Requirement for endocytic antigen processing and influence of invariant chain and H-2M deficiencies in CNS autoimmunity. by Slavin, A, Soos, J, Stuve, O, Patarroyo, J, Weiner, H, Fontana, A, Bikoff, E, Zamvil, S

“…Ii- and H-2M-deficient mice were not susceptible to EAE by immunization with p35-55 or MOG or by adoptive transfer of encephalitogenic T cells. …”

Highly avid, oligoclonal, early-differentiated antigen-specific CD8 + T cells in chronic HIV-2 infection by Leligdowicz, A, Onyango, C, Yindom, L, Peng, Y, Cotten, M, Jaye, A, McMichael, A, Whittle, H, Dong, T, Rowland-Jones, S

“…A detailed study of HIV-2 infection may identify protective immune responses. Robust gag p26-specific T-cell responses are elicited during HIV-2 infection and correlate with control of viremia. …”

Insights into function of the immunological synapse from studies with supported planar bilayers by Dustin, M

“…Innate and adaptive immunity is dependent upon reliable cell-cell communication mediated by direct interactions of cell surface receptors with ligands integrated into the surface of apposing cells or bound directly to the surface as in complement deposition or antibody mediated recognition through Fc receptors. …”

IRAK4 deficiency presenting with anti-NMDAR encephalitis and HHV6 reactivation by Nishimura, S, Kobayashi, Y, Ohnishi, H, Moriya, K, Tsumura, M, Sakata, S, Mizoguchi, Y, Takada, H, Kato, Z, Sancho-Shimizu, V, Picard, C, Irani, S, Ohara, O, Casanova, J-L, Puel, A, Ishikawa, N, Okada, S, Kobayashi, M

“…IRAK4 deficiency is an inborn error of immunity predisposing patients to invasive pyogenic infections. …”

Induction of protective cytotoxic T cells with viral proteins. by Bachmann, M, Kündig, T, Freer, G, Li, Y, Kang, C, Bishop, D, Hengartner, H, Zinkernagel, R

“…Our data show that immunization of mice with as little as 10 micrograms of non-infectious viral proteins triggered long-lasting CD8+ T cell-mediated antiviral immunity. …”

Inferring the evolution of the major histocompatibility complex of wild pigs and peccaries using hybridisation DNA capture-based sequencing by Lee, C, Moroldo, M, Perdomo-Sabogal, A, Mach, N, Marthey, S, Lecardonnel, J, Wahlberg, P, Chong, AY, Estellé, J, Ho, SYW, Rogel-Gaillard, C, Gongora, J

“…These findings contribute to better understanding of the evolutionary history of the MHC, specifically, the class I genes, and provide useful data for investigating the immune response of wild populations against pathogens.…”

Comparison of different methods for isolating CD8+ T lymphocyte-derived extracellular vesicles and supramolecular attack particles by Jainarayanan, AK, Capera, J, Céspedes, PF, Conceição, M, Elanchezhian, M, Thomas, T, Bonner, S, Valvo, S, Kurz, E, Mahla, RS, Berridge, G, Hester, S, Fischer, R, Dustin, LB, Wood, MJA, Dustin, ML

“…CD8+ T lymphocytes play vital roles in killing infected or deranged host cells, recruiting innate immune cells, and regulating other aspects of immune responses. …”

Biomarkers of mortality in adults and adolescents with advanced HIV in sub-Saharan Africa by Riitho, V, Connon, R, Gwela, A, Namusanje, J, Nhema, R, Siika, A, Bwakura-Dangarembizi, M, Musiime, V, Berkley, JA, Szubert, AJ, Gibb, DM, Walker, AS, Klein, N, Prendergast, AJ

“…Our findings highlight how the immune milieu shapes outcomes following ART initiation, and how adjunctive antimicrobials can modulate the gut environment in advanced HIV.…”

Design of modulatory peptides against chemokines by Darlot, B

“…Although, chemokines are critical to orchestrate effective immune response, many have been associated to several inflammatory disorders. …”

Identifying CNS-colonizing T cells as potential therapeutic targets to prevent progression of multiple sclerosis by Kaufmann, M, Evans, H, Schaupp, A-L, Engler, JB, Kaur, G, Willing, A, Kursawe, N, Schubert, C, Attfield, KE, Fugger, L, Friese, MA

“…Here, we investigate whether the therapeutic resistance of progressive MS can be attributed to chronic immune cell accumulation behind the blood-brain barrier (BBB). …”

Remission of collagen-induced arthritis is associated with high levels of transforming growth factor-beta expression in the joint. by Marinova-Mutafchieva, L, Gabay, C, Funa, K, Williams, R

“…Immunization of genetically susceptible strains of mice with heterologous type II collagen leads to the induction of a self-limiting polyarthritis that begins to subside around 10 days after onset of clinical disease. …”

Resolving postoperative neuroinflammation and cognitive decline. by Terrando, N, Eriksson, L, Ryu, J, Yang, T, Monaco, C, Feldmann, M, Jonsson Fagerlund, M, Charo, I, Akassoglou, K, Maze, M

“…Surgery engages the innate immune system that launches a systemic inflammatory response that, if unchecked, can cause multiple organ dysfunction. …”

Interleukin-1 beta modulates the acute release of growth hormone-releasing hormone and somatostatin from rat hypothalamus in vitro, whereas tumor necrosis factor and interleukin-6... by Honegger, J, Spagnoli, A, D'Urso, R, Navarra, P, Tsagarakis, S, Besser, G, Grossman, AB

“…There is clear evidence for communication between the immune and neuroendocrine systems. However, the effect of cytokines as major immune mediators on the hypothalamic growth peptides, GHRH and somatostatin (SRIH), is not well established. …”

Low Zika virus seroprevalence in Vientiane, Laos, 2003-2015 by Pastorino, B, Sengvilaipaseuth, O, Chanthongthip, A, Vongsouvath, M, Souksakhone, C, Mayxay, M, Thirion, L, Newton, P, De Lamballerie, X, Dubot-Pérès, A

“…Here, with the aim of providing information on ZIKV circulation and population immunity, we conducted a seroprevalence study among blood donors in Vientiane, Laos. …”

A systematic review and meta-analysis of animal studies investigating the relationship between serum antibody, T lymphocytes, and respiratory syncytial virus disease by McGinley, J, Thwaites, R, Brebner, W, Greenan-Barrett, L, Aerssens, J, Öner, D, Bont, L, Wildenbeest, J, Martinón-Torres, F, Nair, H, Pollard, AJ, Openshaw, P, Drysdale, S

“…<p><strong>Background</strong></p> Respiratory syncytial virus (RSV) infections occur in human populations around the globe, causing disease of variable severity, disproportionately affecting infants and older adults (>65 years of age). Immune responses can be protective but also contribute to disease. …”

Characterization of two vaccinia CD36 recombinant-virus-generated monoclonal antibodies (10/5, 13/10): effects on malarial cytoadherence and platelet functions. by Daviet, L, Craig, A, McGregor, L, Pinches, R, Wild, T, Berendt, A, Newbold, C, McGregor, J

“…In an attempt to identify new functional sites of this surface glycoprotein, anti-CD36 monoclonal antibodies were prepared using a vaccinia CD36 recombinant virus as a highly efficient immunization vector. In functional studies, one of these antibodies (clone 10/5) strongly inhibited the adhesion of P. falciparum-infected erythrocytes to purified CD36. …”

CD8+ T cell responses to human immunodeficiency viruses type 2 (HIV-2) and type 1 (HIV-1) gag proteins are distinguishable by magnitude and breadth but not cellular phenotype by Gillespie, G, Pinheiro, S, Sayeid-Al-Jamee, M, Alabi, A, Kaye, S, Sarge-Njie, R, Njai, H, Joof, K, Jaye, A, Whittle, H, Rowland-Jones, S, Dorrell, L

“…The mechanisms underlying the relatively slow progression of human immunodeficiency virus type 2 (HIV-2) compared with HIV-1 infection are undefined and could be a result of more effective immune responses. We used HIV-2 and HIV-1 IFN-γ enzyme-linked immunospot assays to evaluate CD8+ T cell responses in antiretroviral-naive HIV-2-('HIV-2+') and HIV-1-infected ('HIV-1+') individuals. …”

Mesenchymal stem cells used as carrier cells of oncolytic adenovirus results in enhanced oncolytic virotherapy by Mahasa, K, De Pillis, L, Ouifki, R, Eladdadi, A, Maini, P, Yoon, A, Yun, C

“…We used the model to describe both the growth dynamics in our experiments of firefly luciferase-expressing Hep3B tumor xenografts and the effects of the immune response during the MSCs-based virotherapy. …”

Recombinant polymorphic membrane protein D in combination with a novel, second-generation lipid adjuvant protects against intra-vaginal Chlamydia trachomatis infection in mice. by Paes, W, Brown, N, Brzozowski, A, Coler, R, Reed, S, Carter, D, Bland, M, Kaye, P, Lacey, C

“…The development of a chlamydial vaccine that elicits protective mucosal immunity is of paramount importance in combatting the global spread of sexually transmitted Chlamydia trachomatis (Ct) infections. …”

Insights into function of the immunological synapse from studies with supported planar bilayers. by Dustin, M

“…Innate and adaptive immunity is dependent upon reliable cell-cell communication mediated by direct interactions of cell surface receptors with ligands integrated into the surface of apposing cells or bound directly to the surface as in complement deposition or antibody mediated recognition through Fc receptors. …”