A randomised, double-blind, placebo-controlled trial of repeated nebulisation of non-viral cystic fibrosis transmembrane conductance regulator (CFTR) gene therapy in patients with... by Alton, EWFW, Armstrong, DK, Ashby, D, Bayfield, KJ, Bilton, D, Bloomfield, EV, Boyd, AC, Brand, J, Buchan, R, Calcedo, R, Carvelli, P, Chan, M, Cheng, SH, Collie, DS, Cunningham, S, Davidson, HE, Davies, G, Davies, JC, Davies, LA, Dewar, MH, Doherty, A, Donovan, J, Dwyer, NS, Elgmati, HI, Featherstone, RF, Gavino, J, Gea-Sorli, S, Geddes, DM, Gibson, JSR, Gill, DR, Greening, AP, Griesenbach, U, Hansell, DM, Harman, K, Higgins, TE, Hodges, SL, Hyde, SC, Hyndman, L, Innes, JA, Jacob, J, Jones, N, Keogh, BF, Limberis, MP, Lloyd-Evans, P, Maclean, AW, Manvell, MC, McCormick, D, McGovern, M, McLachlan, G, Meng, C, Montero, MA, Milligan, H, Moyce, LJ, Murray, GD, Nicholson, AG, Osadolor, T, Parra-Leiton, J, Porteous, DJ, Pringle, IA, Punch, EK, Pytel, KM, Quittner, AL, Rivellini, G, Saunders, CJ, Scheule, RK, Sheard, S, Simmonds, NJ, Smith, K, Smith, SN, Soussi, N, Soussi, S, Spearing, EJ, Stevenson, BJ, Sumner-Jones, SG, Turkkila, M, Ureta, RP, Waller, MD, Wasowicz, MY, Wilson, JM, Wolstenholme-Hogg, P, UK Cystic Fibrosis Gene Therapy Consortium

“…A mechanistic study was performed in a subgroup in whom transgene deoxyribonucleic acid (DNA) and messenger ribonucleic acid (mRNA) was measured alongside nasal and lower airway potential difference.There was a significant (p = 0.046) treatment effect (TE) of 3.7% [95% confidence interval (CI) 0.1% to 7.3%] in the primary end point at 12 months and in secondary end points, including forced vital capacity (FVC) (p = 0.031) and CT gas trapping (p = 0.048). …”

Metabolomics combined with proteomics analysis of femur provides a comprehensive interpretation of the changes in postmenopausal osteoporosis under salidroside treatment by Yuanyuan Zhai, Xin Li, Yifei Wang, Mengting Gao, Li Feng, Jinjun Shan, Tong Xie, Yudan Cao, Fangfang Cheng, Beihua Bao, Li Zhang, Anwei Ding, Zhipeng Li, Weifeng Yao

“…Materials and method: Firstly, we established the mice models of PMOP and detected the changes of biochemical indices in serum and histomorphometric analysis in femur to explore the effects of salidroside (SA) in treating the disease. Then, the gas chromatography-mass spectrometry (GC-MS) based metabolomics and Tandem Mass Tag (TMT) labeled proteomics of femur samples have been developed to find the possible significant metabolites and proteins in PMOP mice and all difference alters were further integrated to find the potential pathways related to PMOP. …”
Get full text

Identification and analysis of key Factors affecting the provision of suitable housing for low-income groups in the city of Tabriz by Leila Sohelivand, Farzin Haghparast, ALIREZA soltani, mahsa faramarzi

“…Introduction Due to the need to provide housing in different countries, governments have taken comprehensive measures and planning to provide housing for different groups, especially the low-income classes. …”
Get full text

棕榈油与红棕油替代牛油对传统火锅底料 风味物质布料吸附特性的影响 Effect of palm oil and red palm oil as substitutes for tallow on the cloth-adsorbed flavor substances of traditional hotpot season... by 何雨婕1，詹莹娇1，陈诗晴2，YOONG Jun Hao2，雷 激1 HE Yujie1, ZHAN Yingjiao1, CHEN Shiqing2, YOONG Jun Hao2, LEI Ji1

“…GC×GC-MS results showed that there were great differences in the cloth-adsorbed flavor substances of hotpot seasoning prepared with different oils. …”
Get full text

Secondary aerosol formation during a special dust transport event: impacts from unusually enhanced ozone and dust backflows over the ocean by D. Lu, H. Li, M. Tian, G. Wang, X. Qin, N. Zhao, J. Huo, F. Yang, Y. Lin, J. Chen, Q. Fu, Y. Duan, X. Dong, C. Deng, S. F. Abdullaev, K. Huang, K. Huang

“…This particular dust event stood out from others due to its unique characteristics, including low wind speed, high relative humidity, elevated levels of gaseous precursors, and contrasting wind patterns at different altitudes. During this event, three distinct dust stages were identified. …”
Get full text

3D-printed sheet jet for stable megahertz liquid sample delivery at X-ray free-electron lasers by Patrick E. Konold, Tong You, Johan Bielecki, Joana Valerio, Marco Kloos, Daniel Westphal, Alfredo Bellisario, Tej Varma Yenupuri, August Wollter, Jayanath C. P. Koliyadu, Faisal H.M. Koua, Romain Letrun, Adam Round, Tokushi Sato, Petra Mészáros, Leonardo Monrroy, Jennifer Mutisya, Szabolcs Bódizs, Taru Larkiala, Amke Nimmrich, Roberto Alvarez, Patrick Adams, Richard Bean, Tomas Ekeberg, Richard A. Kirian, Andrew V. Martin, Sebastian Westenhoff, Filipe R. N. C. Maia

“…Although their use has increased for soft X-ray applications in recent years, there has not yet been wide-scale adoption at XFELs. Here, gas-accelerated liquid sheet jet sample injection is demonstrated at the European XFEL SPB/SFX nano focus beamline. …”
Get full text

Assessing the sustainable development of free trade-industrial zones in Iran by Mansour Jangizehi, Mohammad Reza Maleki, Ali Salmasnia

“…Moreover, the dispersion of internal effect indicators is more than that of internal cause ones while there is a slight difference between the dispersions of external cause and effect indicators. …”
Get full text

State of the climate in 2010 by Ganesan, Anita Lakshmi, Blunden, Jessica, Arndt, Derek, Baringer, M. O.

“…Sea ice conditions in the Arctic were significantly different than those in the Antarctic during the year. …”
Get full text

Development of fuel electrode materials for solid oxide electrolysis cells by Kittiwat, Kamlungsua

“…Moreover, the main difference between Ba and K is their oxidation states. …”
Get full text

Development of serum alternative with fermented soybean residue (okara): towards cultured meat production application by Teng, Ting Shien

“…Metabolomics analysis by GC-MS was performed to elucidate the difference between fermented and unfermented okara samples. …”
Get full text

Design for disassembly of adhesively bonded joints by Caglar, Hasan

“…The dissimilar joint configurations were made of CFRP/Ti-6Al-4V and GFRP/Ti-6Al-4V by adding different Fe3O4 contents (0 wt.%, 2 wt.%, 5 wt.% and 10 wt.%). …”
Get full text

Carbon-doped Tio2: synthesis, characterization and visible light photocatalytic activities for environmental remediation by Zhang, Li

“…The C-TiO2 nanoparticles in coated form were first evaluated for the destruction of gaseous toluene as a probe VOC in the custom-built test system under both static and dynamic flow conditions with tunable light sources/intensity, feed pollutant concentration, humidity level, balancing gas and flow rates. The photocatalytic disinfection of Gram-negative Escherichia coli (E. coli) and Gram-positive Enterococcus faecalis (E. faecalis) with different cell wall structures in aqueous suspension were then investigated under different light irradiation conditions. …”
Get full text

Microbiological and biochemical quality of patin (pangasius pangasius) fillets under modified atmosphere packaging by Shariat, Maryam

“…Thus, the present study was undertaken to determine the effects of vacuum packaging and MAP with different gas mixtures on the shelf life of patin fillets stored in refrigeration temperature. …”
Get full text

Generation of meaty flavoring using chicken feather keratin hydrolysate-glucose interaction model by Opeyemi, Lasekan Adeseye

“…The extraction of volatiles was done by the headspace sampling of vials containing the solution with different solid phase microextraction (SPME) fibers followed by injection into a gas chromatography system coupled to a flame ionisation detector (FID) and mass spectrometer (MS). …”
Get full text

On the Cosmic Evolution of AGN Obscuration and the X-Ray Luminosity Function: XMM-Newton and Chandra Spectral Analysis of the 31.3 deg2 Stripe 82X by Alessandro Peca, Nico Cappelluti, C. Megan Urry, Stephanie LaMassa, Stefano Marchesi, Tonima Tasnim Ananna, Mislav Baloković, David Sanders, Connor Auge, Ezequiel Treister, Meredith Powell, Tracey Jane Turner, Allison Kirkpatrick, Chuan Tian

“…Our results agree with the evolutionary models in which the bulk of AGN activity is triggered by gas-rich environments and in a downsizing scenario. …”
Get full text

Digital breakdown and switching behaviours in high-K dielectrics in nano-scale mosfets by Liu, Wenhu.

“…The physical analyses of recovered MOSFETs suffering BD support this model. This means that BD transistors can be “repaired” electrically by a reverse voltage, introducing a significant impact on the conventional device lifetime projection. …”
Get full text

Aerosol properties derived from ground-based Fourier transform spectra within the COllaborative Carbon Column Observing Network by Ó. Alvárez, Á. Barreto, Á. Barreto, O. E. García, F. Hase, R. D. García, R. D. García, J. Gröbner, S. F. León-Luis, S. F. León-Luis, E. Sepúlveda, E. Sepúlveda, V. Carreño, A. Alcántara, R. Ramos, A. F. Almansa, A. F. Almansa, A. F. Almansa, S. Kazadzis, N. Taquet, N. Taquet, C. Toledano, E. Cuevas

“…The co-located AERONET–COCCON database was used to cross-validate these two independent techniques in the common spectral range (870–1640 <span class="inline-formula">nm</span>), demonstrating an excellent agreement at the near-coincident spectral bands (mean AOD differences limited to 0.005, standard deviations up to 0.021 and Pearson regression coefficients up to 0.97). …”
Get full text

Approach to Equilibrium of Statistical Systems: Classical Particles and Quantum Fields Off-Equilibrium by Ramon F. Álvarez-Estrada

“…A non-equilibrium quantum anharmonic oscillator is analyzed differently, through functional integral methods. The latter allows an extension to relativistic quantum <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msup><mi>ϕ</mi><mn>4</mn></msup></semantics></math></inline-formula> field theory (a meson gas off-equilibrium, without <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>h</mi><mi>b</mi></mrow></semantics></math></inline-formula>), facing ultraviolet divergences and renormalization. …”
Get full text

Evaluation of efficiency of innovation projects in housing and communal services by Novikova Maryna Mykolaivna, Burmaka Tet’ana Mykolaivna

“…Harmonizing conditions of comparing different variants of the innovation project. 4. …”
Get full text

Optimization and kinetic study of lipase-catalyzed synthesis of palm-based kojic acid ester by Ashari, Siti Efliza

“…The chemical characterization was determined by Fourier-Transform Infrared spectroscopy, Gas Chromatography- Flame Ionization Detector and Nuclear Magnetic Resonance in order to verify and elucidate the structure of product. …”
Get full text