Perception and Experience of Dupilumab in Atopic Dermatitis: A Real-Life Study by Antoine L, Puzenat E, Popescu D, Charollais R, Dresco F, Dupond AS, Salard D, Drobacheff-Thiebaut MC, Zanella A, Ducournau A, Gallais-Serezal I, Aubin F

“…Léa Antoine,1 Eve Puzenat,1 Dragos Popescu,2 Romain Charollais,3 Flora Dresco,3 Anne-Sophie Dupond,2 Dominique Salard,4 Marie-Christine Drobacheff-Thiebaut,1 Anaïs Zanella,1 Anne Ducournau,2 Iréne Gallais-Serezal,1 François Aubin1,5 1Department of Dermatology, University Hospital, Besançon, France; 2Department of Dermatology, Hôpital Nord Franche Comté, Trevenans, France; 3Department of Dermatology, Centre Hospitalier, Vesoul, France; 4Department of Dermatology, Centre Hospitalier, Pontarlier, France; 5Inserm 1098 RIGHT, University of Franche Comté, Besançon, FranceCorrespondence: François Aubin, Centre hospitalier Universitaire, Service de Dermatologie, 3 Bd Fleming, Besançon, 25000, France, Email francois.aubin@univ-fcomte.frPurpose: There are few data on the practical use of dupilumab by the patients and on the patients’ experience with this treatment.Objective: The objective of our study was to describe the experience and perception of dupilumab treatment in patients with atopic dermatitis (AD).Patients and Methods: We conducted a multicenter retrospective observational study including adult patients with moderate to severe AD treated with dupilumab between January 2017 and December 2021. …”
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Anti-colorectal cancer of Ardisia gigantifolia Stapf. and targets prediction via network pharmacology and molecular docking study by Weibo Dai, Jing Yang, Xin Liu, Quanxi Mei, Weijie Peng, Xianjing Hu

“…Eleven active ingredients, including, 11-O-galloylbergenin, 11-O-protocatechuoylbergenin, 11-O-syringylbergenin, ardisiacrispin B, bergenin, epicatechin-3-gallate, gallic acid, quercetin, stigmasterol, stigmasterol-3-o-β-D-glucopyranoside were identified. …”
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Compositions and Lipid-lowering Effects of Water Extract and Theabrownin from Ripe Pu-erh Tea Prepared by Controlled Fermentation by SHAN Bo, GONG Jiashun, WANG Qiuping, GAO Linrui, JIA Man, CHEN Dandan, DING Zhengjiao

“…There were significant differences in the contents of catechin and its derivatives such as gallic acid (GA), epicatechin (EC) and epicatechin gallate (EGCG) between WE and crude TB extract (P < 0.05). …”
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GC/MS Analysis, Antioxidant Activity, and Antimicrobial Effect of <i>Pelargonium peltatum</i> (Geraniaceae) by Alan-Misael Alonso, Oscar Kevin Reyes-Maldonado, Ana María Puebla-Pérez, Martha Patricia Gallegos Arreola, Sandra Fabiola Velasco-Ramírez, Victor Zúñiga-Mayo, Rosa E. Sánchez-Fernández, Jorge-Iván Delgado-Saucedo, Gilberto Velázquez-Juárez

“…According to the GC-MS analysis, the main compounds were 1,2,3-Benzenetriol (Pyrogallol), with 77.38% of relative abundance in the Lf-EtOAc and 71.24% in the Fwr-EtOAc, followed by ethyl gallate (13.10%) in the Fwr-EtOAc and (Z)-9-Octadecenamide (13.63% and 6.75%) in both Lf-EtOAc and Fwr-EtOAc, respectively.…”
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Changes in the Volatile Composition of Fresh Pork Sausage with Natural Antioxidants During Long-Term Frozen Storage by A.C. Tolentino, A. J. Pham-Mondala, J. B. Williams, N. Dhowlaghar, Thu Dinh, Wes Schilling, Yan Campbell, Youling L. Xiong

“…Pre-rigor meat was formulated into fresh pork sausages with a combination of synthetic antioxidants (butylated hydroxyanisole, butylated hydroxytoluene, and propyl gallate) or the same synthetic antioxidants in combination with rosemary (R, 1500, 2000, 2500 mg/kg) and green tea (G, 100, 200, 300 mg/kg). …”
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Profiling Anticancer and Antioxidant Activities of Phenolic Compounds Present in Black Walnuts (<i>Juglans nigra</i>) Using a High-Throughput Screening Approach by Khanh-Van Ho, Anuradha Roy, Sarah Foote, Phuc H. Vo, Namrita Lall, Chung-Ho Lin

“…Out of 16 phenolic compounds tested, several compounds (penta-<i>O</i>-galloyl-<i>β</i>-<span style="font-variant: small-caps;">d</span>-glucose, epicatechin gallate, quercetin, (–)-epicatechin, rutin, quercetin 3-<i>β</i>-<span style="font-variant: small-caps;">d</span>-glucoside, gallic acid, (+)-catechin, ferulic acid, syringic acid) exerted antioxidant activities that were significantly higher compared to Trolox, which was used as a control. …”
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Polyphenolic Characterization and Antioxidant Activity of Malus domestica and Prunus domestica Cultivars from Costa Rica by Mirtha Navarro, Ileana Moreira, Elizabeth Arnaez, Silvia Quesada, Gabriela Azofeifa, Felipe Vargas, Diego Alvarado, Pei Chen

“…A total of 52 compounds were identified, including 21 proanthocyanidins ([(+)-catechin and (−)-epicatechin]) flavan-3-ols monomers, five procyanidin B-type dimers and two procyanidin A-type dimers, five procyanidin B-type trimers and two procyanidin A-type trimers, as well as one procyanidin B-type tetramer, two procyanidin B-type pentamers, and two flavan-3-ol gallates); 15 flavonoids (kaempferol, quercetin and naringenin derivatives); nine phenolic acids (protochatechuic, caffeoylquinic, and hydroxycinnamic acid derivatives); five hydroxychalcones (phloretin and 3-hydroxyphloretin derivatives); and two isoprenoid glycosides (vomifoliol derivatives). …”
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Anti-Alzheimer Activity of Combinations of Cocoa with Vinpocetine or Other Nutraceuticals in Rat Model: Modulation of Wnt3/β-Catenin/GSK-3β/Nrf2/HO-1 and PERK/CHOP/Bcl-2 Pathways by Karema Abu-Elfotuh, Amina M. A. Tolba, Furqan H. Hussein, Ahmed M. E. Hamdan, Mohamed A. Rabeh, Saad A. Alshahri, Azza A. Ali, Sarah M. Mosaad, Nihal A. Mahmoud, Magdy Y. Elsaeed, Ranya M. Abdelglil, Rehab R. El-Awady, Eman Reda M. Galal, Mona M. Kamal, Ahmed M. M. Elsisi, Alshaymaa Darwish, Ayah M. H. Gowifel, Yasmen F. Mahran

“…Rats were divided into nine groups: control, aluminum chloride (AlCl₃) alone, AlCl₃ with cocoa alone, AlCl₃ with vinpocetine (VIN), AlCl₃ with epigallocatechin-3-gallate (EGCG), AlCl₃ with coenzyme Q10 (CoQ10), AlCl₃ with wheatgrass (WG), AlCl₃ with vitamin (Vit) B complex, and AlCl₃ with a combination of Vit C, Vit E, and selenium (Se). …”
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<i>Agaricus bisporus</i> Crude Extract: Characterization and Analytical Application by Maria A. Morosanova, Tatyana V. Fedorova, Alexandra S. Polyakova, Elena I. Morosanova

“…ABE substrate specificity has been studied using 19 phenolic compounds: polyphenols (catechol, gallic, caffeic, chlorogenic, and ferulic acids, quercetin, rutin, dihydroquercetin, <span style="font-variant: small-caps;">l</span>-dihydroxyphenylalanine, resorcinol, propyl gallate) and monophenols (<span style="font-variant: small-caps;">l</span>-tyrosine, phenol, <i>p</i>-nitrophenol, <i>o</i>-nitrophenol, guaiacol, <i>o</i>-cresol, <i>m</i>-cresol, <i>p</i>-cresol). …”
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Phytoconstituents of Kenyan stinging nettle (Urtica species) and their molecular docking interactions revealed anti-inflammatory potential as cyclooxygenase-2 inhibitors by Jacqueline Wambui, Robert I.O. Ikedi, Rosaline W. Macharia, Francisca Kama-Kama, Evans N. Nyaboga

“…From these identified compounds quercetin attained the lowest binding energy when complexed with COX-2, followed by rhamnetin, quercetin rhamnoside, epigallocatechin gallate and chlorogenic acid. Molecular docking studies supported the in vivo findings and confirmed the anti-inflammatory potential of Urtica sp. …”
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From desert flora to cancer therapy: systematic exploration of multi-pathway mechanisms using network pharmacology and molecular modeling approaches by Adel Alblihy, Adel Alblihy

“…Following that, a compound–target protein–pathway network was constructed, which uncovered that, namely, hispidulin, stigmasterol, ascorbic acid, octopamine, cyperene, kaempferol, pungenin, citric acid, d-tartaric acid, beta-sitosterol, (−)-epicatechin gallate, and (+)-catechin demonstrably influence cell proliferation and growth by impacting the AKT1 and VEGFA proteins. …”
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Metabolomic Profiling of Antioxidant Compounds in Five <i>Vachellia</i> Species by Garland Kgosi More, Stephen Meddows-Taylor, Gerhard Prinsloo

“…Annotation of metabolites was carried out using the ultra-high-performance liquid chromatography–quadrupole time-of-flight mass spectrometry (UHPLC-qTOF-MS), and it tentatively identified 23 metabolites of significance, including epigallocatechin (<i>m/z</i> = 305.0659), methyl gallate (<i>m/z</i> = 183.0294) and quercetin (<i>m/z</i> = 301.0358), amongst others. …”
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Understanding Aβ dimer/inhibitor interactions from computer simulations by Zhang, Tong

“…The polyphenol (-)-epigallocatechin gallate (EGCG) and 1,4-naphthoquinon-2-yl-L-tryptophan (NQTrp) molecules have been reported to alter Aβ self-assembly and reduce toxicity. …”
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Phytochemicals from Mangifera pajang Kosterm and their biological activities by Ahmad, Sadikah, Sukari, Mohd Aspollah, Ismail, Nurussaadah, Ismail, Intan Safinar, Abdul, Ahmad Bustamam, Abu Bakar, Mohd Fadzelly, Kifli, Nurolaini, Ee, Gwendoline Cheng Lian

“…Results: Phytochemical investigation on the kernel, stem bark and leaves of Mangifera pajang led to the isolation of methyl gallate (1), mixture of benzaldehyde (2) and benzyl alcohol (3), mangiferonic acid (4), 3β-hydroxy-cycloart24-ene-26-oic acid (5), 3β,23-dihydroxy-cycloart-24-ene-26-oic acid (6), lupeol(7) lupenone(8), β-sitosterol(9), stigmasterol(10), trans-sobrerol(11) and quercitrin (12). …”
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Principal's technology leadership and technological integration in Kedah National secondary schools: Professional development as a moderator by Thannimalai, Raamani, Raman, Arumugam

“…Purpose - Principals as technology leaders and teachers as facilitators must have the skills and knowledge to implement the 21st Century Education (Roblyer & Doering, 2015).A principal’s responsibility is becoming even more challenging as schools have to produce skilled and creative workforce to meet the demands of the Industrial Revolution 4.0 and the Digital Economy.Therefore, principals should possess ICT skills and knowledge to guide and motivate teachers to integrate technology in the classroom in line with the seventh shift of the Malaysia Education Blueprint (2013-2025) (Ministry Of Education, 2013) and the National Transformation 2050.In the past three decades, most studies related to technology use in secondary schools (Fullan, 2001; Senge, 1990; Michael, 1983; Johnson and Cooley, 2001; Hamzah, Juraime, Hamid, Nordin & Attan, 2014) agree that principal’s leadership plays a major role in the technology integration in the classroom. …”
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Structural and Biophysical Characterization of Purified Recombinant Arabidopsis thaliana's Alternative Oxidase 1A (rAtAOX1A): Interaction With Inhibitor(s) and Activator by Tadiboina Veera Sankar, Moumita Saharay, Dharawath Santhosh, Abhaypratap Vishwakarma, Abhaypratap Vishwakarma, Kollipara Padmasree

“…The present study aims to characterize the purified rAtAOX1A protein and its interaction with inhibitors, such as salicylhydroxamic acid (SHAM) and n-propyl gallate (n-PG), as well as pyruvate (activator), using biophysical/in silico studies. …”
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An Evaluation of a Nutraceutical with Berberine, Curcumin, Inositol, Banaba and Chromium Picolinate in Patients with Fasting Dysglycemia by Derosa G, D'Angelo A, Vanelli A, Maffioli P

“…Giuseppe Derosa, 1&ndash;3 Angela D&rsquo;Angelo, 1, 2 Arianna Vanelli, 4 Pamela Maffioli 1, 3 1Center of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; 2Laboratory of Molecular Medicine, University of Pavia, Pavia, Italy; 3Center for Prevention, Surveillance, Diagnosis and Treatment of Rare Diseases, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; 4Nutrilinea srl, Gallarate, ItalyCorrespondence: Giuseppe DerosaDepartment of Internal Medicine and Therapeutics, University of Pavia, and Fondazione IRCCS Policlinico San Matteo, P.le C. …”
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Antioxidant Activity and Phenolic Compound Identification and Quantification in Western Australian Honeys by Ivan Lozada Lawag, Md Khairul Islam, Tomislav Sostaric, Lee Yong Lim, Katherine Hammer, Cornelia Locher

“…Kojic acid and epigallocatechin gallate were found in all honeys, whilst other constituents (e.g., m-coumaric acid, lumichrome, gallic acid, taxifolin, luteolin, epicatechin, hesperitin, eudesmic acid, syringic acid, protocatechuic acid, t-cinnamic acid, o-anisic acid) were only identified in some of the honeys. …”
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The biosynthesis of EGCG, theanine and caffeine in response to temperature is mediated by hormone signal transduction factors in tea plant (Camellia sinensis L.) by Qiufang Zhu, Lijia Liu, Xiaofeng Lu, Xinxin Du, Ping Xiang, Ping Xiang, Bosi Cheng, Meng Tan, Jiaxin Huang, Lijiao Wu, Weilong Kong, Yutao Shi, Yutao Shi, Liangyu Wu, Jinke Lin

“…As the main flavor components of tea, the contents of epigallocatechin-3-gallate (EGCG), theanine and caffeine are regulated by ambient temperature. …”
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Nutritional, Antioxidant, Antimicrobial, and Anticholinesterase Properties of <i>Phyllanthus emblica</i>: A Study Supported by Spectroscopic and Computational Investigations by Mohamed A. A. Orabi, Aso Hameed Hasan, Sameh F. AbouZid, Dalia El Amir, Mona H. Hetta, Ahmed Abdullah Al Awadh, Omaish Salman Alqahtani, Tsutomu Hatano, Mohamed A. El-Shanawany

“…The structures were identified by spectroscopic data and comparison with the literature values as gallic acid (<b>1</b>), naringenin 7-<i>O</i>-(6″-<i>O</i>-galloyl)-<i>β</i>-D-glucopyranoside (<b>2</b>), 3,3′-di-<i>O</i>-methyl ellagic acid-4′-<i>O</i>-<i>β</i>-<span style="font-variant: small-caps;">d</span>-glucopyranoside (<b>3</b>), 1-<i>O</i>-galloyl glycerol (<b>4</b>), 1,6-di-<i>O</i>-galloyl-<i>β</i>-<span style="font-variant: small-caps;">d</span>-glucopyranoside (<b>5</b>), flavogallonic acid bislactone (<b>6</b>), corilagin (<b>7</b>), ethyl gallate (<b>8</b>), urolithin M5 (<b>9</b>), (E)-<i>p</i>-coumaroyl-1-<i>O</i>-<i>β</i>-<span style="font-variant: small-caps;">d</span>-glucopyranoside (<b>10</b>), and 1,2,4,6-tetra-<i>O</i>-galloyl-<i>β</i>-<span style="font-variant: small-caps;">d</span>-glucopyranoside (<b>11</b>). …”
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