Effectiveness and safety of human type 5 recombinant adenovirus (H101) in malignant tumor with malignant pleural effusion and ascites: A multicenter, observational, real‐world stud... by Baocheng Wang, Chen Zhong, Zijun Liao, Haitao Wang, Xiuyu Cai, Yanbing Zhang, Jun Wang, Tianxiao Wang, Hongtao Yao

“…Results A total of 643 eligible patients were enrolled, and 467 received H101 monotherapy and 176 received H101 combined with chemotherapy. …”
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Psychological distress among women undergoing in vitro fertilization-embryo transfer: A cross-sectional and longitudinal network analysis by Liuliu Wu, Lijing Sun, Juan Wang, Yaoyao Sun, Xuan Zhang, Yongqi Huang, Yan’e Lu, Fenglin Cao

“…Furthermore, the change trajectory network indicated that “suicide ideation” became more closely related to guilt but not to worrying too much over time.ConclusionThis study provides novel insights into the changes in central features, connections, and bridge symptoms during IVF-ET treatment and identified several bridge symptoms separately at different stages, which could activate the connection between psychopathology symptoms. …”
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Therapeutic Evaluation of <i>Bifidobacterium animalis</i> subsp. <i>lactis</i> MH-02 as an Adjunctive Treatment in Patients with Reflux Esophagitis: A Randomized, Double-Blind, Pla... by Lihong Gan, Yufan Wang, Shenan Huang, Li Zheng, Qi Feng, Hui Liu, Peng Liu, Kaige Zhang, Tingtao Chen, Nian Fang

“…Collectively, these results support the beneficial effects of MH-02 as a novel complementary strategy in RE routine treatment.…”
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Underlying beneficial effects of Rhubarb on constipation-induced inflammation, disorder of gut microbiome and metabolism by Han Gao, Chengwei He, Rongxuan Hua, Chen Liang, Boya Wang, Yixuan Du, Shuzi Xin, Yuexin Guo, Lei Gao, Lucia Zhang, Hongwei Shang, Jingdong Xu

“…Despite the usage of rhubarb extract to relieve constipation, novel targets and genes implicated in target-relevant pathways with remarkable functionalities should still be sought for.Materials and methods: We established a reliable constipation model in C57B/6N male mice using intragastric administration diphenoxylate, and the eligible subjects received 600 mg/25 g rhubarb extract to alleviate constipation. …”
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The Effectiveness of Interventions Delivered Using Digital Food Environments to Encourage Healthy Food Choices: A Systematic Review and Meta-Analysis by Rebecca Wyse, Jacklyn Kay Jackson, Tessa Delaney, Alice Grady, Fiona Stacey, Luke Wolfenden, Courtney Barnes, Matthew McLaughlin, Sze Lin Yoong

“…As such, digital food environments represent a novel platform to deliver strategies to improve public health nutrition. …”
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Clinical Characteristics of Patients with Myocarditis following COVID-19 mRNA Vaccination: A Systematic Review and Meta-Analysis by Reem H. Matar, Rania Mansour, Hayato Nakanishi, Karen Smayra, Joe El Haddad, Dilip K. Vankayalapati, Rohan Suresh Daniel, Danijel Tosovic, Christian A. Than, Mohamad H. Yamani

“…This meta-analysis presents novel evidence to suggest possible myocarditis post mRNA vaccination in certain individuals, especially young male patients. …”
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Successful therapeutic strategy for a patient with obese end-stage kidney disease by simultaneous laparoscopic sleeve gastrectomy and implantation of a buried peritoneal dialysis c... by Tomohisa Yamashita, Tomohisa Yamashita, Tatsuya Sato, Tatsuya Sato, Kazuyuki Yamamoto, Atsuko Abiko, Keitaro Nishizawa, Masahiro Matsuda, Yuma Ebihara, Takeshi Maehana, Toshiaki Tanaka, Toshiyuki Yano, Hironori Kobayashi

“…He hoped for kidney transplantation but was not eligible due to his high body mass index (BMI) (36.9 kg/m2). …”
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Identifying misdiagnosed bipolar disorder using support vector machine: feature selection based on fMRI of follow-up confirmed affective disorders by Xiaowei Jiang, Bo Cao, Chao Li, Linna Jia, Yi Jing, Wei Cai, Wenhui Zhao, Qikun Sun, Feng Wu, Lingtao Kong, Yanqing Tang

“…After follow-up, 23 patients transformed into BD (tBD), and 69 patients whose diagnoses remained unchanged were eligible for unipolar depression (UD). A support vector machine classifier was trained on the amygdala-based functional connectivity (FC) of 48 BD and 50 UD patients using a novel region-based feature selection. …”
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Prostate Cancer Brain Metastasis: Review of a Rare Complication with Limited Treatment Options and Poor Prognosis by Kobisha Rajeswaran, Kaitlin Muzio, Juan Briones, Mary Jane Lim-Fat, Chia-Lin Tseng, Martin Smoragiewicz, Jay Detsky, Urban Emmenegger

“…Future research is needed to study the impact of novel prostate cancer therapeutics on BM incidence, to identify patients at risk of BM, and to characterize molecular treatment targets.…”
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Mezagitamab in systemic lupus erythematosus: clinical and mechanistic findings of CD38 inhibition in an autoimmune disease by Richard A Furie, Van Anh Nguyen, Feng Hong, Scott R P McDonnell, Noah M Walton, Carsten Merkwirth, Deborah Berg, Elena Tomaselli Muensterman

“…These findings reveal novel insights into the drug’s mechanism of action and support the continued investigation of mezagitamab in autoimmune diseases.…”
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AI as a Medical Device for Ophthalmic Imaging in Europe, Australia, and the United States: Protocol for a Systematic Scoping Review of Regulated Devices by Ariel Yuhan Ong, Henry David Jeffry Hogg, Aditya U Kale, Priyal Taribagil, Ashley Kras, Eliot Dow, Trystan Macdonald, Xiaoxuan Liu, Pearse A Keane, Alastair K Denniston

“… BackgroundArtificial intelligence as a medical device (AIaMD) has the potential to transform many aspects of ophthalmic care, such as improving accuracy and speed of diagnosis, addressing capacity issues in high-volume areas such as screening, and detecting novel biomarkers of systemic disease in the eye (oculomics). …”
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Advanced Non-Clear Cell Renal Cell Carcinoma Treatments and Survival: A Real-World Single-Centre Experience by Davide Bimbatti, Francesco Pierantoni, Eleonora Lai, Melissa Ballestrin, Nicolò Cavasin, Elisa Erbetta, Chiara De Toni, Umberto Basso, Marco Maruzzo

“…Prospective trials for nccRCC patients utilizing novel therapies are ongoing and their results eagerly awaited.…”
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Immune Checkpoint Inhibitors as a Neoadjuvant/Adjuvant Treatment of Muscle-Invasive Bladder Cancer: A Systematic Review by Biagio Barone, Armando Calogero, Luca Scafuri, Matteo Ferro, Giuseppe Lucarelli, Erika Di Zazzo, Enrico Sicignano, Alfonso Falcone, Lorenzo Romano, Luigi De Luca, Francesco Oliva, Benito Fabio Mirto, Federico Capone, Ciro Imbimbo, Felice Crocetto

“…Immune checkpoint inhibitors represent a novel class of immunotherapy drugs that restore natural antitumoral immune activity via the blockage of inhibitory receptors and ligands expressed on antigen-presenting cells, T lymphocytes and tumour cells. …”
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Inflammatory and Nutritional Scoring System for Predicting Prognosis in Patients with Newly Diagnosed Multiple Myeloma by Zhang L, Chen S, Wang W, Wang Y, Liang Y

“…In the time-dependent ROC analysis, our nomogram model exhibited better performance than other staging systems for multiple myeloma.Conclusion: The INS represents an independent prognostic signature in patients with NDMM. Our novel nomogram based on INS may aid in predicting survival probability and stratifying risk.Keywords: multiple myeloma, survival, prognostic, nomogram…”
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Intracranial Treatment in Melanoma Patients with Brain Metastasis Is Associated with Improved Survival in the Era of Immunotherapy and Anti-BRAF Therapy by Céline Dalmasso, Cécile Pagès, Léonor Chaltiel, Vincent Sibaud, Elisabeth Moyal, Ciprian Chira, Jean Christophe Sol, Igor Latorzeff, Nicolas Meyer, Anouchka Modesto

“…BMs occurred in 106 of 250 eligible patients (42.4%), 64 of whom received LT. …”
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Psychometric Evaluation of a Tablet-Based Tool to Detect Mild Cognitive Impairment in Older Adults: Mixed Methods Study by Josephine McMurray, AnneMarie Levy, Wei Pang, Paul Holyoke

“…The BrainFx SCREEN is a novel digital tool designed to assess cognitive impairment. …”
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Augmenting Traditional Support Groups for Adolescents With Type 1 Diabetes Using Instagram: Mixed Methods Feasibility Study by Faisal S Malik, Cara Lind, Sarah Duncan, Connor Mitrovich, Michael Pascual, Joyce P Yi-Frazier

“…Additionally, the use of Instagram posts helped facilitate peer discussions during the in-person support groups. ConclusionsThe novel combination of using Instagram to augment traditional in-person support groups was feasible and acceptable to adolescents with T1D. …”
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Next-Generation Sequencing Comparative Analysis of DNA Mutations between Blood-Derived Extracellular Vesicles and Matched Cancer Tissue in Patients with Grade 4 Glioblastoma by Paolo Rosa, Elena De Falco, Luca Pacini, Amedeo Piazza, Paolo Ciracì, Luca Ricciardi, Francesco Fiorentino, Sokol Trungu, Massimo Miscusi, Antonino Raco, Antonella Calogero

“…The understanding and monitoring of the mutational profile is important not only to reveal novel therapeutic targets in this set of patients, but also to ameliorate the clinical stratification of subjects and the prognostic significance. …”
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A new nomogram prediction model for pulmonary embolism in older hospitalized patients by Qingjun Liu, Jichen Xiao, Le Liu, Jiaolei Liu, Hong Zhu, Yanping Lai, Lin Wang, Xin Li, Yubao Wang, Jing Feng

“…Results: In total, 447 eligible older patients (290 PE patients and 157 non-PE patients) were enrolled. …”
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Adult mortality patterns in Yemen before and during armed conflict: evidence from a web survey of the global diaspora by Catherine R. McGowan, Mervat Alhaffar, Promise Ekoriko, Sawsan Al-Refai, Jamal Badr, Lucy Bell, Francesco Checchi

“…As the security situation has limited access to affected populations we have designed a novel alternative to local mortality surveys. Methods We used a web-based, respondent-driven sampling method to disseminate a mortality survey amongst the global Yemeni diaspora. …”
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