Feasibility, acceptability, and outcome responsiveness of the SYMPERHEART intervention to support symptom perception in persons with heart failure and their informal caregivers: a... by Gabrielle Cécile Santos, Maria Liljeroos, Kelly Tschann, Kris Denhaerynck, Justine Wicht, Corrine Y. Jurgens, Roger Hullin, Petra Schäfer-Keller

“…We aimed to test the feasibility, acceptability, and outcome responsiveness of a novel intervention (SYMPERHEART) delivered to persons with HF with their informal caregiver. …”
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Patient-reported measures for person-centered coordinated care: a comparative domain map and web-based compendium for supporting policy development and implementation by Lloyd, H, Wheat, H, Horrell, J, Sugavanam, T, Fosh, B, Valderas, J, Close, J

“…If chosen carefully and used efficiently, these tools can help improve care delivery through a variety of novel ways, including system-level feedback for health care management and commissioning. …”

Data Resource Profile: the Virtual International Care Homes Trials Archive (VICHTA) by Lisa Irvine, Jennifer Kirsty Burton, Myzoon Ali, Joanne Booth, James Desborough, Pip Logan, Esme Moniz-Cook, Claire Surr, David Wright, Claire Goodman

“…Conclusions VICHTA collates and makes accessible data on a complex and under-represented research population for novel analyses, and to inform design of future studies. …”
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Evaluation of the effectiveness of the Family Nurse Partnership home visiting programme in first time young mothers in Scotland: a protocol for a natural experiment by Fiona V Lugg-Widger, Michael Robling, Mandy Lau, Shantini Paranjothy, Jill Pell, Julia Sanders, James White, Rebecca Cannings-John

“…Discussion: The study protocol is based upon the specification of FNP commissioned by the Scottish Government. This study design is novel for the evaluation of the FNP/NFP programmes which are primarily evaluated with an RCT. …”
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Efficacy and safety of immune checkpoint inhibitors for patients with prostate cancer: a systematic review and meta-analysis by Maryam Noori, Maryam Noori, Shadi Azizi, Aref Mahjoubfar, Farhan Abbasi Varaki, Farimah Fayyaz, Farimah Fayyaz, Farimah Fayyaz, Amir-Hossein Mousavian, Amir-Hossein Mousavian, Davood Bashash, Mehdi Kardoust Parizi, Mehdi Kardoust Parizi, Amir Kasaeian, Amir Kasaeian, Amir Kasaeian

“…Future studies evaluating the efficacy and safety of novel combination therapies with ICIs are warranted.…”
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Reference values and biological determinants for cardiac myosin-binding protein C concentrations assessed with an enzyme-linked immunosorbent assay by Kloska Sylwester M., Kozinski Marek, Stefanska Anna, Bergmann Katarzyna, Mankowska-Cyl Aneta, Siodmiak Joanna, Sypniewska Grazyna, Krintus Magdalena

“…Background: Cardiac myosin-binding protein C (cMyC) is a novel cardio-specific biomarker of potential diagnostic and prognostic value for cardiovascular events. …”
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Impact of sampling and data collection methods on maternity survey response: a randomised controlled trial of paper and push-to-web surveys and a concurrent social media survey by Siân Harrison, Fiona Alderdice, Maria A. Quigley

“…Abstract Background Novel survey methods are needed to tackle declining response rates. …”
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Physical and Mental Effects of Foot Baths Among Women in Labor: Protocol for a Pre-Post Test Experimental Design by Naoko Hikita, Ritsuko Iso, Kiyoko Mizuhata, Akemi Isoyama, Ayumi Kobayashi, Rika Muroi

“…The findings on the effects of foot baths on women in labor will provide novel insights that may improve the outcomes of delivery. …”
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Efficacy of immersive extended reality (XR) interventions on different symptom domains of schizophrenia spectrum disorders. A systematic review by Roope Holopainen, Jari Tiihonen, Jari Tiihonen, Jari Tiihonen, Markku Lähteenvuo

“…IntroductionExtended reality (XR) is an umbrella term for virtual reality (VR) and augmented reality (AR), both novel vectors for therapeutic intervention modalities. …”
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Prognostic value of circulating plasma cells detected by flow cytometry in newly diagnosed multiple myeloma patients: a systematic review and meta-analysis by Jie Ma, Mengmeng Zhang, Xiaoyan Liu, Wu Ye, Jili Deng, Feifei Wu, Congli Zhang, Qingfeng Yu, Li Cao, Silin Gan

“…The heterogeneity may stem from the use of novel agents or traditional chemotherapy as initial treatment.Conclusion This meta-analysis indicates CPCs+ had an adverse impact on the prognosis of NDMM patients in the total population, and the adverse impact could not be eliminated by ASCT.PROSPERO registration number CRD42021272381.…”
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MITIG.RA: study protocol of a tailored psychological intervention for managing fatigue in rheumatoid arthritis randomized controlled trial by Cátia Duarte, Ruben L. F. Spilker, Cláudia Paiva, Ricardo J. O. Ferreira, José A. Pereira da Silva, Ana M. Pinto

“…This study primarily aims to examine the efficacy of the Compassion and Mindfulness Intervention for RA (MITIG.RA), a novel intervention combining different components of CCBT, compared to treatment-as-usual (TAU) in the management of RA-associated fatigue. …”
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Leveraging mHealth and Patient Supporters for African Americans' and Latinxs' Engagement in HIV Care (LEAN): Protocol for a Randomized, Controlled, Effectiveness-Implementation Tri... by Joyce Jones, Jane McKenzie-White, Ronald Saxton, Suzanne M Grieb, Bareng Nonyane, Cadeesha Graham, Anthony Cano, Sheridan Johnson, Lanisha Childs, Adena Greenbaum, Colin Flynn, Marcia Pearlowitz, Shivaun Celano, Larry W Chang, Kathleen R Page

“… BackgroundDespite substantial investments in ending the HIV epidemic, disparities in HIV care persist, and there is an urgent need to evaluate novel and scalable approaches to improving HIV care engagement and viral suppression in real-world settings. …”
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How to create value with unobtrusive monitoring technology in home-based dementia care: a multimethod study among key stakeholders by Christian Wrede, Annemarie Braakman-Jansen, Lisette van Gemert-Pijnen

“…Besides, our study highlights the complexity of implementing novel UM technology in home-based dementia care. …”
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Biomarkers in psoriatic arthritis: A meta-analysis and systematic review by Theo Wirth, Nathalie Balandraud, Nathalie Balandraud, Laurent Boyer, Pierre Lafforgue, Thao Pham

“…More recently, research has aimed to improve PsA diagnosis and prognosis by identifying novel disease biomarkers.MethodsHere, we conducted a systematic review of the published literature on candidate biomarkers for PsA diagnosis and prognosis in MEDLINE(Pubmed), EMBase and the Cochrane library with the goal to identify clinically applicable PsA biomarkers. …”
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“Children are precious cargo; we don’t let them take any risks!”: Hearing from adults on safety and risk in children’s active play in schools: a systematic review by Alethea Jerebine, Katie Fitton-Davies, Natalie Lander, Emma L. J. Eyre, Michael J. Duncan, Lisa M. Barnett

“…Records were screened against eligibility criteria using Covidence software, and data extraction and synthesis were performed using predesigned coding forms in Microsoft Excel and NVivo. …”
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Twice-Weekly Outpatient Rehabilitation Intervention for Young Children With Spinal Muscular Atrophy Treated With Genetic-Based Therapies: Protocol for a Feasibility Study by Christina Ippolito, Lathushikka Canthiya, Amanda Floreani, Kathleen Luckhart, Andrea Hoffman, Laura McAdam

“…Pragmatically, the results of the feasibility trial will inform changes to the protocol and the start-up of a definitive multisite trial. ConclusionsThis novel twice-weekly outpatient rehabilitation intervention will be the first step toward filling the need for an evidence-based rehabilitation intervention for children with SMA treated with genetic-based therapies. …”
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Modified-dropless protocol (nil intraocular) for micro-incision vitrectomy surgery (MIVS): a retrospective pilot study by Noraliz Garcia-O’Farrill, Gordon T. Brown, Allan A. Hunter

“…The purpose of this study is to evaluate the outcomes of a novel, modified-dropless protocol for 23-gauge (23-G), 25-gauge (25-G) and 27-gauge (27-G) micro-incision vitrectomy surgery (MIVS) that omits any intraocular injections of antibiotics or steroids. …”
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Use of virtual reality in port implantation to reduce perioperative anxiety and pain: protocol for a randomised controlled pilot trial at a single German university hospital (VIP-t... by Christoph W Michalski, Felix J Hüttner, Colette Dörr-Harim, Sandra Graf, Hannah Feldmann, Lisa S Hunold, Kira C Steinkraus, Nadir Nasir

“…A total of 120 adult patients are included after screening for eligibility and obtaining informed consent. Patients are randomised preoperatively in a 1:1 ratio to the trial groups. …”
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rAAV immunogenicity, toxicity, and durability in 255 clinical trials: A meta-analysis by Weiran Shen, Shengjiang Liu, Li Ou, Li Ou

“…However, there was high variability in the eligibility criteria with cut-off tiers ranging from 1:1 to 1:1,600. …”
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Evaluation of Digital Interventions for Physical Activity Promotion: Protocol for a Scoping Review by Karina Karolina De Santis, Tina Jahnel, Lea Mergenthal, Hajo Zeeb, Katja Matthias

“…Our scoping review is needed because it addresses novel objectives that focus on such evaluations and are not answered in the published reviews identified in our search. …”
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