary artery disease. …”
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A novel risk score to predict deep vein thrombosis after spontaneous intracerebral hemorrhage by Ruijun Ji, Ruijun Ji, Ruijun Ji, Ruijun Ji, Ruijun Ji, Linlin Wang, Xinyu Liu, Yanfang Liu, Yanfang Liu, Dandan Wang, Dandan Wang, Wenjuan Wang, Wenjuan Wang, Runhua Zhang, Runhua Zhang, Ruixuan Jiang, Ruixuan Jiang, Jiaokun Jia, Jiaokun Jia, Hao Feng, Hao Feng, Zeyu Ding, Zeyu Ding, Yi Ju, Yi Ju, Jingjing Lu, Jingjing Lu, Gaifen Liu, Gaifen Liu, Yongjun Wang, Yongjun Wang, Yongjun Wang, Yongjun Wang, Yongjun Wang, Xingquan Zhao, Xingquan Zhao, Xingquan Zhao, Xingquan Zhao, Xingquan Zhao, Beijing Registration of Intracerebral Hemorrhage investigators

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Pharmacokinetics of hydroxychloroquine in paediatric lupus: data from a novel, direct-to-family clinical trial by E Schmitt, C Smith, G Schulert, S Canna, A Grom, E Mellins, A Brown, J Smith, A Stevens, M Watson, S Jones, K Stewart, E Baker, A Kemp, T Davis, A Smith, S Jackson, C Williams, K Jones, T Mason, A Hanson, Y Zhao, B Thomas, A Reed, J Jones, J Cooper, T Lee, J Chang, M Holland, S Joshi, L Lim, C Ramírez, A Murphy, K Moore, E Pagano, B ferreira, S Li, P Lee, H Schmeling, K Abulaban, R Agbayani, S Akoghlanian, E Anderson, L Barillas-Arias, K Baszis, M Becker, H Bell-Brunson, H Benham, S Benseler, T Beukelman, H Brunner, H Bukulmez, L Cerracchio, E Chalom, K Chundru, J Dean, F Dedeoglu, V Dempsey, J Drew, B Feldman, P Ferguson, C Fleming, L Franco, I Goh, D Goldsmith, B Gottlieb, T Graham, T Griffin, M Hance, K Hickey, M Hollander, J Hsu, A Huber, C Hung, A Huttenlocher, L Imundo, C Inman, J Jaquith, L Jung, D Kingsbury, K Klein, M Klein-Gitelman, S Kramer, S Lapidus, D Latham, B Malla, M Malloy, A Martyniuk, K McConnell, D McCurdy, C McMullen-Jackson, L Moorthy, E Muscal, J Olson, K Onel, L Ponder, S Prahalad, C Rabinovich, S Ringold, M Riordan, A Robinson, M Rosenkranz, B Rosolowski, N Ruth, K Schikler, H Stapp, R Syed, M Tesher, A Thatayatikom, R Vehe, E von Scheven, D Wahezi, A Watts, J Weiss, J Wagner, S Kim, Y Zhang, L Favier, J Patel, S Morgan, A Jackson, J Stokes, L Marques, Stephen J Balevic, K Hayward, A White, J Nicholas, D Lovell, A Zeft, J Harris, E Lawson, C Moss, N George, M Sutter, A Cooper, M Adams, S Cooper, M Miller, C Black, R Schneider, J Taylor, R Sran, M Oliver, M Twilt, M Tóth, J Walker, M Mitchell, F De Benedetti, N Singer, M Fox, K Kaufman, A Merritt, R Stevenson, J Fuller, M Fitzgerald, A Davis, C Davis, L Henderson, J Woo, S Mohan, H Reid, Y Kimura, L Harel, R Laxer, K McCarthy, I Ferguson, E McCormick, A Hay, M Guzman, E Fox, P Hill, A PARSONS, S McGuire, J Lam, C Sandborg, B Stevens, J Boland, S Ballinger, E MENDOZA, J NOCTON, M Ritter, N Johnson, J Shirley, S Bowman, M Ibarra, S Hong, M Guevara, K James, L Santiago, A Adams, B DONALDSON, M Son, C Kremer, K Schmidt, T Wright, L Cannon, R Nicolai, M Freeman, S Spence, D Levy, J Paredes, K Gerhold, A Insalaco, T O'Brien, W Bernal, E Kessler, C Lin, M Lerman, T Hahn, B O'Brien, Michael Cohen-Wolkowiez, Christoph P Hornik, N Abel, J Aiello, C Alejandro, E Allenspach, R Alperin, M Alpizar, G Amarilyo, W Ambler, S Ardoin, S Armendariz, I Balboni, S Balevic, L Ballenger, N Balmuri, F Barbar-Smiley, M Basiaga, E Beltz, T Bigley, B Binstadt, M Blakley, J Bohnsack, A Boneparth, C Bracaglia, E Brooks, M Brothers, M Buckley, D Bullock, B Cameron, P Carper, V Cartwright, E Cassidy, A Chang-Hoftman, V Chauhan, P Chira, T Chinn, H Clairman, D Co, A Confair, H Conlon, R Connor, C Correll, R Corvalan, D Costanzo, R Cron, L Curiel-Duran, T Curington, M Curry, A Dalrymple, D De Ranieri, M De Guzman, N Delnay, E DeSantis, T Dickson, J Dingle, E Dorsey, S Dover, J Dowling, K Driest, Q Du, K Duarte, D Durkee, E Duverger, J Dvergsten, A Eberhard, M Eckert, K Ede, B Edelheit, C Edens, Y Edgerly, M Elder, B Ervin, S Fadrhonc, C Failing, D Fair, M Falcon, S Federici, J Fennell, R Ferrucho, K Fields, T Finkel, O Flynn, L Fogel, K Fritz, S Froese, R Fuhlbrigge, D Gerstbacher, M Gilbert, M Gillispie-Taylor, E Giverc, C Godiwala, H Goheer, E Gotschlich, A Gotte, C Gracia, S Grevich, J Griswold, P Guittar, M Hager, O Halyabar, E Hammelev, S Haro, O Harry, E Hartigan, J Hausmann, J Heiart, K Hekl, M Henrickson, A Hersh, S Hillyer, L Hiraki, M Hiskey, P Hobday, C Hoffart, M Horwitz, J Huggins, J HuiYuen, J Huntington, G Janow, S Jared, C Justice, A Justiniano, N Karan, U Khalsa, B Kienzle, M Kitcharoensakkul, T Klausmeier, B Kompelien, A Kosikowski, L Kovalick, J Kracker, J Lai, B Lang, B Lapin, A Lasky, L Lentini, S Lieberman, N Ling, M Lingis, M Lo, D Lowman, N Luca, S Lvovich, C Madison, J Madison, S Magni Manzoni, J Maller, M Mannion, C Manos, S Mathus, L McAllister, P McCurdy Stokes, I McHale, A McMonagle, E Meidan, R Mercado, L Michalowski, P Miettunen, D Milojevic, E Mirizio, E Misajon, R Modica, E Morgan Dewitt, T Moussa, V Mruk, R Nadler, B Nahal, K Nanda, N Nasah, L Nassi, S Nativ, M Natter, J Neely, B Nelson, L Newhall, L Ng, P Nigrovic, B Nolan, E Oberle, B Obispo, O Okeke, K O'Neil, A Orandi, M Orlando, S Osei-Onomah, R Oz, A Paller, N Pan, S Panupattanapong, M Pardeo, K Pentakota, P Pepmueller, T Pfeiffer, K Phillippi, D Pires Marafon, R Pooni, S Pratt, S Protopapas, B Puplava, J Quach, M Quinlan-Waters, S Radhakrishna, J Rafko, J Raisian, A Rakestraw, E Ramsay, S Ramsey, R Randell, K Remmel, A Repp, A Reyes, A Richmond, M Riebschleger, M Riskalla, R Rivas-Chacon, E Rodela, M Rodriquez, K Rojas, T Ronis, H Rothermel, D Rothman, E Roth-Wojcicki, K Rouster-Stevens, T Rubinstein, N Saad, S Sabbagh, E Sacco, R Sadun, A Sanni, A Sarkissian, S Savani, L Scalzi, L Schanberg, S Scharnhorst, A Schlefman, K Schollaert-Fitch, T Seay, C Seper, J Shalen, R Sheets, A Shelly, S Shenoi, K Shergill, M Shishov, C Shivers, E Silverman, V Sivaraman, J Sletten, E Smitherman, J Soep, L Spiegel, J Spitznagle, H Srinivasalu, K Steigerwald, Y Sterba Rakovchik, S Stern, C Stingl, M Stoll, E Stringer, S Sule, J Sumner, R Sundel, G Syverson, A Szymanski, S Taber, R Tal, A Tambralli, A Taneja, T Tanner, S Tapani, G Tarshish, S Tarvin, L Tate, A Taxter, M Terry, K Tiffany, T Ting, A Tipp, D Toib, K Torok, C Toruner, H Tory, S Tse, V Tubwell, S Uriguen, T Valcarcel, H Van Mater, L Vannoy, C Varghese, N Vasquez, K Vazzana, K Veiga, J Velez, J Verbsky, G Vilar, N Volpe, S Vora, L Wagner-Weiner, H Waite, H Walters, T Wampler Muskardin, L Waqar, M Waterfield, P Weiser, P Weiss, E Wershba, A Wise, L Woolnough, E Wu, A Yalcindag, M Yee, E Yen, R Yeung, K Yomogida, Q Yu, R Zapata, A Zartoshti, R Zeft, A Zhu, C Zic, Daniel Weiner, Daniel Gonzalez, Rachel Randell, Claire Beard

“…Children enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry with a diagnosis of pSLE were eligible if they were receiving HCQ as standard of care for ≥3 months. …”
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The Application of Next-Generation Sequencing to Define Factors Related to Oral Cancer and Discover Novel Biomarkers by Soyeon Kim, Joo Won Lee, Young-Seok Park

“…The findings of existing miRNAs (e.g., miR-21) as well as novel discoveries pertaining to OSCC are also covered. …”
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Epicardial Adipose Tissue: A Novel Potential Imaging Marker of Comorbidities Caused by Chronic Inflammation by Maria Grazia Tarsitano, Carla Pandozzi, Giuseppe Muscogiuri, Sandro Sironi, Arturo Pujia, Andrea Lenzi, Elisa Giannetta

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Identification of novel drug targets and screening potential drugs against Cryptococcus gattii: An in silico approach by Tanjin Barketullah Robin, Nurul Amin Rani, Nadim Ahmed, Anindita Ash Prome, Md Nazmul Islam Bappy, Foeaz Ahmed

“…The subcellular locations and their interactions with a high number of proteins also demonstrate their eligibility as putative drug targets. These proteins were docked with 21 potential antifungal plant metabolites. …”
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A Novel UHPLC-MS/MS Method for the Quantification of Seven Opioids in Different Human Tissues by Alessandra Manca, Amedeo De Nicolò, Elisa Delia De Vivo, Micol Ferrara, Sharon Oh, Sahar Khalili, Niamh Higgins, Robert G. Deiss, Stefano Bonora, Jessica Cusato, Alice Palermiti, Jacopo Mula, Sara Gianella, Antonio D’Avolio

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Probiotic management and inflammatory factors as a novel treatment in cirrhosis: A systematic review and meta-analysis by Xia Qinglan, Lei Yumeng, Wang Jiadun, Wang Qiang

“…Up to December 2022, eligible studies were identified by searching the following databases: National Knowledge Infrastructure (CNKI), Wanfang Data, Web of Science, PubMed, Embase, Medline, and the Cochrane Library. …”
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Percutaneous retrieval of embolized Amplatzer septal occluder from pulmonary artery using a novel method by Özkan Candan, Müslüm Şahin, Muhsin Türkmen

“…Presently described is the retrieval of an embolized device with a novel percutaneous technique.…”
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Initial Experience in Transvenous Implantation of a Left Ventricular Lead With a Novel Venogram Balloon Catheter by Jiangbo Duan, Dandan Yang, Jinshan He, Xuebin Li, Long Wang, Cuncao Wu, Ding Li, Feng Ze, Cuizhen Yuan, Jingliang Zhou, Xu Zhou

“…This paper reports the initial clinical experience of CS cannulation and left ventricular lead implantation guided by a novel venogram balloon catheter (Lee’s venogram balloon catheter).Methods and ResultsConsecutive patients eligible for CRT were deemed suitable for this novel venogram balloon catheter. …”
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A Novel Measurement-Based Method for Assessing Global Warming Mitigation via High-Albedo Solutions by Federico Rossi, Mirko Filipponi, Beatrice Castellani, Stefania Bonafoni, Chaouki Ghenai

“…In our study, we propose a novel procedure to measure <i>RF</i> continuous time history by means of ground measurements, astronomical equations, and satellite calibration. …”
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A spiraling journey into the small bowel: a case series of novel motorized power spiral enteroscopies by Madhura Prasad, MD, MRCP(UK) DNB(Gastro), FTE, V.G. Mohan Prasad, MD, DM(Gastro), FASGE, FRCP(E), FICP, FSGEI, A. Sangameswaran, MD, DM(Gastro), FTE, Sunil Chacko Verghese, MD, DM(Gastro), Vamsi Murthy, MD, DM(Gastro), Mithra Prasad, MD, DM(Hepatology), Gokul Kruba Shanker, MS, Santhosh Koppal, MS

“…Background and aims: The small bowel has, to date, remained a difficult area to access via endoscopy. The novel motorized power spiral enteroscopy, recently introduced, has more depth of insertion and is of shorter duration. …”
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A Novel Conserved Protein in Streptococcus agalactiae, BvaP, Is Important for Vaginal Colonization and Biofilm Formation by Lamar S. Thomas, Laura C. Cook

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Eradication of early MRSA infection in cystic fibrosis: a novel study design for the STAR-ter trial by Fiona Cunningham, Ellen Caldwell, Nicole Mayer-Hamblett, Christopher H. Goss, Marianne S. Muhlebach

“…Our prior randomised study (Staph Aureus Resistance-Treat Or Observe (STAR-too)) showed improved clearance and outcomes with aggressive therapy compared to no treatment. We present a novel trial design to guide treatment for eradicating incident infection with a focus on feasibility. …”
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