Exosomes as a delivery tool of exercise-induced beneficial factors for the prevention and treatment of cardiovascular disease: a systematic review and meta-analysis by Zhijie Lai, Jiling Liang, Jingfeng Zhang, Yuheng Mao, Xinguang Zheng, Xiang Shen, Wentao Lin, Wentao Lin, Guoqin Xu, Guoqin Xu

“…Exercise-derived exosomes have been identified as novel players in mediating cell-to-cell communication in the beneficial effects of improving cardiovascular disease (CVD). …”
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Noninvasive, patient-specific computational fluid dynamics simulations of dural venous sinus pressures in idiopathic intracranial hypertension by Patrick Fillingham, Swati Rane Levendovszky, Jalal Andre, Michael Bindschadler, Seth Friedman, Mehmet Kurt, Alberto Aliseda, Michael R. Levitt

“…Objective: To develop a novel method of non-invasive, patient-specific computational fluid dynamic (CFD) simulation of venous sinus hemodynamics for evaluating stenting eligibility. …”
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Association between Temporal Muscle Thickness and Overall Survival in Non-Small Cell Lung Cancer Patients with Brain Metastasis by Young Il Kim, Ja Young Shin, Seung Ho Yang, Hyun Ho Kim, Byoung Yong Shim, Stephen Ahn

“…Temporal muscle thickness (TMT) has recently been suggested as a novel biomarker of sarcopenia in head and neck malignancies. …”
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Quantitative serial MRI of the treated fibroid uterus. by Kirsty I Munro, Michael J Thrippleton, Alistair R W Williams, Graham McKillop, Jane Walker, Andrew W Horne, David E Newby, Richard A Anderson, Scott I Semple, Ian Marshall, Steff C Lewis, Robert P Millar, Mark E Bastin, Hilary O D Critchley

“…There are no long-term medical treatments for uterine fibroids, and non-invasive biomarkers are needed to evaluate novel therapeutic interventions. The aim of this study was to determine whether serial dynamic contrast-enhanced MRI (DCE-MRI) and magnetization transfer MRI (MT-MRI) are able to detect changes that accompany volume reduction in patients administered GnRH analogue drugs, a treatment which is known to reduce fibroid volume and perfusion. …”
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Social vulnerability indices: a scoping review by Jasmine Cassy Mah, Jodie Lynn Penwarden, Henrique Pott, Olga Theou, Melissa Kathryn Andrew

“…Conclusions We provide an overview of SVIs in the literature up to December 2021, providing a novel summary of commonly used variables for social vulnerability indices. …”
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Four-dimensional flow cardiovascular magnetic resonance in tetralogy of Fallot: a systematic review by Ayah Elsayed, Kathleen Gilbert, Miriam Scadeng, Brett R. Cowan, Kuberan Pushparajah, Alistair A. Young

“…Results Of the 635 articles identified, 26 studies met eligibility for systematic review. None of these were below 59% applicability on the modified CASP score. …”
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Upper extremity asymmetry due to nerve injuries or central neurologic conditions: a scoping review by Sandesh G. Bhat, Alexander Y. Shin, Kenton R. Kaufman

“…A wide variety of validated and novel tests and sensors have been utilized to determine the upper extremity asymmetry. …”
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Understanding people’s decisions when choosing or declining a kidney transplant: a qualitative evidence synthesis by Jane Noyes, Leah McLaughlin, Emma Louise Jones, Kate Shakespeare

“…A new enhanced theoretical model was developed to aid understanding of the complexities of decision-making in people with kidney disease, by integrating the Theory of Planned Behaviour and the Adaptive Decision Maker Framework to incorporate the novel findings.Conclusion The synthesis provides a better understanding of the extremely complex decision-making processes of people with kidney disease, which are aligned to their kidney transplantation preferences. …”
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457 A Phase I Trial of Tazemetostat and Venetoclax in Relapsed and Refractory non-Hodgkin Lymphoma by Erin Mulvey, Lisa Roth

“…Phenotypic analysis (including BCL2 expression) and quantification of the tumor microenvironment in pre-treatment samples (using image mass cytometry)Explorato DISCUSSION/SIGNIFICANCE: There is a need for novel therapeutic approaches to improve the prognosis for patients with R/R NHL. …”
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A snapshot of nutrition incentive adaptation during COVID-19 by Cody Gusto, John Diaz, Laura Warner, Christine Overdevest, Catherine Campbell, Sebastian Galindo

“… Exacerbated food insecurity has been among the many challenges presented by the emergence of the novel coronavirus 2019 in the United States. In the wake of the pandemic, expanded focus has turned to the capacities of established federal nutrition assistance programs and emergent nutrition access models to address these challenges. …”
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Effects of early‐life exposure to dust mite allergen and endotoxin on the development of asthma and wheezing: The Japan Environment and Children's Study by Hideki Hasunuma, Yoshiko Yoda, Narumi Tokuda, Naoko Taniguchi, Yasuhiro Takeshima, Masayuki Shima, The Japan Environment and Children's Study (JECS) Group

“…We investigated the association of early‐life exposure (0–36 months old) to house dust mite allergen and endotoxin with asthma incidence. Methods In this novel, large‐scale, nationwide birth cohort study, 5017 participants were randomly selected from those who met the eligibility criteria. …”
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A Retrospective Narrative Mini-Review Regarding the Seminal Microbiota in Infertile Male by Bogdan Doroftei, Ovidiu-Dumitru Ilie, Ana-Maria Dabuleanu, Delia Hutanu, Constantin-Cristian Vaduva

“…<i>Background</i>: Infertility is a global burden that affects both sexes with the male component remaining as an explored yet crucial research field that might offer novel evidence. <i>Material and Methods</i>: The present narrative mini-review aims to summarize all existing literature regarding the composition of the seminal microflora in infertile men. …”
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Shared decision-making in advanced kidney disease: a scoping review by Anne M Stiggelbout, Noel Engels, Paul van der Nat, Marinus van den Dorpel, Gretchen N de Graav

“…Sixteen (n=16, 11%) were novel interventions currently under investigation. …”
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Rapid systematic review on developing web-based interventions to support people affected by cancer by David Nelson, Mark Gussy, Ros Kane, Samuel Cooke, Heidi Green, Kathie McPeake

“…Resource design and content should be developed around the user’s needs and preferences and evaluated through usability, feasibility or acceptability testing using quantitative, qualitative or mixed methods.Conclusion The findings of this rapid review provide novel methodological insights into the approaches used to design web-based interventions to support PABC. …”
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Do single‐case experimental designs lead to randomised controlled trials of cognitive behavioural therapy interventions for adolescent anxiety and related disorders recommended in... by Tom Cawthorne, Anton Käll, Sophie Bennett, Elena Baker, Emily Cheung, Roz Shafran

“…Nineteen articles met eligibility criteria including a total of 107 participants. …”
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Virtual focus groups among individuals with use disorders: assessing feasibility and acceptability in an underserved clinical population by Cecilia L. Bergeria, Brandon Park, Prem Umang Satyavolu, Kelly E. Dunn, Robert H. Dworkin, Eric C. Strain

“…Virtual focus groups are an innovative method for collecting data from individuals via a discreet and accessible platform which can inform novel as well as existing treatment approaches. This article reports on the feasibility and acceptability of virtual focus groups as a mechanism to recruit and engage geographically and demographically diverse samples of participants with substance use disorders that are otherwise logistically difficult to assess.MethodParticipants were assessed for eligibility for a virtual focus group study based on demographic features, drug use history, and psychiatric history via a remote, interview-based screening. …”
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Co-designing care for multimorbidity: a systematic review by Jennifer Sumner, Celeste Wen Ting Ng, Kimberly Ee Lin Teo, Adena Li Tyin Peh, Yee Wei Lim

“…Co-design aided the design of novel services and interventions for those with multimorbidity, improving their relevance, usability and acceptability. …”
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Valve-controlled chronic subdural hematoma drainage: A feasibility study by Vasileios Anagnostopoulos, Alexandros G. Brotis, Christos Tzerefos, Alexandra Charalambidou, Anastasia Tasiou, Antonios Karavelis, Konstantinos N. Paterakis

“…Research question: To study the feasibility and safety of a novel CSDH evacuation technique using a valve-controlled method to avoid pneumocephalus. …”
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“They say it’s fentanyl, but they honestly look like Perc 30s”: Initiation and use of counterfeit fentanyl pills by Raminta Daniulaityte, Kaylin Sweeney, Seol Ki, Bradley N. Doebbeling, Natasha Mendoza

“…Conclusion Our findings highlight the need for the implementation of novel policy, treatment, and harm reduction approaches to address the growing unpredictability of drug supply and NPF pill-specific risks, attitudes, and behaviors.…”
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Integrating patient values and preferences in healthcare: a systematic review of qualitative evidence by Tringale, M, Stephen, G, Boylan, A-M, Heneghan, C

“…Themes in this review provide a novel framework for understanding and addressing values integration in clinical care and provide useful insights for policymakers, educators and practitioners.…”