The Italian registry of pulmonary non-tuberculous mycobacteria - IRENE: the study protocol by Stefano Aliberti, Luigi Ruffo Codecasa, Andrea Gori, Giovanni Sotgiu, Maura Spotti, Antonio Di Biagio, Andrea Calcagno, Stefano Nardini, Baroukh Maurice Assael, Enrico Tortoli, Giorgio Besozzi, Maurizio Ferrarese, Alberto Matteelli, Enrico Girardi, Saverio De Lorenzo, Manuela Seia, Andrea Gramegna, Bruno Del Prato, Leonardo Terranova, Martina Oriano, Nicola Sverzellati, Mehdi Mirsaeidi, James D. Chalmers, Charles S. Haworth, Michael R. Loebinger, Timothy Aksamit, Kevin Winthrop, Felix C. Ringshausen, Giuliana Previdi, Francesco Blasi, on behalf of the IRENE Network

“…Abstract Background A substantial increase in pulmonary and extra-pulmonary diseases due to non-tuberculous mycobacteria (NTM) has been documented worldwide, especially among subjects suffering from chronic respiratory diseases and immunocompromised patients. …”
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METTL1 promotes neuroblastoma development through m7G tRNA modification and selective oncogenic gene translation by Ying Huang, Jieyi Ma, Cuiyun Yang, Paijia Wei, Minghui Yang, Hui Han, Hua Dong Chen, Tianfang Yue, Shu Xiao, Xuanyu Chen, Zuoqing Li, Yanlai Tang, Jiesi Luo, Shuibin Lin, Libin Huang

“…Abstract Background Neuroblastoma (NBL) is the most common extra-cranial solid tumour in childhood, with prognosis ranging from spontaneous remission to high risk for rapid and fatal progression. …”
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Enfermagem sob a ótica de cuidadores principais de indivíduos com doença crônica no ambiente hospitalar [Nursing as seen by primary caregivers of individuals with chronic disease i... by Andressa Cunha de Paula, Paulie Marcelly Ribeiro dos Santos Carvalho, Claci Fátima Weirich Rosso, Márcia Maria de Souza, Nélio Barbosa Boccanera, Marcos André de Matos

“…Conclusion: caregivers still have a narrow and limited view of nursing, and do not consider that the profession acts with scientific evidence-based rigor and in articulation with social utility. …”
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CARCINOMA TÍMICO: ESTUDO DIAGNÓSTICO POR CITOMETRIA DE FLUXO E IMUNO-HISTOQUÍMICA by JGR Santos, MC Goncalves, DC Daniel, TP Silva, ACT Silva, TT Takao, AF Sandes, MCA Silva, CRGCM Oliveira, MV Gonçalves

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Evaluation of management drives impacts on development of historical-cultural tourism (Case study: Tabriz metropolis) by Ali Modabber Khaknezhad, Karim Hosseinzadeh Dalir, Bakhtyar ezatpanah

“…Thus, the discussion of management is an important part of planning and as the basis of work, which is the act of directing and controlling a task or organization. …”
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Structure and composition design of ternary metal oxide anodes for rechargeable lithium ion batteries by Yu, Hong

“…As indicated in the first project that when an alloy reaction based metal ions is used at A site of AB2O4, capacity contribution from the side effect is less. Moreover an extra alloy reaction would inherent the material more specific capacity. …”
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The politics of knowledge that leads elsewhere by Henry, U

“…</p> <p>By conclusion, if the educational 'turn' in art is to fully realise its emancipatory dimension it must not only align itself to the extra-institutional realm of the artworld, but must forge a counter turn inside the official educational art institution, the primary site of education's struggle and agency. …”

Tailoring Surface Frustrated Lewis Pairs of In2O3−x(OH)y for Gas‐Phase Heterogeneous Photocatalytic Reduction of CO2 by Isomorphous Substitution of In3+ with Bi3+ by Yuchan Dong, Kulbir Kaur Ghuman, Radian Popescu, Paul N. Duchesne, Wenjie Zhou, Joel Y. Y. Loh, Feysal M. Ali, Jia Jia, Di Wang, Xiaoke Mu, Christian Kübel, Lu Wang, Le He, Mireille Ghoussoub, Qiang Wang, Thomas E. Wood, Laura M. Reyes, Peng Zhang, Nazir P. Kherani, Chandra Veer Singh, Geoffrey A. Ozin

“…According to density functional theory calculations at the optimal Bi3+ substitution level, the 6s2 electron pair of Bi3+ hybridizes with the oxygen in the neighboring InOH Lewis base site, leading to mildly increased Lewis basicity without influencing the Lewis acidity of the nearby In Lewis acid site. Meanwhile, Bi3+ can act as an extra acid site, serving to maximize the heterolytic splitting of reactant H2, and results in a more hydridic hydride for more efficient CO2 reduction. …”
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Deep multi-agent reinforcement learning by Foerster, J

“…</p> <p>So far we have assumed the agents act fully decentralised, i.e., without directly communicating with each other. …”

ANKLE2‐related microcephaly: A variable microcephaly syndrome resembling Zika infection by Ajay X. Thomas, Nichole Link, Laurie A. Robak, Gail Demmler‐Harrison, Emily C. Pao, Audrey E. Squire, Savannah Michels, Julie S. Cohen, Anne Comi, Paolo Prontera, Alberto Verrotti di Pianella, Giuseppe Di Cara, Livia Garavelli, Stefano Giuseppe Caraffi, Carlo Fusco, Roberta Zuntini, Kendall C. Parks, Elliott H. Sherr, Mais O. Hashem, Sateesh Maddirevula, Fowzan S. Alkuraya, Isphana A. F. Contractar, Jennifer E. Neil, Christopher A. Walsh, Hugo J. Bellen, Hsiao‐Tuan Chao, Robin D. Clark, Ghayda M. Mirzaa

“…We identified a broad range of brain abnormalities including simplified cortical gyral pattern, full or partial callosal agenesis, increased extra‐axial spaces, hypomyelination, cerebellar vermis hypoplasia, and enlarged cisterna magna. …”
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Hyperforin-mediated anticancer mechanisms in MDA-MB-231 cell line: insights into apoptotic mediator modulation and caspase activation by Muttiah Barathan, Ahmad Khusairy Zulpa, Kumutha Malar Vellasamy, Zaridatul Aini Ibrahim, See Mee Hoong, Vanitha Mariappan, Gopinath Venkatraman, Jamuna Vadivelu

“…The results suggest that hyperforin may act as a good cell death-inducing agent.ABBREVIATIONS: TNBC: Triple negative breast cancer; DNA: Deoxyribonucleic acid; RNA: Ribonucleic acid; ROS: Reactive oxygen species; 5-FU: Fluorouracil; TRAIL: TNF-related apoptosis-inducing ligand; AKT: Protein kinase B; COX-2: Cyclooxygenase-2; PCR: Polymerase chain reaction; Bax: Bcl-2-associated X protein; BCL-2: B-cell lymphoma 2; MTT: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; mRNA: Messenger ribonucleic acid; MCL1: Myeloid-cell leukemia 1; LDH: Lactate dehydrogenase; ELISA: Enzyme-linked immunosorbent assay; MMP: Mitochondrial membrane potential; MCP-1: Monocyte chemoattractant protein-1; ATCC: American Type Culture Collection; RPMI: Roswell Park Memorial Institute; XIAP: X-linked inhibitor of apoptosis protein; FBS: Fetal bovine serum; MCL-1: Myeloid-cell leukemia 1; DMEM: Dulbecco’s Modified Eagle Medium; DMSO: Dimethyl sulfoxide; CASP3: Caspase 3; RPMI: Roswell Park Memorial Institute; DMEM: Dulbecco’s Modified Eagle Medium; FBS: Fetal bovine serum; h: Hour; TNF-α: Tumour necrosis factor alpha; P53: Tumor protein P53; min: Minutes; cps: Count presecond; OD: Optical density; rpm: Revolutions per minute; PI: Propidium iodide; SD: Standard deviation; DDR: Death Domoin Receptor; TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain; HRK: Harakiri, BCL2 Interacting Protein; RIPK2: Receptor-interacting serine/threonine-protein kinase 2; BIK: BCL2 interacting killer; DCF: 2’, 7’ –dichlorofluorescein; DCF-DA: Dichlorofluorescin Diacetate; FADD: Fas Associated Via Death Domain; TNFRSF: Tumor necrosis factor receptor superfamily; FITC: Fluorescein isothiocyanate; DMSO: Dimethyl sulfoxide; CFLAR: CASP8 And FADD Like Apoptosis Regulator; BID: BH3-interacting domain death agonist; BIRC: Baculoviral IAP repeat-containing protein; CIDEA: Cell death activator CIDE-A; CIDEB: Cell Death Inducing DFFA Like Effector B; BrdU: Bromodeoxyuridine; RFU: Relative fluorescence unit; NF-kB: Nuclear Factor kappa-light-chain-enhancer of activated B cells; %: Percentage; µL: microliter; µM: Micromolar; °C: degree Celcius; ng/mL: Nanograms per millimeter; mg/mL: Milligrams per milliliter; µg/mL: Micrograms per milliliter; ΔΨm: Mitochondrial membrane potential; TNFα: Tumour necrosis factor α; Bcl-xL: B-cell lymphoma-extra large; MDR1: Multidrug Resistance Mutation; AIB1: Amplified in breast cancer 1; LTBR: Lymphotoxin Beta Receptor HighlightsUtilization of hyperforin as anticancer agent against triple negative breast cancer.Hyperforin exhibited a lower IC50 compared to taxol in inhibiting growth of MDA-MB-231 cells.Hyperforin shows similar potential anticancer activity as taxol.Hyperforin uses mitochondrial death pathway to induce cell death in MDA-MB-231 cells.…”
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Structural integrity of reinforced polymer matrix composites subjected to hygrothermal conditioning by Zhong, Yucheng

“…These damages in turn provided extra free spaces for moisture absorption. Consequently, after the saturation level was reached the laminates continued to absorb moisture, resulting in the Stage III moisture uptake state. …”
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Investigations into the robustness of statistical decisions by Watson, J

“…<p>Decision theory is a cornerstone of Statistics, providing a principled framework in which to act under uncertainty. It underpins Bayesian theory via the Savage axioms, game theory via Wald's minimax, and supplies a mathematical formulation of 'rational choice'. …”

Chemical modifications of lysozyme by Farmer, P, Farmer, P. B.

“…The only significant enzyme functional groups in this region are the carboxylic acids Asp 52 and Glu 35, and it is generally accepted that Glu 35, which is in a hydrophobic environment and which would be expected to be unionised at the optimum pH for lysozyme action, acts as a general acid catalyst in the cleavage of the glycoside.…”

Photoalignment and spatial patterning of liquid crystalline conjugated polymers for polarised light emission by Shi, Y

“…It is also shown that LC alignment itself is responsible for a smeared X-ray diffraction ring and extra lower-energy absorbing species in the nematic polydomain F8BT glass film, in line with the formation of a minor (~5%) fraction of the locally and spontaneously oriented polymeric nanocrystals embedded in an amorphous matrix. …”

Violências contra mulheres por parceiro íntimo em área urbana economicamente vulnerável, Brasília, DF Violencias contra mujeres por pareja íntima en área urbana económicamente vuln... by Leides Barroso Azevedo Moura, Lenora Gandolfi, Ana Maria Nogales Vasconcelos, Riccardo Pratesi

“…Independent variables considered were women's sociodemographic, family and community context characteristics, in addition to their partners' sociodemographic and behavior characteristics (frequency of alcohol or illicit drug use and extra-marital relationship). RESULTS: The highest prevalence was that of psychological violence: 80.2% (n=223) of the women interviewed reported at least one act throughout their lives and 50% (n=139) in the last 12 months. …”
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Five years of variability in the global carbon cycle: comparing an estimate from the Orbiting Carbon Observatory-2 and process-based models by Zichong Chen, Deborah N Huntzinger, Junjie Liu, Shilong Piao, Xuhui Wang, Stephen Sitch, Pierre Friedlingstein, Peter Anthoni, Almut Arneth, Vladislav Bastrikov, Daniel S Goll, Vanessa Haverd, Atul K Jain, Emilie Joetzjer, Etsushi Kato, Sebastian Lienert, Danica L Lombardozzi, Patrick C McGuire, Joe R Melton, Julia E M S Nabel, Julia Pongratz, Benjamin Poulter, Hanqin Tian, Andrew J Wiltshire, Sönke Zaehle, Scot M Miller

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Power quality and stability improvement of more-electronics power systems by Fang, Jingyang

“…To reap these benefits, the LCL-based trap filters containing extra LC resonant trap(s), represented by LLCL filters, become a hot research topic. …”
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Universal Upper End of the Stellar Initial Mass Function in the Young and Compact LEGUS Clusters by Dooseok Escher Jung, Daniela Calzetti, Matteo Messa, Mark Heyer, Mattia Sirressi, Sean T. Linden, Angela Adamo, Rupali Chandar, Michele Cignoni, David O. Cook, Clare L. Dobbs, Bruce G. Elmegreen, Aaron S. Evans, Michele Fumagalli, John S. Gallagher III, Deidre A. Hunter, Kelsey E. Johnson, Robert C. Kennicutt Jr., Mark R. Krumholz, Daniel Schaerer, Elena Sabbi, Linda J. Smith, Monica Tosi, Aida Wofford

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Heterotopic ossification secondary to injury: insights from a novel zebrafish model by Kaliya Perumal, Arun Kumar

“…Heterotopic ossification is the formation of bone, either solitary or multiple, in the extra-skeletal soft tissues of the body where it would not normally be present. …”
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