Modelling α-synuclein processing in primary patient cells for pharmacological intervention by Jessica K. Smith, George D. Mellick, Alex M. Sykes

“…Methods: Primary patient olfactory neuroepithelial-derived cells (ONS) were exposed to α-synuclein and examined for cytotoxicity, processing, and solubility over 48 h. Epigallocatechin gallate (EGCG), which is known to destabilise α-synuclein fibrils, was used to investigate the solubilisation of α-synuclein in the model system. …”
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Changes in N-nitrosamines, Residual Nitrites, Lipid Oxidation, Biogenic Amines, and Microbiota in Chinese Sausages Following Treatment with Tea Polyphenols and Their Palmitic Acid-... by Qin Zhou, Min Mo, Anliang Wang, Bobin Tang, Qiang He

“…This study aimed to investigate the effects of tea polyphenol (TP), epigallocatechin gallate (EGCG), and their palmitic acid-modified derivatives palmitoyl-TP (pTP) and palmitoyl-EGCG (pEGCG) on the accumulation of N-nitrosamine and biogenic amines (BAs), residual nitrites, and lipid oxidation in Chinese sausages. …”
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Recent Progress in Nanotechnology Improving the Therapeutic Potential of Polyphenols for Cancer by Italo Rennan Sousa Vieira, Leticia Tessaro, Alan Kelbis Oliveira Lima, Isabela Portella Silva Velloso, Carlos Adam Conte-Junior

“…Notably, compounds such as quercetin, curcumin, epigallocatechin-3-gallate (EGCG), and resveratrol have been highlighted as antiproliferative agents for cancer. …”
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Natural polyphenol-loaded cross-linked lipoic acid vesicles treat triple-negative breast cancer by cancer cell killing and metastasis inhibition by Pei Jing, Hongli Luo, Jiangbing Tan, Chunyan Liao, Shiyong Zhang

“…Herein, we developed a fairly safe anticancer nanodrug for TNBC treatment by loading Epigallocatechin-3-gallate (EGCG) in cross-linked lipoic acid vesicles (EGCG@cLAVs), which cannot only directly kill TNBC cells through inducing apoptosis, but also significantly suppress the TNBC metastasis by metalloproteinases (MMPs) inhibition, a key event in tumor extracellular matrix (ECM) remodeling. …”
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The Activity of Cotinus coggygria Scop. Leaves on Staphylococcus aureus Strains in Planktonic and Biofilm Growth Forms by Katarína Rendeková, Silvia Fialová, Lucia Jánošová, Pavel Mučaji, Lívia Slobodníková

“…The phytochemical analysis of C. coggygria leaves 60% methanol extract performed by LC-DAD-MS/MS revealed quercetin rhamnoside, methyl gallate, and methyl trigallate as main constituents. …”
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Caloric restriction-mimetics for the reduction of heart failure risk in aging heart: with consideration of gender-related differences by Lei Pang, Xi Jiang, Xin Lian, Jie Chen, Er-Fei Song, Lei-Gang Jin, Zheng-Yuan Xia, Hai-Chun Ma, Yin Cai

“…This review will discuss three areas: (1) mechanisms underlying age-related cardiac remodeling; (2) gender-related differences and potential mechanisms underlying diminished cardiac response in older men and women; (3) we select a few polyphenol or polyamine rich compounds as the CR-mimetics, such as resveratrol, quercetin, curcumin, epigallocatechin gallate and spermidine, due to their capability to extend health-span and induce autophagy. …”
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The Anti-Inflammatory and Immunomodulatory Activities of Natural Products to Control Autoimmune Inflammation by Kamal D. Moudgil, Shivaprasad H. Venkatesha

“…Here, we describe the basic characteristics, mechanisms of action, and preventive/therapeutic applications of 5 well-characterized natural product compounds (Resveratrol, Curcumin, Boswellic acids, Epigallocatechin-3-gallate, and Triptolide). These compounds have been tested extensively in animal models of autoimmunity as well as in limited clinical trials in patients having the corresponding diseases. …”
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Pharmaceutical Drugs and Natural Therapeutic Products for the Treatment of Type 2 Diabetes Mellitus by Jana Blahova, Monika Martiniakova, Martina Babikova, Veronika Kovacova, Vladimira Mondockova, Radoslav Omelka

“…Natural health substances including non-flavonoid polyphenols (e.g., resveratrol, curcumin, tannins, and lignans), flavonoids (e.g., anthocyanins, epigallocatechin gallate, quercetin, naringin, rutin, and kaempferol), plant fruits, vegetables and other products (e.g., garlic, green tea, blackcurrant, rowanberry, bilberry, strawberry, cornelian cherry, olive oil, sesame oil, and carrot) may be a safer alternative to primary pharmacological therapy. …”
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Preparation of a novel brain-targeted EGCG liposome and its antioxidative neuroprotection by Chen Xia, Chunmei Gu, Gang Liu, Jiayuan Zhao, Siqi Wang, Chunyan Yang, Yongqing Zhu, Junlin Deng, Zuoya Xiang, Manyou Yu, Yi Guo, Yong Wu, Jian Chen

“…(-)-Epigallocatechin-3-gallate (EGCG) possesses potent antioxidant and neuroprotective properties. …”
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Natural Products in Renal-Associated Drug Discovery by Wasco Wruck, Afua Kobi Ampem Genfi, James Adjaye

“…Additionally, we conducted a meta-analysis to identify gene signatures and associated biological processes perturbed in human and mouse cells treated with antioxidants such as epigallocatechin gallate (EGCG), the active ingredient in green tea, and the mushroom Ganoderma lucidum (GL) and in kidney disease rodent models. …”
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Effectiveness of Breaded Chicken Coated with Whey Protein Isolate on Oil Absorption during Frying in Antioxidant-Rich Frying Oil by Qi Jin, Abigail Garrett, Robert Brannan

“…Chicken fritters with and without a 10% WPI post-breading dip were fried successively for 6 h per day over five days in oil without antioxidant or with either 1000 ppm rosemary extract or propyl gallate. The control oil became spent at 12 h of frying (>24% TPM, <50% DEGLEV). …”
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Green Tea (<i>Camellia sinensis</i>) Extract Induces p53-Mediated Cytotoxicity and Inhibits Migration of Breast Cancer Cells by Ronimara A. Santos, Emmanuele D. S. Andrade, Mariana Monteiro, Eliane Fialho, Jerson L. Silva, Julio B. Daleprane, Danielly C. Ferraz da Costa

“…For this study, epigallocatechin gallate (EGCG) and epigallocatechin (EGC) were identified in GTE, representing 42 and 40% of the total polyphenols, respectively. …”
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Screening of Bioactive Fraction of Radix Paeoniae Alba and Enhancing Anti-Allergic Asthma by Stir-Frying Through Regulating PI3K/AKT Signaling Pathway by Xia’nan Sang, Jialiang Ying, Xuedong Wan, Xin Han, Qiyuan Shan, Qiang Lyu, Qiao Yang, Kuilong Wang, Min Hao, Erlong Liu, Gang Cao

“…Finally, the contents of compounds with a significant difference in the FRPA dichloromethane fraction were paeoniflorin, ethyl gallate, pentagalloylglucose, galloylpaeoniflorin, and others by UPLC/Q-TOF-MS analysis. …”
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Transcriptional Comparison of New Hybrid Progenies and Clone-Cultivars of Tea (<i>Camellia sinensis</i> L.) Associated to Catechins Content by Hani Widhianata, Panjisakti Basunanda, Supriyadi Supriyadi, Taryono Taryono

“…The content of EGCG (epigallocatechin gallate) and C (catechin) was higher in ‘Kiara-8’ × ‘Sukoi’, ‘Tambi-2’ × ‘Suka Ati’, and ‘Tambi-2’ × ‘TRI-2025’ than the other hybrid and clone-cultivars. …”
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Application of Green Tea Catechin for Inducing the Osteogenic Differentiation of Human Dedifferentiated Fat Cells in Vitro by Koji Kaida, Yoshitomo Honda, Yoshiya Hashimoto, Masahiro Tanaka, Shunsuke Baba

“…We attempted to investigate whether epigallocatechin-3-gallate (EGCG), the main component of green tea catechin, facilitates early osteogenic differentiation and mineralization on DFAT cells in vitro. …”
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Fatty Acid Synthase Inhibitor G28 Shows Anticancer Activity in EGFR Tyrosine Kinase Inhibitor Resistant Lung Adenocarcinoma Models by Emma Polonio-Alcalá, Sònia Palomeras, Daniel Torres-Oteros, Joana Relat, Marta Planas, Lidia Feliu, Joaquim Ciurana, Santiago Ruiz-Martínez, Teresa Puig

“…Using EGFR mutated (EGFRm) NSCLC sensitive and EGFR TKIs’ resistant models (Gefitinib Resistant, GR) we studied the role of the natural polyphenolic anti-FASN compound (−)-epigallocatechin-3-gallate (EGCG), and its derivative G28 to overcome EGFR TKIs’ resistance. …”
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Modified black phosphorus quantum dots promotes spinal cord injury repair by targeting the AKT signaling pathway by Dong-Mei Xie, Chuanwei Sun, Qingqiang Tu, Suyi Li, Yu Zhang, Xifan Mei, Yuanlong Li

“…Hydrogel with neuron-protective behaviors attracts tremendous attention, and black phosphorus quantum dots (BPQDs) encapsulating with Epigallocatechin-3-gallate (EGCG) hydrogels (E@BP) is designed for inflammatory modulation and SCI treatment in this study. …”
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Polyphenol Iongel Patches with Antimicrobial, Antioxidant and Anti-Inflammatory Properties by Gisela C. Luque, Melissa Moya, Matias L. Picchio, Vanessa Bagnarello, Idalia Valerio, José Bolaños, María Vethencourt, Sue-Hellen Gamboa, Liliana C. Tomé, Roque J. Minari, David Mecerreyes

“…In this work, we report the preparation and characterization of soft and bioactive iongel materials for patches, based on polymeric poly(vinyl alcohol) (PVA) and four ionic liquids containing the cholinium cation and different phenolic acid anions, namely cholinium salicylate ([Ch][Sal]), cholinium gallate ([Ch][Ga]), cholinium vanillate ([Ch][Van]), and cholinium caffeate ([Ch][Caff]). …”
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Effects of SAHA and EGCG on Growth Potentiation of Triple-Negative Breast Cancer Cells by Kayla A. Lewis, Harrison R. Jordan, Trygve O. Tollefsbol

“…Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase (HDAC) inhibitor currently used in the treatment of cutaneous T cell lymphoma, was administered to triple-negative breast cancer cells alone or in combination with epigallocatechin-3-gallate (EGCG), a DNA methyltransferase (DNMT) inhibitor isolated from green tea. …”
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Study of the Phenolic Compound Profile of <i>Arbutus unedo</i> L. Fruits at Different Ripening Stages by HPLC-TQ-MS/MS by Sergio Izcara, Sonia Morante-Zarcero, Natalia Casado, Isabel Sierra

“…High amounts of (+)-catechin, procyanidin B2, epigallocatechin, and (−)-epigallocatechin gallate were observed in the unripe fruits. Naringin and vitexin were also quantified. …”
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