-
3461
Bioassay-Guided Assessment of Antioxidative, Anti-Inflammatory and Antimicrobial Activities of Extracts from Medicinal Plants via High-Performance Thin-Layer Chromatography
Published 2023-10-01“…Although earlier studies have related green tea’s anti-inflammatory properties to the presence of catechins, particularly epigallocatechin-3-gallate, the FTIR spectrum of the compound from the most intense bioactive zone showed the strongest anti-inflammatory activity can be attributed to amino acids and heterocyclic compounds. …”
Get full text
Article -
3462
MT1-MMP Cooperates with TGF-β Receptor-Mediated Signaling to Trigger SNAIL and Induce Epithelial-to-Mesenchymal-like Transition in U87 Glioblastoma Cells
Published 2021-11-01“…Those inductions were antagonized by the TGF-β receptor kinase inhibitor galunisertib, the JAK/STAT inhibitors AG490 and tofacitinib, and by the diet-derived epigallocatechin gallate (EGCG). Transient gene silencing of MT1-MMP prevented the induction of SNAIL by ConA and abrogated TGF-β-induced cell chemotaxis. …”
Get full text
Article -
3463
Antibacterial and Disinfecting Effects of Standardised Tea Extracts on More than 100 Clinical Isolates of Methicillin-Resistant <i>Staphylococcus aureus</i>
Published 2023-09-01“…To investigate the possibility of sterilising MRSA-infected surfaces, including skin with tea extracts, we determined the MICs for different extracts from green and black tea (<i>Camellia sinensis</i>), including epigallocatechin gallate (EGCG), on a large number of clinical isolates of MRSA, selected to represent a high genetic diversity. …”
Get full text
Article -
3464
Channel activity of SARS-CoV-2 viroporin ORF3a inhibited by adamantanes and phenolic plant metabolites
Published 2023-04-01“…Kaempferol, quercetin, epigallocatechin gallate, nobiletin, resveratrol and curcumin were ORF3a inhibitors, with IC50 values ranging between 1 and 6 µM, while 6-gingerol, apigenin, naringenin and genistein were inactive. …”
Get full text
Article -
3465
LCMS/MS Phytochemical Profiling, Molecular, Pathological, and Immune-Histochemical Studies on the Anticancer Properties of <i>Annona muricata</i>
Published 2023-07-01“…Among them, four compounds were tentatively characterized as new compounds (<b>1</b>–<b>4</b>), including an acid derivative, protocatechuic-coumaroyl-quinic acid (<b>1</b>), and three flavonoid derivatives, dihydromyricetin galloyl hexoside (<b>2</b>), apigenin gallate (<b>3</b>), and dihydromyricetin hexouronic acid hexoside (<b>4</b>). …”
Get full text
Article -
3466
The Effect of Angiotensin II, Retinoic Acid, EGCG, and Vitamin C on the Cardiomyogenic Differentiation Induction of Human Amniotic Fluid-Derived Mesenchymal Stem Cells
Published 2020-11-01“…We investigated the potential of biologically active compounds, namely, angiotensin II, retinoic acid (RA), epigallocatechin-3-gallate (EGCG), vitamin C alone, and the combinations of RA, EGCG, and vitamin C with angiotensin II to induce cardiomyogenic differentiation of AF-MSCs. …”
Get full text
Article -
3467
Quantitative Analysis of Flavonoids in Fruiting Bodies of <i>Sanghuangporus</i> Using Ultra-High-Performance Liquid Chromatography Coupled with Triple Quadrupole Mass Spectrometry
Published 2023-07-01“…This method enabled the simultaneous detection of 10 flavonoids (sakuranetin, quercitrin, myricitrin, kaempferol, luteolin, rutin, hyperoside, kaempferol-3-<i>O</i>-rutinoside, catechin, and catechin gallate) in the fruiting bodies of <i>Sanghuangporus</i>. …”
Get full text
Article -
3468
De Novo Missense Mutations in <i>TNNC1</i> and <i>TNNI3</i> Causing Severe Infantile Cardiomyopathy Affect Myofilament Structure and Function and Are Modulated by Troponin Targetin...
Published 2021-09-01“…The two troponin targeting agents levosimendan and green tea extract (-)-epigallocatechin-3-gallate (EGCg) stabilized the structural integrity of reconstituted thin filaments and ameliorated contractile function in vitro in some, but not all, aspects to a similar degree for both mutations.…”
Get full text
Article -
3469
Macrophage metabolism reprogramming EGCG-Cu coordination capsules delivered in polyzwitterionic hydrogel for burn wound healing and regeneration
Published 2023-11-01“…Here, a novel bioactive, anti-fouling, flexible polyzwitterionic hydrogel encapsulated with epigallocatechin gallate (EGCG)-copper (Cu) capsules (termed as EGCG-Cu@CBgel) is engineered for burn wound management, which is dedicated to synergistically exerting ROS-scavenging, immune metabolic regulation and pro-angiogenic effects. …”
Get full text
Article -
3470
Composition and Antioxidant Activity of Phenolic Compounds in Fruit of the Genus <i>Rosa</i> L.
Published 2021-04-01“…The following phenolic compounds were identified in fruit samples: caffeic acid, chlorogenic acid, quercetin, quercitrin, (+)-catechin, (−)-epicatechin, (−)-epicatechin gallate, rutin, phloridzin, and kaempferol-3-O-glycoside. …”
Get full text
Article -
3471
Investigating the Theranostic Potential of Graphene Quantum Dots in Alzheimer’s Disease
Published 2023-05-01“…In PHFs, GQD28 interacted strongly near the protofibril interface at the putative disaggregation site for epigallocatechin-3-gallate, and GQD7 largely interacted with PHF6. Our analyses revealed several key GQD binding sites that may be used for detecting, preventing, and disassembling the Tau aggregates in AD.…”
Get full text
Article -
3472
EGCG-NPs inhibition HO-1-mediated reprogram iron metabolism against ferroptosis after subarachnoid hemorrhage
Published 2024-04-01“…. (-)-Epigallocatechin-3-gallate (EGCG) is one of major bioactive compounds of tea catechin because of its well-known iron-chelating and antioxidative activities. …”
Get full text
Article -
3473
Targeted and activatable nanosystem for fluorescent and optoacoustic imaging of immune-mediated inflammatory diseases and therapy via inhibiting NF-κB/NLRP3 pathways
Published 2022-04-01“…A ROS-activatable prodrug BH-EGCG is synthesized by coupling a near-infrared chromophore with the NF-κB/NLRP3 inhibitor epigallocatechin-3-gallate (EGCG) through boronate bond which serves as both the fluorescence quencher and ROS-responsive moiety. …”
Get full text
Article -
3474
Augmentation of Bone Regeneration by Depletion of Stress-Induced Senescent Cells Using Catechin and Senolytics
Published 2020-06-01“…Parallel to LS-G implantation, local epigallocatechin gallate (EGCG) administration, and systemic senolytic (dasatinib and quercetin: D+Q) administration were used to eliminate SIPS cells. …”
Get full text
Article -
3475
Genetic behavior of rice (Oryza sativa) genotypes under normal and infested weed conditions
Published 2020-09-01“…The highest desirable SCA effects were obtained by the crosses; Egyptian Yasmin × Dullar, Sakha 104 × Egyptian Yasmin, Egyptian Yasmin × Rikuto Norin 22 and Giza 177 × Rikuto Norin 22 for flag leaf area, No. of panicles/plant and grain yield/plant. …”
Get full text
Article -
3476
Natural Products and Derivatives as Potential <i>Zika virus</i> Inhibitors: A Comprehensive Review
Published 2023-05-01“…The highest values of the selectivity index, the ratio between cytotoxicity and antiviral activity (SI = CC<sub>50</sub>/EC<sub>50</sub>), were reported for epigallocatechin gallate (SI ≥ 25,000) and anisomycin (SI ≥ 11,900) obtained from <i>Streptomyces</i> bacteria, dolastane (SI = 1246) isolated from the marine seaweed <i>Canistrocarpus cervicorni</i>, and the flavonol myricetin (SI ≥ 862). …”
Get full text
Article -
3477
Spontaneous Osteogenic Differentiation of Human Mesenchymal Stem Cells by Tuna-Bone-Derived Hydroxyapatite Composites with Green Tea Polyphenol-Reduced Graphene Oxide
Published 2023-05-01“…The method uses epigallocatechin-3-<i>O</i>-gallate (EGCG) as a reducing agent to synthesize rGO (E-rGO), and HAp powder is obtained from Atlantic bluefin tuna (<i>Thunnus thynnus</i>). …”
Get full text
Article -
3478
Anti-hepatitis B virus activity of food nutrients and potential mechanisms of action
Published 2023-07-01“…Recent studies suggest resveratrol, vitamin E, lactoferrin, selenium, curcumin, luteolin-7-O-glucoside, moringa extracts, chlorogenic acid, and epigallocatechin-3-gallate may be beneficial for patients with hepatitis B. …”
Get full text
Article -
3479
EGCG-Mediated Potential Inhibition of Biofilm Development and Quorum Sensing in <i>Pseudomonas aeruginosa</i>
Published 2021-05-01“…The present study has evaluated the anti-QS and anti-infective activity of epigallocatechin-3-gallate (EGCG), a bioactive ingredient of the traditional green tea, against <i>P. aeruginosa</i>. …”
Get full text
Article -
3480
Investigating the role of uncoupling of Troponin I phosphorylation from changes in myofibrillar Ca2+-sensitivity in the pathogenesis of Cardiomyopathy
Published 2014-08-01“…Recently, it has been found that Ca2+-sensitizing drugs can promote uncoupling, whilst one Ca2+-desensitising drug Epigallocatechin 3-Gallate (EGCG) can reverse uncoupling.We will discuss recent findings about the role of uncoupling in the development of cardiomyopathies and the molecular mechanism of the process.…”
Get full text
Article