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Pembrolizumab for patients with leptomeningeal metastasis from solid tumors: efficacy, safety, and cerebrospinal fluid biomarkers
Published 2021-08-01“…Sixty-two percent of patients had tumors not traditionally ICI-responsive (hormone-receptor (HR)-positive breast carcinoma=39%; high-grade glioma=23%), while 38% had ICI-responsive tumors (non-small cell lung cancer (NSCLC)=23%, head and neck carcinoma=8%, cutaneous squamous carcinoma (CSC)=8%). …”
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Oncologic Drugs Approval in Europe for Solid Tumors: Overview of the Last 6 Years
Published 2022-02-01“…Immune check point inhibitors (ICIs) and signal transduction inhibitors were the two most representative drug categories (62%). …”
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Anticancer Drug Conjugates Incorporating Estrogen Receptor Ligands
Published 2022-12-01“…Hormone-dependent cancers, such as certain types of breast cancer are characterized by over-expression of estrogen receptors (ERs). …”
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Evaluation of PD-L1 Expression in Undifferentiated Pleomorphic Sarcomas, Liposarcomas and Chondrosarcomas
Published 2022-02-01Get full text
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Expression of overall survival-EMT-immune cell infiltration genes predict the prognosis of glioma
Published 2024-06-01Get full text
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Characteristics of the immunogenicity and tumor immune microenvironment in HER2-amplified lung adenocarcinoma
Published 2022-12-01“…ObjectiveBesides breast and gastric cancer, HER2 amplification/mutation are also found in lung adenocarcinoma (LUAD). …”
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High CTLA-4 transcriptomic expression correlates with high expression of other checkpoints and with immunotherapy outcome
Published 2024-01-01“…Results: The most common tumor types were colorectal (140/514, 27%), pancreatic (55/514, 11%), breast (49/514, 10%), and ovarian cancers (43/514, 8%). …”
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The Prognostic Value and Potential Immune Mechanisms of lncRNAs Related to Immunogenic Cell Death in Papillary Thyroid Carcinoma
Published 2024-03-01“…Additionally, we conducted GO and KEGG enrichment analyses, assessed immune cell infiltration (ICI) using CIBERSORT and ssGSEA, examined immune checkpoint expression, tumor mutation burden (TMB), tumor microenvironment (TME), T-cell dysfunction and exclusion (TIDE), TCIA, and drug sensitivity across various groups. …”
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Partial response to niraparib in combination with tislelizumab in a patient with metastatic undifferentiated tonsillar carcinoma: a case report and literature review
Published 2023-05-01“…Immune checkpoint inhibitors (ICIs) provide a treatment option for unresectable head and neck cancer. …”
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ANXA1-derived peptide for targeting PD-L1 degradation inhibits tumor immune evasion in multiple cancers
Published 2023-03-01“…Moreover, expression levels of both USP7 and PD-L1 are significantly higher in breast cancer, non-small cell lung cancer and skin melanoma tissues than those in their corresponding normal tissues and are positively correlated in cancer tissues, and both proteins for predicting efficacy of PD-1 mAb immunotherapy and patient prognosis are superior to individual protein.Conclusion Our results reveal that A11 competes with USP7 to bind and degrade PD-L1 in cancer cells, A11 exhibits obvious antitumor effects and synergistic antitumor activity with PD-1 mAb via inhibiting tumor immune evasion and A11 can serve as an alternative strategy for ICIs therapy in multiple cancers.…”
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Antitumor effect of anti-vascular therapy with STING agonist depends on the tumor microenvironment context
Published 2023-08-01“…Therefore, our aim was to examine whether combination of immunotherapy and anti-vascular treatment will succeed in poorly immunogenic, difficult-to-treat melanoma and triple-negative breast tumor models.MethodsOur study was performed on B16-F10 melanoma and 4T1 breast tumor murine models. …”
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Tumor-associated neutrophils and macrophages exacerbate antidrug IgG-mediated anaphylactic reaction against an immune checkpoint inhibitor
Published 2022-12-01“…Background With the increased use of immune checkpoint inhibitors (ICIs), side effects and toxicity are a great concern. …”
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