Published 2023-03-01
“…Mette Louise Andersen,
1–
3 Line Riis
Jølving,
1,2 Egon Stenager,
4,5 Torben Knudsen,
4,6 Bente Mertz
Nø
rgå
rd1,2 1Center for Clinical Epidemiology, Odense University Hospital, Odense, Denmark;
2Research Unit of Clinical Epidemiology, Department of Clinical Research, University of Southern Denmark, Odense, Denmark;
3Department of Gynecology and Obstetrics, University Hospital of Southern Jutland,
Esbjerg, Denmark;
4Department of Regional Research, University of Southern Denmark, Odense, Denmark;
5Multiple Sclerosis Clinic Hospital of Southern Jutland, Aabenraa, University of Southern Denmark, Odense, Denmark;
6Department of Gastroenterology, University Hospital of Southern Jutland,
Esbjerg, DenmarkCorrespondence: Mette Louise Andersen, Center for Clinical Epidemiology, Odense University Hospital, Kloevervaenget
30, Entrance 216, Odense,
DK- 5000, Denmark, Email mette.louise.andersen@rsyd.
dkObjective: To summarize the available literature and provide an overview of in utero exposure to maternal multiple sclerosis (
MS) and the influence on offspring health outcomes.Methods:
We conducted
a systematic review by searching Embase, Medline and
PubMed.gov databases, and
we used covidence.org to conduct
a thorough sorting of the articles into three groups;
1) women with
MS and the influence on birth outcomes;
2) women with
MS treated with disease-modifying therapy (DMT) during pregnancy and the influence on birth outcomes; and
3) women with
MS and the influence on long-term health outcomes in the children.Results: In total,
22 cohort studies were identified. …”
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