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3481
EGCG, a Green Tea Compound, Increases NO Production and Has Antioxidant Action in a Static and Shear Stress In Vitro Model of Preeclampsia
Published 2024-01-01“…Preeclampsia (PE) is a gestational hypertensive disease characterized by endothelial dysfunction. Epigallocatechin-3-gallate (EGCG), the main compound in green tea, is a promising therapeutic target for the disease. …”
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3482
Detection of Antioxidant Phytochemicals Isolated from <i>Camellia japonica</i> Seeds Using HPLC and EPR Imaging
Published 2020-06-01“…HPLC chromatograms indicated that hydrophilic antioxidant compounds—namely, gallic acid, gallocatechin, epigallocatechin, caffeine, catechin, epicatechin, and epicatechin gallate—were found in the methanolic extract. Lipophilic antioxidant compounds—including α-tocopherol, γ-tocopherol, β-tocopherol, δ-tocopherol, α-tocotrienol, γ-tocotrienol, and δ-tocotrienol—were found in the hexane extract. …”
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3483
Brewer’s Spent Grain, Coffee Grounds, Burdock, and Willow–Four Examples of Biowaste and Biomass Valorization through Advanced Green Extraction Technologies
Published 2023-03-01“…Extracts rich in linoleic and oleic acids are expected from the seeds, while the roots extracts are rich in sugars, phenolic acids such as chlorogenic, caffeic, <i>o</i>-coumaric, syringic, cinnamic, gentisitic, etc. acids, and, interestingly, the high-value compound epicatechin gallate. Willow is well known for being rich in salicin, but picein, (+)-catechin, triandrin, glucose, and fructose are also obtained from the extracts. …”
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3484
Tea Polyphenols Prevent and Intervene in COVID-19 through Intestinal Microbiota
Published 2022-02-01“…Among them, (−)-epigallocatechin-3-gallate (EGCG), one of the main monomers of catechins, may be activated as nuclear factor erythroid 2 p45-related factor 2 (Nrf2). …”
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3485
Qualitative Analysis of Grapevine Tannins by Mass Spectrometry and their Inhibitory Effect on Stilbene Oxidase of Botrytis cinerea
Published 2003-10-01“… The pure tannin extracts from grape berries of Gamay and Gamaret varieties contain a mixture of proanthocyanidins and proanthocyanidin gallates. A sensitive LC-MS method has been developed for the qualitative analysis of the oligomers and polymeric fractions. …”
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3486
The Role of Eosinophil-Derived Neurotoxin and Vascular Endothelial Growth Factor in the Pathogenesis of Eosinophilic Asthma
Published 2023-05-01“…We identified lichochalcone A, bevacizumab, azithromycin (AZT), vitamin D, diosmetin, epigallocatechin gallate, IGFBP-3, Neovastat (AE-941), endostatin, PEDF, and melatonin as putative add-on drugs in asthma with anti-VEGF properties. …”
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3487
Genotoxicity of chlorinated hydrophobic organic compounds extracted from a source of drinking water
Published 2023-11-01“…Protective effects of antioxidants (catalase, vitamin C and epigallocatechin 3-gallate (EGCG)) on genotoxicity of the chlorinated samples were investigated. …”
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3488
EGCG Inhibits Tumor Growth in Melanoma by Targeting JAK-STAT Signaling and Its Downstream PD-L1/PD-L2-PD1 Axis in Tumors and Enhancing Cytotoxic T-Cell Responses
Published 2021-10-01“…Here, we report that epigallocatechin gallate (EGCG), the most abundant catechin in green tea, inhibits melanoma growth by modulating an immune response against tumors. …”
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3489
<i>Saxifraga spinulosa</i>-Derived Components Rapidly Inactivate Multiple Viruses Including SARS-CoV-2
Published 2020-06-01“…Among our findings, we found that <i>SS</i>-derived gallocatechin gallate compounds were capable of inactivating all viruses tested. …”
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3490
Plant Phenolics and Extracts in Animal Models of Preeclampsia and Clinical Trials—Review of Perspectives for Novel Therapies
Published 2021-03-01“…The aim of our research review was to identify and analyze the results of already available studies on baicalin, curcumin, epigallocatechin gallate, punicalagin, quercetin, resveratrol, salvianolic acid A (danshensu), silibinin, and vitexin, as well as plant extracts from <i>Brassica oleracea</i> L., <i>Euterpe oleracea</i> Mart., <i>Moringa oleifera</i> Lam., <i>Punica granatum</i> L., <i>Silybum marianum</i> (L.) …”
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3491
Label Free Inhibitor Screening of Hepatitis C Virus (HCV) NS5B Viral Protein Using RNA Oligonucleotide
Published 2011-06-01“…Among the inhibitors screened, (−)-Epigallocatechin gallate showed high binding inhibition effect on HCV NS5B viral protein. …”
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3492
Assessment of the range of the HIV-1 infectivity enhancing effect of individual human semen specimen and the range of inhibition by EGCG
Published 2012-01-01“…Moreover, we confirm that the infectivity enhancing property can be inhibited by the major green tea ingredient epigallocatechin-3-gallate (EGCG) at non-toxic concentrations. The median inhibition of infection by treatment with 0.4 mM EGCG was 70.6% (p < 0.0001) in our cohort. …”
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3493
Tea polyphenol-engineered hybrid cellular nanovesicles for cancer immunotherapy and androgen deprivation therapy
Published 2024-04-01“…Herein, we developed a biomimetic nanotherapeutic platform by deriving cell membrane nanovesicles from cancer cells and probiotics to yield the hybrid cellular nanovesicles (hNVs), loading flutamide (Flu) into the resulting hNVs, and finally modifying the hNVs@Flu with Epigallocatechin-3-gallate (EGCG). In this nanotherapeutic platform, the hNVs significantly improved the accumulation of hNVs@Flu-EGCG in tumor sites and reprogramed immunosuppressive M2 macrophages into antitumorigenic M1 macrophages, the Flu acted on androgen receptors and inhibited tumor proliferation, and the EGCG promoted apoptosis of prostate cancer cells by inhibiting the NF-κB pathway, thus synergistically stimulating the antitumor immunity and reducing the side effects and resistance of ADT. …”
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3494
Dietary Polyphenols, Microbiome, and Multiple Sclerosis: From Molecular Anti-Inflammatory and Neuroprotective Mechanisms to Clinical Evidence
Published 2023-04-01“…Clinical evidence for the use of polyphenols as adjuvant therapy in MS is restricted to a smaller number of substances, mainly curcumin and epigallocatechin gallate. In the last part of the review, a clinical trial studying the effects of these polyphenols in MS patients will also be revised.…”
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3495
Investigation of Phenolic Compounds and Antioxidant Activity of <i>Sorbaria pallasii</i> (Rosaceae) Microshoots Grown In Vitro
Published 2023-02-01“…Concentrations of epigallocatechin gallate (0.38 mg/(g of ADM)) and (−)-epicatechin (0.55 mg/(g of ADM)) were significantly lower. …”
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3496
Interactions of Galloylated Polyphenols with a Simple Gram-Negative Bacterial Membrane Lipid Model
Published 2024-02-01“…Differential scanning calorimetry (DSC) was used to explore the interactions of isolated polyphenolic compounds, including (-)-epigallocatechin gallate ((-)-EGCg), tellimagrandins I and II (Tel-I and Tel-II), and 1,2,3,4,6-penta-<i>O</i>-galloyl-<span style="font-variant: small-caps;">d</span>-glucose (PGG), with a model Gram-negative bacterial membrane with a view to investigating their antimicrobial properties. …”
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3497
Anti-Diabetic Effects of Different Phenolic-Rich Fractions from Rhus Chinensis Mill. Fruits in vitro
Published 2021-03-01“…Correlation analysis indicated that myricetin-3-O-(6″-galloyl) glycoside and myricetin O-gallate contributed significantly on α-glucosidase inhibition, while di-O-galloyl-glucoside and its isomer may contribute remarkably toward DPP-IV inhibition. …”
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3498
Polyphenolics with Strong Antioxidant Activity from <i>Acacia nilotica</i> Ameliorate Some Biochemical Signs of Arsenic-Induced Neurotoxicity and Oxidative Stress in Mice
Published 2022-02-01“…Gallic acid methyl ester, catechin and catechin-7-gallate were identified in the polyphenolics as the major active compounds. …”
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3499
Influence of Tea Consumption on the Development of Second Esophageal Neoplasm in Patients with Head and Neck Cancer
Published 2019-03-01“…In vitro studies were conducted to investigate the effect of epigallocatechin gallate (EGCG) on the betel alkaloid, arecoline-stimulated carcinogenesis in two ESCC cell lines. …”
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3500
Screening and Analysis of Possible Drugs Binding to PDGFRα: A Molecular Modeling Study
Published 2023-06-01“…Among these 27 compounds, the drugs Bafetinib, Radotinib, Flumatinib, and Imatinib showed higher affinity for this tyrosine kinase receptor, lying in the nanomolar order, while the natural products included in this group, such as curcumin, luteolin, and epigallocatechin gallate (EGCG), showed sub-micromolar affinities. …”
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