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Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features
Published 2021“…Here, we use seven experimental assays to characterize all common variants at the multiple disease-associated TNFAIP3 locus in five disease-relevant immune cell lines, based on a set of features related to regulatory potential. …”
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305
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Identification and Functional Validation of the Novel Antimalarial Resistance Locus PF10_0355 in Plasmodium falciparum
Published 2012“…In addition, we performed a genome-wide association study (GWAS), searching for loci correlated with resistance to thirteen antimalarials; we detected both known and novel resistance loci, including a new halofantrine resistance locus, PF10_0355. Through functional testing we demonstrated that PF10_0355 overexpression decreases sensitivity to halofantrine, mefloquine, and lumefantrine, but not to structurally unrelated antimalarials, and that increased gene copy number mediates resistance. …”
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307
Large 3‐Mb deletions at 22q11.2 locus in Parkinson's disease and schizophrenia
Published 2020Get full text
Journal Article -
308
Charactering the ZFAND3 gene mapped in the sex-determining locus in hybrid tilapia (Oreochromis spp.)
Published 2018“…The OsZFAND3 gene was mapped in the sex-determining locus on linkage group 1 (LG1). The three SNPs in the OsZFAND3 gene were strictly associated with sex phenotype, suggesting that the OsZFAND3 gene is tightly linked to the sex-determining locus. …”
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309
PERANAN MODERATOR LOCUS OF CONTROL DALAM PENGARUH JOB INSECURITY TERHADAP TURNOVER INTENTION SALESMAN
Published 2012“…The research results found the effect of job insecurity towards turnover intention moderated by locus of control salesman is significant through the different influence of job insecurity on turnover intention between internal locus of control and external locus of control. …”
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Studi Interkorelasi antara "Locus Of Control" Internal Motif Berprestasi dan Kepribadian Tipe A
Published 1990“…Dari berbagai teori dapat disimpulkan bahwa ada banyak kesamaan ciri dan karakter antara individu yang mempunyai locus of control internal, kepribadian tipe A dan individu yang memiliki motif berprestasi tinggi. …”
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Molecular mechanisms underlying haplotypespecific regulation of gene expression at the microtubule associated protein tau locus
Published 2016“…Comparative sequence analysis of whole-locus genomic H1 and H2 MAPT (143 kb) vectors showed they capture over 86% of the <em>MAPT</em> sequence diversity. …”
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19p13.1 is a triple-negative-specific breast cancer susceptibility locus.
Published 2012“…The 19p13.1 breast cancer susceptibility locus is a modifier of breast cancer risk in BRCA1 mutation carriers and is also associated with the risk of ovarian cancer. …”
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314
Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes
Published 2011“…This trans-eQTL network provides a mechanistic understanding of the effect of the KLF14 locus on metabolic disease risk and offers a potential model for other complex traits.…”
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315
Gene expression in the Gitr locus is regulated by NF-κB and Foxp3 through an enhancer.
Published 2014Journal article -
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Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models.
Published 2007Journal article -
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A small deletion in the Duchenne/Becker muscular dystrophy locus--a functionally important region?
Published 1987“…The occurrence of this deletion in DXS164 would appear to confirm that this region is part of the BMD locus. Many DMD patients have deletions in and around this region, adding further evidence for the allelic nature of the two disorders. …”
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Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes
Published 2011“…This trans-eQTL network provides a mechanistic understanding of the effect of the KLF14 locus on metabolic disease risk and offers a potential model for other complex traits. © 2011 Nature America, Inc. …”
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320
External locus of control but not self-esteem predicts increasing social anxiety among bullied children
Published 2022“…Lower self-esteem and more external locus of control are associated with bullying and social anxiety but the impact of these factors over time among bullied children is less clear.…”
Journal article