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3661
Searching potential antiviral candidates for the treatment of the 2019 novel coronavirus based on DFT calculations and molecular docking
Published 2020-08-01“…In the present work, the succinic acid (SA), L-pyroglutamic acid (L-PGA), N-phenyl-thioacetamide (N-NPTA), 2-amino-5-chloropyridine hydrogen succinate (ACPS), epigallocatechine Gallate (EGCG) or KDH and, selenomethionine (SeM) compounds have been proposed as potential antiviral candidates to treatment of COVID-19 based on B3LYP/6-311++G∗∗ calculations and molecular docking. …”
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3662
Therapeutic potential of polyphenols against aging- induced idiopathic pulmonary fibrosis (IPF) via Bioinformatics analysis
Published 2024-02-01“…Results: The present study aimed at investigating the possible dietary flavonoid therapy (Quercetin, baicalin, luteolin, curcumin, rutin, and epigallocatechin gallate (EGCG)) attenuating the activation of mTORC1 in the lung epithelia by molecular docking approaches to ascertain the binding affinities of phytoflavonoids towards AhR and FK506 binding protein (FKBP12) over the known IPF synthetic inhibitors - pirfenidone and nintedanib. …”
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3663
A novel extraction method enhanced the osteogenic and anti-osteoporosis effect of tea extract without any hepatotoxicity in ovariectomized rats
Published 2022-08-01“…Tea (Camellia sinensis) has several reported health benefits, including that on bone health attributed to catechins of which the most abundant is epigallocatechin-3-gallate (EGCG). However, several preclinical and clinical studies raise safety concerns about EGCG in tea extract causing acute liver failure. …”
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3664
The roles of theaflavins in reducing dentin erosion
Published 2023-06-01“…For the effect of TFs on dentin erosion, 6 experimental groups (n = 5) were treated with 1% epigallocatechin gallate [EGCG], 1% chlorhexidine [CHX], 1%, 2%, 4%, and 8% TFs for the 30 s and then subjected to erosion cycles (4 cycles/d for 7 d). …”
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3665
Exploration and Comparison of the Behavior of Some Indigenous and International Varieties (<i>Vitis vinifera</i> L.) Grown in Climatic Conditions of Herzegovina: The Influence of V...
Published 2023-02-01“…The most abundant polyphenols in the analyzed grape samples were quercetin 3-<i>O</i>-glucoside and catechin gallate, followed by kaempferol 3-<i>O</i>-glucoside. …”
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3666
The therapeutic role and potential mechanism of EGCG in obesity-related precocious puberty as determined by integrated metabolomics and network pharmacology
Published 2023-06-01“…Objective(-)-Epigallocatechin-3-gallate (EGCG) has preventive effects on obesity-related precocious puberty, but its underlying mechanism remains unclear. …”
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3667
Stenotrophomonas maltophilia as an Emerging Ubiquitous Pathogen: Looking Beyond Contemporary Antibiotic Therapy
Published 2017-11-01“…Incorporating several other proven approaches like bioengineered bacteriophage therapy, Epigallocatechin-3-gallate (EGCG), essential oil, nanoemulsions, and use of cationic compounds are promising alternatives which can be incorporated in Stenotrophomonas control arsenal.…”
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3668
Beyond Antioxidant Activity: Redox Properties of Catechins May Affect Changes in the DNA Methylation Profile—The Example of <i>SRXN1</i> Gene
Published 2023-03-01“…Based on these findings, we present a proof-of-concept that DNA methylation, which limits <i>SRXN1</i> expression and thus restricts the multidirectional antioxidant action of SRXN1, may represent a mechanism protecting cells against reductive stress caused by particularly fast-reacting reductants such as EGC and (−)-epicatechin gallate (ECG) in our study.…”
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3669
Transport of Dietary Anti-Inflammatory Peptide, γ-Glutamyl Valine (γ-EV), across the Intestinal Caco-2 Monolayer
Published 2021-04-01“…Cytochalasin-D disintegrated the tight-junction proteins of the Caco-2 monolayer and increased the P<sub>app</sub> of γ-EV to 4.36 × 10<sup>−6</sup> ± 0.16 × 10<sup>−6</sup> cm/s (<i>p</i> < 0.001), while theaflavin 3′-gallate and Gly-Sar significantly decreased the P<sub>app</sub> (<i>p</i> < 0.05), with wortmannin having no effects on the peptide transport, indicating that the transport route of γ-EV could be via both PepT1-mediated and paracellular.…”
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3670
Valorisation of Grape Stems as a Source of Phenolic Antioxidants by Using a Sustainable Extraction Methodology
Published 2020-05-01“…Forty-two phenolic compounds were identified in the optimal extract, mainly polymer procyanidins and, to a lesser extent, monomers and oligomers of flavan-3-ols, quercetin-3-<i>O</i>-glucuronide, ε-viniferin, gallic and caftaric acid. Ethyl gallate, ellagic acid, protocatechuic aldehyde, delphinidin-7-<i>O</i>-glucoside and cyanidin-3-<i>O</i>-glucoside were reported for the first time in grape stem extracts. …”
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3671
Resveratrol, EGCG and Vitamins Modulate Activated T Lymphocytes
Published 2021-09-01“…We investigated the effects of vitamins (vitamin A (VA), D (VD), E (VE)) and bioactives (i.e., resveratrol (Res), epigallocatechin-3-gallate (EGCG)) on the adaptive immune response, as well as their synergistic or antagonistic interactions. …”
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3672
Comparison of phenolic composition in date (Phoenix dactylifera L.) flesh and seeds extracted by an ultrasonic-assisted and conventional method
Published 2023-12-01“…The extract also contained epicatechin (36.12 μg/g), coumaric acid (27.05 μg/g), p-hydroxybenzoic acid (21.03 μg/g), syringic acid (19.85 μg/g), and epicatechin gallate (11.67 μg/g). The results showed that ultrasonic-assisted extraction could significantly increase the quantities of functional components of the extracts obtained from fresh date fruit samples.…”
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3673
Phytochemical Profiles, Antioxidant Activity and Antiproliferative Mechanism of <i>Rhodiola rosea</i> L. Phenolic Extract
Published 2022-08-01“…High-performance liquid chromatography (HPLC) results demonstrated that the main phenolics of were epigallocatechin (EGC), epigallocatechin gallate (EGCG), gallic acid (GA) and catechin. Gas chromatography–mass spectrometry (GC-MS) analysis found that <i>Rhodiola rosea</i> L. was rich in volatile phytochemicals. …”
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3674
Curso online masivo abierto para mejorar la práctica preprofesional en la Universidad Nacional de Educación
Published 2021-02-01“…Para ello, se han tomado como principales referencias teóricas los aportes de Aguerrondo (1992); Fullan (1998); y Blanco y Messina (2000). Este trabajo sistematiza los elementos innovadores que se congregaron en el Curso Online Masivo y Abierto (MOOC) en la Aproximación al modelo de Práctica Preprofesional. …”
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3675
Naringin from Coffee Inhibits Foodborne <i>Aspergillus fumigatus</i> via the NDK Pathway: Evidence from an In Silico Study
Published 2023-07-01“…As determined by the molecular docking interactions of the library compounds indicated, the best interactions were found to occur between the nucleoside-diphosphate kinase protein 6XP7 and the test molecules Naringin (−6.771 kcal/mol), followed by Epigallocatechin gallate (−5.687 kcal/mol). Therefore, Naringin was opted for further validation with molecular dynamic simulations. …”
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3676
Dynamic changes in chemical composition and microbial community characteristics during pile-fermentation process of Phyllanthus emblica Linn. fruit
Published 2023-10-01“…Among these, 5 compounds, such as 2-O-galloyl-1,4-galactolactone and 1-methyl-2-gallate galactose ester, showed a downward trend, whereas 13 compounds, including corilagin and chebulitic acid, exhibited an upward trend. …”
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3677
Divya-WeightGo combined with moderate aerobic exercise remediates adiposopathy, insulin resistance, serum biomarkers, and hepatic lipid accumulation in high-fat diet-induced obese...
Published 2023-07-01“…Ultra-high performance liquid chromatography (UHPLC) analysis revealed the presence of phytocompounds including gallic acid, methyl gallate, corilagin, ellagic acid, pentagalloyl glucose, withaferin A and hydroxycitric acid, proven to aid in weight loss. …”
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3678
Metabolomic NMR analysis and organoleptic perceptions of pomegranate wines: Influence of cultivar and yeast on the product characteristics
Published 2023-06-01“…In particular, a higher content of citrate and gallate was observed for the Smith cv. and, on the contrary, a statistically significant higher content of fructose, malate, glycerol, 2,3 butanediol, trigonelline, aromatic amino acids and 4-hydrophenylacetate was observed in Jolly Red pomegranate wines samples. …”
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3679
Chemical and Pharmacological Potential of <i>Coccoloba cowellii</i>, an Endemic Endangered Plant from Cuba
Published 2021-02-01“…The major constituents were glucuronides and glycosides of myricetin and quercetin, as well as epichatechin-3-<i>O</i>-gallate, catechin, epicatechin and gallic acid, all of them being reported for the first time in <i>C. cowellii</i> leaves. …”
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3680
Comprehensive and Rapid Quality Evaluation Method for the Ayurvedic Medicine Divya-Swasari-Vati Using Two Analytical Techniques: UPLC/QToF MS and HPLC–DAD
Published 2021-03-01“…Eleven marker components, namely gallic acid, protocatechuic acid, methyl gallate, ellagic acid, coumarin, cinnamic acid, glycyrrhizin, eugenol, 6-gingerol, piperine and glabridin, were selected out of seventy-four identified makers for the quantitative analysis in DSV formulation. …”
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