Structural basis of Janus kinase trans-activation by Nathanael A. Caveney, Robert A. Saxton, Deepa Waghray, Caleb R. Glassman, Naotaka Tsutsumi, Stevan R. Hubbard, K. Christopher Garcia

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Nerve injury disrupts temporal processing in the spinal cord dorsal horn through alterations in PV+ interneurons by Genelle Rankin, Anda M. Chirila, Alan J. Emanuel, Zihe Zhang, Clifford J. Woolf, Jan Drugowitsch, David D. Ginty

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Combinatorial expression motifs in signaling pathways by Alejandro A. Granados, Nivedita Kanrar, Michael B. Elowitz

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Homeodomain Proteins Directly Regulate ATM Kinase Activity by Tanya E. Johnson, Ji-Hoon Lee, Logan R. Myler, Yi Zhou, Trenell J. Mosley, Soo-Hyun Yang, Nadima Uprety, Jonghwan Kim, Tanya T. Paull

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A structural blueprint for interleukin-21 signal modulation by Gita C. Abhiraman, Theodora U.J. Bruun, Nathanael A. Caveney, Leon L. Su, Robert A. Saxton, Qian Yin, Shaogeng Tang, Mark M. Davis, Kevin M. Jude, K. Christopher Garcia

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Structural homology screens reveal host-derived poxvirus protein families impacting inflammasome activity by Ian N. Boys, Alex G. Johnson, Meghan R. Quinlan, Philip J. Kranzusch, Nels C. Elde

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Cytoskeletal Control of Antigen-Dependent T Cell Activation by Huw Colin-York, Yousef Javanmardi, Mark Skamrahl, Sudha Kumari, Veronica T. Chang, Satya Khuon, Aaron Taylor, Teng-Leong Chew, Eric Betzig, Emad Moeendarbary, Vincenzo Cerundolo, Christian Eggeling, Marco Fritzsche

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Structural changes in the SARS-CoV-2 spike E406W mutant escaping a clinical monoclonal antibody cocktail by Amin Addetia, Young-Jun Park, Tyler Starr, Allison J. Greaney, Kaitlin R. Sprouse, John E. Bowen, Sasha W. Tiles, Wesley C. Van Voorhis, Jesse D. Bloom, Davide Corti, Alexandra C. Walls, David Veesler

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The human inactive X chromosome modulates expression of the active X chromosome by Adrianna K. San Roman, Alexander K. Godfrey, Helen Skaletsky, Daniel W. Bellott, Abigail F. Groff, Hannah L. Harris, Laura V. Blanton, Jennifer F. Hughes, Laura Brown, Sidaly Phou, Ashley Buscetta, Paul Kruszka, Nicole Banks, Amalia Dutra, Evgenia Pak, Patricia C. Lasutschinkow, Colleen Keen, Shanlee M. Davis, Nicole R. Tartaglia, Carole Samango-Sprouse, Maximilian Muenke, David C. Page

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TRIM21-dependent target protein ubiquitination mediates cell-free Trim-Away by Tycho E.T. Mevissen, Anisa V. Prasad, Johannes C. Walter

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The human Y and inactive X chromosomes similarly modulate autosomal gene expression by Adrianna K. San Roman, Helen Skaletsky, Alexander K. Godfrey, Neha V. Bokil, Levi Teitz, Isani Singh, Laura V. Blanton, Daniel W. Bellott, Tatyana Pyntikova, Julian Lange, Natalia Koutseva, Jennifer F. Hughes, Laura Brown, Sidaly Phou, Ashley Buscetta, Paul Kruszka, Nicole Banks, Amalia Dutra, Evgenia Pak, Patricia C. Lasutschinkow, Colleen Keen, Shanlee M. Davis, Angela E. Lin, Nicole R. Tartaglia, Carole Samango-Sprouse, Maximilian Muenke, David C. Page

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Clinical Sphingolipids Pathway in Parkinson’s Disease: From GCase to Integrated-Biomarker Discovery by Ali Esfandiary, David Isaac Finkelstein, Nicolas Hans Voelcker, David Rudd

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Cohesin Can Remain Associated with Chromosomes during DNA Replication by James D.P. Rhodes, Judith H.I. Haarhuis, Jonathan B. Grimm, Benjamin D. Rowland, Luke D. Lavis, Kim A. Nasmyth

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Expandable Sendai-Virus-Reprogrammed Human iPSC-Neuronal Precursors: Post-Grafting Safety Characterization in Rats and Adult Pig by Yoshiomi Kobayashi, Michiko Shigyo, Oleksandr Platoshyn, Silvia Marsala, Tomohisa Kato, Naoki Takamura, Kenji Yoshida, Akiyoshi Kishino, Mariana Bravo-Hernandez, Stefan Juhas, Jana Juhasova, Hana Studenovska, Vladimir Proks, Shawn P. Driscoll, Thomas D. Glenn, Samuel L. Pfaff, Joseph D. Ciacci, Martin Marsala

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Sensory deficit screen identifies nsf mutation that differentially affects SNARE recycling and quality control by Yan Gao, Yousuf A. Khan, Weike Mo, K. Ian White, Matthew Perkins, Richard A. Pfuetzner, Josef G. Trapani, Axel T. Brunger, Teresa Nicolson

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The Non-dominant AAA+ Ring in the ClpAP Protease Functions as an Anti-stalling Motor to Accelerate Protein Unfolding and Translocation by Hema Chandra Kotamarthi, Robert T. Sauer, Tania A. Baker

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Interleukin-6 Derived from the Central Nervous System May Influence the Pathogenesis of Experimental Autoimmune Encephalomyelitis in a Cell-Dependent Manner by Paula Sanchis, Olaya Fernández-Gayol, Gemma Comes, Anna Escrig, Mercedes Giralt, Richard D. Palmiter, Juan Hidalgo

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SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions by Haining Zhou, Wenzhi Feng, Juntao Yu, Tiasha A. Shafiq, Joao A. Paulo, Jiuchun Zhang, Zhenhua Luo, Steven P. Gygi, Danesh Moazed

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Time-resolved correlation of distributed brain activity tracks E-I balance and accounts for diverse scale-free phenomena by Aditya Nanda, Graham W. Johnson, Yu Mu, Misha B. Ahrens, Catie Chang, Dario J. Englot, Michael Breakspear, Mikail Rubinov

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Epigenetic Regulation of Peroxisome Proliferator-Activated Receptor Gamma Mediates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease by Tahar Hajri, Mohamed Zaiou, Thomas V. Fungwe, Khadija Ouguerram, Samuel Besong

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