Date (<i>Phoenix dactylifera</i> L. cv. Medjool) Seed Flour, a Potential Ingredient for the Food Industry: Effect of Particle Size on Its Chemical, Technological, and Functional Pr... by Nuria Muñoz-Tebar, Laura Candela-Salvador, José Ángel Pérez-Álvarez, José Manuel Lorenzo, Juana Fernández-López, Manuel Viuda-Martos

“…The main polyphenolic compounds in all the samples were catechin, epicatechin, and epigallocatechin-3-gallate. The antioxidant activity significantly improved with reductions in the particle size of the date seed flour, with the ABTS, DPPH, and FRAP values ranging between 8.99 and 20.68, 0.66 and 2.35, and 1.94 and 4.91 mg Trolox equivalent/g of date seed flour. …”
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Flavonoids as Potential Anti-Inflammatory Molecules: A Review by Jameel M. Al-Khayri, Gandasi Ravikumar Sahana, Praveen Nagella, Biljo V. Joseph, Fatima M. Alessa, Muneera Q. Al-Mssallem

“…Flavonoids such as quercetin, genistein, apigenin, kaempferol, and epigallocatechin 3-gallate modulate the expression and activation of a cytokine such as interleukin-1beta (IL-1β), Tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-8 (IL-8); regulate the gene expression of many pro-inflammatory molecules such s nuclear factor kappa-light chain enhancer of activated B cells (NF-κB), activator protein-1 (AP-1), intercellular adhesion molecule-1 (ICAM), vascular cell adhesion molecule-1 (VCAM), and E-selectins; and also inhibits inducible nitric oxide (NO) synthase, cyclooxygenase-2, and lipoxygenase, which are pro-inflammatory enzymes. …”
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Study of the Biologically Active Properties of Medicinal Plant <i>Cotinus coggygria</i> by Stanislav Sukhikh, Svetlana Noskova, Artem Pungin, Svetlana Ivanova, Liubov Skrypnik, Evgeny Chupakhin, Olga Babich

“…It has been established that the <i>Cotinus coggygria</i> extract contains rutin, hyperoside, ferulic acid, quercetin, kaempferol, disulphuretin, sulphurein, sulphurein, gallic acid, methyl gallate, pentagalloyl glucose, 3,3′,4′,5,6,7-hexahydroxyflavonone, 3,3′,4′,5,5′,7-hexahydroxyflavonone, 3-<i>O</i>-α-L-rhamnofuranoside, 3,3′,4′,5,5′,7-hexahydroxyflavulium(1+), 7-<i>O</i>-β-D glucopyranoside, and 3,3′,4′,7-tetrahydroxyflavonone. …”
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PERBANDINGAN METODE UJI KANDUNGAN TOTAL FENOLIK DARI EKSTRAK RUMPUT LAUT EUCHEUMA COTTONII LONTAR BANTEN by Denni Kartika Sari, Ahmad Deza, Ina Amilatul Ilma, Retno Sulistyo Dhamar Lestari

“…Rumput laut Eucheuma Cottonii terdapat senyawa flavonoid seperti catechin (gallocathecin, epicathecin, catechin gallate), flavonols, flavonol glycosides, caffeic acid, hesperidin, myricetin yang berfungsi sebagai antioksidan. …”
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Cheminformatics Identification of Phenolics as Modulators of Penicillin-Binding Protein 2a of <i>Staphylococcus aureus</i>: A Structure–Activity-Relationship-Based Study by Jamiu Olaseni Aribisala, Saheed Sabiu

“…The leads, while promoting the thermodynamic stability of PBP2a, showed a more promising affinity at the allosteric site than the active site, with silicristin (−25.61 kcal/mol) and epicatechin gallate (−47.65 kcal/mol) having the best affinity at the active and allosteric sites, respectively. …”
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Vasodilation of Tea Polyphenols Ex Vivo Is Mediated by Hydrogen Peroxide under Rapid Compound Decay by Mario Lorenz, Stephanie Lehmann, Ilija Djordjevic, Thomas Düsterhöft, Benno F. Zimmermann, Karl Stangl, Verena Stangl

“…Vasorelaxation of rat aortic rings was assessed in an organ chamber model with low concentrations of epigallocatechin-3-gallate (EGCG), theaflavin-3,3’-digallate (TF3), and with green and black tea, with or without pretreatment with catalase or superoxide dismutase (SOD). …”
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Cytotoxic Activity of Epigallocatechin and Trans-Cinnamaldehyde in Gastric Cancer Cell Line by Attabak Toofani Milani, Siamak Rashidi, Reza Mahmoudi, Bahareh Karimi Douna

“…Introduction: Herbal medication is currently being utilized for treatment of numerous diseases, such as cancer which showed successful therapeutic efficacy in numerous studies. Epigallocatechin gallate (EGCG) is a compound of green tea that its role in tumor cell death has been reported. …”
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EGCG‐LYS Fibrils‐Mediated CircMAP2K2 Silencing Decreases the Proliferation and Metastasis Ability of Gastric Cancer Cells in Vitro and in Vivo by Jiaqi Dong, Zhousan Zheng, Mi Zhou, Yunfei Wang, Jiajie Chen, Junjie Cen, Tiefeng Cao, Taowei Yang, Yi Xu, Guannan Shu, Xuanxuan Lu, Yanping Liang

“…To establish novel GC treatment, epigallocatechin‐3‐gallate‐lysozyme (EGCG‐LYS) fibrils are synthesized, and in vitro experiments demonstrate that EGCG‐LYS has a higher siRNA delivery efficiency than Lipofectamine 2000 (lipo2000), which effectively silences the expression of circMAP2K2. …”
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Impact of dietary plant flavonoids on 7,8‐dihydroxyflavone transepithelial transport in human intestinal Caco‐2 cells by Yufeng Chen, Guobin Xia, Chunfeng Wang, Huawei Wu, Xiaogang Xu, Genxiang Mao, Jiong Wu, Zhenlei Zhao

“…The results showed that among the 14 plant flavonoids, hesperetin, epigallocatechin gallate, fisetin, kaempferol, quercetin, and isoorientin increased and the apparent permeability coefficients (Papp) of 7,8‐DHF at AP → BL direction and lowered Papp value at BL → AP direction to varying degrees, reducing the efflux ratio of 7,8‐DHF less than 1.5. …”
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Self-Healing, Stretchable, Biocompatible, and Conductive Alginate Hydrogels through Dynamic Covalent Bonds for Implantable Electronics by Yeonsun Choi, Kyuha Park, Heewon Choi, Donghee Son, Mikyung Shin

“…Herein, plant-inspired conductive alginate hydrogels composed of “boronic acid modified alginate” and “oligomerized epigallocatechin gallate,” which are extracted from plant compounds, are proposed. …”
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Effect of Acute and Chronic Dietary Supplementation with Green Tea Catechins on Resting Metabolic Rate, Energy Expenditure and Respiratory Quotient: A Systematic Review by Mariangela Rondanelli, Antonella Riva, Giovanna Petrangolini, Pietro Allegrini, Simone Perna, Milena Anna Faliva, Gabriella Peroni, Maurizio Naso, Mara Nichetti, Federica Perdoni, Clara Gasparri

“…Eligible studies considered both the chronic and acute intake of GTC-based supplements, with epigallocatechin gallate (EGCG) doses ranging between 100–800 mg. Findings from 15 studies (<i>n</i> = 499 participants) lasting 8–12 weeks (for chronic consumption) or 1–3 days (for acute intake) are summarized. …”
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Synergism of the Combination of Traditional Antibiotics and Novel Phenolic Compounds against <i>Escherichia coli</i> by Md. Akil Hossain, Hae-Chul Park, Sung-Won Park, Seung-Chun Park, Min-Goo Seo, Moon Her, JeongWoo Kang

“…This study was designed to improve the effectiveness of traditional antibiotics against <i>E. coli</i> using a combination of the gallic acid (GA), hamamelitannin, epicatechin gallate, epigallocatechin, and epicatechin. The fractional inhibitory concentration index (FICI) of each of the phenolic compound-antibiotic combinations against <i>E. coli</i> was ascertained. …”
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Therapeutic Potential of Flavonoids and Tannins in Management of Oral Infectious Diseases—A Review by Ján Kováč, Lívia Slobodníková, Eva Trajčíková, Katarína Rendeková, Pavel Mučaji, Alice Sychrová, Silvia Bittner Fialová

“…This review presents selected flavonoids (such as apigenin, quercetin, kaempferol, kurarinone, and morin) and tannins (including oligomeric proanthocyanidins, gallotannins, ellagitannins, catechins, and epigallocatechin gallate), but also medicinal plants rich in these compounds as potential therapeutic agents in oral infectious diseases based on traditional usages such as <i>Agrimonia eupatoria</i> L., <i>Hamamelis virginiana</i> L., <i>Matricaria chamomilla</i> L., <i>Vaccinium myrtillus</i> L., <i>Quercus robur</i> L., <i>Rosa gallica</i> L., <i>Rubus idaeus</i> L., or <i>Potentilla erecta</i> (L.). …”
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Work-related symptoms among workers exposed to black tea dust by Agnieszka Lipińska-Ojrzanowska, Marta Wiszniewska, Diana Tymoszuk, Cezary Pałczyński, Jolanta Walusiak-Skorupa

“…All of these types are derived from Camellia sinensis, the Tea Plant, which contains the low molecular weight (LMW) agent Epigallocatechin gallate (EGCg), probably responsible for allergic reactions. …”
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Fish β-parvalbumin acquires allergenic properties by amyloid assembly by Javier Martínez, Rosa Sánchez, Milagros Castellanos, Ana M Fernández-Escamilla, Sonia Vazquez-Cortés, Montserrat Fernández-Rivas, Maria Gasset

“…Incorporation of the anti-amyloid compound epigallocatechin gallate prevents rGad m 1 fibrillation, facilitates its protease digestion and impairs its recognition by IgE. …”
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Insights into the Antimicrobial, Antioxidant, Anti-SARS-CoV-2 and Cytotoxic Activities of <i>Pistacia lentiscus</i> Bark and Phytochemical Profile; In Silico and In Vitro Study by Samy Selim, Mohammed S. Almuhayawi, Mohanned T. Alharbi, Soad K. Al Jaouni, Afaf Alharthi, Basel A. Abdel-Wahab, Mervat A. R. Ibrahim, Amnah Mohammed Alsuhaibani, Mona Warrad, Khaled Rashed

“…Deep phytochemical exploration led to the identification of methyl gallate, gallic acid, kaempferol, quercetin, kaempferol 3-O-α-rhamnoside, kaempferol 3-O-β-glucoside, and Quercetin-3-O-β-glucoside. …”
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Neurotoxicity of bisphenol A exposure on Caenorhabditis elegans induced by disturbance of neurotransmitter and oxidative damage by Yun Wang, Tingting Gai, Lianfeng Zhang, Liangwen Chen, Shunchang Wang, Tao Ye, Weiru Zhang

“…Finally, we showed that epigallocatechin-3-gallate partially rescued BPA-induced reactive oxygen species (ROS) production and neurobehavioral toxicity. …”
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Preventing Persistence of HPV Infection with Natural Molecules by Antonio Simone Laganà, Vito Chiantera, Sandro Gerli, Sara Proietti, Elisa Lepore, Vittorio Unfer, Jose Carugno, Alessandro Favilli

“…We review the current insight into the roles of natural molecules in HPV infection with a special focus on epigallocatechin gallate (EGCG), folic acid, vitamin B12, and hyaluronic acid (HA). …”
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A molecular modeling approach for structure-based virtual screening and identification of novel anti-hypercholesterolemic agents from Grape by Precious A. Akinnusi, Samuel O. Olubode, Adebowale A. Alade, Samad A. Ahmed, Susan F. Ayekolu, Taiwo M. Ogunlade, Damilola J. Gbore, Olayemi D. Rotimi, Abigail O. Ayodele

“…On the other hand, Rutin, Isoquercitrin, Isorhamnetin 3-O-glucoside, Hyperoside, and Gallocatechin gallate were predicted allosteric inhibitors for Proprotein convertase subtilisin/kexin type 9. …”
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Synergistics of Carboxymethyl Chitosan and Mangosteen Extract as Enhancing Moisturizing, Antioxidant, Antibacterial, and Deodorizing Properties in Emulsion Cream by Nareekan Chaiwong, Yuthana Phimolsiripol, Pimporn Leelapornpisid, Warintorn Ruksiriwanich, Kittisak Jantanasakulwong, Pornchai Rachtanapun, Phisit Seesuriyachan, Sarana Rose Sommano, Noppol Leksawasdi, Mario J. Simirgiotis, Francisco J. Barba, Winita Punyodom

“…Trans-2-nonenal, as an unsatisfied odor component, was also evaluated against components of the mangosteen extract deodorant cream, which were compared to the standard, epigallocatechin gallate (EGCG). In addition, DPPH and ABTS radical scavenging activity, ferric reducing antioxidant power (FRAP), and antibacterial activities were examined for the mangosteen extract deodorant cream using 0.5% H-CMCH. …”
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