Evaluation of the shielding initiative in Wales (EVITE Immunity): protocol for a quasiexperimental study by Stephen Jolles, Ashley Akbari, Andrew Carson-Stevens, Helen Snooks, Alan Watkins, Adrian Edwards, Ann John, Alison Porter, Victoria Williams, Bridie Angela Evans, Ronan Lyons, Bernadette Sewell, Mark Rhys Kingston, Tony Whiffen, Jane Lyons, Rowena Bailey, Catherine A Thornton, Lesley Bethell, Samantha Bufton, Lucy Dixon

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Biallelic disruption of DDX41 activity is associated with distinct genomic and immunophenotypic hallmarks in acute leukemia by Anne Tierens, Elizabeth Kagotho, Satoru Shinriki, Andrew Seto, Adam C. Smith, Adam C. Smith, Melanie Care, Dawn Maze, Hassan Sibai, Karen W. Yee, Andre C. Schuh, Dennis Dong Hwan Kim, Vikas Gupta, Mark D. Minden, Hirotaka Matsui, José-Mario Capo-Chichi, José-Mario Capo-Chichi

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Gain-of-function variants in the ion channel gene TRPM3 underlie a spectrum of neurodevelopmental disorders by Lydie Burglen, Evelien Van Hoeymissen, Leila Qebibo, Magalie Barth, Newell Belnap, Felix Boschann, Christel Depienne, Katrien De Clercq, Andrew GL Douglas, Mark P Fitzgerald, Nicola Foulds, Catherine Garel, Ingo Helbig, Katharina Held, Denise Horn, Annelies Janssen, Angela M Kaindl, Vinodh Narayanan, Christina Prager, Mailys Rupin-Mas, Alexandra Afenjar, Siyuan Zhao, Vincent Th Ramaekers, Sarah M Ruggiero, Simon Thomas, Stéphanie Valence, Lionel Van Maldergem, Tibor Rohacs, Diana Rodriguez, David Dyment, Thomas Voets, Joris Vriens

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Speed breeding is a powerful tool to accelerate crop research and breeding by Watson, Amy, Ghosh, Sreya, Williams, Matthew J., Cuddy, William S., Simmonds, James, Rey, María Dolores, Md Hatta, Muhammad Asyraf, Hinchliffe, Alison, Steed, Andrew, Reynolds, Daniel, Adamski, Nikolai M., Breakspear, Andy, Korolev, Andrey, Rayner, Tracey, Dixon, Laura E., Riaz, Adnan, Martin, William, Ryan, Merrill, Edwards, David, Batley, Jacqueline, Raman, Harsh, Carter, Jeremy, Rogers, Christian, Domoney, Claire, Moore, Graham, Harwood, Wendy, Nicholson, Paul, Dieters, Mark J., DeLacy, Ian H., Ji, Zhou, Uauy, Cristobal, Boden, Scott A., Park, Robert F., Wulff, Brande B. H., Hickey, Lee T.

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Body size and risk of colorectal cancer molecular defined subtypes and pathways: Mendelian randomization analysesResearch in context by Nikos Papadimitriou, Conghui Qu, Tabitha A. Harrison, Alaina M. Bever, Richard M. Martin, Konstantinos K. Tsilidis, Polly A. Newcomb, Stephen N. Thibodeau, Christina C. Newton, Caroline Y. Um, Mireia Obón-Santacana, Victor Moreno, Hermann Brenner, Marko Mandic, Jenny Chang-Claude, Michael Hoffmeister, Andrew J. Pellatt, Robert E. Schoen, Sophia Harlid, Shuji Ogino, Tomotaka Ugai, Daniel D. Buchanan, Brigid M. Lynch, Stephen B. Gruber, Yin Cao, Li Hsu, Jeroen R. Huyghe, Yi Lin, Robert S. Steinfelder, Wei Sun, Bethany Van Guelpen, Syed H. Zaidi, Amanda E. Toland, Sonja I. Berndt, Wen-Yi Huang, Elom K. Aglago, David A. Drew, Amy J. French, Peter Georgeson, Marios Giannakis, Meredith Hullar, Johnathan A. Nowak, Claire E. Thomas, Loic Le Marchand, Iona Cheng, Steven Gallinger, Mark A. Jenkins, Marc J. Gunter, Peter T. Campbell, Ulrike Peters, Mingyang Song, Amanda I. Phipps, Neil Murphy

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The fatal trajectory of pulmonary COVID-19 is driven by lobular ischemia and fibrotic remodelling by Maximilian Ackermann, Jan C. Kamp, Christopher Werlein, Claire L. Walsh, Helge Stark, Verena Prade, Rambabu Surabattula, Willi L. Wagner, Catherine Disney, Andrew J. Bodey, Thomas Illig, Diana J. Leeming, Morten A. Karsdal, Alexandar Tzankov, Peter Boor, Mark P. Kühnel, Florian P. Länger, Stijn E. Verleden, Hans M. Kvasnicka, Hans H. Kreipe, Axel Haverich, Stephen M. Black, Axel Walch, Paul Tafforeau, Peter D. Lee, Marius M. Hoeper, Tobias Welte, Benjamin Seeliger, Sascha David, Detlef Schuppan, Steven J. Mentzer, Danny D. Jonigk

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TOI-3984 A b and TOI-5293 A b: Two Temperate Gas Giants Transiting Mid-M Dwarfs in Wide Binary Systems by Caleb I. Cañas, Shubham Kanodia, Jessica Libby-Roberts, Andrea S. J. Lin, Maria Schutte, Luke Powers, Sinclaire Jones, Andrew Monson, Songhu Wang, Guđmundur Stefánsson, William D. Cochran, Paul Robertson, Suvrath Mahadevan, Adam F. Kowalski, John Wisniewski, Brock A. Parker, Alexander Larsen, Franklin A. L. Chapman, Henry A. Kobulnicky, Arvind F. Gupta, Mark E. Everett, Bryan Edward Penprase, Gregory Zeimann, Corey Beard, Chad F. Bender, Knicole D. Colón, Scott A. Diddams, Connor Fredrick, Samuel Halverson, Joe P. Ninan, Lawrence W. Ramsey, Arpita Roy, Christian Schwab

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Non-canonical Hedgehog signaling mediates profibrotic hematopoiesis-stroma crosstalk in myeloproliferative neoplasms by Jessica E. Pritchard, Juliette E. Pearce, Inge A.M. Snoeren, Stijn N.R. Fuchs, Katrin Götz, Fabian Peisker, Silke Wagner, Adam Benabid, Niklas Lutterbach, Vanessa Klöker, James S. Nagai, Monica T. Hannani, Anna K. Galyga, Ellen Sistemich, Bella Banjanin, Niclas Flosdorf, Eric Bindels, Kathrin Olschok, Katharina Biaesch, Nicolas Chatain, Neha Bhagwat, Andrew Dunbar, Rita Sarkis, Olaia Naveiras, Marie-Luise Berres, Steffen Koschmieder, Ross L. Levine, Ivan G. Costa, Hélène F.E. Gleitz, Rafael Kramann, Rebekka K. Schneider

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Excessive use of electronic devices among children and adolescents is associated with musculoskeletal symptoms, visual symptoms, psychosocial health, and quality of life: a cross-s... by Sharon M. H. Tsang, Gladys L. Y. Cheing, Andrew K. C. Lam, Andrew K. C. Lam, Andrew K. C. Lam, Andrew M. H. Siu, Peter C. K. Pang, Peter C. K. Pang, Peter C. K. Pang, Kin-Chung Yip, Jess W. K. Chan, Mark P. Jensen

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Mental health in UK Biobank: development, implementation and results from an online questionnaire completed by 157 366 participants – CORRIGENDUM by Katrina A. S. Davis, Jonathan R. I. Coleman, Mark Adams, Naomi Allen, Gerome Breen, Breda Cullen, Chris Dickens, Elaine Fox, Nick Graham, Jo Holliday, Louise M. Howard, Ann John, William Lee, Rose McCabe, Andrew McIntosh, Robert Pearsall, Cathie Sudlow, Joey Ward, Stan Zammit, Matthew Hotopf

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Randomised, placebo-controlled, phase 3 trial of the effect of the omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) on colorectal cancer recurrence and survival after... by Helen Marshall, Mark A Hull, David A Cairns, Andrew T Chan, Mingyang Song, Robert Jones, Peter S Hall, Catherine Moriarty, David A Drew, Wendy S Garrett, Giles J Toogood, Paul M Loadman, Andrew J Cockbain, Omer Yilmaz, Pei Loo Ow, Sharon Ruddock, Tim Brend, Alexandra F Smith, Fiona Collinson

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The JWST Early Release Science Program for Direct Observations of Exoplanetary Systems. IV. NIRISS Aperture Masking Interferometry Performance and Lessons Learned by Steph Sallum, Shrishmoy Ray, Jens Kammerer, Anand Sivaramakrishnan, Rachel Cooper, Alexandra Z. Greebaum, Deepashri Thatte, Matthew De Furio, Samuel M. Factor, Michael R. Meyer, Jordan M. Stone, Aarynn Carter, Beth Biller, Sasha Hinkley, Andrew Skemer, Genaro Suárez, Jarron M. Leisenring, Marshall D. Perrin, Adam L. Kraus, Olivier Absil, William O. Balmer, Sarah K. Betti, Anthony Boccaletti, Mariangela Bonavita, Mickael Bonnefoy, Mark Booth, Brendan P. Bowler, Zackery W. Briesemeister, Marta L. Bryan, Per Calissendorff, Faustine Cantalloube, Gael Chauvin, Christine H. Chen, Elodie Choquet, Valentin Christiaens, Gabriele Cugno, Thayne Currie, Camilla Danielski, Trent J. Dupuy, Jacqueline K. Faherty, Michael P. Fitzgerald, Jonathan J. Fortney, Kyle Franson, Julien H. Girard, Carol A. Grady, Eileen C. Gonzales, Thomas Henning, Dean C. Hines, Kielan K. W. Hoch, Callie E. Hood, Alex R. Howe, Markus Janson, Paul Kalas, Grant M. Kennedy, Matthew A. Kenworthy, Pierre Kervella, Daniel Kitzmann, Masayuki Kuzuhara, Anne-Marie Lagrange, Pierre-Olivier Lagage, Kellen Lawson, Cecilia Lazzoni, Ben W. P. Lew, Michael C. Liu, Pengyu Liu, Jorge Llop-Sayson, James P. Lloyd, Anna Lueber, Bruce Macintosh, Elena Manjavacas, Sebastian Marino, Mark S. Marley, Christian Marois, Raquel A. Martinez, Brenda C. Matthews, Elisabeth C. Matthews, Dimitri Mawet, Johan Mazoyer, Michael W. McElwain, Stanimir Metchev, Brittany E. Miles, Maxwell A. Millar-Blanchaer, Paul Molliere, Sarah E. Moran, Caroline V. Morley, Sagnick Mukherjee, Paulina Palma-Bifani, Eric Pantin, Polychronis Patapis, Simon Petrus, Laurent Pueyo, Sascha P. Quanz, Andreas Quirrenbach, Isabel Rebollido, Jea Adams Redai, Bin B. Ren, Emily Rickman, Matthias Samland, B. A. Sargent, Joshua E. Schlieder, Glenn Schneider, Karl R. Stapelfeldt, Ben J. Sutlieff, Motohide Tamura, Xianyu Tan, Christopher A. Theissen, Taichi Uyama, Arthur Vigan, Malavika Vasist, Johanna M. Vos, Kevin Wagner, Jason J. Wang, Kimberly Ward-Duong, Niall Whiteford, Schuyler G. Wolff, Kadin Worthen, Mark C. Wyatt, Marie Ygouf, Xi Zhang, Keming Zhang, Zhoujian Zhang, Yifan Zhou, Alice Zurlo

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Predicting the causative pathogen among children with pneumonia using a causal Bayesian network. by Yue Wu, Steven Mascaro, Mejbah Bhuiyan, Parveen Fathima, Ariel O Mace, Mark P Nicol, Peter C Richmond, Lea-Ann Kirkham, Michael Dymock, David A Foley, Charlie McLeod, Meredith L Borland, Andrew Martin, Phoebe C M Williams, Julie A Marsh, Thomas L Snelling, Christopher C Blyth

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Protocol for an OpenSAFELY cohort study collecting patient-reported outcome measures using the TPP Airmid smartphone application and linked big data to quantify the health and econ... by Michael Marks, Mark Jit, Frank Sandmann, Ben Goldacre, Liam Smeeth, Laurie A Tomlinson, Liang-Yu Lin, Emily Herrett, Deb Smith, Jessica Morley, Andrew Briggs, Seb Bacon, Amir Mehrkar, John Parry, Keith Tomlin, Viyaasan Mahalingasivam, Christopher Bates, Benjamin Butler-Cole, Alan Dennison, Ethan Gabriel, Rosalind M M Eggo

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Predicting and reasoning about replicability using structured groups by Bonnie C. Wintle, Eden T. Smith, Martin Bush, Fallon Mody, David P. Wilkinson, Anca M. Hanea, Alexandru Marcoci, Hannah Fraser, Victoria Hemming, Felix Singleton Thorn, Marissa F. McBride, Elliot Gould, Andrew Head, Daniel G. Hamilton, Steven Kambouris, Libby Rumpff, Rink Hoekstra, Mark A. Burgman, Fiona Fidler

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Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth by Pathum Thilakasiri, Jennifer Huynh, Ashleigh R Poh, Chin Wee Tan, Tracy L Nero, Kelly Tran, Adam C Parslow, Shoukat Afshar‐Sterle, David Baloyan, Natalie J Hannan, Michael Buchert, Andrew Mark Scott, Michael DW Griffin, Frederic Hollande, Michael W Parker, Tracy L Putoczki, Matthias Ernst, Ashwini L Chand

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A Segmental Approach from Molecular Profiling to Medical Imaging to Study Bicuspid Aortic Valve Aortopathy by Froso Sophocleous, Estefania De Garate, Maria Giulia Bigotti, Maryam Anwar, Eva Jover, Aranzazu Chamorro-Jorganes, Cha Rajakaruna, Konstantina Mitrousi, Viola De Francesco, Aileen Wilson, Serban Stoica, Andrew Parry, Umberto Benedetto, Pierpaolo Chivasso, Frances Gill, Mark C. K. Hamilton, Chiara Bucciarelli-Ducci, Massimo Caputo, Costanza Emanueli, Giovanni Biglino

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Class IIa HDACs inhibit cell death pathways and protect muscle integrity in response to lipotoxicity by Sheree D. Martin, Timothy Connor, Andrew Sanigorski, Kevin A. McEwen, Darren C. Henstridge, Brunda Nijagal, David De Souza, Dedreia L. Tull, Peter J. Meikle, Greg M. Kowalski, Clinton R. Bruce, Paul Gregorevic, Mark A. Febbraio, Fiona M. Collier, Ken R. Walder, Sean L. McGee

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AMPK is a mechano-metabolic sensor linking cell adhesion and mitochondrial dynamics to Myosin-dependent cell migration by Eva Crosas-Molist, Vittoria Graziani, Oscar Maiques, Pahini Pandya, Joanne Monger, Remi Samain, Samantha L. George, Saba Malik, Jerrine Salise, Valle Morales, Adrien Le Guennec, R. Andrew Atkinson, Rosa M. Marti, Xavier Matias-Guiu, Guillaume Charras, Maria R. Conte, Alberto Elosegui-Artola, Mark Holt, Victoria Sanz-Moreno

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RNA m6A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression by Zheng Zhang, Keren Zhou, Li Han, Andrew Small, Jianhuang Xue, Huilin Huang, Hengyou Weng, Rui Su, Brandon Tan, Chao Shen, Wei Li, Zhicong Zhao, Ying Qing, Xi Qin, Kitty Wang, Keith Leung, Mark Boldin, Chun-Wei Chen, David Ann, Zhijian Qian, Xiaolan Deng, Jianjun Chen, Zhenhua Chen

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