A bidirectional YAC walk from the Norrie disease (NDP) locus. by Black, G, Coleman, M, Chen, Z, Nemeth, A, Davies, K, Craig, I

A chloroquine resistance locus in the rodent malaria parasite Plasmodium chabaudi. by Carlton, J, Mackinnon, M, Walliker, D

“…We have located a possible chloroquine resistance locus in the genome of the rodent malaria parasite Plasmodium chabaudi. …”

Global Genetic Architecture of an Erythroid Quantitative Trait Locus, HMIP-2 by Menzel, S, Rooks, H, Zelenika, D, Mtatiro, SN, Gnanakulasekaran, A, Drasar, E, Cox, S, Liu, L, Masood, M, Silver, N, Garner, C, Vasavda, N, Howard, J, Makani, J, Adekile, A, Pace, B, Spector, T, Farrall, M, Lathrop, M, Thein, S

“…HMIP-2 is a human quantitative trait locus affecting peripheral numbers, size and hemoglobin composition of red blood cells, with a marked effect on the persistence of the fetal form of hemoglobin, HbF, in adults. …”

Locus-specific expression of transposable elements in single cells with CELLO-seq by Berrens, RV, Yang, A, Laumer, CE, Lun, ATL, Bieberich, F, Law, C-T, Lan, G, Imaz, M, Bowness, JS, Brockdorff, N, Gaffney, DJ, Marioni, JC

“…Across both species, old and young TEs showed evidence of locus-specific expression with simulations demonstrating that only a small number of very young elements in the mouse could not be mapped back to the reference with high confidence. …”

Definition of transcriptional promoters in the human beta globin locus control region. by Routledge, S, Proudfoot, N

“…Our previous studies on the human beta globin gene cluster revealed the presence of intergenic transcripts throughout the locus, and demonstrated that transcription of the locus control region (LCR) initiates within an ERV9 endogenous retroviral long-terminal repeat (LTR) upstream of DNase I hypersensitive site 5. …”

DYNAMIC PERFORMANCE, INTERACTION, AND THE CHARACTERISTIC LOCUS METHOD - A QUANTITATIVE APPROACH by Kouvaritakis, B, Trimboli, M

“…The characteristic locus method, in addition to its role in the assessment of system stability, is also an effective approach for evaluating tracking accuracy, interaction and dynamic/static loop performance. …”

Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus. by Hamilton, G, Killick, R, Lambert, J, Amouyel, P, Carrasquillo, M, Pankratz, V, Graff-Radford, N, Dickson, D, Petersen, R, Younkin, S, Powell, J, Wade-Martins, R

“…Here, we have developed a novel functional genomics methodology to express common locus haplotypes to assess functional differences. …”

Common variation at the adiponectin locus is not associated with colorectal cancer risk in the UK. by Carvajal-Carmona, L, Spain, S, Kerr, D, Houlston, R, Cazier, J, Tomlinson, I

“…A recent study examined common genetic variants at the adiponectin locus (ADIPOQ) in two case-control colorectal cancer (CRC) series from the USA and reported a positive association between a single nucleotide polymorphism (SNP) in the 5' region of the gene (rs266729) and decreased disease risk. …”

The evolution of a genetic locus encoding small serine proteinase inhibitors. by Clauss, A, Lilja, H, Lundwall, A

“…We previously identified a locus on human chromosome 20 that encompasses 14 genes of postulated WFDC-type proteinase inhibitors with a potential role in innate immunity. …”

Illness beliefs and locus of control: a comparison of patients with pseudoseizures and epilepsy. by Stone, J, Binzer, M, Sharpe, M

“… PURPOSE: The aim of this study was to examine the illness beliefs and locus of control of patients with recent onset pseudoseizures and to compare these with patients with recent onset epilepsy. …”

Association of the TSHR gene with Graves' disease: The first disease specific locus by Dechairo, B, Zabaneh, D, Collins, J, Brand, O, Dawson, G, Green, A, Mackay, I, Franklyn, J, Connell, J, Wass, J, Wiersinga, WM, Hegedus, L, Brix, T, Robinson, BG, Hunt, P, Weetman, A, Carey, A, Gough, S

“…These results in two independent Caucasian data sets suggest that the TSHR is the first replicated GD-specific locus meriting further fine mapping and functional analysis to identify the aetiological variants. © 2005 Nature Publishing Group. …”

Locus-wide studies into the transcriptional regulation of Runx1 in developmental hematopoiesis by Jarratt, A

Remapping the insulin gene/IDDM2 locus in type 1 diabetes. by Barratt, B, Payne, F, Lowe, C, Hermann, R, Healy, B, Harold, D, Concannon, P, Gharani, N, McCarthy, M, Olavesen, MG, McCormack, R, Guja, C, Ionescu-Tîrgovişte, C, Undlien, D, Rønningen, K, Gillespie, K, Tuomilehto-Wolf, E, Tuomilehto, J, Bennett, S, Clayton, D, Cordell, H, Todd, J

“…Type 1 diabetes susceptibility at the IDDM2 locus was previously mapped to a variable number tandem repeat (VNTR) 5' of the insulin gene (INS). …”

Molecular and functional sex differences of noradrenergic neurons in the mouse locus coeruleus by Mulvey, B, Bhatti, DL, Gyawali, S, Lake, AM, Kriaucionis, S, Ford, CP, Bruchas, MR, Heintz, N, Dougherty, JD

“…Broadly, we present a means of transcriptionally profiling locus coeruleus under baseline and experimental conditions. …”

Functional dissection of a single enhancer at the mouse α-globin locus by Francis, H

“…In my DPhil, I aim to probe a single enhancer sequence in situ, using the strongest enhancer at the mouse α-globin locus as a model. The project addresses four main issues. …”

Evidence that a locus for familial psoriasis maps to chromosome 4q. by Matthews, D, Fry, L, Powles, A, Weber, J, McCarthy, M, Fisher, E, Davies, K, Williamson, R

“…Parametric linkage analysis indicated that a susceptibility locus for familial psoriasis was located on chromosome 4q. …”

Functional evaluation of the human fat distribution HOXC13 gene locus by Kuo, F

“…Detailed annotation of HOTAIR-haplotype tagging single nucleotide polymorphisms (SNPs) identified the minor allele of rs76084431 as a GSAT HOTAIR expression quantitative trait locus (eQTL) associated with increased android to gynoid fat mass ratio in females. …”

A major quantitative trait locus influences hyperactivity in the WKHA rat. by Moisan, M, Courvoisier, H, Bihoreau, M, Gauguier, D, Hendley, E, Lathrop, M, James, MR, Mormède, P

R-loop stabilization represses antisense transcription at the Arabidopsis FLC locus. by Sun, Q, Csorba, T, Skourti-Stathaki, K, Proudfoot, N, Dean, C

“…We have identified a homeodomain protein, AtNDX, that regulates COOLAIR, a set of antisense transcripts originating from the 3' end of Arabidopsis FLOWERING LOCUS C (FLC). AtNDX associates with single-stranded DNA rather than double-stranded DNA non-sequence-specifically in vitro, and localizes to a heterochromatic region in the COOLAIR promoter in vivo. …”

EXTENSIONS OF THE FRAME ALIGNMENT TECHNIQUE AND THEIR USE IN THE CHARACTERISTIC LOCUS DESIGN METHOD by Edmunds, J, Kouvaritakis, B

“…Frame alignment, performed by the ALIGN algorithm, plays an important role in the characteristic locus design method. A number of extensions to ALIGN intended to enhance the effectiveness of the design technique are proposed. …”