Chemoprophlaxis trial designs in epidemics: insights from a systematic review of COVID-19 study registrations by Manoharan, L, Olliaro, P, Horby, P, Watson, C

“…Trial components were screened for eligibility and relevant studies extracted. Key trial design features were assessed. …”

Protocol to evaluate sequential electronic health record-based strategies to increase genetic testing for breast and ovarian cancer risk across diverse patient populations in gynec... by Heather Symecko, Robert Schnoll, Rinad S. Beidas, Justin E. Bekelman, Daniel Blumenthal, Anna-Marika Bauer, Peter Gabriel, Leland Boisseau, Abigail Doucette, Jacquelyn Powers, Jacqueline Cappadocia, Danielle B. McKenna, Robert Richardville, Lauren Cuff, Ryan Offer, Elizabeth G. Clement, Alison M. Buttenheim, David A. Asch, Katharine A. Rendle, Rachel C. Shelton, Oluwadamilola M. Fayanju, E. Paul Wileyto, Martina Plag, Sue Ware, Lawrence N. Shulman, Katherine L. Nathanson, Susan M. Domchek

“…Methods Patients meeting eligibility for germline genetic testing for breast and ovarian cancer will be identified using electronic phenotyping algorithms. …”
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Lessons learnt from a discontinued randomised controlled trial: adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous... by Nefyn H. Williams, Alison Jenkins, Nia Goulden, Zoe Hoare, Dyfrig A. Hughes, Eifiona Wood, Nadine E. Foster, David Walsh, Dawn Carnes, Valerie Sparkes, Elaine M. Hay, John Isaacs, Kika Konstantinou, Dylan Morrissey, Jaro Karppinen, Stephane Genevay, Clare Wilkinson

“…Additional preparatory work might be required before testing novel treatments. A randomised controlled trial of tumour necrosis factor-α blockade is still needed to determine its cost-effectiveness in severe sciatica. …”
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Prevalence and characteristics of long COVID in elderly patients: An observational cohort study of over 2 million adults in the US. by Kin Wah Fung, Fitsum Baye, Seo H Baik, Zhaonian Zheng, Clement J McDonald

“…While long COVID is sometimes considered a novel disease, many viral or bacterial infections have been known to cause prolonged illnesses. …”
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CD19-CAR-DNT cells (RJMty19) in patients with relapsed or refractory large B-cell lymphoma: a phase 1, first-in-human studyResearch in context by Xibin Xiao, Hui Liu, Xi Qiu, Panpan Chen, Xian Li, Dan Wang, Guangrong Song, Yu Cheng, Liming Yang, Wenbin Qian

“…We aimed to evaluate the safety and antitumor activity of a novel off-the-shelf anti-CD19 CAR-engineered allogeneic double-negative T cells (RJMty19) in patients with relapsed/refractory large B-cell lymphoma. …”
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Essays in empirical political economy by Cantoni, Enrico

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Outcomes of patients with secondary central nervous system lymphoma following CAR T-cell therapy: a multicenter cohort study by Narendranath Epperla, Lei Feng, Nirav N. Shah, Lindsey Fitzgerald, Harsh Shah, Deborah M. Stephens, Catherine J. Lee, Thomas Ollila, Geoffrey Shouse, Alexey V. Danilov, Kevin A. David, Pallawi Torka, Hamza Hashmi, Brian Hess, Stefan K. Barta, Jason T. Romancik, Jonathon B. Cohen, Kaitlin Annunzio, Adam S. Kittai, John Reneau, Joanna Zurko, Imran A. Nizamuddin, Jane N. Winter, Leo I. Gordon, Shuo Ma, Romil Patel, Loretta Nastoupil, Sairah Ahmed, Reem Karmali

“…The current study provides a benchmark for future trials exploring novel therapeutic options in SCNSL.…”
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Real-world evaluation of AI driven COVID-19 triage for emergency admissions: External validation & operational assessment of lab-free and high-throughput screening solutions by Soltan, A, Yang, J, Pattanshetty, R, Novak, A, Yang, Y, Rohanian, O, Beer, S, Soltan, M, Thickett, D, Fairhead, R, Zhu, T, Eyre, D, Clifton, D

“…Here, we aimed to improve the time from arrival to the emergency department to the availability of a result, do external and prospective validation, and deploy a novel laboratory-free screening tool in a UK emergency department. …”

Personalized Risk Assessment for Prevention and Early Detection of Breast Cancer: Integration and Implementation (PERSPECTIVE I&I) by Jennifer D. Brooks, Hermann Nabi, Irene L. Andrulis, Antonis C. Antoniou, Jocelyne Chiquette, Philippe Després, Peter Devilee, Michel Dorval, Arnaud Droit, Douglas F. Easton, Andrea Eisen, Laurence Eloy, Samantha Fienberg, David Goldgar, Eric Hahnen, Yann Joly, Bartha Maria Knoppers, Aisha Lofters, Jean-Yves Masson, Nicole Mittmann, Jean-Sébastien Paquette, Nora Pashayan, Rita Schmutzler, Tracy Stockley, Sean V. Tavtigian, Meghan J. Walker, Michael Wolfson, Anna Maria Chiarelli, Jacques Simard

“…Furthermore, while breast cancer risk is highly variable within the population, most screening programs use age to determine eligibility. A risk-based approach is expected to improve the benefit-harm ratio of breast cancer screening programs. …”
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Virtual reality supported therapy for the negative symptoms of schizophrenia: the V-NeST feasibility RCT by Cella Matteo, Tomlin Paul, Robotham Daniel, Green Patrick, Griffiths Helena, Stahl Daniel, Valmaggia Lucia

“…Objectives This study evaluates, for the first time, the feasibility and acceptability of a novel Virtual Reality Supported Therapy for the Negative SympToms of Psychosis. …”
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Preventing kidney transplant failure by screening for antibodies against human leucocyte antigens followed by optimised immunosuppression: OuTSMART RCT by Stringer Dominic, Gardner Leanne, Shaw Olivia, Clarke Brendan, Briggs David, Worthington Judith, Buckland Matthew, Hilton Rachel, Picton Michael, Thuraisingham Raj, Borrows Richard, Baker Richard, Tinch-Taylor Rose, Horne Robert, McCrone Paul, Kelly Joanna, Murphy Caroline, Peacock Janet, Dorling Anthony

“…Over 37 months, 5519 patients were screened for eligibility and 2037 were randomised (1028 to unblinded BLC and 1009 to double-blinded SC). …”
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Effect of the decision to perform hysteroscopy on asymptomatic patients before undergoing assisted reproduction technologies—a systematic review and meta-analysisAJOG Global Report... by Greg J. Marchand, MD, FACS, FICS, FACOG, Ahmed Taher Masoud, MD, Hollie Ulibarri, BS, Julia Parise, BS, Amanda Arroyo, BS, Catherine Coriell, BS, Sydnee Goetz, BS, Carmen Moir, BS, Atley Moberly, BS

“…OBJECTIVE: Routine hysteroscopic evaluation before assisted reproductive technology treatment is a novel approach with the potential to reduce assisted reproductive technology failure even in the absence of evidence of uterine pathology. …”
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A PHASE 3, TWO-STAGE, RANDOMIZED STUDY OF MEZIGDOMIDE, CARFILZOMIB, AND DEXAMETHASONE (MEZIKD) VERSUS CARFILZOMIB AND DEXAMETHASONE (KD) IN RELAPSED/REFRACTORY MULTIPLE MYELOMA (RR... by PGR Md, MA Phd, JRB Md, CCM Phd, MAD Md, CTH Md, JKM Phd, AOM Phd, RZOM Phd, Md HQ, MSR Md, ARM Phd, DW Md, ZZ Phd, VHM Phd, JKM Phd

“…Introduction: Mezigdomide (MEZI), a novel oral cereblon E3 ligase modulator (CELMoD™), induces maximal degradation of Ikaros/Aiolos leading to increased MM cell apoptosis and immune-stimulatory effects. …”
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Real-world evaluation of rapid and laboratory-free COVID-19 triage for emergency care: external validation and pilot deployment of artificial intelligence driven screening by Soltan, AAS, Yang, J, Pattanshetty, R, Novak, A, Yang, Y, Rohanian, O, Beer, S, Soltan, MA, Thickett, DR, Fairhead, R, Zhu, T, Eyre, DW, Clifton, DA

“…Here, we aimed to improve the time from arrival to the emergency department to the availability of a result, do external and prospective validation, and deploy a novel laboratory-free screening tool in a UK emergency department. …”

Memory-Focused Cognitive Therapy for Cocaine Use Disorder: Theory, Procedures and Preliminary Evidence From an External Pilot Randomised Controlled Trial by John Marsden, Camille Goetz, Tim Meynen, Luke Mitcheson, Garry Stillwell, Brian Eastwood, John Strang, Nick Grey

“…We tested the feasibility, safety and preliminary efficacy of a novel, adjunctive psychosocial intervention for CUD, called ‘memory-focused cognitive therapy’ (MFCT). …”
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Artificial intelligence technologies and compassion in healthcare: A systematic scoping review by Elizabeth Morrow, Teodor Zidaru, Fiona Ross, Cindy Mason, Kunal D. Patel, Melissa Ream, Rich Stockley

“…Presentation of the scoping review conforms with PRISMA-ScR (Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews). Eligibility criteria were defined according to 3 concept constructs (AI technologies, compassion, healthcare) developed from the literature and informed by medical subject headings (MeSH) and key words for the electronic searches. …”
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Optimized immunosuppression to prevent graft failure in renal transplant recipients with HLA antibodies (OuTSMART): a randomised controlled trialResearch in context by Dominic Stringer, Leanne Gardner, Olivia Shaw, Brendan Clarke, David Briggs, Judith Worthington, Matthew Buckland, Guilherme Danzi, Rachel Hilton, Michael Picton, Raj Thuraisingham, Richard Borrows, Richard Baker, Keith McCullough, John Stoves, Mysore Phanish, Sapna Shah, Kin Yee Shiu, Stephen B. Walsh, Aimun Ahmed, Waqar Ayub, Janet Hegarty, Rose Tinch-Taylor, Evangelos Georgiou, Natalie Bidad, Ayşenur Kılıç, Zoe Moon, Robert Horne, Paul McCrone, Joanna Kelly, Caroline Murphy, Janet Peacock, Anthony Dorling

“…Whilst DSA predicts increased risk of allograft failure, novel interventions are needed before screening can be used to direct therapy. …”
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Identifying models of care to improve outcomes for older people with urgent care needs: a mixed methods approach to develop a system dynamics model by Conroy Simon, Brailsford Sally, Burton Christopher, England Tracey, Lalseta Jagruti, Martin Graham, Mason Suzanne, Maynou-Pujolras Laia, Phelps Kay, Preston Louise, Regen Emma, Riley Peter, Street Andrew, van Oppen James

“…Results WP1 – identifying best practice WP 1.1 review of reviews In total, 806 articles were retrieved; 18 eligible reviews were identified, published between 2005 and 2019. …”
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School-based interventions TO Prevent Dating and Relationship Violence and Gender-Based Violence: STOP-DRV-GBV systematic review by GJ Melendez-Torres, Noreen Orr, Caroline Farmer, Naomi Shaw, Annah Chollet, Andrew J Rizzo, Fraizer Kiff, Emma Rigby, Ann Hagell, Sidnei R Priolo Filho, Bruce Taylor, Honor Young, Chris Bonell, Vashti Berry

“…Of these, 247 reports were identified as eligible for inclusion, and these were coded into 68 outcome evaluations and 137 process evaluations. …”
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Behavioural intervention to reduce sexually transmitted infections in people aged 16–24 years in the UK: the safetxt RCT by Caroline Free, Melissa J Palmer, Kimberley Potter, Ona L McCarthy, Lauren Jerome, Sima Berendes, Anasztazia Gubijev, Megan Knight, Zahra Jamal, Farandeep Dhaliwal, James R Carpenter, Tim P Morris, Phil Edwards, Rebecca French, Louis Macgregor, Katy ME Turner, Paula Baraitser, Ford CI Hickson, Kaye Wellings, Ian Roberts, Julia V Bailey, Graham Hart, Susan Michie, Tim Clayton, Karen Devries

“…Future work: Randomised controlled trials evaluating novel interventions in this complex area are needed. …”
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