Pembrolizumab for patients with leptomeningeal metastasis from solid tumors: efficacy, safety, and cerebrospinal fluid biomarkers by Nickolas Papadopoulos, Chen Hu, Julie R Brahmer, Patrick M Forde, Evan J Lipson, Jarushka Naidoo, Wei Fu, Joanne Riemer, Chetan Bettegowda, Cesar A Santa-Maria, Matthias Holdhoff, Amanda Barnes, Nafi Aygun, Lawrence Kleinberg, Christopher Douville, Arun Venkatesan, Karisa C Schreck, Alexander Carvajal-Gonzalez, Roisin M Connolly, Kristin J Redmond, Brandi Page, Kenneth W Kinzler, Stuart A Grossman

“…Sixty-two percent of patients had tumors not traditionally ICI-responsive (hormone-receptor (HR)-positive breast carcinoma=39%; high-grade glioma=23%), while 38% had ICI-responsive tumors (non-small cell lung cancer (NSCLC)=23%, head and neck carcinoma=8%, cutaneous squamous carcinoma (CSC)=8%). …”
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Oncologic Drugs Approval in Europe for Solid Tumors: Overview of the Last 6 Years by Rosa Falcone, Pasquale Lombardi, Marco Filetti, Simona Duranti, Antonella Pietragalla, Alessandra Fabi, Domenica Lorusso, Valeria Altamura, Francesco Paroni Sterbini, Giovanni Scambia, Gennaro Daniele

“…Immune check point inhibitors (ICIs) and signal transduction inhibitors were the two most representative drug categories (62%). …”
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Construction of disulfidptosis-based immune response prediction model with artificial intelligence and validation of the pivotal grouping oncogene c-MET in regulating T cell exhaus... by Pengping Li, Shaowen Wang, Hong Wan, Yuqing Huang, Kexin Yin, Ke Sun, Haigang Jin, Zhenyu Wang

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ISG15 targets glycosylated PD-L1 and promotes its degradation to enhance antitumor immune effects in lung adenocarcinoma by Tongyuan Qu, Wenshuai Zhang, Chenhui Yan, Danyang Ren, Yalei Wang, Yuhong Guo, Qianru Guo, Jinpeng Wang, Liren Liu, Lei Han, Lingmei Li, Qiujuan Huang, Lu Cao, Zhaoxiang Ye, Bin Zhang, Qiang Zhao, Wenfeng Cao

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Anticancer Drug Conjugates Incorporating Estrogen Receptor Ligands by Darius P. Zlotos, Thales Kronenberger, Stefan A. Laufer

“…Hormone-dependent cancers, such as certain types of breast cancer are characterized by over-expression of estrogen receptors (ERs). …”
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Bladder cancer intrinsic LRFN2 drives anticancer immunotherapy resistance by attenuating CD8+ T cell infiltration and functional transition by Xu Chen, Anze Yu, Jiao Hu, Liangmin Fu, Gaowei Huang, Dingshan Deng, Mingxiao Zhang, Yinghan Wang, Guannan Shu, Lanyu Jing, Huihuang Li, Taowei Yang, Jinhuan Wei, Zhenhua Chen, Xiongbing Zu, Junhang Luo

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Evaluation of PD-L1 Expression in Undifferentiated Pleomorphic Sarcomas, Liposarcomas and Chondrosarcomas by Yifan Zhang, Yi Chen, Andri Papakonstantinou, Panagiotis Tsagkozis, Christina Linder-Stragliotto, Felix Haglund

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Expression of overall survival-EMT-immune cell infiltration genes predict the prognosis of glioma by Lei Zheng, Jin-jing He, Kai-xiang Zhao, Ya-fei Pan, Wei-xian Liu

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Characteristics of the immunogenicity and tumor immune microenvironment in HER2-amplified lung adenocarcinoma by Qinyang Wang, Ziyang Mao, Wenyuan Li, Shumei Wang, Lei Wang, Lin Chen, Zhe Yang, Xiaolan Fu, Panpan Jiang, Yixue Bai, Longwen Xu, Shirong Zhang, Yuzhu Hou, Xiaohui Jia, Lili Jiang, Mengjie Liu, Guanjun Zhang, Yina Jiang, Hui Guo, Hui Guo, Hui Guo

“…ObjectiveBesides breast and gastric cancer, HER2 amplification/mutation are also found in lung adenocarcinoma (LUAD). …”
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High CTLA-4 transcriptomic expression correlates with high expression of other checkpoints and with immunotherapy outcome by Nithya Krishnamurthy, Daisuke Nishizaki, Scott M. Lippman, Hirotaka Miyashita, Mary K. Nesline, Sarabjot Pabla, Jeffrey M. Conroy, Paul DePietro, Shumei Kato, Razelle Kurzrock

“…Results: The most common tumor types were colorectal (140/514, 27%), pancreatic (55/514, 11%), breast (49/514, 10%), and ovarian cancers (43/514, 8%). …”
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The Prognostic Value and Potential Immune Mechanisms of lncRNAs Related to Immunogenic Cell Death in Papillary Thyroid Carcinoma by Wang Y, Li X, Huang Y, Gang Q, Liu M, Zhang H, Shen S, Qi Y, Zhang J

“…Additionally, we conducted GO and KEGG enrichment analyses, assessed immune cell infiltration (ICI) using CIBERSORT and ssGSEA, examined immune checkpoint expression, tumor mutation burden (TMB), tumor microenvironment (TME), T-cell dysfunction and exclusion (TIDE), TCIA, and drug sensitivity across various groups. …”
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Partial response to niraparib in combination with tislelizumab in a patient with metastatic undifferentiated tonsillar carcinoma: a case report and literature review by Jing Zhang, Jing Zhang, Zi Dai, Zi Dai, Pei Liao, Pei Liao, Jieshan Guan

“…Immune checkpoint inhibitors (ICIs) provide a treatment option for unresectable head and neck cancer. …”
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Case Report: The application of associating liver partition and portal vein ligation for staged hepatectomy in patients with hepatitis b virus-related hepatocellular carcinoma afte... by Cong Ning, Guanmo Liu, Junwei Zhang, Xiaobo Yang, Yiyao Xu, Haitao Zhao

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Immune checkpoint status and oncogenic mutation profiling of rectal cancer after neoadjuvant chemotherapy (KSCC1301‐A2) by Yu Miyashita, Eiji Oki, Tomohiro Kamori, Yoshito Akagi, Shinichiro Mori, Norifumi Hattori, Kazuma Kobayashi, Mototsugu Shimokawa, Yoshinao Oda, Masaki Mori

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ANXA1-derived peptide for targeting PD-L1 degradation inhibits tumor immune evasion in multiple cancers by Wei Huang, Qi Wen, Ting Zeng, Di Wu, Li Yuan, Wei Zhu, Zheng-Zheng Yu, Yun-Ya Liu, Ding Xiao, Shan-Shan Lu, Hong Yi, Xue-Ping Feng, Jie-Ya Qiu, Jian-Hua Zhou, Wei Zhuang, Zhi-Qiang Xiao

“…Moreover, expression levels of both USP7 and PD-L1 are significantly higher in breast cancer, non-small cell lung cancer and skin melanoma tissues than those in their corresponding normal tissues and are positively correlated in cancer tissues, and both proteins for predicting efficacy of PD-1 mAb immunotherapy and patient prognosis are superior to individual protein.Conclusion Our results reveal that A11 competes with USP7 to bind and degrade PD-L1 in cancer cells, A11 exhibits obvious antitumor effects and synergistic antitumor activity with PD-1 mAb via inhibiting tumor immune evasion and A11 can serve as an alternative strategy for ICIs therapy in multiple cancers.…”
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Antitumor effect of anti-vascular therapy with STING agonist depends on the tumor microenvironment context by Justyna Czapla, Alina Drzyzga, Sybilla Matuszczak, Tomasz Cichoń, Marek Rusin, Magdalena Jarosz-Biej, Ewelina Pilny, Ryszard Smolarczyk

“…Therefore, our aim was to examine whether combination of immunotherapy and anti-vascular treatment will succeed in poorly immunogenic, difficult-to-treat melanoma and triple-negative breast tumor models.MethodsOur study was performed on B16-F10 melanoma and 4T1 breast tumor murine models. …”
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Biomarkers predicting clinical outcomes in nasopharyngeal cancer patients receiving immune checkpoint inhibitors: A systematic review and meta-analysis by Xiaoyan Qian, Haizhu Chen, Haizhu Chen, Yunxia Tao

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Effectiveness and safety of first-line immune checkpoint inhibitors for patients with extensive-stage small cell lung carcinoma: A systematic review and network meta-analysis by Jincheng Du, Xinyu Wang, Liwen Fan, Xinyuan Shan, Muyao Li, Linlin Liu

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Tumor-associated neutrophils and macrophages exacerbate antidrug IgG-mediated anaphylactic reaction against an immune checkpoint inhibitor by Ayu Terui, Tomomi Kokubo, Akihiro Hisaka, Hiroto Hatakeyama, Takahiro Arai, Hiroto Kawashima, Ruiheng Tang, Hirohito Abo, Jotaro Hirakawa, Hidetaka Akita

“…Background With the increased use of immune checkpoint inhibitors (ICIs), side effects and toxicity are a great concern. …”
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Implementation of microsatellite instability testing for the assessment of solid tumors in clinical practice by Izuma Nakayama, Eiji Shinozaki, Hiroshi Kawachi, Takashi Sasaki, Mayu Yunokawa, Junichi Tomomatsu, Takeshi Yuasa, Satoru Kitazono, Kokoro Kobayashi, Keiko Hayakawa, Arisa Ueki, Shunji Takahashi, Kensei Yamaguchi

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