Phenotypic and molecular characterisation of CDK13-related congenital heart defects, dysmorphic facial features and intellectual developmental disorders by Bret L. Bostwick, Scott McLean, Jennifer E. Posey, Haley E. Streff, Karen W. Gripp, Alyssa Blesson, Nina Powell-Hamilton, Jessica Tusi, David A. Stevenson, Ellyn Farrelly, Louanne Hudgins, Yaping Yang, Fan Xia, Xia Wang, Pengfei Liu, Magdalena Walkiewicz, Marianne McGuire, Dorothy K. Grange, Marisa V. Andrews, Marybeth Hummel, Suneeta Madan-Khetarpal, Elena Infante, Zeynep Coban-Akdemir, Karol Miszalski-Jamka, John L. Jefferies, Members of the Undiagnosed Diseases Network, Jill A. Rosenfeld, Lisa Emrick, Kimberly M. Nugent, James R. Lupski, John W. Belmont, Brendan Lee, Seema R. Lalani

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Endothelial ERα promotes glucose tolerance by enhancing endothelial insulin transport to skeletal muscle by Anastasia Sacharidou, Ken Chambliss, Jun Peng, Jose Barrera, Keiji Tanigaki, Katherine Luby-Phelps, İpek Özdemir, Sohaib Khan, Shashank R. Sirsi, Sung Hoon Kim, Benita S. Katzenellenbogen, John A. Katzenellenbogen, Mohammed Kanchwala, Adwait A. Sathe, Andrew Lemoff, Chao Xing, Kenneth Hoyt, Chieko Mineo, Philip W. Shaul

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Using the multiphase optimization strategy to adapt cognitive processing therapy (CPT MOST): study protocol for a randomized controlled factorial experiment by Rebecca K. Sripada, Cassaundra L. Peterson, John J. Dziak, Inbal Nahum-Shani, Erika M. Roberge, Amber A. Martinson, Katherine Porter, Peter Grau, Diana Curtis, Sydney McElroy, Sarah Bryant, Isabel Gracy, Cosette Pryor, Heather M. Walters, Karen Austin, Carolina Ehlinger, Nina Sayer, Shannon Wiltsey-Stirman, Kathleen Chard

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Single-Cell Transcriptomic Profiling Identifies Molecular Phenotypes of Newborn Human Lung Cells by Soumyaroop Bhattacharya, Jacquelyn A. Myers, Cameron Baker, Minzhe Guo, Soula Danopoulos, Jason R. Myers, Gautam Bandyopadhyay, Stephen T. Romas, Heidie L. Huyck, Ravi S. Misra, Jennifer Dutra, Jeanne Holden-Wiltse, Andrew N. McDavid, John M. Ashton, Denise Al Alam, S. Steven Potter, Jeffrey A. Whitsett, Yan Xu, Gloria S. Pryhuber, Thomas J. Mariani

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Hydroxyurea Optimization through Precision Study (HOPS): study protocol for a randomized, multicenter trial in children with sickle cell anemia by Emily R. Meier, Susan E. Creary, Matthew M. Heeney, Min Dong, Abena O. Appiah-Kubi, Stephen C. Nelson, Omar Niss, Connie Piccone, Maa-Ohui Quarmyne, Charles T. Quinn, Kay L. Saving, John P. Scott, Ravi Talati, Teresa S. Latham, Amanda Pfeiffer, Lisa M. Shook, Alexander A. Vinks, Adam Lane, Patrick T. McGann

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Attention-guided deep learning for gestational age prediction using fetal brain MRI by Liyue Shen, Jimmy Zheng, Edward H. Lee, Katie Shpanskaya, Emily S. McKenna, Mahesh G. Atluri, Dinko Plasto, Courtney Mitchell, Lillian M. Lai, Carolina V. Guimaraes, Hisham Dahmoush, Jane Chueh, Safwan S. Halabi, John M. Pauly, Lei Xing, Quin Lu, Ozgur Oztekin, Beth M. Kline-Fath, Kristen W. Yeom

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Conserved chromatin and repetitive patterns reveal slow genome evolution in frogs by Jessen V. Bredeson, Austin B. Mudd, Sofia Medina-Ruiz, Therese Mitros, Owen Kabnick Smith, Kelly E. Miller, Jessica B. Lyons, Sanjit S. Batra, Joseph Park, Kodiak C. Berkoff, Christopher Plott, Jane Grimwood, Jeremy Schmutz, Guadalupe Aguirre-Figueroa, Mustafa K. Khokha, Maura Lane, Isabelle Philipp, Mara Laslo, James Hanken, Gwenneg Kerdivel, Nicolas Buisine, Laurent M. Sachs, Daniel R. Buchholz, Taejoon Kwon, Heidi Smith-Parker, Marcos Gridi-Papp, Michael J. Ryan, Robert D. Denton, John H. Malone, John B. Wallingford, Aaron F. Straight, Rebecca Heald, Dirk Hockemeyer, Richard M. Harland, Daniel S. Rokhsar

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Airway inflammation accelerates pulmonary exacerbations in cystic fibrosis by Theodore G. Liou, Natalia Argel, Fadi Asfour, Perry S. Brown, Barbara A. Chatfield, David R. Cox, Cori L. Daines, Dixie Durham, Jessica A. Francis, Barbara Glover, My Helms, Theresa Heynekamp, John R. Hoidal, Judy L. Jensen, Christiana Kartsonaki, Ruth Keogh, Carol M. Kopecky, Noah Lechtzin, Yanping Li, Jerimiah Lysinger, Osmara Molina, Craig Nakamura, Kristyn A. Packer, Robert Paine, III, Katie R. Poch, Alexandra L. Quittner, Peggy Radford, Abby J. Redway, Scott D. Sagel, Rhonda D. Szczesniak, Shawna Sprandel, Jennifer L. Taylor-Cousar, Jane B. Vroom, Ryan Yoshikawa, John P. Clancy, J. Stuart Elborn, Kenneth N. Olivier, Frederick R. Adler

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Expert Perspectives on Hereditary Angioedema: Key Areas for Advancements in Care across the Patient Journey by Aleena Banerji M.D., Murat Baş M.D., Jonathan A. Bernstein M.D., Isabelle Boccon-Gibod M.D., Maria Bova M.D., Ph.D., John Dempster, Anete Sevciovic Grumach M.D., Ph.D., Markus Magerl M.D., Kimberly Poarch PA-C, Manuel Branco Ferreira M.D., Ph.D.

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The heart of the matter: Right heart imaging indicators for treatment escalation in pulmonary arterial hypertension by Paul Forfia, Raymond Benza, Michele D'Alto, Teresa De Marco, Jean M. Elwing, Robert Frantz, Francois Haddad, Ronald Oudiz, Ioana R. Preston, Stephan Rosenkranz, John Ryan, Robert Schilz, Oksana A. Shlobin, Jean‐Luc Vachiery, Carmine Dario Vizza, Anton Vonk Noordegraaf, Margaret R. Sketch, Meredith Broderick, Vallerie McLaughlin

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Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways by Benoit Ballester, Alejandra Medina-Rivera, Dominic Schmidt, Mar Gonzàlez-Porta, Matthew Carlucci, Xiaoting Chen, Kyle Chessman, Andre J Faure, Alister PW Funnell, Angela Goncalves, Claudia Kutter, Margus Lukk, Suraj Menon, William M McLaren, Klara Stefflova, Stephen Watt, Matthew T Weirauch, Merlin Crossley, John C Marioni, Duncan T Odom, Paul Flicek, Michael D Wilson

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Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death by Jerry H. Houl, Zu Ye, Chris A. Brosey, Lakshitha P. F. Balapiti-Modarage, Sarita Namjoshi, Albino Bacolla, Daniel Laverty, Brian L. Walker, Yasin Pourfarjam, Leslie S. Warden, Naga Babu Chinnam, Davide Moiani, Roderick A. Stegeman, Mei-Kuang Chen, Mien-Chie Hung, Zachary D. Nagel, Tom Ellenberger, In-Kwon Kim, Darin E. Jones, Zamal Ahmed, John A. Tainer

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Sedentary Bout Patterns and Metabolic Health in the Hispanic Community Health Study/Study of Latino Youth (SOL Youth) by Jordan A. Carlson, Paul R. Hibbing, Bethany Forseth, Keith M. Diaz, Daniela Sotres‐Alvarez, Carolina M. Bejarano, Andrea T. Duran, Sheila F. Castañeda, Melawhy L. Garcia, Krista M. Perreira, Martha L. Daviglus, Linda Van Horn, Marc D. Gellman, Carmen R. Isasi, Jianwen Cai, Alan M. Delamater, Vincent S. Staggs, John Thyfault, Linda C. Gallo

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Placebo‐Controlled Randomized Trial of an Intestinal Bile Salt Transport Inhibitor for Pruritus in Alagille Syndrome by Benjamin L. Shneider, Cathie Spino, Binita M. Kamath, John C. Magee, Lee M. Bass, Kenneth D. Setchell, Alexander Miethke, Jean P. Molleston, Cara L. Mack, Robert H. Squires, Karen F. Murray, Kathleen M. Loomes, Philip Rosenthal, Saul J. Karpen, Daniel H. Leung, Stephen L. Guthery, Danny Thomas, Averell H. Sherker, Ronald J. Sokol, for the Childhood Liver Disease Research Network

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Mediport use as an acceptable standard for CAR T cell infusion by Maya Eylon, Snehit Prabhu, Samuel John, Maxwell J. M. King, Dhruv Bhatt, Kevin J. Curran, Courtney Erickson, Nicole A. Karras, Christine L. Phillips, Christine L. Phillips, Prakash Satwani, Michelle Hermiston, Erica Southworth, Susanne H. C. Baumeister, Julie-An Talano, Margaret L. MacMillan, Jenna Rossoff, Challice L. Bonifant, Gary Doug Myers, Rayne H. Rouce, Keri Toner, Timothy A. Driscoll, Emmanuel Katsanis, Dana B. Salzberg, Deborah Schiff, Satiro N. De Oliveira, Christian M. Capitini, Holly L. Pacenta, Holly L. Pacenta, Thomas Pfeiffer, Niketa C. Shah, Van Huynh, Jodi L. Skiles, Ellen Fraint, Kevin O. McNerney, Troy C. Quigg, Joerg Krueger, John A. Ligon, Vanessa A. Fabrizio, Christina Baggott, Theodore W. Laetsch, Liora M. Schultz

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One-Year Outcomes of the Multi-Center StudY to Transplant Hepatitis C-InfeCted kidneys (MYTHIC) Trial by Meghan Elizabeth Sise, David Seth Goldberg, Douglas Earl Schaubel, Robert J. Fontana, Jens J. Kort, Rita R. Alloway, Christine M. Durand, Emily A. Blumberg, E. Steve Woodle, Kenneth E. Sherman, Robert S. Brown, Jr., John J. Friedewald, Niraj M. Desai, Samuel T. Sultan, Josh Levitsky, Meghan D. Lee, Ian A. Strohbehn, J. Richard Landis, Melissa Fernando, Jenna L. Gustafson, Raymond T. Chung, Peter Philip Reese

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Phase I Clinical Trial of an Autologous Dendritic Cell Vaccine Against HER2 Shows Safety and Preliminary Clinical Efficacy by Hoyoung M. Maeng, Brittni N. Moore, Hadi Bagheri, Seth M. Steinberg, Jon Inglefield, Kim Dunham, Wei-Zen Wei, John C. Morris, Masaki Terabe, Lee C. England, Brenda Roberson, Douglas Rosing, Vandana Sachdev, Svetlana D. Pack, Markku M. Miettinen, Frederic G. Barr, Louis M. Weiner, Sandhya Panch, David F. Stroncek, Lauren V. Wood, Jay A. Berzofsky

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Deep profiling of multiple ischemic lesions in a large, multi-center cohort: Frequency, spatial distribution, and associations to clinical characteristics by Anna K. Bonkhoff, Teresa Ullberg, Teresa Ullberg, Martin Bretzner, Martin Bretzner, Sungmin Hong, Markus D. Schirmer, Robert W. Regenhardt, Kathleen L. Donahue, Marco J. Nardin, Adrian V. Dalca, Adrian V. Dalca, Anne-Katrin Giese, Mark R. Etherton, Brandon L. Hancock, Steven J. T. Mocking, Elissa C. McIntosh, John Attia, John Attia, John W. Cole, Amanda Donatti, Christoph J. Griessenauer, Christoph J. Griessenauer, Laura Heitsch, Laura Heitsch, Lukas Holmegaard, Lukas Holmegaard, Katarina Jood, Katarina Jood, Jordi Jimenez-Conde, Jordi Jimenez-Conde, Steven J. Kittner, Robin Lemmens, Robin Lemmens, Christopher R. Levi, Christopher R. Levi, Caitrin W. McDonough, James F. Meschia, Chia-Ling Phuah, Stefan Ropele, Jonathan Rosand, Jonathan Rosand, Jonathan Rosand, Jaume Roquer, Jaume Roquer, Tatjana Rundek, Ralph L. Sacco, Reinhold Schmidt, Pankaj Sharma, Agnieszka Slowik, Alessandro Sousa, Tara M. Stanne, Daniel Strbian, Turgut Tatlisumak, Turgut Tatlisumak, Vincent Thijs, Vincent Thijs, Achala Vagal, Daniel Woo, Ramin Zand, Patrick F. McArdle, Bradford B. Worrall, Bradford B. Worrall, Christina Jern, Christina Jern, Arne G. Lindgren, Arne G. Lindgren, Jane Maguire, Ona Wu, Petrea Frid, Natalia S. Rost, Johan Wasselius, Johan Wasselius

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Use of funded multicenter prospective longitudinal databases to inform clinical trials in rare diseases—Examination of cholestatic liver disease in Alagille syndrome by Benjamin L. Shneider, Binita M. Kamath, John C. Magee, Nathan P. Goodrich, Kathleen M. Loomes, Wen Ye, Cathie Spino, Estella M. Alonso, Jean P. Molleston, Jorge A. Bezerra, Kasper S. Wang, Saul J. Karpen, Simon P. Horslen, Stephen L. Guthery, Philip Rosenthal, Robert H. Squires, Ronald J. Sokol, for the Childhood Liver Disease Research Network (ChiLDReN)

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T cell dynamics and response of the microbiota after gene therapy to treat X-linked severe combined immunodeficiency by Erik L. Clarke, A. Jesse Connell, Emmanuelle Six, Nadia A. Kadry, Arwa A. Abbas, Young Hwang, John K. Everett, Casey E. Hofstaedter, Rebecca Marsh, Myriam Armant, Judith Kelsen, Luigi D. Notarangelo, Ronald G. Collman, Salima Hacein-Bey-Abina, Donald B. Kohn, Marina Cavazzana, Alain Fischer, David A. Williams, Sung-Yun Pai, Frederic D. Bushman

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