Sources of inter-individual variability leading to significant changes in anti-PD-1 and anti-PD-L1 efficacy identified in mouse tumor models using a QSP framework by Jessica C. Leete, Jessica C. Leete, Michael G. Zager, Cynthia J. Musante, Blerta Shtylla, Wenlian Qiao, Wenlian Qiao

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TUBERCULOSIS PULMONAR (TB), ALTO COMISIONADO DE LAS NACIONES UNIDAS PARA LOS REFUGIADOS (ACNUR) Y ADMINISTRACION PARA LOS ASUNTOS DE LOS REFUGIADOS Y RETORNADOS (ARRA) Pulmonary Tu... by Berhanu Dibaba Kuma, Nereyda Cantelar de Francisco, Antonio E. Pérez Rodríguez, Fidel Cathcart Roca

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Induction of endoplasmic reticulum stress is associated with the anti‐tumor activity of monepantel across cancer types by Tiffany J. Harris, Yang Liao, Wei Shi, Marco Evangelista, Bhupinder Pal, Hamsa Puthalakath, Roger Aston, Richard Mollard, John M. Mariadason, Erinna F. Lee, Walter D. Fairlie

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Physiological and Ecological Correlates of the Cellular and Humoral Innate Immune Responses in an Insular Desert Bat: The Fish-Eating Myotis (<i>Myotis vivesi</i>) by Aída Otálora-Ardila, José Juan Flores-Martínez, Carlos Rosales, Arturo Salame-Méndez, L. Gerardo Herrera Montalvo.

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Incentivized self-vaccination for global measles eradication by Benjamin L. Sievers, Robert E. Sievers, Eric L. Sievers

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Constructions of the gaucho as vagrant and idle and as a born criminal: Portraits of Juan Moreira (Argentina, 19th and 20th centuries) by Marisa A. Miranda

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Targeting male mosquito mating behaviour for malaria control by Abdoulaye Diabate, Frédéric Tripet

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Bird roadkill occurences in Aragon, Spain by Vidal–Vallés, D., Rodríguez, A., Pérez–Collazos, E.

“…In this study we used data from La Alfranca Wildlife Rehabilitation Centre database to determine location, season and incidence of avian–vehicle collisions in the autonomous county of Aragon (Spain). …”
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Sec22b-dependent antigen cross-presentation is a significant contributor of T cell priming during infection with the parasite Trypanosoma cruzi by Lucía Biscari, Ma Carmen Maza, Ma Carmen Maza, Cecilia Farré, Cecilia Farré, Cintia Daniela Kaufman, Sebastian Amigorena, Manuel Fresno, Manuel Fresno, Manuel Fresno, Núria Gironès, Núria Gironès, Núria Gironès, Andrés Alloatti

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Optimization of Dieldrin Selection for the Genetic Sexing of <i>Aedes albopictus</i> by Sarah Scussel, Benjamin Gaudillat, Jérémy Esnault, Quentin Lejarre, Marianne Duployer, Daouia Messaoudi, Patrick Mavingui, Pablo Tortosa, Julien Cattel

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Rural risk reduction in Mexico : making national plans for post-earthquake reconstruction more effective at the local level by Sato Matsumoto Miranda, Akemi

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Bio efficacy, and photocatalytic activity of the silver nanoparticles synthesized from Cryptolepis buchanani leaf extract by Sudipta Panja, Anutosh Patra, Kalyani Khanra, Indranil Choudhuri, Bikash Pati, Nandan Bhattacharyya

“…The nanoparticles are biologically active. It killed > 90 % of HeLa cells at 25 μg mL-1 concentration in-vitro cell cytotoxicity assay, with a LD50 value of 3.98 μg mL-1. …”
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Terpinen-4-ol, the Main Bioactive Component of Tea Tree Oil, as an Innovative Antimicrobial Agent against <i>Legionella pneumophila</i> by Francesca Mondello, Stefano Fontana, Maria Scaturro, Antonietta Girolamo, Marisa Colone, Annarita Stringaro, Maura Di Vito, Maria Luisa Ricci

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Dual-responsive and controlled-release paclitaxel-loaded mesoporous silicon nanoparticles with cell membrane coating for homologous targeted therapy of tongue squamous cell carcino... by Yuqi Liu, Shengzhen Li, Chuanyang Ding, Zhangjie Ge, Abida Aierken, Jiamin Li, Liying Qin, Jiayi Liu, Xiaolong Guo, Yixi Wang, Zhankui Xing, Fusong Yuan, Ping Zhou

“…Our nanocomposite material could be effectively taken up by Tca8113 cells but not by L929 and HeLa cells. Moreover, excellent tumor killing performance was measured both in vitro and in vivo. …”
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An Adenovirus Vector Containing the Suicide Gene Thymidine Kinase for a Broad Application in Cancer Gene Therapy by GS Magalhães, AR Muotri, MCN Marchetto, CFM Menck, AM Ventura

“…In the experiments presented here, we report the construction of a recombinant adenovirus carrying TK gene (Ad-TK) driven by three strong promoters (P CMV IE, SV40 and EN1) and its effectiveness in two cell types. Human HeLa and mouse CCR2 tumor cells were transduced with Ad-TK and efficiently killed after addition of GCV. …”
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Nanotherapeutic approaches to overcome distinct drug resistance barriers in models of breast cancer by Saha Tanmoy, Mondal Jayanta, Khiste Sachin, Lusic Hrvoje, Hu Zhang-Wei, Jayabalan Ruparoshni, Hodgetts Kevin J., Jang HaeLin, Sengupta Shiladitya, Lee Somin Eunice, Park Younggeun, Lee Luke P., Goldman Aaron

“…Targeted delivery of drugs to tumor cells, which circumvent resistance mechanisms and induce cell killing, is a lingering challenge that requires innovative solutions. …”
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Pioneering siRNA-Mediated Protection of Mammalian Cells against Zika Virus (MR-766) Infection by Benedita K. L. Feron, Joachim J. Bugert, Simon C. W. Richardson

“…Here, we show for the first time that siRNA can significantly reduce ZIKV-induced cell killing. Future work will require quantitating ZIKV mRNA in relation to siRNA treatment, as well as testing the siRNAs and delivery systems within more complex models.…”
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2-Phenoxy-3-Trichloromethylquinoxalines Are Antiplasmodial Derivatives with Activity against the Apicoplast of <i>Plasmodium falciparum</i> by Dyhia Amrane, Christophe-Sébastien Arnold, Sébastien Hutter, Julen Sanz-Serrano, Miguel Collia, Amaya Azqueta, Lucie Paloque, Anita Cohen, Nadia Amanzougaghene, Shahin Tajeri, Jean-François Franetich, Dominique Mazier, Françoise Benoit-Vical, Pierre Verhaeghe, Nadine Azas, Patrice Vanelle, Cyrille Botté, Nicolas Primas

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Lack of Toxic Interaction between Fusariotoxins in Broiler Chickens Fed throughout Their Life at the Highest Level Tolerated in the European Union by Jean-Paul Metayer, Angelique Travel, Amandine Mika, Jean-Denis Bailly, Didier Cleva, Cyril Boissieu, Jean Le Guennec, Pascal Froment, Olivier Albaric, Sophie Labrut, Gurvan Lepivert, Eric Marengue, Didier Tardieu, Philippe Guerre

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Laurel Wilt: Current and Potential Impacts and Possibilities for Prevention and Management by Rabiu O. Olatinwo, Stephen W. Fraedrich, Albert E. Mayfield

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