Bioassay-Guided Assessment of Antioxidative, Anti-Inflammatory and Antimicrobial Activities of Extracts from Medicinal Plants via High-Performance Thin-Layer Chromatography by Marko D. Jović, Snezana Agatonovic-Kustrin, Petar M. Ristivojević, Jelena Đ. Trifković, David W. Morton

“…Although earlier studies have related green tea’s anti-inflammatory properties to the presence of catechins, particularly epigallocatechin-3-gallate, the FTIR spectrum of the compound from the most intense bioactive zone showed the strongest anti-inflammatory activity can be attributed to amino acids and heterocyclic compounds. …”
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MT1-MMP Cooperates with TGF-β Receptor-Mediated Signaling to Trigger SNAIL and Induce Epithelial-to-Mesenchymal-like Transition in U87 Glioblastoma Cells by Souad Djediai, Narjara Gonzalez Suarez, Layal El Cheikh-Hussein, Sahily Rodriguez Torres, Loraine Gresseau, Sheraz Dhayne, Zoé Joly-Lopez, Borhane Annabi

“…Those inductions were antagonized by the TGF-β receptor kinase inhibitor galunisertib, the JAK/STAT inhibitors AG490 and tofacitinib, and by the diet-derived epigallocatechin gallate (EGCG). Transient gene silencing of MT1-MMP prevented the induction of SNAIL by ConA and abrogated TGF-β-induced cell chemotaxis. …”
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Antibacterial and Disinfecting Effects of Standardised Tea Extracts on More than 100 Clinical Isolates of Methicillin-Resistant <i>Staphylococcus aureus</i> by Ruth Feilcke, Volker Bär, Constanze Wendt, Peter Imming

“…To investigate the possibility of sterilising MRSA-infected surfaces, including skin with tea extracts, we determined the MICs for different extracts from green and black tea (<i>Camellia sinensis</i>), including epigallocatechin gallate (EGCG), on a large number of clinical isolates of MRSA, selected to represent a high genetic diversity. …”
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Channel activity of SARS-CoV-2 viroporin ORF3a inhibited by adamantanes and phenolic plant metabolites by Marina Sherif Fam, Christine Adel Sedky, Nancy Osama Turky, Hans-Georg Breitinger, Ulrike Breitinger

“…Kaempferol, quercetin, epigallocatechin gallate, nobiletin, resveratrol and curcumin were ORF3a inhibitors, with IC50 values ranging between 1 and 6 µM, while 6-gingerol, apigenin, naringenin and genistein were inactive. …”
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LCMS/MS Phytochemical Profiling, Molecular, Pathological, and Immune-Histochemical Studies on the Anticancer Properties of <i>Annona muricata</i> by Rehab H. Abdallah, Muneera S. M. Al-Saleem, Wael M. Abdel-Mageed, Al-Sayed R. Al-Attar, Youssef M. Shehata, Doaa M. Abdel-Fattah, Rahnaa M. Atta

“…Among them, four compounds were tentatively characterized as new compounds (<b>1</b>–<b>4</b>), including an acid derivative, protocatechuic-coumaroyl-quinic acid (<b>1</b>), and three flavonoid derivatives, dihydromyricetin galloyl hexoside (<b>2</b>), apigenin gallate (<b>3</b>), and dihydromyricetin hexouronic acid hexoside (<b>4</b>). …”
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The Effect of Angiotensin II, Retinoic Acid, EGCG, and Vitamin C on the Cardiomyogenic Differentiation Induction of Human Amniotic Fluid-Derived Mesenchymal Stem Cells by Monika Gasiūnienė, Elvina Valatkaitė, Aistė Navakauskaitė, Rūta Navakauskienė

“…We investigated the potential of biologically active compounds, namely, angiotensin II, retinoic acid (RA), epigallocatechin-3-gallate (EGCG), vitamin C alone, and the combinations of RA, EGCG, and vitamin C with angiotensin II to induce cardiomyogenic differentiation of AF-MSCs. …”
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Quantitative Analysis of Flavonoids in Fruiting Bodies of <i>Sanghuangporus</i> Using Ultra-High-Performance Liquid Chromatography Coupled with Triple Quadrupole Mass Spectrometry by Zhongjing Zhou, Zhiping Deng, Shuang Liang, Xiaowei Zou, Yi Teng, Weike Wang, Lizhong Fu

“…This method enabled the simultaneous detection of 10 flavonoids (sakuranetin, quercitrin, myricitrin, kaempferol, luteolin, rutin, hyperoside, kaempferol-3-<i>O</i>-rutinoside, catechin, and catechin gallate) in the fruiting bodies of <i>Sanghuangporus</i>. …”
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De Novo Missense Mutations in <i>TNNC1</i> and <i>TNNI3</i> Causing Severe Infantile Cardiomyopathy Affect Myofilament Structure and Function and Are Modulated by Troponin Targetin... by Roua Hassoun, Heidi Budde, Hans Georg Mannherz, Mária Lódi, Setsuko Fujita-Becker, Kai Thorsten Laser, Anna Gärtner, Karin Klingel, Desirée Möhner, Robert Stehle, Innas Sultana, Thomas Schaaf, Mario Majchrzak, Verena Krause, Christian Herrmann, Marc M. Nowaczyk, Andreas Mügge, Gabriele Pfitzer, Rasmus R. Schröder, Nazha Hamdani, Hendrik Milting, Kornelia Jaquet, Diana Cimiotti

“…The two troponin targeting agents levosimendan and green tea extract (-)-epigallocatechin-3-gallate (EGCg) stabilized the structural integrity of reconstituted thin filaments and ameliorated contractile function in vitro in some, but not all, aspects to a similar degree for both mutations.…”
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Macrophage metabolism reprogramming EGCG-Cu coordination capsules delivered in polyzwitterionic hydrogel for burn wound healing and regeneration by Qinghua Li, Huijuan Song, Shuangyang Li, Pengbo Hu, Chuangnian Zhang, Ju Zhang, Zujian Feng, Deling Kong, Weiwei Wang, Pingsheng Huang

“…Here, a novel bioactive, anti-fouling, flexible polyzwitterionic hydrogel encapsulated with epigallocatechin gallate (EGCG)-copper (Cu) capsules (termed as EGCG-Cu@CBgel) is engineered for burn wound management, which is dedicated to synergistically exerting ROS-scavenging, immune metabolic regulation and pro-angiogenic effects. …”
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Composition and Antioxidant Activity of Phenolic Compounds in Fruit of the Genus <i>Rosa</i> L. by Mindaugas Liaudanskas, Irena Noreikienė, Kristina Zymonė, Rugilė Juodytė, Vaidotas Žvikas, Valdimaras Janulis

“…The following phenolic compounds were identified in fruit samples: caffeic acid, chlorogenic acid, quercetin, quercitrin, (+)-catechin, (−)-epicatechin, (−)-epicatechin gallate, rutin, phloridzin, and kaempferol-3-O-glycoside. …”
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Investigating the Theranostic Potential of Graphene Quantum Dots in Alzheimer’s Disease by Max Walton-Raaby, Riley Woods, Subha Kalyaanamoorthy

“…In PHFs, GQD28 interacted strongly near the protofibril interface at the putative disaggregation site for epigallocatechin-3-gallate, and GQD7 largely interacted with PHF6. Our analyses revealed several key GQD binding sites that may be used for detecting, preventing, and disassembling the Tau aggregates in AD.…”
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EGCG-NPs inhibition HO-1-mediated reprogram iron metabolism against ferroptosis after subarachnoid hemorrhage by Liyong Huang, Xue Wang, Yanning Zheng, Dongcen Lang, Jian Wang, Shuaiguo Yan, Ying Chen

“…. (-)-Epigallocatechin-3-gallate (EGCG) is one of major bioactive compounds of tea catechin because of its well-known iron-chelating and antioxidative activities. …”
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Targeted and activatable nanosystem for fluorescent and optoacoustic imaging of immune-mediated inflammatory diseases and therapy via inhibiting NF-κB/NLRP3 pathways by Lihe Sun, Juan Ouyang, Zhuo Zeng, Cheng Zeng, Yunqing Ma, Fang Zeng, Shuizhu Wu

“…A ROS-activatable prodrug BH-EGCG is synthesized by coupling a near-infrared chromophore with the NF-κB/NLRP3 inhibitor epigallocatechin-3-gallate (EGCG) through boronate bond which serves as both the fluorescence quencher and ROS-responsive moiety. …”
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Augmentation of Bone Regeneration by Depletion of Stress-Induced Senescent Cells Using Catechin and Senolytics by Yoshitomo Honda, Anqi Huang, Tomonari Tanaka, Xiaoyu Han, Beiyuan Gao, Haitao Liu, Xinchen Wang, Jianxin Zhao, Yoshiya Hashimoto, Kazuyo Yamamoto, Naoyuki Matsumoto, Shunsuke Baba, Makoto Umeda

“…Parallel to LS-G implantation, local epigallocatechin gallate (EGCG) administration, and systemic senolytic (dasatinib and quercetin: D+Q) administration were used to eliminate SIPS cells. …”
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Genetic behavior of rice (Oryza sativa) genotypes under normal and infested weed conditions by Abd EL-Aty M S, El Hity M A, M I Abo-Youssef, M A Abo Omar, M M Kamara

“…The highest desirable SCA effects were obtained by the crosses; Egyptian Yasmin × Dullar, Sakha 104 × Egyptian Yasmin, Egyptian Yasmin × Rikuto Norin 22 and Giza 177 × Rikuto Norin 22 for flag leaf area, No. of panicles/plant and grain yield/plant. …”
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Natural Products and Derivatives as Potential <i>Zika virus</i> Inhibitors: A Comprehensive Review by Rosângela Santos Pereira, Françoise Camila Pereira Santos, Priscilla Rodrigues Valadares Campana, Vivian Vasconcelos Costa, Rodrigo Maia de Pádua, Daniele G. Souza, Mauro Martins Teixeira, Fernão Castro Braga

“…The highest values of the selectivity index, the ratio between cytotoxicity and antiviral activity (SI = CC₅₀/EC₅₀), were reported for epigallocatechin gallate (SI ≥ 25,000) and anisomycin (SI ≥ 11,900) obtained from <i>Streptomyces</i> bacteria, dolastane (SI = 1246) isolated from the marine seaweed <i>Canistrocarpus cervicorni</i>, and the flavonol myricetin (SI ≥ 862). …”
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Spontaneous Osteogenic Differentiation of Human Mesenchymal Stem Cells by Tuna-Bone-Derived Hydroxyapatite Composites with Green Tea Polyphenol-Reduced Graphene Oxide by Moon Sung Kang, Rowoon Park, Hyo Jung Jo, Yong Cheol Shin, Chang-Seok Kim, Suong-Hyu Hyon, Suck Won Hong, Junghwan Oh, Dong-Wook Han

“…The method uses epigallocatechin-3-<i>O</i>-gallate (EGCG) as a reducing agent to synthesize rGO (E-rGO), and HAp powder is obtained from Atlantic bluefin tuna (<i>Thunnus thynnus</i>). …”
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Anti-hepatitis B virus activity of food nutrients and potential mechanisms of action by Alexis Jose-Abrego, Ingrid Rivera-Iñiguez, Luis A. Torres-Reyes, Sonia Roman

“…Recent studies suggest resveratrol, vitamin E, lactoferrin, selenium, curcumin, luteolin-7-O-glucoside, moringa extracts, chlorogenic acid, and epigallocatechin-3-gallate may be beneficial for patients with hepatitis B. …”
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EGCG-Mediated Potential Inhibition of Biofilm Development and Quorum Sensing in <i>Pseudomonas aeruginosa</i> by Suqi Hao, Dan Yang, Ling Zhao, Fei Shi, Gang Ye, Hualin Fu, Juchun Lin, Hongrui Guo, Ran He, Jianlong Li, Hongwei Chen, Muhammad Faraz Khan, Yinglun Li, Huaqiao Tang

“…The present study has evaluated the anti-QS and anti-infective activity of epigallocatechin-3-gallate (EGCG), a bioactive ingredient of the traditional green tea, against <i>P. aeruginosa</i>. …”
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Investigating the role of uncoupling of Troponin I phosphorylation from changes in myofibrillar Ca2+-sensitivity in the pathogenesis of Cardiomyopathy by Andrew Easton Messer, Steven Baxter Marston

“…Recently, it has been found that Ca2+-sensitizing drugs can promote uncoupling, whilst one Ca2+-desensitising drug Epigallocatechin 3-Gallate (EGCG) can reverse uncoupling.We will discuss recent findings about the role of uncoupling in the development of cardiomyopathies and the molecular mechanism of the process.…”
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