Protocol for a feasibility randomised controlled study of a multicomponent intervention to promote a sustainable return to work of workers on long-term sick leave — PROWORK: PROmot... by Veronica Varela-Mato, Kate Godfree, Anwar Adem, Holly Blake, Craig Bartle, Guy Daly, Juliet Hassard, Richard Kneller, Caroline Meyer, Sean Russell, Steven Marwaha, Charlotte Kershaw, Kristina Newman, Joanna Yarker, Louise Thomson, Fehmidah Munir

“…Exploratory economic evaluation will be conducted to further inform a definitive trial. Discussion This is a novel intervention using a worker-manager approach to promote a sustainable return to work of workers on long-term sick leave due to poor mental wellbeing. …”
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Impact of genomic testing on urologists' treatment preference in favorable risk prostate cancer: A randomized trial by Samuel Carbunaru, Zequn Sun, Cordero McCall, Bernice Ofori, Norma Marshall, Heidy Wang, Michael Abern, Li Liu, Courtney M. P. Hollowell, Roohollah Sharifi, Patricia Vidal, Andre Kajdacsy‐Balla, Marin Sekosan, Karen Ferrer, Shoujin Wu, Marlene Gallegos, Peter H. Gann, Daniel Moreira, Lisa K. Sharp, Carol E. Ferrans, Adam B. Murphy

“…Abstract Introduction The Oncotype Dx Genomic Prostate Score (GPS) is a 17‐gene relative expression assay that predicts adverse pathology at prostatectomy. We conducted a novel randomized controlled trial to assess the impact of GPS on urologist's treatment preference for favorable risk prostate cancer (PCa): active surveillance versus active treatment (i.e., prostatectomy/radiation). …”
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Evaluation of C-reactive protein as predictor of adverse prognosis in acute myocardial infarction after percutaneous coronary intervention: A systematic review and meta-analysis fr... by Shijie Liu, Shijie Liu, Hongcheng Jiang, Hongcheng Jiang, Menaka Dhuromsingh, Menaka Dhuromsingh, Lei Dai, Lei Dai, Yue Jiang, Hesong Zeng, Hesong Zeng

“…Although recently emerges plenty of novel inflammatory biomarkers, the canonical inflammatory mediator C-reactive protein still plays an important role in prognosing adverse post-infarction complications.MethodsPubMed, Embase, and Medline were systematically searched from the establishment of databases up to December 2021, conforming with standards set forth by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.ResultsA total of 23 studies were eventually eligible for this meta-analysis, including 18,715 individuals. …”
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Association between organic cation transporter genetic polymorphisms and metformin response and intolerance in T2DM individuals: a systematic review and meta-analysis by Aiyu Peng, Aiyu Peng, Aiyu Peng, Chunmei Gong, Yuanfei Xu, Xiongshun Liang, Xiaoping Chen, Wenxu Hong, Junxia Yan, Junxia Yan

“…This evidence may provide novel insight into gene-oriented personalized medicine for diabetes.…”
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Proactive and Integrated Management and Empowerment in Parkinson’s Disease protocol for a randomised controlled trial (PRIME-UK) to evaluate a new model of care by Fiona E. Lithander, Emma Tenison, Jan Ypinga, Angelika Halteren, Matthew D. Smith, Katherine Lloyd, Edward W. Richfield, Danielle E. Brazier, Mícheál Ó Breasail, Agnes J. Smink, Chris Metcalfe, William Hollingworth, Bas Bloem, Marten Munneke, Yoav Ben-Shlomo, Sirwan K. L. Darweesh, Emily J. Henderson

“…Discussion This trial tests whether a novel model of care improves health and disease-related metrics including goal attainment and decreases hospitalisations whilst being more cost-effective than the current usual care. …”
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The Potential of Autologous Platelet-Rich Plasma Gel for Diabetic Foot Ulcer Care Among Older Adults: A Systematic Review and Meta-Analysis by Platini H, Adammayanti KA, Maulana S, Putri PMK, Layuk WG, Lele JAJMN, Haroen H, Pratiwi SH, Musthofa F, Mago A

“…Additionally, it does not lead to any rejection reaction.Objective: This study aims to assess the safety and efficacy of APG as a novel treatment of DFU compared with standard treatment in older adult patients.Methods: Randomized Controlled Trials (RCTs) were searched using PubMed, Cochrane, Google Scholar, Wiley, and PlosOne. …”
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Investigation of the Impact of Wellinks on the Quality of Life and Clinical Outcomes in Patients With Chronic Obstructive Pulmonary Disease: Interventional Research Study by Kerri A Pierz, Nicholas Locantore, Gretchen McCreary, Robert J Calvey, Nickole Hackney, Pooja Doshi, John Linnell, Abirammy Sundaramoorthy, Carol R Reed, Julie Yates

“… BackgroundWellinks is a remote disease management solution that provides novel chronic obstructive pulmonary disease (COPD) care delivery. …”
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Transcatheter mitral valve replacement in native mitral valve with severe mitral annular calcification: Skirting the Sapien 3 to reduce the risk of paravalvular leaks by Alberto Pozzoli, Tiziano Torre, Giovanni Pedrazzini, Giovanni Pedrazzini, Stefanos Demertzis, Stefanos Demertzis, Enrico Ferrari, Enrico Ferrari

“…The risk is further increased when patients fail to be eligible for any percutaneous treatment, particularly because circumferential calcifications involving the anterior leaflet suggest a critical obstruction of the left ventricular outflow tract (LVOT).ObjectivesThe objective of this study was to evaluate residual mitral regurgitation (MR) after surgical mitral valve replacement using a Sapien 3 Ultra (Edwards Lifesciences, CA, USA) transcatheter aortic valve implantation (TAVI) prosthesis, reinforced with a pericardial skirt, in high-risk selected patients with severe MAC.MethodsSince 2020, five high-risk patients (mean age 70 years; 63–76; four women) with severe mitral disease in the context of severe MAC (computed tomography-based mean MAC Score 8.2 ± 1.1) were operated on after we adopted this novel technique. …”
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Genetic epidemiology of inherited retinal diseases in a large patient cohort followed at a single center in Italy by Marianthi Karali, Francesco Testa, Valentina Di Iorio, Annalaura Torella, Roberta Zeuli, Margherita Scarpato, Francesca Romano, Maria Elena Onore, Mariateresa Pizzo, Paolo Melillo, Raffaella Brunetti-Pierri, Ilaria Passerini, Elisabetta Pelo, Frans P. M. Cremers, Gabriella Esposito, Vincenzo Nigro, Francesca Simonelli, Sandro Banfi

“…We identified a total of 1319 causative sequence variations in 132 genes, including 353 novel variants, and 866 possibly actionable genotypes for therapeutic approaches. …”
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Sarcoma Patients Admitted to the Intensive Care Unit (ICU): Predictive Relevance of Common Sepsis and Performance Parameters by Striefler JK, Binder PT, Brandes F, Rau D, Wittenberg S, Kaul D, Roohani S, Jarosch A, Schäfer FM, Öllinger R, Märdian S, Bullinger L, Eckardt KU, Kruse J, Flörcken A

“…Medizinische Klinik und Poliklinik, Klinik für Onkologie, Hämatologie und Knochenmarktransplantation mit Sektion Pneumologie, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, Hamburg, D-20246, Germany, Tel +49 152 228 24370, Fax +49 40 7410-58054, Email j.striefler@uke.dePurpose: Prognosis of sarcoma patients is improving, with a better understanding of sarcomagenesis revealing novel therapeutic targets. However, aggressive chemotherapy remains an essential part of treatment, bearing the risk of severe side effects that require intensive medical treatment. …”
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Essays on human capital development and effective public policy delivery in Peru by Smarrelli, G

“…I explore this empirically in the context of a Peruvian training intervention where principals had discretionary power over their decisions. Using novel data, I first find that higher alignment with the intervention is strongly associated with better school principals’ performance (measured using an index of task completion). …”

Pediatric post-discharge mortality in resource-poor countries: a systematic review and meta-analysisResearch in context by Martina Knappett, Vuong Nguyen, Maryum Chaudhry, Jessica Trawin, Jerome Kabakyenga, Elias Kumbakumba, Shevin T. Jacob, J. Mark Ansermino, Niranjan Kissoon, Nathan Kenya Mugisha, Matthew O. Wiens

“…Methods: Eligible studies published between January 1, 2017 and January 31, 2023, were retrieved using MEDLINE, Embase, and CINAHL databases. …”
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Chimeric antigen receptor (CAR) T‐cell therapy for people with relapsed or refractory diffuse large B‐cell lymphoma by Ernst, M, Oeser, A, Besiroglu, B, Caro-Valenzuela, J, Abd El Aziz, M, Monsef, I, Borchmann, P, Estcourt, LJ, Skoetz, N, Goldkuhle, M

“…With the introduction of chimeric antigen receptor (CAR) T‐cell therapy, a novel treatment option for these people is available. …”

Rationale and design of an investigator-initiated, multicenter, prospective, placebo-controlled, double-blind, randomized trial to evaluate the effects of finerenone on vascular st... by Atsushi Tanaka, Hirotaka Shibata, Takumi Imai, Hisako Yoshida, Motoaki Miyazono, Naohiko Takahashi, Daiju Fukuda, Yosuke Okada, Hiroki Teragawa, Satoru Suwa, Keisuke Kida, Masao Moroi, Isao Taguchi, Shigeru Toyoda, Michio Shimabukuro, Kengo Tanabe, Kenichi Tanaka, Masaomi Nangaku, Koichi Node, the FIVE-STAR trial investigators

“…Recently, it has been found that finerenone, a novel nonsteroidal selective MR antagonist, can robustly improve cardiorenal outcomes in patients with type 2 diabetes (T2D) and a wide spectrum of chronic kidney disease (CKD). …”
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Efficacy of adjunctive intensive transcranial direct current stimulation of different cortices in treatment-resistant depression: a study protocol for a randomized double-blinded s... by Yiming Chen, Dongbin Lyu, Fan Wang, Qinte Huang, Weichieh Yang, Mengke Zhang, Zheyi Wei, Shuxiang Shi, Shuqi Kong, Shentse Chen, Shuang He, Vivien Yang, Yiru Fang, Wu Hong

“…Our study may suggest that adjunctive intensive tDCS with left DLPFC positive stimulation or right OFC negative stimulation may be effective as a novel method to relieve depressive symptoms in patients with TRD. …”
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A Probiotic Intervention With Bifidobacterium longum NCC3001 on Perinatal Mood Outcomes (PROMOTE Study): Protocol for a Decentralized Randomized Controlled Trial by Melissa P S Toh, Chui Yuen Yang, Phei Cze Lim, Hui Li J Loh, Gabriela Bergonzelli, Luca Lavalle, Elias Mardhy, Tinu Mary Samuel, Elvira Suniega-Tolentino, Irma Silva Zolezzi, Lisa R Fries, Shiao Yng Chan

“…This decentralized trial design sets a precedent for similar studies, in addition to potentially providing novel evidence on the impact of BL NCC3001 on symptoms of perinatal mood disturbances. …”
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Impact of MAFLD on HBV-Related Stage 0/A Hepatocellular Carcinoma after Curative Resection by Yen-Po Lin, Shu-Hsien Lin, Chih-Chi Wang, Chih-Che Lin, Ding-Wei Chen, Ching-Hui Chuang, Pao-Yuan Huang, Chao-Hung Hung, Shih-Yu Yang, Wei-Ru Cho, Yu-Syuan Chen, Ming-Chao Tsai

“…Backgrounds and Aim: Metabolic-associated fatty liver dis-ease (MAFLD) is a novel term proposed in 2020 to avoid the exclusion of certain subpopulations, though the application of this term in the real world is very limited. …”
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Cardiovascular Toxicities Secondary to Biotherapy and Molecular Targeted Therapies in Neuroendocrine Neoplasms: A Systematic Review and Meta-Analysis of Randomized Placebo-Controll... by Charalampos Aktypis, Maria-Eleni Spei, Maria Yavropoulou, Göran Wallin, Anna Koumarianou, Gregory Kaltsas, Eva Kassi, Kosmas Daskalakis

“…A broad spectrum of novel targeted therapies with prime antitumor activity and/or ample control of hormonal symptoms together with an overall acceptable safety profile have emerged for patients with metastatic neuroendocrine neoplasms (NENs). …”
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Targeting Patients’ Cognitive Load for Telehealth Video Visits Through Student-Delivered Helping Sessions at a United States Federally Qualified Health Center: Equity-Focused, Mixe... by Marcy G Antonio, Alicia Williamson, Vaishnav Kameswaran, Ashley Beals, Elizabeth Ankrah, Shannon Goulet, Yucen Wang, Grecia Macias, Jade James-Gist, Lindsay K Brown, Sage Davis, Srijanani Pillai, Lorraine Buis, Tawanna Dillahunt, Tiffany C Veinot

“…We demonstrate how to design and report recruitment methods, reach, delivery process, and the preliminary impact of a novel equity-focused intervention. MethodsEarly into the COVID-19 pandemic a telehealth helping session was offered to patients at FQHC via phone. …”
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Community indicators for mental health in Europe: a scoping review by Petra Schoenweger, Petra Schoenweger, Michaela Kirschneck, Michaela Kirschneck, Katharina Biersack, Anna-Francesca Di Meo, Anna-Francesca Di Meo, Philipp Reindl-Spanner, Barbara Prommegger, Claudia Ditzen-Janotta, Claudia Ditzen-Janotta, Peter Henningsen, Helmut Krcmar, Jochen Gensichen, Caroline Jung-Sievers, Caroline Jung-Sievers, for the POKAL-Group, Jochen Vukas, Puya Younesi, Feyza Gökce, Victoria von Schrottenberg, Petra Schönweger, Hannah Schillock, Jonas Raub, Philipp Reindl-Spanner, Lisa Hattenkofer, Lukas Kaupe, Carolin Haas, Julia Eder, Vita Brisnik, Constantin Brand, Katharina Biersack

“…After the removal of duplicates, 10,059 records were screened against the eligibility criteria. In total, 169 studies were included in the final analysis. …”
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