Combination fixed-dose β agonist and steroid inhaler as required for adults or children with mild asthma: a Cochrane systematic review by Crossingham, I, Turner, S, Ramakrishnan, S, Fries, A, Gowell, M, Farhat, Y, Richardson, R, Webb, P, O'Boyle, E, Hinks, TSC

“…</p> <p><strong>Search methods</strong> We searched the Cochrane Airways Trials Register, Cochrane Central Register of Controlled Trials, MEDLINE and Embase, ClinicalTrials.gov and the WHO trials portal on 19 March 2021.</p> <p><strong>Interventions</strong> A single fixed-dose FABA/ICS inhaler used as required compared with no treatment, placebo, short-acting beta agonist (SABA) as required, regular ICS with SABA as required, regular fixed-dose combination ICS/long-acting beta agonist (LABA), or regular fixed-dose combination ICS/FABA with as required ICS/FABA.We included randomised controlled trials (RCTs) and cross-over trial. …”

Tropical tropospheric aerosol sources and chemical composition observed at high altitude in the Bolivian Andes by C. I. Moreno, R. Krejci, J.-L. Jaffrezo, G. Uzu, G. Uzu, A. Alastuey, M. F. Andrade, M. F. Andrade, V. Mardóñez, A. M. Koenig, D. Aliaga, C. Mohr, C. Mohr, L. Ticona, F. Velarde, L. Blacutt, R. Forno, D. N. Whiteman, A. Wiedensohler, P. Ginot, P. Ginot, P. Laj, P. Laj

“…<span class="inline-formula">−</span>16.346950°, long. <span class="inline-formula">−</span>68.128250°) providing a unique long-term record spanning from December 2011 to March 2020. …”
Get full text

Deep X-Ray and Radio Observations of the First Outburst of the Young Magnetar Swift J1818.0−1607 by A. Y. Ibrahim, A. Borghese, N. Rea, F. Coti Zelati, E. Parent, T. D. Russell, S. Ascenzi, R. Sathyaprakash, D. Götz, S. Mereghetti, M. Topinka, M. Rigoselli, V. Savchenko, S. Campana, G. L. Israel, A. Tiengo, R. Perna, R. Turolla, S. Zane, P. Esposito, G. A. Rodríguez Castillo, V. Graber, A. Possenti, C. Dehman, M. Ronchi, S. Loru

“…We report here on the long-term X-ray monitoring campaign of this young magnetar using XMM-Newton, NuSTAR, and Swift from the activation of its first outburst in 2020 March until 2021 October, as well as INTEGRAL upper limits on its hard X-ray emission. …”
Get full text

Multisystem inflammatory syndrome in children (MIS-C) during SARS-CoV-2 pandemic in Brazil: a multicenter, prospective cohort study by Fernanda Lima-Setta, Maria Clara de Magalhães-Barbosa, Gustavo Rodrigues-Santos, Elaine Augusta das Neves Figueiredo, Melissa de Lorena Jacques, Raquel de Seixas Zeitel, Roberto Sapolnik, Cibelle Teixeira da Siva Borges, Vanessa Soares Lanziotti, Roberta Esteves Vieira de Castro, Ana Paula Novaes Bellinat, Thiago Peres da Silva, Felipe Rezende Caino de Oliveira, Bárbara Carvalho Santos dos Reis, Natália Almeida de Arnaldo Silva Rodriguez Castro, João Henrique Garcia Cobas Macedo, Ana Carolina Cabral Pinheiro Scarlato, Paula Marins Riveiro, Isabele Coelho Fonseca da Mota, Vivian Botelho Lorenzo, Natalia Martins Lima de Lucena, Zina Maria Almeida de Azevedo, Antonio José L.A. Cunha, Arnaldo Prata-Barbosa

“…Method: Multicenter, prospective cohort study, conducted in 17 pediatric intensive care units in five states in Brazil, from March to July 2020. Patients from 1 month to 19 years who met the MIS-C diagnostic criteria were included consecutively. …”
Get full text

伴大核心梗死的前循环串联闭塞的急性期同期血管内治疗研究 Emergent Management of Anterior Circulation Tandem Occlusion with Large Core Infarction by 刘承春, 唐春花, 黄书翰, 吴娅, 李小树, 李玮, 张猛

“…Two patients underwent ipsilateral ICA stenting immediately after MCA recanalization; in the other two patients, ICA stenting was performed after MCA recanalization and a long time of reperfusion observation; and one patient only underwent balloon dilation of carotid artery after recanalization. …”
Get full text

A full year of aerosol size distribution data from the central Arctic under an extreme positive Arctic Oscillation: insights from the Multidisciplinary drifting Observatory for the... by M. Boyer, D. Aliaga, J. B. Pernov, H. Angot, L. L. J. Quéléver, L. Dada, L. Dada, B. Heutte, M. Dall'Osto, D. C. S. Beddows, Z. Brasseur, I. Beck, S. Bucci, M. Duetsch, A. Stohl, T. Laurila, E. Asmi, A. Massling, D. C. Thomas, J. K. Nøjgaard, J. K. Nøjgaard, T. Chan, S. Sharma, P. Tunved, R. Krejci, H. C. Hansson, F. Bianchi, K. Lehtipalo, A. Wiedensohler, K. Weinhold, M. Kulmala, T. Petäjä, M. Sipilä, J. Schmale, T. Jokinen, T. Jokinen

“…This is the first continuous, year-long data set of aerosol PNSD ever collected over the sea ice in the central Arctic Ocean. …”
Get full text

The Effect and the Potential Use of Magnetic–Dam Barrier in Guided Bone Regeneration: A Laboratory Study by Lucia Memè, Fabrizio Bambini, Gianni Gallusi, Davide Sartini, Valentina Pozzi, Monica Emanuelli, Enrico M. Strappa, Stefano Mummolo

Get full text

The Task and Ministry of Peacemaking in Mindanao: Understanding a Peacemaker’s Recipe for Peace by Noel Asiones

“…Peacemaking: From Practice to Theory. Volume 1. Praeger. Bacongco, Kieth. 12 February 2010. …”
Get full text

Genotypic influence in the juvenile to adult transition in olive seedlings by Pedro Valverde, Pedro Valverde, Concepción Munoz Diez, Rustu Efe Deger, Diego Barranco, Carlos Trapero

Get full text

ROAD SAFETY: A MAJOR PUBLIC HEALTH ISSUE by AKHTAR SHERIN

“…Worldwide, about 3,700 people lose their lives daily and 1.35 million people die annually due to RTCs. Majority of these deaths occur among children and young adults and almost 93% deaths are from low- and middle-income countries (LMIC). …”
Get full text

Ciclo de vida, estruturas reprodutivas e dispersão de populações experimentais de capim-carrapicho (Cenchrus echinatus L.) Life cycle, reproductive structures and dispersion of exp... by R.P. de B. Pacheco, G. De Marinis

“…Also, the initiation of flowering was th e most precocious (2 nd month), the period of fascicle dispersal the longest (210 days), the dispersal index the highest (72%) and the life cycle long (210 days). The second period includ es sowings made in Februa ry and March and is characterized by the lowest production of racemes, fas cicles and caryopses (2% of the total) . …”
Get full text

Viral Diversity in Benthic Abyssal Ecosystems: Ecological and Methodological Considerations by Umberto Rosani, Cinzia Corinaldesi, Gabriella Luongo, Marco Sollitto, Simeone Dal Monego, Danilo Licastro, Lucia Bongiorni, Paola Venier, Alberto Pallavicini, Antonio Dell’Anno

Get full text

Chain Mediating Effects of Stressful Life Events and the Time Taken to Fall Asleep in the Relationship between Yin-deficiency Constitution and Depressed Mood in Junior High School... by YU Xinlian, DAI Xinyue, ZHAO Xicun, XU Ying

“…Objective To explore the relationship between yin-deficiency constitution and depressed mood in junior high school students, as well as the mediating effect of stressful life events and the time taken to fall asleep. Methods On March 2022, a convenient sample of junior high school students from a middle school in Meishan City, Sichuan Province were surveyed on their general data (gender, ethnicity, region of origin, grade), prevalence of yin-deficiency constitution assessed using the yin-deficiency Constitution subscale of the Traditional Chinese Medicine Constitution Scale for 7-14-year-olds, prevalence of stressful life events assessed using the Adolescent Self-Rating Life Events Checklist (ASLEC), and the time taken to fall asleep assessed using the items assessing how long it takes to fall asleep in the Munich Chronotype Questionnaire (MCTQ), and prevalence of depressed mood assessed using the Center for Epidemiologic Studies Depression (CES-D). …”
Get full text

Improved SARS-CoV-2 sequencing surveillance allows the identification of new variants and signatures in infected patients by Antonio Grimaldi, Francesco Panariello, Patrizia Annunziata, Teresa Giuliano, Michela Daniele, Biancamaria Pierri, Chiara Colantuono, Marcello Salvi, Valentina Bouché, Anna Manfredi, Maria Concetta Cuomo, Denise Di Concilio, Claudia Tiberio, Mariano Fiorenza, Giuseppe Portella, Ilaria Cimmino, Antonio Sorrentino, Giovanna Fusco, Maria Rosaria Granata, Pellegrino Cerino, Antonio Limone, Luigi Atripaldi, Andrea Ballabio, Davide Cacchiarelli

“…This allowed us to (i) identify three new viral variants that specifically originated in the Campania region, (ii) map SARS-CoV-2 intrahost variability during long-term infections and in one case identify an increase in the number of mutations in the viral genome, and (iii) identify host gene expression signatures correlated with viral load in upper respiratory ways. …”
Get full text

Development of a novel dementia risk prediction model in the general population: A large, longitudinal, population-based machine-learning study by Jia You, Ya-Ru Zhang, Hui-Fu Wang, Ming Yang, Jian-Feng Feng, Jin-Tai Yu, Wei Cheng

“…Methods: In this longitudinal population-based cohort of the UK Biobank (UKB), 425,159 non-demented participants were enrolled from 22 recruitment centres across the UK between March 1, 2006 and October 31, 2010. We implemented a data-driven strategy to identify predictors from 366 candidate variables covering a comprehensive range of genetic and environmental factors and developed the ML model to predict incident dementia and Alzheimer's Disease (AD) within five, ten, and much longer years (median 11.9 [Interquartile range 11.2–12.5] years). …”
Get full text

Trigger‐Associated Clinical Implications and Outcomes in Takotsubo Syndrome: Results From the Multicenter GEIST Registry by Toni Pätz, Francesco Santoro, Rosa Cetera, Ilaria Ragnatela, Ibrahim El‐Battrawy, Matthias Mezger, Elias Rawish, Mireia Andrés‐Villarreal, Manuel Almendro‐Delia, Manuel Martinez‐Sellés, Aitor Uribarri, Alberto Pérez‐Castellanos, Federico Guerra, Giuseppina Novo, Enrica Mariano, Maria Beatrice Musumeci, Luca Arcari, Luca Cacciotti, Roberta Montisci, Ibrahim Akin, Holger Thiele, Natale Daniele Brunetti, Oscar Vedia, Ivan J. Núñez‐Gil, Ingo Eitel, Thomas Stiermaier

Get full text

Primary Dermal Melanoma: A Rare Clinicopathological Variant Mimicking Metastatic Melanoma by Oriana Simonetti, Elisa Molinelli, Valerio Brisigotti, Donatella Brancorsini, Davide Talevi, Annamaria Offidani

Get full text

Impact of a social prescribing intervention in North East England on adults with type 2 diabetes: the SPRING_NE multimethod study by Moffatt Suzanne, Wildman John, Pollard Tessa M, Gibson Kate, Wildman Josephine M, O’Brien Nicola, Griffith Bethan, Morris Stephanie L, Moloney Eoin, Jeffries Jayne, Pearce Mark, Mohammed Wael

“…Intervention The intervention was a community-based link worker social prescribing intervention for people aged 40–74 years who had at least one of eight LTCs (i.e. diabetes type 1 or 2, chronic obstructive pulmonary disease, asthma, coronary heart disease, heart failure, epilepsy or osteoporosis, with or without anxiety and/or depression). …”
Get full text

Empleo, desempleo y salario real: análisis del mercado laboral de la ciudad de Medellín (1995-2006) by Carlos Andrés Cano, Adriana María Ochoa

Get full text

Mechanisms and management of loss of response to anti-TNF therapy for patients with Crohn's disease: 3-year data from the prospective, multicentre PANTS cohort study by Chanchlani, N, Lin, S, Bewshea, C, Hamilton, B, Thomas, A, Smith, R, Roberts, C, Bishara, M, Nice, R, Lees, CW, Sebastian, S, Irving, PM, Russell, RK, McDonald, TJ, Goodhand, JR, Ahmad, T, Kennedy, NA

“…</p> <br> <p><strong>Findings:</strong> Between March 19, 2014, and Sept 21, 2017, 389 (41%) of 955 patients treated with infliximab and 209 (32%) of 655 treated with adalimumab in the PANTS study entered the PANTS-extension study (median age 32·5 years [IQR 22·1–46·8], 307 [51%] of 598 were female, and 291 [49%] were male). …”