EGCG, a Green Tea Compound, Increases NO Production and Has Antioxidant Action in a Static and Shear Stress In Vitro Model of Preeclampsia by Mariana Bertozzi-Matheus, Thaina Omia Bueno-Pereira, Priscila Rezeck Nunes, Valeria Cristina Sandrim

“…Preeclampsia (PE) is a gestational hypertensive disease characterized by endothelial dysfunction. Epigallocatechin-3-gallate (EGCG), the main compound in green tea, is a promising therapeutic target for the disease. …”
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Detection of Antioxidant Phytochemicals Isolated from <i>Camellia japonica</i> Seeds Using HPLC and EPR Imaging by Chalermpong Saenjum, Thanawat Pattananandecha, Kouichi Nakagawa

“…HPLC chromatograms indicated that hydrophilic antioxidant compounds—namely, gallic acid, gallocatechin, epigallocatechin, caffeine, catechin, epicatechin, and epicatechin gallate—were found in the methanolic extract. Lipophilic antioxidant compounds—including α-tocopherol, γ-tocopherol, β-tocopherol, δ-tocopherol, α-tocotrienol, γ-tocotrienol, and δ-tocotrienol—were found in the hexane extract. …”
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Brewer’s Spent Grain, Coffee Grounds, Burdock, and Willow–Four Examples of Biowaste and Biomass Valorization through Advanced Green Extraction Technologies by Massimiliano Errico, Jose A. P. Coelho, Roumiana P. Stateva, Knud V. Christensen, Rime Bahij, Stefania Tronci

“…Extracts rich in linoleic and oleic acids are expected from the seeds, while the roots extracts are rich in sugars, phenolic acids such as chlorogenic, caffeic, <i>o</i>-coumaric, syringic, cinnamic, gentisitic, etc. acids, and, interestingly, the high-value compound epicatechin gallate. Willow is well known for being rich in salicin, but picein, (+)-catechin, triandrin, glucose, and fructose are also obtained from the extracts. …”
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Tea Polyphenols Prevent and Intervene in COVID-19 through Intestinal Microbiota by Qiao Xiang, Lu Cheng, Ruilin Zhang, Yanan Liu, Zufang Wu, Xin Zhang

“…Among them, (−)-epigallocatechin-3-gallate (EGCG), one of the main monomers of catechins, may be activated as nuclear factor erythroid 2 p45-related factor 2 (Nrf2). …”
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Qualitative Analysis of Grapevine Tannins by Mass Spectrometry and their Inhibitory Effect on Stilbene Oxidase of Botrytis cinerea by Camille Perret, Roger Pezet, Raffaele Tabacchi

“… The pure tannin extracts from grape berries of Gamay and Gamaret varieties contain a mixture of proanthocyanidins and proanthocyanidin gallates. A sensitive LC-MS method has been developed for the qualitative analysis of the oligomers and polymeric fractions. …”
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The Role of Eosinophil-Derived Neurotoxin and Vascular Endothelial Growth Factor in the Pathogenesis of Eosinophilic Asthma by Maciej Tota, Julia Łacwik, Julia Laska, Łukasz Sędek, Krzysztof Gomułka

“…We identified lichochalcone A, bevacizumab, azithromycin (AZT), vitamin D, diosmetin, epigallocatechin gallate, IGFBP-3, Neovastat (AE-941), endostatin, PEDF, and melatonin as putative add-on drugs in asthma with anti-VEGF properties. …”
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Genotoxicity of chlorinated hydrophobic organic compounds extracted from a source of drinking water by Binbin Wu, Yanling Zhang, Yuehua You, Yan Liang

“…Protective effects of antioxidants (catalase, vitamin C and epigallocatechin 3-gallate (EGCG)) on genotoxicity of the chlorinated samples were investigated. …”
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EGCG Inhibits Tumor Growth in Melanoma by Targeting JAK-STAT Signaling and Its Downstream PD-L1/PD-L2-PD1 Axis in Tumors and Enhancing Cytotoxic T-Cell Responses by Dinoop Ravindran Menon, Yang Li, Takeshi Yamauchi, Douglas Grant Osborne, Prasanna Kumar Vaddi, Michael F Wempe, Zili Zhai, Mayumi Fujita

“…Here, we report that epigallocatechin gallate (EGCG), the most abundant catechin in green tea, inhibits melanoma growth by modulating an immune response against tumors. …”
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<i>Saxifraga spinulosa</i>-Derived Components Rapidly Inactivate Multiple Viruses Including SARS-CoV-2 by Yohei Takeda, Toshihiro Murata, Dulamjav Jamsransuren, Keisuke Suganuma, Yuta Kazami, Javzan Batkhuu, Duger Badral, Haruko Ogawa

“…Among our findings, we found that <i>SS</i>-derived gallocatechin gallate compounds were capable of inactivating all viruses tested. …”
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Plant Phenolics and Extracts in Animal Models of Preeclampsia and Clinical Trials—Review of Perspectives for Novel Therapies by Marcin Ożarowski, Tomasz M. Karpiński, Michał Szulc, Karolina Wielgus, Radosław Kujawski, Hubert Wolski, Agnieszka Seremak-Mrozikiewicz

“…The aim of our research review was to identify and analyze the results of already available studies on baicalin, curcumin, epigallocatechin gallate, punicalagin, quercetin, resveratrol, salvianolic acid A (danshensu), silibinin, and vitexin, as well as plant extracts from <i>Brassica oleracea</i> L., <i>Euterpe oleracea</i> Mart., <i>Moringa oleifera</i> Lam., <i>Punica granatum</i> L., <i>Silybum marianum</i> (L.) …”
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Label Free Inhibitor Screening of Hepatitis C Virus (HCV) NS5B Viral Protein Using RNA Oligonucleotide by Sang Eun Kim, Sung-Kee Jo, Changhyun Roh

“…Among the inhibitors screened, (−)-Epigallocatechin gallate showed high binding inhibition effect on HCV NS5B viral protein. …”
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Assessment of the range of the HIV-1 infectivity enhancing effect of individual human semen specimen and the range of inhibition by EGCG by Hartjen Philip, Frerk Sebastian, Hauber Ilona, Matzat Verena, Thomssen Adriana, Holstermann Barbara, Hohenberg Heinrich, Schulze Wolfgang, Schulze zur Wiesch Julian, van Lunzen Jan

“…Moreover, we confirm that the infectivity enhancing property can be inhibited by the major green tea ingredient epigallocatechin-3-gallate (EGCG) at non-toxic concentrations. The median inhibition of infection by treatment with 0.4 mM EGCG was 70.6% (p < 0.0001) in our cohort. …”
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Tea polyphenol-engineered hybrid cellular nanovesicles for cancer immunotherapy and androgen deprivation therapy by Yiming Guo, Jicheng Wu, Lefan Chen, Lujie Liu, Tianxiang Bi, Yuanwei Pan, Qian-Fang Meng, Chaoliang Wang, Lang Rao, Qi Li

“…Herein, we developed a biomimetic nanotherapeutic platform by deriving cell membrane nanovesicles from cancer cells and probiotics to yield the hybrid cellular nanovesicles (hNVs), loading flutamide (Flu) into the resulting hNVs, and finally modifying the hNVs@Flu with Epigallocatechin-3-gallate (EGCG). In this nanotherapeutic platform, the hNVs significantly improved the accumulation of hNVs@Flu-EGCG in tumor sites and reprogramed immunosuppressive M2 macrophages into antitumorigenic M1 macrophages, the Flu acted on androgen receptors and inhibited tumor proliferation, and the EGCG promoted apoptosis of prostate cancer cells by inhibiting the NF-κB pathway, thus synergistically stimulating the antitumor immunity and reducing the side effects and resistance of ADT. …”
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Dietary Polyphenols, Microbiome, and Multiple Sclerosis: From Molecular Anti-Inflammatory and Neuroprotective Mechanisms to Clinical Evidence by Giuliana La Rosa, Maria Serena Lonardo, Nunzia Cacciapuoti, Espedita Muscariello, Bruna Guida, Raffaella Faraonio, Mariarosaria Santillo, Simona Damiano

“…Clinical evidence for the use of polyphenols as adjuvant therapy in MS is restricted to a smaller number of substances, mainly curcumin and epigallocatechin gallate. In the last part of the review, a clinical trial studying the effects of these polyphenols in MS patients will also be revised.…”
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Investigation of Phenolic Compounds and Antioxidant Activity of <i>Sorbaria pallasii</i> (Rosaceae) Microshoots Grown In Vitro by Titiana V. Zheleznichenko, Tatiana N. Veklich, Vera A. Kostikova

“…Concentrations of epigallocatechin gallate (0.38 mg/(g of ADM)) and (−)-epicatechin (0.55 mg/(g of ADM)) were significantly lower. …”
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Interactions of Galloylated Polyphenols with a Simple Gram-Negative Bacterial Membrane Lipid Model by Ryan T. Coones, Maarit Karonen, Rebecca J. Green, Richard Frazier

“…Differential scanning calorimetry (DSC) was used to explore the interactions of isolated polyphenolic compounds, including (-)-epigallocatechin gallate ((-)-EGCg), tellimagrandins I and II (Tel-I and Tel-II), and 1,2,3,4,6-penta-<i>O</i>-galloyl-<span style="font-variant: small-caps;">d</span>-glucose (PGG), with a model Gram-negative bacterial membrane with a view to investigating their antimicrobial properties. …”
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Anti-Diabetic Effects of Different Phenolic-Rich Fractions from Rhus Chinensis Mill. Fruits in vitro by Xiaojing Liu, Yishan Fu, Qian Ma, Junjie Yi, Shengbao Cai

“…Correlation analysis indicated that myricetin-3-O-(6″-galloyl) glycoside and myricetin O-gallate contributed significantly on α-glucosidase inhibition, while di-O-galloyl-glucoside and its isomer may contribute remarkably toward DPP-IV inhibition. …”
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Polyphenolics with Strong Antioxidant Activity from <i>Acacia nilotica</i> Ameliorate Some Biochemical Signs of Arsenic-Induced Neurotoxicity and Oxidative Stress in Mice by Tahira Foyzun, Abdullah Al Mahmud, Md. Salim Ahammed, Md. Imran Nur Manik, Md. Kamrul Hasan, KM Monirul Islam, Simin Sobnom Lopa, Md. Yusuf Al-Amin, Kushal Biswas, Mst. Rejina Afrin, AHM Khurshid Alam, Golam Sadik

“…Gallic acid methyl ester, catechin and catechin-7-gallate were identified in the polyphenolics as the major active compounds. …”
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Influence of Tea Consumption on the Development of Second Esophageal Neoplasm in Patients with Head and Neck Cancer by Yao-Kuang Wang, Wei-Chung Chen, Ying-Ho Lai, Yi-Hsun Chen, Ming-Tsang Wu, Chie-Tong Kuo, Yen-Yun Wang, Shyng-Shiou F. Yuan, Yu-Peng Liu, I-Chen Wu

“…In vitro studies were conducted to investigate the effect of epigallocatechin gallate (EGCG) on the betel alkaloid, arecoline-stimulated carcinogenesis in two ESCC cell lines. …”
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Screening and Analysis of Possible Drugs Binding to PDGFRα: A Molecular Modeling Study by Matteo Mozzicafreddo, Devis Benfaremo, Chiara Paolini, Silvia Agarbati, Silvia Svegliati Baroni, Gianluca Moroncini

“…Among these 27 compounds, the drugs Bafetinib, Radotinib, Flumatinib, and Imatinib showed higher affinity for this tyrosine kinase receptor, lying in the nanomolar order, while the natural products included in this group, such as curcumin, luteolin, and epigallocatechin gallate (EGCG), showed sub-micromolar affinities. …”
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