Challenges in mapping European rare disease databases, relevant for ML-based screening technologies in terms of organizational, FAIR and legal principles: scoping review by Ralitsa Raycheva, Ralitsa Raycheva, Kostadin Kostadinov, Kostadin Kostadinov, Elena Mitova, Nataliya Bogoeva, Georgi Iskrov, Georgi Iskrov, Georgi Stefanov, Rumen Stefanov, Rumen Stefanov

“…BackgroundGiven the increased availability of data sources such as hospital information systems, electronic health records, and health-related registries, a novel approach is required to develop artificial intelligence-based decision support that can assist clinicians in their diagnostic decision-making and shorten rare disease patients’ diagnostic odyssey. …”
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Deep learning for real-time detection of breast cancer presenting pathological nipple discharge by ductoscopy by Feng Xu, Chuang Zhu, Zhihao Wang, Lei Zhang, Haifeng Gao, Zhenhai Ma, Yue Gao, Yang Guo, Xuewen Li, Yunzhao Luo, Mengxin Li, Guangqian Shen, He Liu, Yanshuang Li, Chao Zhang, Jianxiu Cui, Jie Li, Hongchuan Jiang, Jun Liu

“…All individuals with PND confirmed from breast lesions by ductoscopy were eligible. Images from Beijing Chao-Yang Hospital were randomly assigned (8:2) to the training (IDBCS development) and internal validation (performance evaluation of the IDBCS) datasets. …”
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PRECISION-TBI: a study protocol for a vanguard prospective cohort study to enhance understanding and management of moderate to severe traumatic brain injury in Australia by Belinda J Gabbe, Rinaldo Bellomo, Terence J O'Brien, Andrew Chow, Anthony Delaney, Michael Reade, Anthony Trapani, Andrew Udy, Melinda Fitzgerald, James Anstey, David Bowen, D James Cooper, Judith Bellapart, Toby Jeffcote, Camila R Battistuzzo, Mark P Plummer, Robert McNamara, Rebecca Roach, Torgeir Westerlund, Shailesh Bihari, Mark Weeden, Rosalind L Jeffree, Alistair D Nichol

“…It will also pilot high-frequency data collection and analysis techniques, novel clinical interventions, and comparative effectiveness methodology.Methods and analysis PRECISION-TBI will initially enrol 300 patients with msTBI with Glasgow Coma Scale (GCS) <13 requiring intensive care unit (ICU) admission for invasive neuromonitoring from 10 Australian neurotrauma centres. …”
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Integrating comprehensive genomic sequencing of non-small cell lung cancer into a public healthcare system by Kirstin Perdrizet, Tracy L. Stockley, Jennifer H. Law, Adam Smith, Tong Zhang, Roxanne Fernandes, Muqdas Shabir, Peter Sabatini, Nadia Al Youssef, Christine Ishu, Janice JN Li, Ming-Sound Tsao, Prodipto Pal, Michael Cabanero, Joerg Schwock, Hyang Mi Ko, Scott Boerner, Heather Ruff, Frances A. Shepherd, Penelope A. Bradbury, Geoffrey Liu, Adrian G. Sacher, Natasha B. Leighl

“…Incremental actionable alterations were identified in 31% of patients. The most common novel targets identified were mutations in ERBB2 (exon 20 insertions), MET (exon 14 skipping) and KRAS (G12C). …”
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An internet-based intervention with brief nurse support to manage obesity in primary care (POWeR+): a pragmatic, parallel-group, randomised controlled trial by Little, P, Stuart, B, Hobbs, F, Kelly, J, Smith, E, Bradbury, K, Hughes, S, Smith, P, Moore, M, Lean, M, Margetts, B, Byrne, C, Griffin, S, Davoudianfar, M, Hooper, J, Yao, G, Zhu, S, Raftery, J, Yardley, L

“…No adverse events were reported.Weight loss can be maintained in some individuals by use of novel written material with occasional brief nurse follow-up. …”

The risk of Plasmodium vivax parasitaemia after P. falciparum malaria: An individual patient data meta-analysis from the WorldWide Antimalarial Resistance Network by Hossain, MS, Commons, RJ, Douglas, NM, Thriemer, K, Alemayehu, BH, Amaratunga, C, Anvikar, AR, Ashley, EA, Asih, PBS, Carrara, VI, Lon, C, D’Alessandro, U, Davis, TME, Dondorp, AM, Edstein, MD, Fairhurst, RM, Ferreira, MU, Hwang, J, Janssens, B, Karunajeewa, H, Kiechel, JR, Ladeia-Andrade, S, Laman, M, Mayxay, M, McGready, R, Moore, BR, Mueller, I, Newton, PN, Thuy-Nhien, NT, Noedl, H, Nosten, F, Phyo, AP, Poespoprodjo, JR, Saunders, DL, Smithuis, F, Spring, MD, Stepniewska, K, Suon, S, Suputtamongkol, Y, Syafruddin, D, Tran, HT, Valecha, N, Van Herp, M, Van Vugt, M, White, NJ, Guerin, PJ, Simpson, JA, Price, RN

“…These P. vivax infections are likely attributable to relapses that could be prevented with radical cure including a hypnozoitocidal agent; however, the benefits of such a novel strategy will vary considerably between…”

2205 Thrombotic complications in single ventricle reconstructions for single ventricle physiology congenital heart disease by Michael H. White, Kavita Patel, Lazaros Kochilas, Robert F. Sidonio

“…Developing a predictive model will be a novel way to identify patients at risk for thrombosis and will set the stage for targeted prevention of thrombosis.…”
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Managing nirmatrelvir/ritonavir during COVID-19: pharmacists’ experiences from the Perak state of Malaysia by Chee Tao Chang, Su Yin Ong, Xin Jie Lim, Lan Sim Chew, Philip Rajan

“…Novel therapeutic agents for SARS-CoV-2 have emerged over time, serving to reduce the severity of the disease, admission and mortality, especially among high-risk populations. …”
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Machine Learning-Based Phenomapping in Patients with Heart Failure and Secondary Prevention Implantable Cardioverter-Defibrillator Implantation: A Proof-of-Concept Study by Yu Deng, Sijing Cheng, Hao Huang, Xi Liu, Yu Yu, Min Gu, Chi Cai, Xuhua Chen, Hongxia Niu, Wei Hua

“…Background: Previous studies have failed to implement risk stratification in patients with heart failure (HF) who are eligible for secondary implantable cardioverter-defibrillator (ICD) implantation. …”
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Risk stratification for early mortality in newly diagnosed acute promyelocytic leukemia: a multicenter, non-selected, retrospective cohort study by Suhyeon Kim, Jiye Jung, Seo-Yeon Ahn, Mihee Kim, So Yeon Jeon, Chang-Hoon Lee, Dae Sik Kim, Se Ryeon Lee, Hwa Jung Sung, Chul Won Choi, Byung-Soo Kim, Hyeoung-Joon Kim, Jae-Yong Kwak, Yong Park, Jae-Sook Ahn, Ho-Young Yhim

“…Our risk model serves as a clinically useful tool to identify high-risk patients for EM who may be candidates for novel treatments and aggressive supportive strategies.…”
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Risk factors for respiratory syncytial virus associated with acute lower respiratory infection in children under five years: Systematic review and meta–analysis by Ting Shi, Evelyn Balsells, Elizabeth Wastnedge, Zeba A Rasmussen, Heather J Zar, Barbara A Rath, Shabir A Madhi, Stuart Campbell, Linda Cheyenne Vaccari, Lisa R Bulkow, Elizabeth D Thomas, Whitney Barnett, Christian Hoppe, Harry Campbell, Harish Nair

“…We carried out a systematic literature review across 4 databases and obtained unpublished studies from RSV Global Epidemiology Network (RSV GEN) collaborators. Quality of all eligible studies was assessed according to modified GRADE criteria. …”
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Diagnostic performance of 99mTc-HYNIC-PSMA SPECT/CT for biochemically recurrent prostate cancer after radical prostatectomy by Bo Li, Bo Li, Lili Duan, Jingqi Shi, Yunyun Han, Wei Wei, Xiaoliang Cheng, Yong Cao, Akeban Kader, Degang Ding, Xinyu Wu, Yongju Gao

“…Objectives99mTc-HYNIC-PSMA is a novel technetium-99m-labeled small-molecule inhibitor of prostate-specific membrane antigen (PSMA) for detection of prostate cancer. …”
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Menstrual symptoms and subjective well-being among postmenarchal adolescentsAJOG Global Reports at a Glance by Pietro Gambadauro, MD, MSc (Med Ed), PhD, Gergö Hadlaczky, MSc, PhD, Danuta Wasserman, MD, PhD, Vladimir Carli, MD, PhD

“…Postmenarchal respondents were eligible for analysis; those with incomplete outcome data or using hormonal contraception were excluded. …”
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Treatment Response After Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) for Peritoneal Metastases of Colorectal Originf by Martin Hübner, MD, S. P. Somashekhar, MD, Hugo Teixeira Farinha, MD, Julio Abba, MD, Ramya G. Rao, PhD, Mohammad Alyami, MD, Wouter Willaert, MD, PhD, on behalf of the PIPAC study group, Brigand Cecile, MD, Delhorme Jean-Baptiste, MD, PhD, Romain Benoit, MD, PhD, Charleux-Muller Diane, MD, Bertin Jean-Baptiste, MD, Rohr Serge, MD, Jager Tarkan, MD, Neureiter Daniel, MD, Schredl Philipp, MD, Weiss Lukas, MD, Klieser Eckhard, MD, Emmanuel Klaus, MD, Sgarbura Olivia, MD, PhD, Bouillin Alix, MD, Khellaf Lakhdar, MD, Nougaret Stephanie, MD, PhD, Samalin Emmanuelle, MD, Mazard Thibault, MD, PhD, Glehen Olivier, MD, PhD, Kepenekian Vahan, MD, PhD, Villeneuve Laurent, PhD, Hubner Martin, Demartines Nicolas, MD, Teixeira-Farinha Hugo, MD, Clerc Daniel, MD, Dromain Clarisse, MD, Sempoux Christine, MD, PhD, Robella Manuela, MD, Vaira Marco, MD, De Simone Michele, MD, Di Giorgio Andrea, MD, Ferracci Federica, MD, Rotolo Stefano, MD, Schena Carlo Alberto, MD, Inzani Frediano, MD, Bagala Cinzia, MD, Babucke Maximilian, MD, Piso Pompiliu, PhD, MD, Somashekhar s p, MD, Ashwin KR, DNB, Rohit Kumar, DNB, Susmita Rakshit, MBBS, MD, Amit Rauthan, DM, Bhatt Aditi, MS, MCh., Shaikh Sakina, BH,MS, MBA, Parikh Loma, MD, Sheth Sandeep, MD, Panchal Amee, MD, Thakkar Shweta, MD, Ezzano Anne-Cecile, MD, Aime Adeline, MD, Eveno Clarisse, MD, PhD, Noiret Barbara, MD, Khomiakov Vladimir, PhD, Ryabov Andrey, PhD, Utkina Anna, PhD, Aksenov Sergey, MD, Bolotina Larisa, PhD, Kaprin Andrey, PhD, Willaert Wouter, MD, PhD, Cosyns Sarah, PhD, MSc, Akhayad Soumaya, BSN, Ceelen Wim, MD, PhD, Gockel Ines, MD, Jansen-Winkeln Boris, MD, Thieme Rene, PhD, Schierle Katrin, MD, Moulla Yusef, MD, Mehdorn Matthias, MD, Abba Julio, MD, Trilling Bertrand, MD, PhD, Tidadini Fatah, MSc, Bonne Aline, MD, Arvieux Catherine, MD, PhD, Orry David, MD, Basso Valeria, MD, Ghiringhelli Francois, MD, PhD, Escayola Cecilia, MD, Torrent Juan Jose, MD, Alyami Mohammad, MD, Alqannas Mashhour, MD, Cortes Guiral Delia, MD, PhD, Alammari samer, MD, Bashanfer Galal, MD, Alshukami Anwar, MD, Reymond Marc A., MD, Solass Wiebke, MD, Nadiradze Giorgi, MD

“…PIPAC has been demonstrated to be a feasible and safe novel treatment for patients with PM of various origins. …”
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The risk of Plasmodium vivax parasitaemia after P. falciparum malaria: An individual patient data meta-analysis from the WorldWide Antimalarial Resistance Network. by Mohammad S Hossain, Robert J Commons, Nicholas M Douglas, Kamala Thriemer, Bereket H Alemayehu, Chanaki Amaratunga, Anupkumar R Anvikar, Elizabeth A Ashley, Puji B S Asih, Verena I Carrara, Chanthap Lon, Umberto D'Alessandro, Timothy M E Davis, Arjen M Dondorp, Michael D Edstein, Rick M Fairhurst, Marcelo U Ferreira, Jimee Hwang, Bart Janssens, Harin Karunajeewa, Jean R Kiechel, Simone Ladeia-Andrade, Moses Laman, Mayfong Mayxay, Rose McGready, Brioni R Moore, Ivo Mueller, Paul N Newton, Nguyen T Thuy-Nhien, Harald Noedl, Francois Nosten, Aung P Phyo, Jeanne R Poespoprodjo, David L Saunders, Frank Smithuis, Michele D Spring, Kasia Stepniewska, Seila Suon, Yupin Suputtamongkol, Din Syafruddin, Hien T Tran, Neena Valecha, Michel Van Herp, Michele Van Vugt, Nicholas J White, Philippe J Guerin, Julie A Simpson, Ric N Price

“…These P. vivax infections are likely attributable to relapses that could be prevented with radical cure including a hypnozoitocidal agent; however, the benefits of such a novel strategy will vary considerably between geographical areas.…”
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Introducing pulse oximetry for outpatient management of childhood pneumonia: An implementation research adopting a district implementation model in selected rural facilities in Ban... by Ahmed Ehsanur Rahman, Shafiqul Ameen, Aniqa Tasnim Hossain, Janet Perkins, Sabrina Jabeen, Tamanna Majid, AFM Azim Uddin, Md. Ziaul Haque Shaikh, Muhammad Shariful Islam, Md. Jahurul Islam, Sabina Ashrafee, Husam Md. Shah Alam, Ashfia Saberin, Sabbir Ahmed, Goutom Banik, ANM Ehtesham Kabir, Anisuddin Ahmed, Mohammod Jobayer Chisti, Steve Cunningham, David H Dockrell, Harish Nair, Shams El Arifeen, Harry Campbell

“…Findings: We observed that IMCI service-providers conducted pulse oximetry assessments on all eligible children in routine outpatient settings, of which 99% of assessments were successful; 85% (95% CI 83,87) in one attempt, and 69% (95% CI 67,71) within one minute. …”
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Application of Virtual Reality-Assisted Exergaming on the Rehabilitation of Children with Cerebral Palsy: A Systematic Review and Meta-Analysis by Muhammad Abubaker Tobaiqi, Emad Ali Albadawi, Hammad Ali Fadlalmola, Muayad Saud Albadrani

“…To overcome this problem, virtual reality VR-assisted exergaming has emerged as a novel modality of physiotherapy that combines fun and motivation with physical activity. …”
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Patient experience with chronic obstructive pulmonary disease: a nationally representative demonstration study on quality and cost of healthcare services by Seyyed-Hadi Ghamari, Farnam Mohebi, Mohsen Abbasi-Kangevari, Soheil Peiman, Besharat Rahimi, Naser Ahmadi, Yousef Farzi, Shahedeh Seyfi, Nazila Shahbal, Mitra Modirian, Mehrdad Azmin, Hossein Zokaei, Maryam Khezrian, Roya Sherafat, Mohammad-Reza Malekpour, Shahin Roshani, Negar Rezaei, Negar Rezaei, Mohammad Javad Fallahi, Mohammad Javad Fallahi, Maryam Haddadzadeh Shoushtari, Zahra Akbaripour, Shahab Khatibzadeh, Saeid Shahraz

“…Pulmonologists confirmed eligible participants and nurses recruited and followed them up for 3  months/in 4 visits. …”
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Analysis of resistance mechanisms to abivertinib, a third-generation EGFR tyrosine kinase inhibitor, in patients with EGFR T790M-positive non-small cell lung cancer from a phase I... by Yi-Chen Zhang, Zhi-Hong Chen, Xu-Chao Zhang, Chong-Rui Xu, Hong-Hong Yan, Zhi Xie, Shao-Kun Chuai, Jun-Yi Ye, Han Han-Zhang, Zhou Zhang, Xiao-Yan Bai, Jian Su, Bin Gan, Jin-Ji Yang, Wen-Feng Li, Wei Tang, Feng Roger Luo, Xiao Xu, Yi-Long Wu, Qing Zhou

“…Here, we report resistance mechanisms to abivertinib, a novel third-generation EGFR TKI, from a phase I dose-escalation/expansion study (NCT02330367). …”
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Safety and efficacy of HSP90 inhibitor ganetespib for neoadjuvant treatment of stage II/III breast cancer by Julie E. Lang, Andres Forero-Torres, Douglas Yee, Christina Yau, Denise Wolf, John Park, Barbara A. Parker, A. Jo Chien, Anne M. Wallace, Rashmi Murthy, Kathy S. Albain, Erin D. Ellis, Heather Beckwith, Barbara B. Haley, Anthony D. Elias, Judy C. Boughey, Rachel L. Yung, Claudine Isaacs, Amy S. Clark, Hyo S. Han, Rita Nanda, Qamar J. Khan, Kristen K. Edmiston, Erica Stringer-Reasor, Elissa Price, Bonnie Joe, Minetta C. Liu, Lamorna Brown-Swigart, Emanuel F. Petricoin, Julia D. Wulfkuhle, Meredith Buxton, Julia L. Clennell, Ashish Sanil, Scott Berry, Smita M. Asare, Amy Wilson, Gillian L. Hirst, Ruby Singhrao, Adam L. Asare, Jeffrey B. Matthews, Michelle Melisko, Jane Perlmutter, Hope S. Rugo, W. Fraser Symmans, Laura J. van ‘t Veer, Nola M. Hylton, Angela M. DeMichele, Donald A. Berry, Laura J. Esserman

“…Patients with HER2-negative breast cancer were eligible for randomization to ganetespib from October 2014 to October 2015. …”
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