Showing 181 - 200 results of 3,649 for search 'Locus', query time: 0.06s Refine Results
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    Genetic variation at the mitochondrial DNA 9-bp repeat locus in the Sakha of Siberia. by Tarskaia, L, Gray, R, Burkley, B, Mulligan, C

    Published 2006
    “…Genetic variation at the mitochondrial DNA 9-bp repeat locus was assayed in 779 Sakha from Siberia. Fourteen deletion (1.8%), nine triplication (1.2%), and two 4-repeat alleles (0.26%) were identified. …”
    Journal article
  4. 184

    Inference from samples of DNA sequences using a two-locus model. by Jenkins, P, Griffiths, R

    Published 2011
    “…The two loci are themselves largely non-recombining, so we obtain a gene tree at each locus and are able to infer in detail the effect of the hotspot on their joint ancestry. …”
    Journal article
  5. 185

    An explanation for the phenotypic differences between patients bearing partial deletions of the DMD locus. by Monaco, A, Bertelson, C, Liechti-Gallati, S, Moser, H, Kunkel, L

    Published 1988
    “…We present a molecular mechanism to explain the clinical difference in severity between DMD and BMD patients who bear partial deletions of the same gene locus. The model is based on the breakpoints of intragenic deletions and their effect on the translation of triplet codons into amino acids of the protein product. …”
    Journal article
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    Fine mapping of the human SCIDX1 locus at Xq12-13.1. by Markiewicz, S, DiSanto, J, Chelly, J, Fairweather, N, Le Marec, B, Griscelli, C, Graeber, M, Müller, U, Fischer, A, Monaco, A

    Published 1993
    “…Previous linkage analysis of families with X-linked severe combined immunodeficiency (SCIDX1) mapped this locus to a large region encompassing about 10 to 20 cM at Xq12-21. …”
    Journal article
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    The thyroglobulin gene: the third locus for autoimmune thyroid disease or a false dawn? by Gough, S

    Published 2004
    “…Despite numerous studies, the identification of a third locus has remained elusive. Genetic-linkage studies have implicated chromosome 8q24 as a susceptibility locus for AITD. …”
    Journal article
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    The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans. by Tobin, D, Vary, J, Ray, J, Walsh, G, Dunstan, S, Bang, N, Hagge, D, Khadge, S, King, M, Hawn, T, Moens, C, Ramakrishnan, L

    Published 2010
    “…A hypersusceptible mutant maps to the lta4h locus encoding leukotriene A(4) hydrolase, which catalyzes the final step in the synthesis of leukotriene B(4) (LTB(4)), a potent chemoattractant and proinflammatory eicosanoid. lta4h mutations confer hypersusceptibility independent of LTB(4) reduction, by redirecting eicosanoid substrates to anti-inflammatory lipoxins. …”
    Journal article
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    High-resolution analysis of cis-acting regulatory networks at the α-globin locus. by Hughes, J, Lower, K, Dunham, I, Taylor, S, De Gobbi, M, Sloane-Stanley, J, McGowan, S, Ragoussis, J, Vernimmen, D, Gibbons, R, Higgs, D

    Published 2013
    “…We have combined the circular chromosome conformation capture protocol with high-throughput, genome-wide sequence analysis to characterize the cis-acting regulatory network at a single locus. In contrast to methods which identify large interacting regions (10-1000 kb), the 4C approach provides a comprehensive, high-resolution analysis of a specific locus with the aim of defining, in detail, the cis-regulatory elements controlling a single gene or gene cluster. …”
    Journal article
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    Multi Locus View: an extensible web-based tool for the analysis of genomic data by Sergeant, MJ, Hughes, JR, Hentges, L, Lunter, G, Downes, DJ, Taylor, S

    Published 2021
    “…Conventional genome browsers are limited to browsing single locations and do not allow for interactions with the dataset as a whole. Multi Locus View (MLV), a web-based tool, has been developed to allow users to fluidly interact with genomics datasets at multiple scales. …”
    Journal article