Bioavailability and efficacy of a gap junction enhancer (PQ7) in a mouse mammary tumor model. by Stephanie N Shishido, Keshar Prasain, Amanda Beck, Thi D T Nguyen, Duy H Hua, Thu Annelise Nguyen

“…PQ7 treatment increased Cx43 expression in the neoplastic tissue during Pre-tumor formation; however, this effect was not observed in Late stage tumor formation. This study shows that the gap junction enhancer, PQ7, has low toxicity to normal tissue in healthy C57BL/6J mice, while having clinical efficacy in the treatment of spontaneous mammary tumors of PyVT mice. …”
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Adherent-invasive <it>Escherichia coli</it>, strain LF82 disrupts apical junctional complexes in polarized epithelia by Ossa Juan C, Wine Eytan, Gray-Owen Scott D, Sherman Philip M

“…Increased permeability was accompanied by a redistribution of the tight junction adaptor protein, zonula occludens-1, demonstrated by confocal microscopy and formation of gaps between cells, as shown by transmission electron microscopy. …”
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The sapheno-femoral junction valvuloplasty in the post-thrombotic syndrome: a proposal with the use of a new device by Sante Camilli, Daniele Camilli

“…In these cases the ablative strategy is generally implemented with positive results in the short-term, but commonly with late varicose recurrences. In two cases the authors preferred a different approach to preserve and recover the GSV vicarious function by sapheno-femoral junction (SFJ) valvuloplasty. …”
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Increased acetylation of microtubules rescues human tau-induced microtubule defects and neuromuscular junction abnormalities in Drosophila by Chuan-Xi Mao, Xue Wen, Shan Jin, Yong Q. Zhang

“…In order to examine directly the role of increased tubulin acetylation against tau toxicity, we generated a site-directed α-tubulinK40Q mutation by CRISPR/Cas9 technology to mimic the acetylated MTs and found that acetylation-mimicking α-tubulin rescued tau-induced MT defects and neuromuscular junction developmental abnormalities. We also showed that late administration of ACY-1215 and tubastatin A, two potent and selective inhibitors of HDAC6, rescued the tau-induced MT defects after the abnormalities had already become apparent. …”
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Transforaminal Endoscopic Lumbar Discectomy for Lumbosacral Junction Adolescent Lumbar Disc Herniation with High Iliac Crests by Lu Mao, Kun Wang, Yong Huang, Feng Wang, Rui Zhang, Bin Zhu, Xiaotao Wu

“…Abstract Objective To investigate the clinical results of transforaminal endoscopic lumbar discectomy for lumbosacral junction adolescent lumbar disc herniation with high iliac crest. …”
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Is Laparoscopic Pyeloplasty for Ureteropelvic Junction Obstruction in Infants Under 1 Year of Age a Good Option? by Corina Zamfir Snykers, Elea De Plaen, Sophie Vermersch, Manuel Lopez, Karim Khelif, Stephane Luyckx, Paul Philippe, Francois Varlet, Henri Steyaert

“…We reviewed the records of the children under 1 year of age operated on for ureteropelvic junction obstruction (UPJO), between 2007 and 2017. …”
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A diagnosis of late-onset Myasthenia gravis unmasked by topical antibiotics by Nooreen Hussain, Faiz Hussain, Danish Haque, Subramanyam Chittivelu

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Staging of Geological Development of an Area of the Southern Cis-Timan in the Late Proterozoic by Yu. G. Paktovskiy

“…The importance of the problem of “triple junctions” or points of triple stretching at the beginning of rifting is shown. …”
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Subcortical Contribution to Late TMS-induced I-waves in Intact Humans by John eCirillo, Monica A. Perez, Monica A. Perez

“…It has been proposed that early and late MEP peaks involve different mechanisms of action, however, little is known about the characteristics of the later peaks. …”
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Prolonged repeated inseminations trigger a local immune response and accelerate aging of the uterovaginal junction in turkey hens by Sunantha Kosonsiriluk, Kent M. Reed, Sally L. Noll, Ben W. Wileman, Marissa M. Studniski, Kahina S. Boukherroub

“…The local immune response that was suppressed during peak lay was increased at the late laying stage. In the semen-inseminated group, the UVJ exhibited advanced aging at the late laying stage, evidenced by reduced telomere maintenance and translation processes. …”
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Elective nodal radiotherapy with a gapless radiation field junction for oligorecurrent prostate cancer after previous radiotherapy by Minglun Li, Yourong Fan, Christian Trapp, Nina Sophie Schmidt-Hegemann, Jing Ma, Alexander Buchner, Shun Lu, Bin Xu, Christian Stief, Xuanbin Wang, Cheng Zhou, Claus Belka, Paul Rogowski

“…Conclusion: ENRT for nodal recurrences after a previous radiotherapy with gapless junction of radiation fields seems to be feasible, applying the dose constraints Dmax-cum ≤ 95 Gy and D1cc-cum < 90 Gy without grade 3 acute or late toxicities exceeding baseline.…”
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Neuromuscular and Neuromuscular Junction Manifestations of the PURA-NDD: A Systematic Review of the Reported Symptoms and Potential Treatment Options by Magdalena Mroczek, Stanley Iyadurai

“…Recently, fluctuating weakness noted in a PURA-NDD patient, accompanied by repetitive nerve stimulation abnormalities, suggested the disease to be a channelopathy and, more specifically, a neuromuscular junction disorder. Treatment with pyridostigmine or salbutamol led to clinical improvement of neuromuscular function in two reported cases. …”
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Outcome analysis of reduction and nonreduction dismembered pyeloplasty in ureteropelvic junction obstruction: A randomized, prospective, comparative study by Enono Yhoshu, Prema Menon, Katragadda Lakshmi, Narasimha Rao, Anish Bhattacharya

“…Materials and Methods: Randomized prospective study of children with ureteropelvic junction obstruction undergoing pyeloplasty with (Group 1) and without (Group 2) pelvis reduction over an 18-month period. …”
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HER2 and PD-L1 Expression in Gastric and Gastroesophageal Junction Cancer: Insights for Combinatorial Targeting Approaches by Marta Baptista Freitas, Irene Gullo, Dina Leitão, Lúcia Águas, Carla Oliveira, António Polónia, Joana Gomes, Fátima Carneiro, Celso Albuquerque Reis, Henrique Oliveira Duarte

“…Gastric and gastroesophageal junction adenocarcinomas (GA/GEJA) are associated with a poor prognosis, primarily due to late disease diagnosis. …”
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Multicenter analysis on the value of standard (chemo)radiotherapy in elderly patients with locally advanced adenocarcinoma of the esophagus or gastroesophageal junction by Tilman Bostel, Eirini Nikolaidou, Daniel Wollschläger, Arnulf Mayer, Justus Kaufmann, Anne Hopprich, Alexander Rühle, Anca-Ligia Grosu, Jürgen Debus, Christian Fottner, Markus Moehler, Peter Grimminger, Heinz Schmidberger, Nils Henrik Nicolay

“…Abstract Background To assess the tolerability and oncological results of chemoradiation in elderly patients with locally advanced adenocarcinoma of the esophagus or gastroesophageal junction. Methods This multi-center retrospective analysis included 86 elderly patients (≥ 65 years) with esophageal or gastroesophageal junction adenocarcinoma (median age 73 years; range 65–92 years) treated with definitive or neoadjuvant (chemo)radiotherapy. …”
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Degradation behavior of ZE21C magnesium alloy suture anchors and their effect on ligament-bone junction repair by Delin Ma, Jun Wang, Mingran Zheng, Yuan Zhang, Junfei Huang, Wenxiang Li, Yiwen Ding, Yunhao Zhang, Shijie Zhu, Liguo Wang, Xiaochao Wu, Shaokang Guan

“…The tail of the ZE21C suture anchor in high stress concentration degraded rapidly during the early implantation stage (0–4weeks), while bone healing accelerated the degradation of the anchor head in the late implantation stage (4–12weeks). Radiological, histological, and biomechanical assays indicated that the ZE21C suture anchor promoted bone healing above the suture anchor and fibrocartilaginous interface regeneration in the ligament-bone junction, leading to better biomechanical strength than the TC4 group. …”
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Late Cenozoic faulting and the stress state in the south-eastern segment of the Siberian platform by V. A. Sankov, A. V. Parfeevets, A. I. Miroshnichenko, L. M. Byzov, M. A. Lebedeva, A. V. Sankov, А. А. Dobrynina, S. N. Kovalenko

“…We have studied the structural geology and geomorphology of the fault zones in the junction area of the Angara-Lena uplift and the Predbaikalsky trough. …”
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Tomographic late evaluation of xenogeneic bone grafts in sockets of impacted third molars by Osny FERREIRA JÚNIOR, Etiene Andrade MUNHOZ, Jéssica de Fátima SEGANTIN, Eduardo Sanches GONÇALES, Paulo Sérgio Perri de CARVALHO

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A review of the Late Mesozoic magmatic arc in Borneo with slab subduction models by Changhai XU, Weilin ZHU, Zongting LIAO

“…Borneo is at the critical junction of two tectonic domains. The Schwaner magma arc and the Meratus and Lupar subduction complexes are the prominent features of Borneo in the Late Mesozoic, which result from the subduction of Tethys or/and paleo-Pacific domains. …”
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Altered Expression of Zonula occludens-1 Affects Cardiac Na⁺ Channels and Increases Susceptibility to Ventricular Arrhythmias by Mona El Refaey, Sara Coles, Hassan Musa, Tyler L. Stevens, Michael J. Wallace, Nathaniel P. Murphy, Steve Antwi-Boasiako, Lindsay J. Young, Heather R. Manring, Jerry Curran, Michael A. Makara, Kelli Sas, Mei Han, Sara N. Koenig, Michel Skaf, Crystal F. Kline, Paul M. L. Janssen, Federica Accornero, Maegen A. Borzok, Peter J. Mohler

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