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3821
Perception and Experience of Dupilumab in Atopic Dermatitis: A Real-Life Study
Published 2023-09-01“…Léa Antoine,1 Eve Puzenat,1 Dragos Popescu,2 Romain Charollais,3 Flora Dresco,3 Anne-Sophie Dupond,2 Dominique Salard,4 Marie-Christine Drobacheff-Thiebaut,1 Anaïs Zanella,1 Anne Ducournau,2 Iréne Gallais-Serezal,1 François Aubin1,5 1Department of Dermatology, University Hospital, Besançon, France; 2Department of Dermatology, Hôpital Nord Franche Comté, Trevenans, France; 3Department of Dermatology, Centre Hospitalier, Vesoul, France; 4Department of Dermatology, Centre Hospitalier, Pontarlier, France; 5Inserm 1098 RIGHT, University of Franche Comté, Besançon, FranceCorrespondence: François Aubin, Centre hospitalier Universitaire, Service de Dermatologie, 3 Bd Fleming, Besançon, 25000, France, Email francois.aubin@univ-fcomte.frPurpose: There are few data on the practical use of dupilumab by the patients and on the patients’ experience with this treatment.Objective: The objective of our study was to describe the experience and perception of dupilumab treatment in patients with atopic dermatitis (AD).Patients and Methods: We conducted a multicenter retrospective observational study including adult patients with moderate to severe AD treated with dupilumab between January 2017 and December 2021. …”
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3822
Anti-colorectal cancer of Ardisia gigantifolia Stapf. and targets prediction via network pharmacology and molecular docking study
Published 2023-01-01“…Eleven active ingredients, including, 11-O-galloylbergenin, 11-O-protocatechuoylbergenin, 11-O-syringylbergenin, ardisiacrispin B, bergenin, epicatechin-3-gallate, gallic acid, quercetin, stigmasterol, stigmasterol-3-o-β-D-glucopyranoside were identified. …”
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3823
Compositions and Lipid-lowering Effects of Water Extract and Theabrownin from Ripe Pu-erh Tea Prepared by Controlled Fermentation
Published 2023-04-01“…There were significant differences in the contents of catechin and its derivatives such as gallic acid (GA), epicatechin (EC) and epicatechin gallate (EGCG) between WE and crude TB extract (P < 0.05). …”
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3824
GC/MS Analysis, Antioxidant Activity, and Antimicrobial Effect of <i>Pelargonium peltatum</i> (Geraniaceae)
Published 2022-05-01“…According to the GC-MS analysis, the main compounds were 1,2,3-Benzenetriol (Pyrogallol), with 77.38% of relative abundance in the Lf-EtOAc and 71.24% in the Fwr-EtOAc, followed by ethyl gallate (13.10%) in the Fwr-EtOAc and (Z)-9-Octadecenamide (13.63% and 6.75%) in both Lf-EtOAc and Fwr-EtOAc, respectively.…”
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3825
Changes in the Volatile Composition of Fresh Pork Sausage with Natural Antioxidants During Long-Term Frozen Storage
Published 2019-06-01“…Pre-rigor meat was formulated into fresh pork sausages with a combination of synthetic antioxidants (butylated hydroxyanisole, butylated hydroxytoluene, and propyl gallate) or the same synthetic antioxidants in combination with rosemary (R, 1500, 2000, 2500 mg/kg) and green tea (G, 100, 200, 300 mg/kg). …”
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3826
Profiling Anticancer and Antioxidant Activities of Phenolic Compounds Present in Black Walnuts (<i>Juglans nigra</i>) Using a High-Throughput Screening Approach
Published 2020-10-01“…Out of 16 phenolic compounds tested, several compounds (penta-<i>O</i>-galloyl-<i>β</i>-<span style="font-variant: small-caps;">d</span>-glucose, epicatechin gallate, quercetin, (–)-epicatechin, rutin, quercetin 3-<i>β</i>-<span style="font-variant: small-caps;">d</span>-glucoside, gallic acid, (+)-catechin, ferulic acid, syringic acid) exerted antioxidant activities that were significantly higher compared to Trolox, which was used as a control. …”
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3827
Polyphenolic Characterization and Antioxidant Activity of Malus domestica and Prunus domestica Cultivars from Costa Rica
Published 2018-01-01“…A total of 52 compounds were identified, including 21 proanthocyanidins ([(+)-catechin and (−)-epicatechin]) flavan-3-ols monomers, five procyanidin B-type dimers and two procyanidin A-type dimers, five procyanidin B-type trimers and two procyanidin A-type trimers, as well as one procyanidin B-type tetramer, two procyanidin B-type pentamers, and two flavan-3-ol gallates); 15 flavonoids (kaempferol, quercetin and naringenin derivatives); nine phenolic acids (protochatechuic, caffeoylquinic, and hydroxycinnamic acid derivatives); five hydroxychalcones (phloretin and 3-hydroxyphloretin derivatives); and two isoprenoid glycosides (vomifoliol derivatives). …”
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3828
Anti-Alzheimer Activity of Combinations of Cocoa with Vinpocetine or Other Nutraceuticals in Rat Model: Modulation of Wnt3/β-Catenin/GSK-3β/Nrf2/HO-1 and PERK/CHOP/Bcl-2 Pathways
Published 2023-07-01“…Rats were divided into nine groups: control, aluminum chloride (AlCl<sub>3</sub>) alone, AlCl<sub>3</sub> with cocoa alone, AlCl<sub>3</sub> with vinpocetine (VIN), AlCl<sub>3</sub> with epigallocatechin-3-gallate (EGCG), AlCl<sub>3</sub> with coenzyme Q10 (CoQ10), AlCl<sub>3</sub> with wheatgrass (WG), AlCl<sub>3</sub> with vitamin (Vit) B complex, and AlCl<sub>3</sub> with a combination of Vit C, Vit E, and selenium (Se). …”
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3829
<i>Agaricus bisporus</i> Crude Extract: Characterization and Analytical Application
Published 2020-12-01“…ABE substrate specificity has been studied using 19 phenolic compounds: polyphenols (catechol, gallic, caffeic, chlorogenic, and ferulic acids, quercetin, rutin, dihydroquercetin, <span style="font-variant: small-caps;">l</span>-dihydroxyphenylalanine, resorcinol, propyl gallate) and monophenols (<span style="font-variant: small-caps;">l</span>-tyrosine, phenol, <i>p</i>-nitrophenol, <i>o</i>-nitrophenol, guaiacol, <i>o</i>-cresol, <i>m</i>-cresol, <i>p</i>-cresol). …”
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3830
Phytoconstituents of Kenyan stinging nettle (Urtica species) and their molecular docking interactions revealed anti-inflammatory potential as cyclooxygenase-2 inhibitors
Published 2024-03-01“…From these identified compounds quercetin attained the lowest binding energy when complexed with COX-2, followed by rhamnetin, quercetin rhamnoside, epigallocatechin gallate and chlorogenic acid. Molecular docking studies supported the in vivo findings and confirmed the anti-inflammatory potential of Urtica sp. …”
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3831
From desert flora to cancer therapy: systematic exploration of multi-pathway mechanisms using network pharmacology and molecular modeling approaches
Published 2024-04-01“…Following that, a compound–target protein–pathway network was constructed, which uncovered that, namely, hispidulin, stigmasterol, ascorbic acid, octopamine, cyperene, kaempferol, pungenin, citric acid, d-tartaric acid, beta-sitosterol, (−)-epicatechin gallate, and (+)-catechin demonstrably influence cell proliferation and growth by impacting the AKT1 and VEGFA proteins. …”
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3832
Metabolomic Profiling of Antioxidant Compounds in Five <i>Vachellia</i> Species
Published 2021-10-01“…Annotation of metabolites was carried out using the ultra-high-performance liquid chromatography–quadrupole time-of-flight mass spectrometry (UHPLC-qTOF-MS), and it tentatively identified 23 metabolites of significance, including epigallocatechin (<i>m/z</i> = 305.0659), methyl gallate (<i>m/z</i> = 183.0294) and quercetin (<i>m/z</i> = 301.0358), amongst others. …”
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3833
Understanding Aβ dimer/inhibitor interactions from computer simulations
Published 2015“…The polyphenol (-)-epigallocatechin gallate (EGCG) and 1,4-naphthoquinon-2-yl-L-tryptophan (NQTrp) molecules have been reported to alter Aβ self-assembly and reduce toxicity. …”
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Thesis -
3834
Phytochemicals from Mangifera pajang Kosterm and their biological activities
Published 2015“…Results: Phytochemical investigation on the kernel, stem bark and leaves of Mangifera pajang led to the isolation of methyl gallate (1), mixture of benzaldehyde (2) and benzyl alcohol (3), mangiferonic acid (4), 3β-hydroxy-cycloart24-ene-26-oic acid (5), 3β,23-dihydroxy-cycloart-24-ene-26-oic acid (6), lupeol(7) lupenone(8), β-sitosterol(9), stigmasterol(10), trans-sobrerol(11) and quercitrin (12). …”
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3835
Principal's technology leadership and technological integration in Kedah National secondary schools: Professional development as a moderator
Published 2017“…Purpose - Principals as technology leaders and teachers as facilitators must have the skills and knowledge to implement the 21st Century Education (Roblyer & Doering, 2015).A principal’s responsibility is becoming even more challenging as schools have to produce skilled and creative workforce to meet the demands of the Industrial Revolution 4.0 and the Digital Economy.Therefore, principals should possess ICT skills and knowledge to guide and motivate teachers to integrate technology in the classroom in line with the seventh shift of the Malaysia Education Blueprint (2013-2025) (Ministry Of Education, 2013) and the National Transformation 2050.In the past three decades, most studies related to technology use in secondary schools (Fullan, 2001; Senge, 1990; Michael, 1983; Johnson and Cooley, 2001; Hamzah, Juraime, Hamid, Nordin & Attan, 2014) agree that principal’s leadership plays a major role in the technology integration in the classroom. …”
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3836
Structural and Biophysical Characterization of Purified Recombinant Arabidopsis thaliana's Alternative Oxidase 1A (rAtAOX1A): Interaction With Inhibitor(s) and Activator
Published 2022-06-01“…The present study aims to characterize the purified rAtAOX1A protein and its interaction with inhibitors, such as salicylhydroxamic acid (SHAM) and n-propyl gallate (n-PG), as well as pyruvate (activator), using biophysical/in silico studies. …”
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3837
An Evaluation of a Nutraceutical with Berberine, Curcumin, Inositol, Banaba and Chromium Picolinate in Patients with Fasting Dysglycemia
Published 2020-03-01“…Giuseppe Derosa, 1–3 Angela D’Angelo, 1, 2 Arianna Vanelli, 4 Pamela Maffioli 1, 3 1Center of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; 2Laboratory of Molecular Medicine, University of Pavia, Pavia, Italy; 3Center for Prevention, Surveillance, Diagnosis and Treatment of Rare Diseases, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; 4Nutrilinea srl, Gallarate, ItalyCorrespondence: Giuseppe DerosaDepartment of Internal Medicine and Therapeutics, University of Pavia, and Fondazione IRCCS Policlinico San Matteo, P.le C. …”
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3838
Antioxidant Activity and Phenolic Compound Identification and Quantification in Western Australian Honeys
Published 2023-01-01“…Kojic acid and epigallocatechin gallate were found in all honeys, whilst other constituents (e.g., m-coumaric acid, lumichrome, gallic acid, taxifolin, luteolin, epicatechin, hesperitin, eudesmic acid, syringic acid, protocatechuic acid, t-cinnamic acid, o-anisic acid) were only identified in some of the honeys. …”
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3839
The biosynthesis of EGCG, theanine and caffeine in response to temperature is mediated by hormone signal transduction factors in tea plant (Camellia sinensis L.)
Published 2023-03-01“…As the main flavor components of tea, the contents of epigallocatechin-3-gallate (EGCG), theanine and caffeine are regulated by ambient temperature. …”
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3840
Nutritional, Antioxidant, Antimicrobial, and Anticholinesterase Properties of <i>Phyllanthus emblica</i>: A Study Supported by Spectroscopic and Computational Investigations
Published 2023-09-01“…The structures were identified by spectroscopic data and comparison with the literature values as gallic acid (<b>1</b>), naringenin 7-<i>O</i>-(6″-<i>O</i>-galloyl)-<i>β</i>-D-glucopyranoside (<b>2</b>), 3,3′-di-<i>O</i>-methyl ellagic acid-4′-<i>O</i>-<i>β</i>-<span style="font-variant: small-caps;">d</span>-glucopyranoside (<b>3</b>), 1-<i>O</i>-galloyl glycerol (<b>4</b>), 1,6-di-<i>O</i>-galloyl-<i>β</i>-<span style="font-variant: small-caps;">d</span>-glucopyranoside (<b>5</b>), flavogallonic acid bislactone (<b>6</b>), corilagin (<b>7</b>), ethyl gallate (<b>8</b>), urolithin M5 (<b>9</b>), (E)-<i>p</i>-coumaroyl-1-<i>O</i>-<i>β</i>-<span style="font-variant: small-caps;">d</span>-glucopyranoside (<b>10</b>), and 1,2,4,6-tetra-<i>O</i>-galloyl-<i>β</i>-<span style="font-variant: small-caps;">d</span>-glucopyranoside (<b>11</b>). …”
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