Adhesion failures determine the pattern of choroidal neovascularization in the eye: a computer simulation study. by Abbas Shirinifard, James Alexander Glazier, Maciej Swat, J Scott Gens, Fereydoon Family, Yi Jiang, Hans E Grossniklaus

“…Next, during Early and Late CNV, the expanding vasculature usually spreads in one of three distinct patterns: in a layer between BrM and the retinal pigment epithelium (sub-RPE or Type 1 CNV), in a layer between the RPE and the photoreceptors (sub-retinal or Type 2 CNV) or in both loci simultaneously (combined pattern or Type 3 CNV). …”
Get full text

Bundling of collagen fibrils influences osteocyte network formation during bone modeling by Mana Hashimoto, Haruka Takahashi, Kaori Tabata-Okubo, Noriyuki Nagaoka, Kazuaki Tokunaga, Haruka Matsumori, Yoshihito Ishihara, Masaru Kaku, Tadahiro Iimura, Toru Hara, Hiroshi Kamioka

“…Abstract Osteocytes form a cellular network by gap junctions between their cell processes. This network is important since intercellular communication via the network is essential for bone metabolism. …”
Get full text

Connexin-43 channels are a novel pathway for discharging lactate from glycolytic pancreatic ductal adenocarcinoma cells by Dovmark, T, Saccomano, M, Hulikova, A, Alves, F, Swietach, P

“…Coupling correlated with expression of Cx43, a protein previously linked to late-stage disease. Evoked lactate dynamics, imaged in Colo357 spheroids using cytoplasmic pH as a read-out, indicated that lactate anions permeate gap junctions faster than highly-buffered H+ ions. …”

Human Astroviruses: A Tale of Two Strains by Virginia Hargest, Amy E. Davis, Shaoyuan Tan, Valerie Cortez, Stacey Schultz-Cherry

“…Since the 1970s, eight closely related serotypes of classical human astroviruses (HAstV) have been associated with gastrointestinal illness worldwide. In the late 2000s, three genetically unique human astrovirus clades, VA1-VA3, VA2-VA4, and MLB, were described. …”
Get full text

Posterior three-column osteotomies for the treatment of rigid thoracic kyphosis - a case series by Marcelo Simoni Simões, Ernani Vianna de Abreu, Bruno Costamilan Winkler

“…Eight complications were observed in six patients (40% of cases): two medical complications, five early and one late surgical complication (over 90 days after surgery). …”
Get full text

Folliculostellate cells in pituitary pars distalis of male viscacha: immunohistochemical, morphometric and ultrastructural study by M. Acosta, V. Filippa, F. Mohamed

“…The ultrastructural study demonstrat- ed that FSC developed junctional complexes and desmosomes between their lateral mem- branes. …”
Get full text

The Heparan Sulfate Proteoglycan Perlecan Regulates Axonal and Synaptic Stability by Guss, Ellen Jane

“…In Chapter 2, I describe how loss of Drosophila Perlecan causes alterations in the axonal cytoskeleton and breakage of axons, followed by synaptic retraction of neuromuscular junctions. These phenotypes are not prevented by blocking Wallerian degeneration and are independent of Perlecan’s role in Wingless signaling. …”
Get full text
Get full text

Reactive interaction between migmatite-related melt and mafic rocks: clues from the Variscan lower crust of Palmi (southwestern Calabria, Italy) by M. R. Renna

“…Amphibolites are mainly composed of plagioclase (An<span class="inline-formula">₈₀₋₉₁)</span> frequently developing triple junctions, amphibole consisting of cummingtonite rimmed by hornblende and variable amounts of biotite. …”
Get full text

Expression of Connexins 37, 43 and 45 in Developing Human Spinal Cord and Ganglia by Marija Jurić, Julia Zeitler, Katarina Vukojević, Ivana Bočina, Maximilian Grobe, Genia Kretzschmar, Mirna Saraga-Babić, Natalija Filipović

“…Direct intercellular communication via gap junctions has an important role in the development of the nervous system, ranging from cell migration and neuronal differentiation to the formation of neuronal activity patterns. …”
Get full text

Central synaptopathy is the most conserved feature of motor circuit pathology across spinal muscular atrophy mouse models by Jannik M. Buettner, Josiane K. Sime Longang, Florian Gerstner, Katharina S. Apel, Beatriz Blanco-Redondo, Leonie Sowoidnich, Eva Janzen, Tobias Langenhan, Brunhilde Wirth, Christian M. Simon

“…The severe SMNΔ7 model exhibits vast motor circuit defects, including degeneration of motor neurons, spinal excitatory synapses, and neuromuscular junctions (NMJs). In contrast, the Taiwanese model shows very mild motor neuron pathology, but early central synaptic loss. …”
Get full text

Electroacupuncture Alleviates Neuroinflammation by Inhibiting the HMGB1 Signaling Pathway in Rats with Sepsis-Associated Encephalopathy by Yueyang Xin, Jinxu Wang, Tiantian Chu, Yaqun Zhou, Cheng Liu, Aijun Xu

“…High mobility group box 1 protein (HMGB1), as a late pro-inflammatory factor, is significantly increased during sepsis in different brain regions, including the hippocampus. …”
Get full text

Repositioning of Anti-Diabetic Drugs against Dementia: Insight from Molecular Perspectives to Clinical Trials by Keren Esther Kristina Mantik, Sujin Kim, Bonsang Gu, Sohee Moon, Hyo-Bum Kwak, Dong-Ho Park, Ju-Hee Kang

“…Although it seems promising and feasible, none of the trials have succeeded in ameliorating cognitive decline in late-onset dementia. We highlight the possibility of repositioning anti-diabetic drugs as a strategy for dementia therapy by reflecting on current and previous clinical trials. …”
Get full text

Molecular genetic dissection of the sex-specific and vital functions of the Drosophila melanogaster sex determination gene fruitless. by Anand, A, Villella, A, Ryner, L, Carlo, T, Goodwin, S, Song, H, Gailey, D, Morales, A, Hall, J, Baker, B, Taylor, B

“…Furthermore, the reduction in the size of the neuromuscular junctions on abdominal muscles in these animals suggests that one of fru's sex-nonspecific functions involves general aspects of neuronal differentiation. …”

Engineered action at a distance: Blood-meal-inducible paralysis in Aedes aegypti by Haghighat-Khah, RE, Harvey-Samuel, T, Basu, S, StJohn, O, Scaife, S, Verkuijl, S, Lovett, E, Alphey, L

“…METHODOLOGY/PRINCIPAL FINDINGS:We sought to engineer female-specific, late-acting lethality through employing the Ae. aegypti VitellogeninA1 promoter to drive blood-meal-inducible, fat-body specific expression of tTAV. …”

Morphodynamics, boundary conditions and pattern evolution within a vegetated linear dunefield by Telfer, M, Hesse, P, Perez-Fernandez, M, Bailey, R, Bajkan, S, Lancaster, N

“…It was hypothesized that morphodynamic influences, via pattern-coarsening, would mean that dunes from the simpler pattern, defined in terms of the frequency of defects (i.e. junctions and terminations), would be more mature, older landforms. …”

The Protein Kinase A Inhibitor KT5720 Prevents Endothelial Dysfunctions Induced by High-Dose Irradiation by François-Xavier Boittin, Nathalie Guitard, Maeliss Toth, Diane Riccobono, Hélène Théry, Régis Bobe

“…High-dose X-irradiation (15 Gy) triggered the late apoptosis of HPMECs independent of the ceramide/P38 MAP kinase pathway or p53. …”
Get full text

Structural, Functional, and Metabolic Alterations in Human Cerebrovascular Endothelial Cells during <i>Toxoplasma gondii</i> Infection and Amelioration by Verapamil In Vitro by Alaa T. Al-sandaqchi, Victoria Marsh, Huw E. L. Williams, Carl W. Stevenson, Hany M. Elsheikha

“…<i>T. gondii</i> proliferated within the BMECs and disrupted the integrity of the cerebrovascular barrier through diminishing the cellular viability, disruption of the intercellular junctions and increasing permeability of the BMEC monolayer, as well as altering lipid homeostasis. …”
Get full text

PETN-Induced Antioxidative Properties in Endothelial Cells as a Target for Secondary Prevention of Endothelial Dysfunction in Pregnancy by Veronika Teichert, Veronika Teichert, Silke Große, Anna Multhaup, Jasmin Müller, Ruby N. Gutierrez-Samudio, Diana M. Morales-Prieto, Tanja Groten

“…PETN treatment showed to delay PE to late pregnancy and achieved a profound risk reduction for FGR and/or perinatal death of 40%. …”
Get full text

Fatty acid metabolism driven mitochondrial bioenergetics promotes advanced developmental phenotypes in human induced pluripotent stem cell derived cardiomyocytes by Ramachandra, Chrishan J. A., Mehta, Ashish, Wong, Philip, Ja, K. P. Myu Mai, Fritsche-Danielson, Regina, Bhat, Ratan V., Hausenloy, Derek J., Kovalik, Jean-Paul, Shim, Winston

“…Metabolomic analysis upon fatty acid supplementation revealed a β-oxidation fueled ATP elevation that coincided with presence of junctional complexes, intercalated discs, t-tubule-like structures and adult isoform of cardiac troponin T. …”
Get full text

Enhanced probiotic potential of Lactobacillus kefiranofaciens OSU-BDGOA1 through co-culture with Kluyveromyces marxianus bdgo-ym6 by Brianda D. González-Orozco, Erica Kosmerl, Rafael Jiménez-Flores, Valente B. Alvarez

“…The observed increase in survival during digestion could be associated with the increased production of EPS during the late exponential and early stationary phases of co-culture that, by enhancing co-aggregation between the yeast and the bacterium, protects the microorganisms from severe gastrointestinal conditions as observed by SEM images. …”
Get full text