Right ventricular dysfunction and pulmonary hypertension in COVID-19: a meta-analysis of prevalence and its association with clinical outcome by Yudi Her Oktaviono, Eka Prasetya Budi Mulia, Kevin Luke, David Nugraha, Irma Maghfirah, Agus Subagjo

“…Bedside echocardiography examination could be considered as a novel risk stratification tool in COVID-19.…”
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Targeting the Alternative Complement Pathway With Iptacopan to Treat IgA Nephropathy: Design and Rationale of the APPLAUSE-IgAN Study by Dana V. Rizk, Brad H. Rovin, Hong Zhang, Naoki Kashihara, Bart Maes, Hernán Trimarchi, Vlado Perkovic, Matthias Meier, Dmitrij Kollins, Olympia Papachristofi, Alan Charney, Jonathan Barratt

“…Conclusions: APPLAUSE-IgAN will evaluate the benefits and safety of iptacopan, a novel targeted therapy for IgAN, in reducing complement-mediated kidney damage and thus slowing or preventing disease progression.…”
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Molecular Biology and Therapeutic Targets of Primitive Tracheal Tumors: Focus on Tumors Derived by Salivary Glands and Squamous Cell Carcinoma by Alessandro Marchioni, Roberto Tonelli, Anna Valeria Samarelli, Gaia Francesca Cappiello, Alessandro Andreani, Luca Tabbì, Francesco Livrieri, Annamaria Bosi, Ottavia Nori, Francesco Mattioli, Giulia Bruzzi, Daniele Marchioni, Enrico Clini

“…The past two decades have seen extraordinary progress in developing novel target treatment options, shifting the treatment paradigm for several cancers such as lung cancer. …”
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Switching from FOLFIRI plus cetuximab to FOLFIRI plus bevacizumab based on early tumor shrinkage in RAS wild‐type metastatic colorectal cancer: A phase II trial (HYBRID) by Hiroyuki Arai, Takashi Tsuda, Yu Sunakawa, Mototsugu Shimokawa, Kohei Akiyoshi, Shinya Tokunaga, Hirokazu Shoji, Kenji Kunieda, Masahito Kotaka, Toshihiko Matsumoto, Yusuke Nagata, Takuro Mizukami, Fumitaka Mizuki, Kathleen D. Danenberg, Narikazu Boku, Takako Eguchi Nakajima

“…Grade ≥3 acneiform rash, dry skin, and pruritus were not observed in any patients. Conclusions Our novel treatment strategy delivered acceptable survival outcomes and reduced severe dermatologic toxicities.…”
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A Target Animal Effectiveness Study on Adjuvant Peptide-Based Vaccination in Dogs with Non-Metastatic Appendicular Osteosarcoma Undergoing Amputation and Chemotherapy by Laura Marconato, Alessia Melacarne, Marina Aralla, Silvia Sabattini, Luca Tiraboschi, Valentina Ferrari, Offer Zeira, Andrea Balboni, Eugenio Faroni, Dina Guerra, Luciano Pisoni, Erica Ghezzi, Letizia Pettinari, Maria Rescigno

“…Despite efforts to develop novel treatment strategies, human and canine osteosarcomas continue to have poor prognosis and limited overall survival. …”
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Case Report: Subtotal Lymphoid and Total Marrow Irradiation as Bridge Therapy to CD19-Directed CAR T Cells in a Chemorefractory DLBCL With Leukemic Involvement by Simonetta Saldi, Vincenzo Maria Perriello, Lorenza Falini, Loredana Ruggeri, Christian Fulcheri, Sara Ciardelli, Alessandra Innocente, Stelvio Ballanti, Nicodemo Baffa, Leonardo Flenghi, Antonio Pierini, Cynthia Aristei, Brunangelo Falini

“…This extended radiotherapy approach may be an effective bridging therapy for chemorefractory DLBCL patients eligible for CAR T cells who present with a high tumor burden, including massive BM involvement associated with leukemic involvement. …”
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Role of Chinese Acupuncture in the Treatment for Chemotherapy-Induced Cognitive Impairment in Older Patients With Cancer: Protocol for a Randomized Controlled Trial by Sunyan Zhao, Jing Zhang, Haijun Wan, Chenjie Tao, Meng Hu, Wei Liang, Zhi Xu, Bingguo Xu, Jiaying Zhang, Guoxin Wang, Ping Li, Guangmei Lyu, Yongling Gong

“…ObjectiveOur study aims to directly contribute to the existing knowledge of this novel Chinese medicine mode in older patients with cancer enrolled at the Department of Oncology/Chinese Medicine, Nanjing First Hospital, China, thereby establishing the basis for further research. …”
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The SCIDOTS Project: evidence of benefits of an integrated tobacco cessation intervention in tuberculosis care on treatment outcomes by Awaisu, Ahmed, Nik Mohamed, Mohamad Haniki, Mohamad Noordin, Noorliza, Abd Aziz, Noorizan, Syed Sulaiman, Syed Azhar, Muttalif, Abdul Razak, Ahmad Mahayiddin, Aziah

“…Eleven sessions of individualized cognitive behavioral therapy with or without nicotine replacement therapy were provided to each participant in the integrated intervention group. The impacts of the novel approach on biochemically validated smoking cessation and TB treatment outcomes were measured periodically as appropriate. …”
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Muscle synergies for evaluating upper limb in clinical applications: A systematic review by Kunkun Zhao, Zhisheng Zhang, Haiying Wen, Bin Liu, Jianqing Li, Andrea d’Avella, Alessandro Scano

“…Most of the studies report that analyses on synergy number, structure, and activations provide novel insights on the physiopathology of motor control that cannot be gained with standard clinical assessments, and suggest that muscle synergies may be useful to personalize therapies and to develop new therapeutic strategies. …”
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Phytochemicals and bioactive compounds effective against acute myeloid leukemia: A systematic review by Chukwuebuka Egbuna, Kingsley C. Patrick‐Iwuanyanwu, Eugene N. Onyeike, Johra Khan, Santwana Palai, Sandip B. Patel, Vijaykumar K. Parmar, Garima Kushwaha, Omkar Singh, Jaison Jeevanandam, Suresh Kumarasamy, Chukwuemelie Zedech Uche, Mathiyazhagan Narayanan, Mithun Rudrapal, Uchenna Odoh, Ikenna Chikeokwu, Mihnea‐Alexandru Găman, Kaliyaperumal Saravanan, Jonathan C. Ifemeje, Shahira M. Ezzat, Michael C. Olisah, Chukwudi Jude Chikwendu, Kamoru A. Adedokun, Sikiru O. Imodoye, Ibrahim O. Bello, Hannington Twinomuhwezi, Chinaza Godswill Awuchi

“…Abstract This systematic review identified various bioactive compounds which have the potential to serve as novel drugs or leads against acute myeloid leukemia. …”
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AlcoChange: A digital therapeutic for patients with alcohol-related liver disease by Gautam Mehta, Su Lin, Aida Nadar, Bharadwaj PV, Ravi Kumar, Anu Balaji, Stewart Macdonald, Mohammed F. Sheikh, MohammadMahdi Saeidinejad, Shiv-Raj Sharma, Ji J. King, Rajeshwar P. Mookerjee, Lorraine McDonagh, Sarah A. Afuwape, Kevin Moore, Rajiv Jalan

“…The aim of this project was to develop and clinically test AlcoChange, a novel digital therapeutic for ARLD. Methods: AlcoChange was developed using validated behaviour change techniques and a digital alcohol breathalyser. …”
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The influence of shunting left/right portal vein branch on post-TIPS hepatic encephalopathy: a study protocol for multicenter randomized blinded controlled trial by Jingqin Ma, Jianjun Luo, Wen Zhang, Yongjie Zhou, Zihan Zhang, Minjie Yang, Zhiquan Zhuang, Li Ma, Jiaze Yu, Xin Zhou, Zhiping Yan

“…The safety and stability of TIPS have been greatly improved due to the improvements of related technologies and the emergence of various novel devices, but the incidence of hepatic encephalopathy (HE) after shunting (10–50%) hindered the widespread use of TIPS. …”
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General Anesthetics in CAncer REsection Surgery (GA-CARES) randomized multicenter trial of propofol vs volatile inhalational anesthesia: protocol description by Elliott Bennett-Guerrero, Jamie L. Romeiser, Samuel DeMaria, Jacob W. Nadler, Timothy D. Quinn, Sanjeev K. Ponnappan, Jie Yang, Aaron R. Sasson

“…This unfunded, pragmatic trial, uses a novel approach for data collection focusing on electronic sources. …”
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Quantitative Flow Ratio to Predict Non–Target‐Vessel Events Before Planned Staged Percutaneous Coronary Intervention in Patients With Acute Coronary Syndrome by Sarah Bär, Raminta Kavaliauskaite, Tatsuhiko Otsuka, Yasushi Ueki, Jonas Häner, Jonas Lanz, Monika Fürholz, Fabien Praz, Lukas Hunziker, George CM Siontis, Thomas Pilgrim, Stefan Stortecky, Sylvain Losdat, Stephan Windecker, Lorenz Räber

“…Quantitative flow ratio (QFR) is a novel noninvasive method to assess the hemodynamic significance of coronary stenoses. …”
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Clinicopathological and prognostic significance of long noncoding RNA MALAT1 in human cancers: a review and meta-analysis by Juan Li, Zhigang Cui, Hang Li, Xiaoting Lv, Min Gao, Zitai Yang, Yanhong Bi, Ziwei Zhang, Shengli Wang, Baosen Zhou, Zhihua Yin

“…Conclusions The present findings demonstrated that MALAT1 may be a novel biomarker for predicting survival outcome, lymph node metastasis and distant metastasis.…”
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Sequential Use of Carfilzomib and Pomalidomide in Relapsed Multiple Myeloma: A Report from the Canadian Myeloma Research Group (CMRG) Database by Arleigh McCurdy, Christopher P. Venner, Esther Masih-Khan, Martha Louzada, Richard LeBlanc, Michael Sebag, Kevin Song, Victor H. Jimenez-Zepeda, Rami Kotb, Moustafa Kardjadj, Hira Mian, Darrell White, Julie Stakiw, Muhammad Aslam, Anthony Reiman, Engin Gul, Donna Reece

“…The treatment of multiple myeloma has dramatically improved due to the availability of novel therapies that are highly effective and are quickly moving into first-line therapy. …”
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Digital Education for Health Professionals: An Evidence Map, Conceptual Framework, and Research Agenda by Lorainne Tudor Car, Selina Poon, Bhone Myint Kyaw, David A Cook, Victoria Ward, Rifat Atun, Azeem Majeed, Jamie Johnston, Rianne M J J van der Kleij, Mariam Molokhia, Florian V Wangenheim, Martin Lupton, Niels Chavannes, Onyema Ajuebor, Charles G Prober, Josip Car

“…ResultsWe identified 77 eligible systematic reviews. All of them included experimental studies and evaluated the effectiveness of digital education interventions in different health care disciplines or different digital education modalities. …”
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A visualized model for identifying optimal candidates for aggressive locoregional surgical treatment in patients with bone metastases from breast cancer by Yuexin Tong, Shaoqing Xu, Liming Jiang, Chengliang Zhao, Dongxu Zhao

“…Besides, there was no difference in survival between the estimated sur-non-benefit subset and the non-surgery group.ConclusionOur study further confirmed the significance of local surgery in BC patients with BM and proposed a novel tool to identify optimal surgical candidates.…”
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A CBT-based mobile intervention as an adjunct treatment for adolescents with symptoms of depression: a virtual randomized controlled feasibility trial by Vera N. Kulikov, Phoebe C. Crosthwaite, Shana A. Hall, Jessica E. Flannery, Gabriel S. Strauss, Elise M. Vierra, Xin L. Koepsell, Jessica I. Lake, Aarthi Padmanabhan

“…Spark was highly acceptable relative to published norms. The study's novel safety protocol efficiently detected and managed adverse events. …”
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Evaluation of an innovative mHealth-based integrated modality for smoking cessation in Chinese smokers: protocol for a randomized controlled trial by Shuilian Chu, Lin Feng, Yingting Zuo, Hang Jing, Di Zhang, Zhaohui Tong, Ju Shi, Haomiao Ma, Zhijin Zhang, Lirong Liang

“…As part of our efforts in smoking cessation, we developed a novel behavioral intervention delivery modality for smoking cessation that integrated three interventions using the WeChat app, called the “Way to Quit” modality (WQ modality). …”
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