Integrating Single-Cell RNA-Seq and Bulk RNA-Seq Data to Explore the Key Role of Fatty Acid Metabolism in Breast Cancer by Yongxing Chen, Wei Wu, Chenxin Jin, Jiaxue Cui, Yizhuo Diao, Ruiqi Wang, Rongxuan Xu, Zhihan Yao, Xiaofeng Li

“…This study significantly demonstrates the substantial impact of FMGs on the immune microenvironment of breast cancer, and that FMGsScores can be used to guide the prediction of immunotherapy efficacy in breast cancer patients. …”
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Immune checkpoint status and exhaustion‐related phenotypes of CD8+ T cells from the tumor‐draining regional lymph nodes in breast cancer by Izel Yilmaz, Ece Tavukcuoglu, Utku Horzum, Kerim Bora Yilmaz, Melih Akinci, Mehmet Ali Gulcelik, Haluk Barbaros Oral, Gunes Esendagli

“…The immunological conditions in the regional lymph nodes should be implicated for immune checkpoint immunotherapy (ICI) of cancer.…”
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PD-1/PD-L1 immune checkpoint inhibitors in metastatic triple-negative breast cancer: a systematic review and meta-analysis by Yinan Yu, Xueying Jin, Xiaoling Zhu, Yan Xu, Wei Si, Jianguo Zhao

“…BackgroundPD-1/PD-L1 immune checkpoint inhibitors (ICIs) have been controversial in the treatment of metastatic triple negative breast cancer (mTNBC). …”
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Immune checkpoint inhibitors in first-line therapies of metastatic or early triple-negative breast cancer: a systematic review and network meta-analysis by Xueyan Liang, Xiaoyu Chen, Xiaoyu Chen, Huijuan Li, Yan Li

“…BackgroundThe optimal first-line immune checkpoint inhibitor (ICI) treatment strategy for metastatic or early triple-negative breast cancer (TNBC) has not yet been determined as a result of various randomized controlled trials (RCTs). …”
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Potential predictive value of circulating tumor DNA (ctDNA) mutations for the efficacy of immune checkpoint inhibitors in advanced triple-negative breast cancer by Qiaorui Tan, Yajing Chi, Yajing Chi, Mu Su, Jinxing Zhou, Dongdong Zhou, Fangchao Zheng, Xiaochu Man, Shujuan Sun, Jie Huang, Huihui Li

“…Background: In recent years, tumor immunotherapy has become a viable treatment option for triple negative breast cancer (TNBC). Among these, immune checkpoint inhibitors (ICIs) have demonstrated good efficacy in advanced TNBC patients with programmed death-ligand 1 (PD-L1) positive expression. …”
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Combination of Immune-Related Network and Molecular Typing Analysis Defines a Three-Gene Signature for Predicting Prognosis of Triple-Negative Breast Cancer by Jinguo Zhang, Shuaikang Pan, Chaoqiang Han, Hongwei Jin, Qingqing Sun, Jun Du, Xinghua Han

“…Recent breakthroughs in immune checkpoint inhibitors (ICIs) have shown promise in triple-negative breast cancer (TNBC). …”
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Schisandrol A Exhibits Estrogenic Activity via Estrogen Receptor α-Dependent Signaling Pathway in Estrogen Receptor-Positive Breast Cancer Cells by Dahae Lee, Young-Mi Kim, Young-Won Chin, Ki Sung Kang

“…Their effects on the proliferation of the estrogen receptor (ER)-positive breast cancer cell line (MCF-7) were evaluated using Ez-Cytox reagents. …”
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Addition of immune checkpoint inhibitors to chemotherapy versus chemotherapy alone in patients with triple‐negative breast cancer: A systematic review and meta‐analysis by Xin Gao, Ying Zhu, Peipei Wang, Lulin Yu, Shanming Ruan, Minhe Shen, Kai Zhang

“…Abstract Background Triple‐negative breast cancer (TNBC) is a relatively common malignant tumor with high mortality rates. …”
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Efficacy and safety of PD-1 and PD-L1 inhibitors combined with chemotherapy in randomized clinical trials among triple-negative breast cancer by Yihang Qi, Yihang Qi, Wenxiang Zhang, Ray Jiang, Olivia Xu, Xiangyi Kong, Lin Zhang, Lin Zhang, Lin Zhang, Yi Fang, Jingping Wang, Jing Wang

“…Background: The combination of immune checkpoint inhibitors (ICIs) and chemotherapy (CT) is a new strategy to explore cancer treatment in recent years, and it is also practiced in triple-negative breast cancer (TNBC). …”
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Disruption of 3D MCF-12A breast cell cultures by estrogens--an in vitro model for ER-mediated changes indicative of hormonal carcinogenesis. by Stephanie Marchese, Elisabete Silva

“…INTRODUCTION:Estrogens regulate the proliferation of normal and neoplastic breast epithelium. Although the intracellular mechanisms of estrogens in the breast are largely understood, little is known about how they induce changes in the structure of the mammary epithelium, which are characteristic of breast cancer. …”
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Editorial: Improvement of melanoma immune checkpoint blockade therapy with potential combinatorial regiments by Xueyan Wang, Xiaowei Liu, Willy Hugo, Lu Si, Hubing Shi

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PD-L1 Expression after Neoadjuvant Chemotherapy in Triple-Negative Breast Cancers Is Associated with Aggressive Residual Disease, Suggesting a Potential for Immunotherapy by Beatriz Grandal, Manon Mangiardi-Veltin, Enora Laas, Marick Laé, Didier Meseure, Guillaume Bataillon, Elsy El-Alam, Lauren Darrigues, Elise Dumas, Eric Daoud, Anne Vincent-Salomon, Laure-Sophie Talagrand, Jean-Yves Pierga, Fabien Reyal, Anne-Sophie Hamy

“…The consequences of neoadjuvant chemotherapy (NAC) for PD-L1 activity in triple-negative breast cancers (TNBC) are not well-understood. This is an important issue as PD-LI might act as a biomarker for immune checkpoint inhibitors’ (ICI) efficacy, at a time where ICI are undergoing rapid development and could be beneficial in patients who do not achieve a pathological complete response. …”
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Effects of human mesenchymal stem cells on ER-positive human breast carcinoma cells mediated through ER-SDF-1/CXCR4 crosstalk by Beckman Barbara S, Elliott Steven, Muir Shannon E, Antoon James W, Rhodes Lyndsay V, Burow Matthew E

“…Inhibition of ER signalling by the pure anti-oestrogen ICI 182,780 decreased the effect of hMSCs on MCF-7 cell proliferation and migration supporting a role for ER signalling in the hMSC/MCF-7 cell interaction. …”
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Inositol 1,4,5-trisphosphate-induced Ca²⁺signalling is involved in estradiol-induced breast cancer epithelial cell growth by Matifat Fabrice, Ouadid-Ahidouch Halima, Parys Jan B, Szatkowski Cécilia

“…Our purpose was to characterize the role of IICS in the control of growth of the estrogen-dependent human breast cancer epithelial cell line MCF-7 and its potential regulation by 17β-estradiol (E₂).…”
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Predictive value of PD-L1 expression to the efficacy of immune checkpoint inhibitors in advanced triple-negative breast cancer: A systematic review and meta-analysis by Yingjie Qi, Xin Yan, Chao Wang, Hui Cao, Guangxuan Liu

“…Background: Immune checkpoint inhibitors (ICIs) have been an emerging treatment strategy for advanced triple-negative breast cancer (TNBC). …”
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Blockade of PD-1, PD-L1, and TIM-3 Altered Distinct Immune- and Cancer-Related Signaling Pathways in the Transcriptome of Human Breast Cancer Explants by Reem Saleh, Salman M. Toor, Dana Al-Ali, Varun Sasidharan Nair, Eyad Elkord

“…We investigated the effects of different ICIs—anti-programmed cell death protein 1 (PD-1), anti-programmed death ligand-1 (PD-L1), and anti-T cell immunoglobulin and mucin-domain containing-3 (TIM-3)—on human primary breast cancer explant cultures using RNA-Seq. …”
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Reconstruction of unreported subgroup survival data with PD-L1-low expression in advanced/metastatic triple-negative breast cancer using innovative KMSubtraction workflow by Xiaoyu Chen, Yan Li, Huijuan Li, Xueyan Liang

“…Background Among patients with advanced/metastatic triple-negative breast cancer (TNBC) with high/positive programmed death-ligand 1 (PD-L1) expression, a superior survival outcome has been demonstrated with immune checkpoint inhibitors (ICIs). …”
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Long-term survival after neoadjuvant therapy for triple-negative breast cancer under different treatment regimens: a systematic review and network meta-analysis by Zhilin Liu, Jinming Li, Fuxing Zhao, Dengfeng Ren, Zitao Li, Yongzhi Chen, Shifen Huang, Zhen Liu, Yi Zhao, Miaozhou Wang, Huihui Li, ZhengBo Xu, Guoshuang Shen, Jiuda Zhao

“…Abstract Background Triple-negative breast cancer (TNBC) is a life-threatening subtype of breast cancer with limited treatment options. …”
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Low-Salt Diet Reduces Anti-CTLA4 Mediated Systemic Immune-Related Adverse Events while Retaining Therapeutic Efficacy against Breast Cancer by Durga Khandekar, Debolanle O. Dahunsi, Isaac V. Manzanera Esteve, Sonya Reid, Jeffrey C. Rathmell, Jens Titze, Venkataswarup Tiriveedhi

“…Immune checkpoint inhibitor (ICI) therapy has revolutionized the breast cancer treatment landscape. …”
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Immunomodulatory Properties of PI3K/AKT/mTOR and MAPK/MEK/ERK Inhibition Augment Response to Immune Checkpoint Blockade in Melanoma and Triple-Negative Breast Cancer by Zhizhu Zhang, Ann Richmond, Chi Yan

“…The immune-modulatory effects of both PI3K and MAPK inhibition suggest that inhibition of these pathways might enhance response to immune checkpoint inhibitors (ICIs). ICIs have become the standard-of-care for metastatic melanoma and are recently an option for TNBC when combined with chemotherapy, but alternative options are needed when resistance develops. …”
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