Utilization of Sodium Nitroprusside as an Intestinal Permeation Enhancer for Lipophilic Drug Absorption Improvement in the Rat Proximal Intestine by Hisanao Kishimoto, Kaori Miyazaki, Hiroshi Tedzuka, Ryosuke Ozawa, Hanai Kobayashi, Yoshiyuki Shirasaka, Katsuhisa Inoue

“…The SNP pretreatment of the rat gastrointestinal sacs significantly increased griseofulvin and flurbiprofen permeation in the duodenum and jejunum but not in the ileum and colon. …”
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Effect of oxycodone combined with ultrasound-guided thoracic paravertebral nerve block on postoperative analgesia in patients with lung cancer undergoing thoracoscopic surgery: pro... by Zheng Liu, Jian Su, Yujie Wang, Guanghan Wu, Hai Feng, Xiumin Wei, Pengcai Shi

“…Participants will be randomly assigned to four groups in a 1:1:1:1 ratio: OCA group (oxycodone: 0.5 mg/kg), OCB group (oxycodone: 1.0 mg/kg), OCC group (oxycodone: 1.5 mg/kg) and one sufentanil group (sufentanil: 2 µg/kg). Flurbiprofen 50 mg and ondansetron 16 mg are added to each group. …”
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Do Different Cyclooxygenase Inhibitors Impair Rotator Cuff Healing in a Rabbit Model? by Yi Lu, Yue Li, Feng-Long Li, Xu Li, Hong-Wu Zhuo, Chun-Yan Jiang

“…After surgery, they were divided randomly into four groups: Ibuprofen (10 mg·kg−1·d−1), celecoxib (8 mg·kg−1·d−1), flurbiprofen axetil (2 mg·kg−1·d−1), and control group (blank group). …”
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CLINICAL EFFECTIVENESS OF NONSTEROID ANTI-INFLAMMATORY MEDICATIONS IN TREATMENT OF ENT-DISEASES IN CHILDREN by M.M. Sergeev, S.L. Kovalenko

“…Thus, ibuprofen suspension and resorption tablets with flurbiprofen provide significant anesthetic effect in children, and they can be used in practice of children’s ENT specialist.Key words: children, ENT diseases, nonsteroid anti-inflammatory medications.…”
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Heat-stone massage for patients with chronic musculoskeletal pain: a protocol for multicenter randomized controlled trial by Li Li, Yawei Xi, Ying Wang, Yinqiu Gao, Xiaoying Lv, Shu Liu, Guangjing Yang, Jingjing Qian, Xiaofang Yang, Nardeen Ayad, Jiayan Zhou, Ya Xuan Sun, Jin Liu, Jinlin Li, Guang Chen

“…The intervention group will receive a 2 week heat-stone massage, 3 times per week, whereas the control group will receive the flurbiprofen plaster twice per day for 2 weeks. The primary end point is the change in Global Pain Scale from baseline to the end of the 2 week intervention. …”
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Addition of preoperative transversus abdominis plane block to multimodal analgesia in open gynecological surgery: a randomized controlled trial by Zhi Yu Geng, Yan Zhang, Hui Bi, Dai Zhang, Zheng Li, Lu Jiang, Lin Lin Song, Xue Ying Li

“…Methods In this prospective, randomized-controlled trial, 64 patients scheduled for open gynecological surgery were randomized to receive preoperative TAP block (Study group, n = 32) or placebo (Control group, n = 32) in addition to MMA protocol comprising dexamethasone, acetaminophen, flurbiprofen and celecoxib, and rescued morphine analgesia. …”
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Effects of propofol anesthesia versus sevoflurane anesthesia on postoperative pain after radical gastrectomy: a randomized controlled trial by Ji F, Wang D, Zhang J, Liu H, Peng K

“…All patients were administered a standardized multimodal analgesic plan, including intraoperative dexmedetomidine, dexamethasone, and postoperative flurbiprofen axetil, as well as patient-controlled fentanyl. …”
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Do NSAIDs and Other Pain Relief Drugs Can Inhibit the Growth of Lactobacillaceae? by Kruszewska Hanna, Zawistowska-Rojek Anna, Tyski Stefan

“…It was found that diclofenac, ibuprofen, ketoprofen, dexketoprofen, flurbiprofen, and acetylsalicylic acid inhibited the growth of lactobacilli at a concentration of 0.05−3.2 mg/ml. …”
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Expanding Access to Optically Active Non-Steroidal Anti-Inflammatory Drugs via Lipase-Catalyzed KR of Racemic Acids Using Trialkyl Orthoesters as Irreversible Alkoxy Group Donors by Beata Zdun, Piotr Cieśla, Jan Kutner, Paweł Borowiecki

“…In turn, the employment of optimal conditions on a preparative-scale enabled us to obtain the (<i>S</i>)-enantiomers of: flurbiprofen in 28% yield and 97% ee, ibuprofen in 45% yield and 56% ee, (<i>S</i>)-ketoprofen in 23% yield and 69% ee, and naproxen in 42% yield and 57% ee, respectively. …”
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National drug utilization trend of analgesics in China: an analysis of procurement data at 793 public hospitals from 2013 to 2018 by Honghao Shi, Xianwen Chen, Xueli Liu, He Zhu, Fei Yu, Carolina Oi Lam Ung, Wai Sin Chan, Hao Hu, Sheng Han

“…The top three opioid drugs were dezocine injection, remifentanil injection, and sufentanil injection solution. the top three NSAIDs were flurbiprofen injection, parecoxib injection, and celecoxib oral solution. …”
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Fascia iliaca compartment block mitigates the fluctuations in heart rate variability and reduces pain with opioid consumption in elderly individuals with hip fractures: A randomize... by Xiaoqi Dai, Dongxue Xing, Juan Luo, Yi Yang, Jiayuan Zhai, Tianwei Tang, Wanchao Yang

“…Moreover, Group F had lower flurbiprofen dosages at 24 h postoperatively (P < 0.05) and lower resting VAS scores at 6 and 24 h postoperatively (P < 0.05). …”
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Transdermal buprenorphine for acute postoperative pain: a systematic review by Felipe Chiodini Machado, Gilson Carone Neto, Luisa Oliveira de Paiva, Tamiris Cristina Soares, Ricardo Kenithi Nakamura, Leonardo de Freitas Nascimento, Camila Sato Campana, Lia Alves Martins Mota Lustosa, Rachel Andrade Cortez, Hazem Adel Ashmawi

“…Most studies showed lower or similar postoperative pain scores, postoperative analgesic consumption and patient satisfaction comparing buprenorphine to placebo, tramadol, celecoxib, flurbiprofen and parecoxib. The incidence of side effects varied between studies, with most showing no increase in drug-related side effects with buprenorphine use, except one study, which compared buprenorphine to oral tramadol, and one to transdermal fentanyl. …”
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Chiral drugs - a standard or a challenge for modern pharmacy? Considerations on selected derivatives of 2-arylpropionic acid. by Natalia Kocot, Rafał Mastalerz, Jacek Dulęba, Tomasz Siódmiak, Michał Piotr Marszałł

“…It is worth noting that studies on the therapeutic activity of (R) -flurbiprofen have shown its antinociceptive and anticancer properties. …”
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Clinical analysis of subxiphoid vs. lateral approaches for treating early anterior mediastinal thymoma by Bin Li, Lijuan Niu, Chenqi Gu, Kaiwen He, Ruizhi Wu, Zhenfeng Pan, Shaomu Chen

“…We compared the intraoperative conditions (such as operation time and intraoperative blood loss), postoperative conditions [such as postoperative pleural drainage volume, extubation time, postoperative hospital stay, and postoperative visual analogue scale (VAS) pain score], and postoperative complications (such as death, pneumonia, delayed wound healing, cardiac arrhythmia, and phrenic nerve injury) of the two groups and analyzed the clinical advantages of the subxiphoid approach for treating early anterior mediastinal thymoma.ResultsThere was no significant difference between the two groups in terms of general clinical features, operation time, and postoperative complications (P &gt; 0.05).However, there was a significant difference in terms of intraoperative blood loss, postoperative pleural drainage volume, tube extubation time, postoperative hospital stay, postoperative VAS pain score, and postoperative analgesics (a significantly decreased flurbiprofen axetil amount) (P &lt; 0.05).ConclusionCompared with the lateral intercostal thoracic approach, the subxiphoid approach had advantages in terms of intraoperative blood loss, postoperative hospital stay, tube extubation time, postoperative pleural drainage volume, postoperative VAS pain score, and analgesics dosage. …”
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Pharmacological interventions for preventing opioid-induced hyperalgesia in adults after opioid-based anesthesia: a systematic review and network meta-analysis by Wei-Ji Xie, Ji-Shuang Hong, Cheng-Fei Feng, Hao-Feng Chen, Wei Li, Yong-Chun Li

“…In terms of postoperative pain intensity, amantadine, magnesium sulphate, pregabalin, dexmedetomidine, ibuprofen, flurbiprofen plus dexmedetomidine, parecoxib, parecoxib plus dexmedetomidine, and S (+)-ketamine plus methadone were all associated with milder pain intensity than placebo, with amantadine being the most effective (SUCRA values = 96.2). …”
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Cranberry Juice Ingestion and Clinical Drug-Drug Interaction Potentials; Review of Case Studies and Perspectives by Nuggehally R Srinivas

“…There is, however, a discrepancy between in vitro and in vivo observations with respect to a number of substrates (cyclosporine, warfarin, flurbiprofen, tizanidine, diclofenac, amoxicillin, ceflacor); with the exception of a single report on midazolam, where there was a moderate increase in the AUC of midazolam in subjects pre-treated with cranberry juice. …”
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NMR Investigation of the Interaction of Three Non-Steroidal Anti-Inflammatory Drugs with Human Serum Albumin by Federica Aiello, Gloria Uccello-Barretta, Claudio Picchi, Samuele Nazzi, Alessandra Recchimurzo, Federica Balzano

“…Affinity indexes for diclofenac were about five-fold higher in comparison with ketorolac and flurbiprofen. Aromatic moieties of the three drugs and methine protons at the chiral centers of ketorolac and flurbiprofen were more involved in the interaction with albumin. …”
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Clinical analysis of acute postoperative pain after total laparoscopic hysterectomy for adenomyosis and uterine fibroids – a prospective observational study by Qing Wu, Yun Zhou, Saijun Sun, Hui Li, Shanshan Cao, Huafeng Shou

“…Postoperative usage of Flurbiprofen in AD group were more than that of UF group (15.48 ± 38.00 vs. 4.79 ± 18.16, p = 0.02). …”
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CLINICAL EFFECTIVENESS OF NONSTEROID ANTI-INFLAMMATORY MEDICATIONS IN TREATMENT OF ENT-DISEASES IN CHILDREN by M.M. Sergeev, S.L. Kovalenko

“…Thus, ibuprofen suspension and resorption tablets with flurbiprofen provide significant anesthetic effect in children, and they can be used in practice of children’s ENT specialist.…”
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Galactosylated Prodrugs: A Strategy to Improve the Profile of Nonsteroidal Anti-Inflammatory Drugs by Federica Sodano, Claudia Cristiano, Barbara Rolando, Elisabetta Marini, Loretta Lazzarato, Mariarosaria Cuozzo, Stefania Albrizio, Roberto Russo, Maria Grazia Rimoli

“…With the aim of validating the galactose-prodrug approach, we have investigated the galactosylated prodrugs ibuprofen, ketoprofen, flurbiprofen and indomethacin, which we have named IbuGAL, OkyGAL, FluGAL and IndoGAL, respectively. …”
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