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Repositioning of Cefuroxime as novel selective inhibitor of the thyroid hormone activating enzyme type 2 deiodinase
Published 2023-03-01“…Here, we describe the cephalosporin Cefuroxime as a novel D2 specific inhibitor. In both in vivo and in vitro settings, Cefuroxime acts as a selective inhibitor of D2 activity, without altering the enzymatic activity of D1 and D3. …”
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A novel CT-emphysema index/FEV1 approach of phenotyping COPD to predict mortality
Published 2018-08-01“…Li-Cher Loh,1 Choo-Khoon Ong,1 Hyun-Jung Koo,2 Sang Min Lee,2 Jae-Seung Lee,3 Yeon-Mok Oh,3 Joon-Beom Seo,2 Sang-Do Lee3 1Department of Medicine, RCSI & UCD Malaysia Campus, Penang, Malaysia; 2Department of Radiology, Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; 3Department of Pulmonary and Critical Care Medicine, and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea Background: COPD-associated mortality was examined using a novel approach of phenotyping COPD based on computed tomography (CT)-emphysema index from quantitative CT (QCT) and post-bronchodilator (BD) forced expiratory volume in 1 second (FEV1) in a local Malaysian cohort.Patients and methods: Prospectively collected data of 112 eligible COPD subjects (mean age, 67 years; male, 93%; mean post-BD FEV1, 45.7%) was available for mortality analysis. …”
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Identifying novel subgroups in heart failure patients with unsupervised machine learning: A scoping review
Published 2022-07-01“…Many studies reported a variety of novel subgroups in heart failure patients, with unsupervised machine learning methods. …”
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Assessment and Prognosis in CSA-AKI Using Novel Kidney Injury Biomarkers: A Prospective Observational Study
Published 2021-08-01“…The TNF-α, MMP-9, IL-18, TIMP-1 and MMP-9/TIMP-1 ratio in the early postoperative period correlated with long-term kidney function impairment; Conclusions: Novel kidney injury biomarkers are an eligible tool for early diagnosis of CSA-AKI. …”
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A Novel Technique of Urethroplasty Could Reduce Urethra-Related Complications in Phalloplasty With Urethral Lengthening
Published 2022-12-01“…Introduction: Urethral lengthening in phalloplasty could bring many postoperative complications, such as urethra fistula and stricture, which greatly affects the patient's mental health and quality of life. Aim: To describe a novel technique of vaginal mucosal graft for prelamination urethra (VMGPU) combined with modified urethral anastomosis (MUA) for the reconstruction of a neourethra. …”
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Prognostic Effect of a Novel Simply Calculated Nutritional Index in Acute Decompensated Heart Failure
Published 2020-10-01“…The TCB index (triglycerides × total cholesterol × body weight), a novel simply calculated nutritional index based on serum triglycerides (TGs), serum total cholesterol (TC), and body weight (BW), was recently reported to be a useful prognostic indicator in patients with coronary artery disease. …”
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A novel risk score to predict deep vein thrombosis after spontaneous intracerebral hemorrhage
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Pharmacokinetics of hydroxychloroquine in paediatric lupus: data from a novel, direct-to-family clinical trial
Published 2022-07-01“…Children enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry with a diagnosis of pSLE were eligible if they were receiving HCQ as standard of care for ≥3 months. …”
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The Application of Next-Generation Sequencing to Define Factors Related to Oral Cancer and Discover Novel Biomarkers
Published 2020-10-01“…The findings of existing miRNAs (e.g., miR-21) as well as novel discoveries pertaining to OSCC are also covered. …”
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Epicardial Adipose Tissue: A Novel Potential Imaging Marker of Comorbidities Caused by Chronic Inflammation
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Identification of novel drug targets and screening potential drugs against Cryptococcus gattii: An in silico approach
Published 2023-01-01“…The subcellular locations and their interactions with a high number of proteins also demonstrate their eligibility as putative drug targets. These proteins were docked with 21 potential antifungal plant metabolites. …”
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A Novel UHPLC-MS/MS Method for the Quantification of Seven Opioids in Different Human Tissues
Published 2023-06-01Get full text
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Probiotic management and inflammatory factors as a novel treatment in cirrhosis: A systematic review and meta-analysis
Published 2023-10-01“…Up to December 2022, eligible studies were identified by searching the following databases: National Knowledge Infrastructure (CNKI), Wanfang Data, Web of Science, PubMed, Embase, Medline, and the Cochrane Library. …”
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Percutaneous retrieval of embolized Amplatzer septal occluder from pulmonary artery using a novel method
Published 2018-09-01“…Presently described is the retrieval of an embolized device with a novel percutaneous technique.…”
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Initial Experience in Transvenous Implantation of a Left Ventricular Lead With a Novel Venogram Balloon Catheter
Published 2022-06-01“…This paper reports the initial clinical experience of CS cannulation and left ventricular lead implantation guided by a novel venogram balloon catheter (Lee’s venogram balloon catheter).Methods and ResultsConsecutive patients eligible for CRT were deemed suitable for this novel venogram balloon catheter. …”
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A Novel Measurement-Based Method for Assessing Global Warming Mitigation via High-Albedo Solutions
Published 2022-08-01“…In our study, we propose a novel procedure to measure <i>RF</i> continuous time history by means of ground measurements, astronomical equations, and satellite calibration. …”
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A spiraling journey into the small bowel: a case series of novel motorized power spiral enteroscopies
Published 2020-11-01“…Background and aims: The small bowel has, to date, remained a difficult area to access via endoscopy. The novel motorized power spiral enteroscopy, recently introduced, has more depth of insertion and is of shorter duration. …”
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Eradication of early MRSA infection in cystic fibrosis: a novel study design for the STAR-ter trial
Published 2022-12-01“…Our prior randomised study (Staph Aureus Resistance-Treat Or Observe (STAR-too)) showed improved clearance and outcomes with aggressive therapy compared to no treatment. We present a novel trial design to guide treatment for eradicating incident infection with a focus on feasibility. …”
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