Induction of IDO1 and kynurenine by serine proteases subtilisin, prostate specific antigen, CD26 and HtrA: a new form of immunosuppression? by Clanchy, FIL, Huang, Y-S, Ogbechi, J, Darlington, LG, Williams, RO, Stone, TW

“…We now report that IDO1 mRNA and IDO1 protein expression (generating kynurenine) are induced in human monocyte-derived macrophages by several chymotryptic serine proteases with direct links to tumorigenesis, including Prostate Specific Antigen (PSA), CD26 (Dipeptidyl-peptidase-4, CD26/DPP-4), High Temperature Requirement protein-A (HtrA), and the bacterial virulence factor subtilisin. …”

Induction of IDO1 and Kynurenine by Serine Proteases Subtilisin, Prostate Specific Antigen, CD26 and HtrA: A New Form of Immunosuppression? by Felix I. L. Clanchy, Felix I. L. Clanchy, Yi-Shu Huang, Joy Ogbechi, L. Gail Darlington, Richard O. Williams, Trevor W. Stone

“…We now report that IDO1 mRNA and IDO1 protein expression (generating kynurenine) are induced in human monocyte-derived macrophages by several chymotryptic serine proteases with direct links to tumorigenesis, including Prostate Specific Antigen (PSA), CD26 (Dipeptidyl-peptidase-4, CD26/DPP-4), High Temperature Requirement protein-A (HtrA), and the bacterial virulence factor subtilisin. …”
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HtrA1 expression associated with the occurrence and development of esophageal cancer by Yu Youtao, Shao Wenlong, Hu Yi, Zhang Jingyan, Song Hao, Zhu Zhi-hua

“…<p>Abstract</p> <p>Background</p> <p>The purposes of this study were to measure both the mRNA and protein expression levels of high-temperature requirement serine peptidase 1 (HtrA1) in human esophageal cancer tissues and their adjacent, comparatively normal esophageal tissues.…”
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The Serine Protease HTRA-1 Is a Biomarker for ROP and Mediates Retinal Neovascularization by Leah A. Owen, Kinsey Shirer, Samuel A. Collazo, Kathryn Szczotka, Shawna Baker, Blair Wood, Lara Carroll, Benjamin Haaland, Takeshi Iwata, Lakshmi D. Katikaneni, Margaret M. DeAngelis, Margaret M. DeAngelis, Margaret M. DeAngelis

“…Analysis in a discovery cohort of 40 maternal-infant pairs found that elevated HTRA-1 (high-temperature requirement-A serine peptidase-1) was significantly associated with increased risk of ROP and the absence of preeclampsia, thus fitting a model of preeclampsia-mediated ROP protection. …”
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Relative contributions of non-essential Sec pathway components and cell envelope-associated proteases to high-level enzyme secretion by Bacillus subtilis by Jolanda Neef, Cristina Bongiorni, Brian Schmidt, Vivianne J. Goosens, Jan Maarten van Dijl

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Molecular verification and bioinformatic analysis of a serine protease gene from Bacillus Pumilus by Elzamzami, Musab Hassan Abdelmagid

“…SMART online tool predicted that the serine protease contains two highly conserved domains; trypsin-like peptidase, and PDZ domains. …”
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Evolution and Role of Proteases in <i>Campylobacter jejuni</i> Lifestyle and Pathogenesis by Bodo Linz, Irshad Sharafutdinov, Nicole Tegtmeyer, Steffen Backert

“…These include serine proteases Cj1365c, Cj0511 and HtrA; AAA+ group proteases ClpP, Lon and FtsH; and zinc-dependent protease PqqE, proline aminopeptidase PepP, oligopeptidase PepF and peptidase C26. …”
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HTRA1-driven detachment of type I collagen from endoplasmic reticulum contributes to myocardial fibrosis in dilated cardiomyopathy by Hongjie Shi, Ming Yuan, Jie Cai, Lan Lan, Yumou Wang, Wei Wang, Jianliang Zhou, Bin Wang, Wenjun Yu, Zhe Dong, Dawei Deng, Qiaofeng Qian, Yang Li, Xianwu Zhou, Jinping Liu

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HTRA1 in Placental Cell Models: A Possible Role in Preeclampsia by Giovanni Tossetta, Sonia Fantone, Stefano Raffaele Giannubilo, Andrea Ciavattini, Martina Senzacqua, Andrea Frontini, Daniela Marzioni

“…The HtrA serine peptidase 1 (HTRA1) is a multidomain secretory protein with serine–protease activity involved in the regulation of many cellular processes in both physiological and pathological conditions. …”
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Current Management and Therapeutic Strategies for Cerebral Amyloid Angiopathy by Yasuteru Inoue, Yukio Ando, Yohei Misumi, Mitsuharu Ueda

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Identifying subtypes of patients with neovascular age-related macular degeneration by genotypic and cardiovascular risk characteristics by Kim Ivana K, Miller Joan W, Durante Richard, Morrison Margaux A, Hartman John, Feehan Michael, DeAngelis Margaret M

“…</p> <p>Methods</p> <p>We identified a sample of patients with neovascular AMD, that in previous studies had been shown to be at elevated risk for the disease through environmental factors such as cigarette smoking and genetic variants including the complement factor H gene (<it>CFH</it>) on chromosome 1q25 and variants in the <it>ARMS2</it>/HtrA serine peptidase 1 (<it>HTRA1</it>) gene(s) on chromosome 10q26. …”
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HTRA1 from OVX rat osteoclasts causes detrimental effects on endplate chondrocytes through NF-κB by Longting Chen, Yiming Zhong, Shang Sun, Zihuan Yang, Haofeng Hong, Da Zou, Chunli Song, Weishi Li, Huijie Leng

“…Osteoclasts were also confirmed in this study to be able to secrete HtrA serine peptidase 1 (HTRA1), which resulted in increased catabolism in endplate chondrocytes through the NF-κB pathway under estrogen deficiency. …”
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Heterozygous Pathogenic and Likely Pathogenic Symptomatic HTRA1 Variant Carriers in Cerebral Small Vessel Disease by Xu SY, Li HJ, Li S, Ren QQ, Liang JL, Li CX

“…Sui-Yi Xu,1,&ast; Hui-Juan Li,2,&ast; Shun Li,2 Qian-Qian Ren,1 Jian-Lin Liang,1 Chang-Xin Li1 1Department of Neurology, Headache Center, The First Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 2Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chang-Xin Li, Department of Neurology, The First Hospital of Shanxi Medical University, Jiefangnan 85 Road, Taiyuan, Shanxi Province, 030001, People’s Republic of China, Tel +86 15103513579, Email lichangxin0351@sina.comAbstract: High temperature requirement serine peptidase A1 (HTRA1) related cerebral small vessel disease (CSVD) includes both symptomatic heterozygous HTRA1 variant carrier and cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) patients. …”
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Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration by Morrison Margaux A, Silveira Alexandra C, Huynh Nancy, Jun Gyungah, Smith Silvia E, Zacharaki Fani, Sato Hajime, Loomis Stephanie, Andreoli Michael T, Adams Scott M, Radeke Monte J, Jelcick Austin S, Yuan Yang, Tsiloulis Aristoteles N, Chatzoulis Dimitrios Z, Silvestri Giuliana, Kotoula Maria G, Tsironi Evangelia E, Hollis Bruce W, Chen Rui, Haider Neena B, Miller Joan W, Farrer Lindsay A, Hageman Gregory S, Kim Ivana K, Schaumberg Debra A, DeAngelis Margaret M

“…After controlling for established AMD risk factors, including polymorphisms of the genes encoding complement factor H (<it>CFH</it>) and age-related maculopathy susceptibility 2/HtrA serine peptidase (<it>ARMS2/HTRA1</it>), and smoking history, we found that ultraviolet irradiance was protective for the development of neovascular AMD (<it>p </it>= 0.001). …”
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