High-Resolution Genomic Profiling of Liver Cancer Links Etiology With Mutation and Epigenetic SignaturesSummary by Shira Perez, Anat Lavi-Itzkovitz, Moriah Gidoni, Tom Domovitz, Roba Dabour, Ishant Khurana, Ateret Davidovich, Ana Tobar, Alejandro Livoff, Evgeny Solomonov, Yaakov Maman, Assam El-Osta, Yishan Tsai, Ming-Lung Yu, Salomon M. Stemmer, Izhak Haviv, Gur Yaari, Meital Gal-Tanamy

“…Results: Regional variation in mutation rate analysis showed significant etiology-dependent regional mutation rates in 12 genes: LRP2, KRT84, TMEM132B, DOCK2, DMD, INADL, JAK2, DNAH6, MTMR9, ATM, SLX4, and ARSD. …”
Get full text

Towards closing the security gap of Tweak-aNd-Tweak (TNT) by Guo, Chun, Guo, Jian, List, Eik, Song, Ling

“…In this work, we show that a variant of Mennink’s distinguisher on CLRW2 with O(n23n/4) data and O(23n/2) time from TCC’18 also applies to TNT. …”
Get full text

Using the microbiome in clinical practice by Sondra Turjeman, Omry Koren

Get full text

Genetic and phenotypic similarity across major psychiatric disorders: a systematic review and quantitative assessment by Vincent-Raphael Bourque, Cécile Poulain, Catherine Proulx, Clara A. Moreau, Ridha Joober, Baudouin Forgeot d’Arc, Guillaume Huguet, Sébastien Jacquemont

“…Our findings highlight that genetic and brain factors may underlie a large proportion, but not all of the diagnostic overlaps observed in the clinic.…”
Get full text

Hyperbaric Oxygen Therapy Alleviates Memory and Motor Impairments Following Traumatic Brain Injury via the Modulation of Mitochondrial-Dysfunction-Induced Neuronal Apoptosis in Rat... by Reem Sakas, Katya Dan, Doron Edelman, Saher Abu-Ata, Aviv Ben-Menashe, Yaseen Awad-Igbaria, Jean Francois-Soustiel, Eilam Palzur

Get full text

Detection of gene mutations and gene–gene fusions in circulating cell‐free DNA of glioblastoma patients: an avenue for clinically relevant diagnostic analysis by Vikrant Palande, Tali Siegal, Rajesh Detroja, Alessandro Gorohovski, Rainer Glass, Charlotte Flueh, Andrew A. Kanner, Yoseph Laviv, Sagi Har‐Nof, Adva Levy‐Barda, Marcela Viviana Karpuj, Marina Kurtz, Shira Perez, Dorith Raviv Shay, Milana Frenkel‐Morgenstern

“…We identified unique mutations in the cfDNA and tumour DNA of each GBM patient, including some of the most frequently mutated genes in GBM according to the COSMIC database (TP53, 18.75%; EGFR, 37.5%; NF1, 12.5%; LRP1B, 25%; IRS4, 25%). Using our gene–gene fusion database, ChiTaRS 5.0, we identified gene–gene fusions in cfDNA and tumour DNA, such as KDR–PDGFRA and NCDN–PDGFRA, which correspond to previously reported alterations of PDGFRA in GBM (44% of all samples). …”
Get full text

Invasion and Metastasis as a Central Hallmark of Breast Cancer by Trishna Saha, Jonathan Solomon, Abraham O. Samson, Hava Gil-Henn

Get full text

Azathioprine and 6-mercaptopurine-induced intrahepatic cholestasis of pregnancy: Case report and review of the literature by Maya Frank Wolf, Ronen Sloma, Luiza Akria, Eli Rimon, Yifat Wiener, Michal Carmiel Haggai, Lior Lowenstein

Get full text

Immunoinformatics and Structural Analysis for Identification of Immunodominant Epitopes in SARS-CoV-2 as Potential Vaccine Targets by Sumit Mukherjee, Dmitry Tworowski, Rajesh Detroja, Sunanda Biswas Mukherjee, Milana Frenkel-Morgenstern

Get full text

Rapid SARS-CoV-2 Detection Using the Lucira™ Check It COVID-19 Test Kit by Maya Zahavi, Hanan Rohana, Maya Azrad, Bracha Shinberg, Avi Peretz

“…The need for the early identification of SARS-CoV-2 has let to a quest for reliable tests that meet the standards of polymerase chain reaction (PCR) tests, on the one hand, and are low-cost, easy-to-use, and fast, on the other hand. …”
Get full text

Characterization of <i>Clostridioides difficile</i> Strains, the Disease Severity, and the Microbial Changes They Induce by Hanan Rohana, Maya Azrad, Orna Nitzan, Amos Adler, Dana Binyamin, Omry Koren, Avi Peretz

Get full text

The Impact of a Positive Biofire^® FilmArray^® Gastrointestinal Panel Result on Clinical Management and Outcomes by David Carmon, Hanan Rohana, Maya Azrad, Avi Peretz

Get full text

Recent Developments in Carbon-11 Chemistry and Applications for First-In-Human PET Studies by Anna Pees, Melissa Chassé, Anton Lindberg, Neil Vasdev

Get full text

The effect of different C. difficile MLST strains on viability and activity of macrophages by Gewa Saad, Maya Azrad, Meral Aias, Tamar Leshem, Zohar Hamo, Layan Abu Rahmoun, Avi Peretz

Get full text

FAK-Mediated Signaling Controls Amyloid Beta Overload, Learning and Memory Deficits in a Mouse Model of Alzheimer’s Disease by Bisan Saleh, Kolluru D. Srikanth, Tal Sneh, Lambert Yue, Steven Pelech, Evan Elliott, Hava Gil-Henn

“…The non-receptor focal adhesion kinase (FAK) is highly expressed in the central nervous system during development, where it regulates neurite outgrowth and axon guidance, but its role in the adult healthy and diseased brain, specifically in Alzheimer’s disease (AD), is largely unknown. Using the 3xTg-AD mouse model, which carries three mutations associated with familial Alzheimer’s disease (APP KM670/671NL Swedish, PSEN1 M146V, MAPT P301L) and develops age-related progressive neuropathology including amyloid plaques and Tau tangles, we describe here, for the first time, the in vivo role of FAK in AD pathology. …”
Get full text

Virtual group-based mindfulness program for autistic women: A feasibility study by Brianne Redquest, Ami Tint, Laura St. John, Sue Hutton, Pamela Palmer, Yona Lunsky

Get full text

Bida Tinggi by Berita Harian, Shamshul Azree Samshir

Get full text

The Potential Use of Peptides in the Fight against Chagas Disease and Leishmaniasis by Hayelom Berhe, Mahesh Kumar Cinthakunta Sridhar, Mulate Zerihun, Nir Qvit

“…Peptide-based drugs are attractive due to their high selectiveness, effectiveness, low toxicity, and ease of production. This paper reviews the potential use of peptides in the treatment of Chagas disease and leishmaniasis. …”
Get full text

Towards a Consensus on Alzheimer’s Disease Comorbidity? by Iska Avitan, Yudit Halperin, Trishna Saha, Naamah Bloch, Dana Atrahimovich, Baruh Polis, Abraham O. Samson, Ori Braitbard

Get full text

A Review of Dendrophthoe pentandra (Mistletoe): Phytomorphology, Extraction Techniques, Phytochemicals, and Biological Activities by Mohd Azrie Awang, Mohd Azrie Awang, Nik Nurul Najihah Nik Mat Daud, Nik Nurul Najihah Nik Mat Daud, Nurul Izzati Mohd Ismail, Nurul Izzati Mohd Ismail, Farah Izana Abdullah, Farah Izana Abdullah, Mohammad Amil Zulhilmi Benjamin, Mohammad Amil Zulhilmi Benjamin

Get full text