The Copenhagen Actinic Keratosis Study (COAKS). A decentralised clinical trial to evaluate tolerability, safety and efficacy of daily field-directed topical treatment with cytosoli... by Merete Haedersdal, Kim Kilov, Vinzent Kevin Ortner, Berit Johansen, Alejandro Castillo Mondragón, Tore Duvold, Jesper Kihl, Felicity J Ashcroft, Astrid J Feuerherm, Charlotte Pind Laugesen, Maiken Lise Marcker Espersen, Ionela Manole, Ari Pall Isberg, Anders Daniel Andersen, Elin Rakvaag, John R Zibert

“…Recruitment using targeted advertising on social media and eligibility prescreening are conducted via the Studies&Me online recruitment platform. …”
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Mapping the Evidence for Opioid-Mediated Changes in Malignancy and Chemotherapeutic Efficacy: Protocol for a Scoping Review by Jonathan E Constance, Mary M McFarland, Tallie Casucci, Michael W Deininger, Elena Y Enioutina, Kathleen Job, Richard S Lemons, Carol S Lim, Robert M Ward, Venkata Yellepeddi, Kevin M Watt

“…By incorporating preclinical and clinical data, this scoping review will invite novel comparisons across study types that could inform new basic, translational, and clinical studies regarding risks and benefits of opioid use among patients with cancer. …”
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Real World Clinical Utility of Neurophysiological Measurement Utilizing Closed-Loop Spinal Cord Stimulation in a Chronic Pain Population: The ECAP Study Protocol by Leitner A, Hanson E, Soliday N, Staats P, Levy R, Pope J, Kallewaard JW, Doleys D, Li S, Weisbein J, Amirdelfan K, Poree L

“…Neurophysiological measurements (measured in-clinic and continuously during home use) and clinical outcomes including pain, quality-of-life, psychological, emotional, and functional assessments will be collected at baseline, trial end, and up to 24-months post-implantation.Discussion: Associations between objective neurophysiological data, clinical evaluation and patient-reported outcomes may have important clinical and scientific implications. They may provide novel insights about the chronic pain pathophysiology, its modulation during CL-SCS, and identification of pain phenotypes and/or mechanisms associated with treatment response during SCS trials and long-term therapy. …”
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Nebulized dexmedetomidine for attenuating hemodynamic response to laryngoscopy and endotracheal intubation in adult patients undergoing surgeries under general anaesthesia: a syste... by Mayank Gupta, Rachna Rohilla, Priyanka Gupta, Hemanthkumar Tamilchelvan, Udita Joshi, Jyoti Kanwat

“…Abstract Background Sympathetic stimulation associated with laryngoscopy and endotracheal intubation (ETI) may lead to adverse cardio-/cerebro-vascular events in susceptible patients. Nebulization is a novel route for dexmedetomidine administration providing a large surface area for absorption while avoiding bradycardia and hypotension associated with intravenous route. …”
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Real World Overall Survival of Patients With Metastatic Renal Cell Carcinoma Treated With Only Available Sunitinib and Pazopanib in First-Line Setting by Predrag Nikic, Predrag Nikic, Nada Babovic, Zoran Dzamic, Zoran Dzamic, Svetlana Salma, Vesna Stojanovic, Suzana Matkovic, Zoran Pejcic, Kristina Juskic, Ivan Soldatovic, Ivan Soldatovic

“…In circumstances of limited availability of cancer medicines, our results can contribute to accelerating patient access to novel cancer therapies that have been shown to prolong survival in mRCC.…”
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α-type-1 polarized dendritic cell-based vaccination in recurrent high-grade glioma: a phase I clinical trial by Akiyama Yasuto, Oshita Chie, Kume Akiko, Iizuka Akira, Miyata Haruo, Komiyama Masaru, Ashizawa Tadashi, Yagoto Mika, Abe Yoshiaki, Mitsuya Koichi, Watanabe Reiko, Sugino Takashi, Yamaguchi Ken, Nakasu Yoko

“…<p>Abstract</p> <p>Background</p> <p>High-grade gliomas including glioblastoma multiforme (GBM) are among the most malignant and aggressive of tumors, and have a very poor prognosis despite a temozolomide-based intensive treatment. Therefore, a novel therapeutic approach to controlling recurrence is needed. …”
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Smartphone Ownership and Usage Among Pregnant Women Living With HIV in South Africa: Secondary Analysis of CareConekta Trial Data by Sandisiwe Noholoza, Tamsin K Phillips, Sindiswa Madwayi, Megan Mrubata, Carol S Camlin, Landon Myer, Kate Clouse

“…More research is needed to establish the appropriateness and feasibility of integrating new mHealth modalities (novel apps and social media apps) in the South African context. …”
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Tissue-preserving treatment with non-invasive physical plasma of cervical intraepithelial neoplasia—a prospective controlled clinical trial by Martin Weiss, Martin Weiss, Marcel Arnholdt, Anna Hißnauer, Irma Fischer, Birgitt Schönfisch, Jürgen Andress, Sophia Gerstner, Dominik Dannehl, Hans Bösmüller, Annette Staebler, Sara Y. Brucker, Melanie Henes

“…To address these concerns, our study introduces a novel, gentle approach for the tissue-preserving treatment of CIN lesions.ResultsWe present findings of a controlled, prospective, single-armed phase IIb clinical trial performed at the Department for Women’s Health, Tübingen, Germany. …”
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Short-course, high-dose primaquine regimens for the treatment of liver-stage vivax malaria in children by Brioni R. Moore, Sam Salman, Roselyn Tobe, John Benjamin, Gumul Yadi, Bernadine Kasian, Moses Laman, Leanne J. Robinson, Madhu Page-Sharp, Inoni Betuela, Kevin T. Batty, Laurens Manning, Ivo Mueller, Timothy M.E. Davis

“…Results: Between August 2013 and May 2018, 707 children were screened and 73 met the eligibility criteria (15, 40, and 16 allocated to groups A, B, and C, respectively). …”
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Calibrating a network meta-analysis of diabetes trials of sodium glucose cotransporter 2 inhibitors, glucagon-like peptide-1 receptor analogues and dipeptidyl peptidase-4 inhibitor... by Naveed Sattar, Sofia Dias, Sarah Wild, Laurie A Tomlinson, David McAllister, Amanda I Adler, Nicky Welton, Lili Wei, Katherine Hughes, Peter Hanlon, Elaine Butterly, Jim Lewsey, John Petrie, Robert Lindsay, Saleh A M Almazam, Khalid Alsallumi, Luke A K Blackbourn, Stuart McGurnaghan, David Phillippo

“…Two independent reviewers will apply eligibility criteria to identify trials for inclusion. …”
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Precise management system for chronic intractable pain patients implanted with spinal cord stimulation based on a remote programming platform: study protocol for a randomized contr... by Yuanchen Cheng, Duo Xie, Yan Han, Siying Guo, Zhenxing Sun, Linkai Jing, Weitao Man, Dongkang Liu, Kaiyuan Yang, Dan Lei, Zhe Meng, Huifang Zhang, Guoqin Wang, Weiwei Wu, Guihuai Wang, Yang Lu

“…Methods Patients with chronic intractable pain will be screened for eligibility, and 82 participants are anticipated to be enrolled in this trial. …”
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Molecular Inversion Probe-Based Sequencing of <i>USH2A</i> Exons and Splice Sites as a Cost-Effective Screening Tool in USH2 and arRP Cases by Janine Reurink, Adrian Dockery, Dominika Oziębło, G. Jane Farrar, Monika Ołdak, Jacoline B. ten Brink, Arthur A. Bergen, Tuula Rinne, Helger G. Yntema, Ronald J. E. Pennings, L. Ingeborgh van den Born, Marco Aben, Jaap Oostrik, Hanka Venselaar, Astrid S. Plomp, M. Imran Khan, Erwin van Wijk, Frans P. M. Cremers, Susanne Roosing, Hannie Kremer

“…Four of the identified SNVs and one CNV were novel. One previously identified synonymous variant was demonstrated to affect pre-mRNA splicing. …”
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Tonsillectomy compared with conservative management in patients over 16 years with recurrent sore throat: the NATTINA RCT and economic evaluation by Janet A Wilson, Tony Fouweather, Deborah D Stocken, Tara Homer, Catherine Haighton, Nikki Rousseau, James O’Hara, Luke Vale, Rebecca Wilson, Sonya Carnell, Scott Wilkes, Jill Morrison, Kim Ah-See, Sean Carrie, Claire Hopkins, Nicola Howe, Musheer Hussain, Lyndsay Lindley, Kenneth MacKenzie, Lorraine McSweeney, Hisham Mehanna, Christopher Raine, Ruby Smith Whelan, Frank Sullivan, Alexander von Wilamowitz-Moellendorff, Dawn Teare

“…Participants A total of 453 eligible participants with recurrent sore throats were recruited to the main trial. …”
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Antidepressants in pregnancy: applying causal epidemiological methods to understand service-use outcomes in women and long-term neurodevelopmental outcomes in exposed children by Heuvelman Hein, Davies Neil M, Ben-Shlomo Yoav, Emond Alan, Evans Jonathan, Gunnell David, Liebling Rachel, Morris Richard, Payne Rupert, Storey Claire, Viner Maria, Rai Dheeraj

“…Of these pregnancies, 45,358 were eligible for record linkage to study secondary care service outcomes. …”
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Understanding suicidal transitions in Australian adults: protocol for the LifeTrack prospective longitudinal cohort study by Philip J Batterham, Monica Gendi, Helen Christensen, Alison L. Calear, Fiona Shand, Matthew Sunderland, Rohan Borschmann, Michelle Banfield, Bridianne O’Dea, Mark Larsen, Cassandra Heffernan, Dominique Kazan, Aliza Werner-Seidler, Andrew J Mackinnon, Emily Hielscher, Jin Han, Katherine M Boydell, Liana Leach, Louise M Farrer

“…Conclusion This study is intended to identify potential targets for novel and tailored therapies for people experiencing suicidal ideation and improve targeting of suicide prevention programs. …”
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Reducing New Chlamydia Infection Among Young Men by Promoting Correct and Consistent Condom Use: Protocol for a Randomized Controlled Trial by Nicole Stone, Rowena Bedford, Katie Newby, Katherine Brown, Louise Jackson, Stephen Bremner, Leanne Morrison, Nuala McGrath, Tom Nadarzynski, Jake Bayley, Nicky Perry, Cynthia Graham

“…Funding for sexual health services in England has declined dramatically, so novel ways of reducing clinic attendance are being sought. …”
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Safety and efficacy of pegunigalsidase alfa in patients with Fabry disease who were previously treated with agalsidase alfa: results from BRIDGE, a phase 3 open-label study by Aleš Linhart, Gabriela Dostálová, Kathy Nicholls, Michael L. West, Camilla Tøndel, Ana Jovanovic, Pilar Giraldo, Bojan Vujkovac, Tarekegn Geberhiwot, Einat Brill-Almon, Sari Alon, Raul Chertkoff, Rossana Rocco, Derralynn Hughes

“…Abstract Background Pegunigalsidase alfa is a novel, PEGylated α-galactosidase-A enzyme-replacement therapy approved in the EU and US to treat patients with Fabry disease (FD). …”
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Association of the systemic immune-inflammation index (SII) and clinical outcomes in patients with stroke: A systematic review and meta-analysis by Yong-Wei Huang, Xiao-Shuang Yin, Zong-Ping Li

“…IntroductionA novel systemic immune-inflammation index (SII) has been proven to be associated with outcomes in patients with cancer. …”
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Echocardiographic and clinical outcomes following beating heart NeoChord DS1000 mitral valve repair: a single centre case series by Amy Brown, Hallie L. Jefferson, Ali Fatehi Hassanabad, Christopher Noss, Nicole Webb, Paul W. M. Fedak, William D. T. Kent, Corey Adams

“…The early surgical outcomes suggest this approach is feasible, safe, and effective in reducing MR. This novel procedure has the advantage of offering a minimally invasive, off-pump option for select patients with high surgical risk.…”
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Association of the stress hyperglycemia ratio and clinical outcomes in patients with stroke: A systematic review and meta-analysis by Yong-Wei Huang, Xiao-Shuang Yin, Zong-Ping Li

“…Meanwhile, whether SHR could become a novel and promising target for early intervention is worthy of attention in further research. …”
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