Comprehensive review of melatonin as a promising nutritional and nutraceutical supplement by Waad W. Kamfar, Husam M. Khraiwesh, Mohammed O. Ibrahim, Alaa H. Qadhi, Wedad F. Azhar, Khloud J. Ghafouri, Maha H. Alhussain, Abdullah F. Aldairi, Abdullah M. AlShahrani, Abdullah F. Alghannam, Rwaa H. Abdulal, Abed H. Al-Slaihat, Maysoun S. Qutob, Mahmoud E. Elrggal, Mazen M. Ghaith, Firas S. Azzeh

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Chronic Administration of Melatonin: Physiological and Clinical Considerations by Donald Givler, Amy Givler, Patrick M. Luther, Danielle M. Wenger, Shahab Ahmadzadeh, Sahar Shekoohi, Amber N. Edinoff, Bradley K. Dorius, Carlo Jean Baptiste, Elyse M. Cornett, Adam M. Kaye, Alan D. Kaye

“…Many countries only allow melatonin prescriptions. In the United States (U.S.), it is classified as a dietary supplement accessible over the counter and can be derived from animals, microorganisms, or, most commonly, made synthetically. …”
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Design and rationale of a randomized controlled trial of melatonin supplementation in men and women with the metabolic syndrome by Terry PD, Goyal A, Phillips LS, Superak HM, Kutner MH

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Prophylactic supplement with melatonin prevented the brain injury after cardiac arrest in rats by Yanan Hu, Xuyan Zhao, Ge Jiang, Mingxin Jin, Wei Jiang, Fei Han

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The Effect of Melatonin Supplement on High Arterial Blood Pressure: An Overview from Clinicaltrials.gov by Ashour AM

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Effects of Melatonin Supplementation on Lipid Metabolism and Body Fat Accumulation in Ovariectomized Rats by Ling-Wen Hsu, Yi-Wen Chien

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Community Pharmacists’ Knowledge, Attitudes and the Perceived Safety and Effectiveness of Melatonin Supplements: A Cross-Sectional Survey by Mansour Tobaiqy, Faris A. AlZahrani, Abdulrahman S. Hassan, Abdullah H. Alirbidi, Osama A. Alraddadi, Omar A. AlSadah, Mohammad B. Yamani, Sulafa T. Alqutub

“…Melatonin, which is classified as a dietary supplement by the Saudi Food and Drug Authority, is used to manage sleep disorders. …”
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Effect of melatonin on sleep quality and EEG features in childhood epilepsy: a possible non-conventional treatment by Giovanni Battista Dell'Isola, Giorgia Tascini, Valerio Vinti, Eleonora Tulli, Gianluca Dini, Elisabetta Mencaroni, Pietro Ferrara, Giuseppe Di Cara, Pasquale Striano, Alberto Verrotti

“…The study consisted of serial controls at enrollment (t0), at 3 months (t1), and at 6 months (t2) including neurological examination, questionnaire about sleep disturbances (CSHQ), and EEG.ResultsA significant improvement in sleep quality and daytime sleepiness was observed after melatonin supplementation. …”
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Controlled‐release oral melatonin supplementation for hypertension and nocturnal hypertension: A systematic review and meta‐analysis by Eric Kam‐Pui Lee, Paul Poon, Chun‐Pong Yu, Vivian Wing‐Yan Lee, Vincent Chi‐Ho Chung, Samuel Yeung‐Shan Wong

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The role of melatonin in anaesthesia and critical care by Madhuri S Kurdi, Tushar Patel

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How effective is daytime oral exogenous melatonin supplementation in improving sleep quality and duration? by Chidiebere Emmanuel Okechukwu, Chidubem Ekpereamaka Okechukwu

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The efficacy of exogenous melatonin supplement in ameliorating irritable bowel syndrome severity: A meta-analysis of randomized controlled trials by Keng-Hsu Chen, Bing-Yan Zeng, Bing-Syuan Zeng, Cheuk-Kwan Sun, Yu-Shian Cheng, Kuan-Pin Su, Yi-Cheng Wu, Tien-Yu Chen, Pao-Yen Lin, Chih-Sung Liang, Chih-Wei Hsu, Che-Sheng Chu, Yen-Wen Chen, Pin-Yang Yeh, Ming-Kung Wu, Ping-Tao Tseng, Chung-Yao Hsu

“…The subgroup without concurrent medication had the same result (p < 0.001). In addition, exogenous melatonin supplement was also associated with significantly better improvement in IBS pain severity (p < 0.001) and quality of life (p = 0.007) than placebo, but not in abdominal distension (p = 0.111) or sleep quality (p = 0.142). …”
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The Effect of Melatonin Supplementation on Cancer-Related Fatigue during Chemotherapy Treatment of Breast Cancer Patients: A Double-Blind, Randomized Controlled Study by Frantzeska Nimee, Aristea Gioxari, Panos Papandreou, Charalampia Amerikanou, Sofia Karageorgopoulou, Andriana C. Kaliora, Maria Skouroliakou

“…No differences in CRF were observed between the groups. In conclusion, melatonin oral supplementation could ameliorate CRF in BC patients.…”
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Comment on Minich et al. Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements. <i>Nutrients</i> 2022, <i>14</i>, 3934... by Ryszard Pluta

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Melatonin supplementation protects against traumatic colon injury by regulating SERPINA3N protein expression by Bo Cao, Jing‐Wang Gao, Qing‐Peng Zhang, Xing‐Ming Xu, Rui‐Yang Zhao, Hang‐Hang Li, Bo Wei

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Melatonin Supplementation Decreases Aerobic Exercise Training Induced-Lipid Peroxidation and Malondialdehyde in Sedentary Young Women by Ziaadini Fatemeh, Aminae Mohsen, Mahsa Rastegar M.M., Abbasian Sadegh, Memari Amir Hossein

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The relationship between anesthesia and melatonin: a review by Rui Guo, Rui Guo, Junming Ye, Baozhen Liao, Xin Luo, Panguo Rao

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Improvement of sleep and melatonin in children with autism spectrum disorder after β‐1,3/1,6‐glucan consumption: An open‐label prospective pilot clinical study by Kadalraja Raghavan, Vidyasagar Devaprasad Dedeepiya, Ramesh Shankar Kandaswamy, Mangaleswaran Balamurugan, Nobunao Ikewaki, Tohru Sonoda, Gene Kurosawa, Masaru Iwasaki, Senthilkumar Preethy, Samuel JK Abraham

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The Effect of Melatonin on Body Weight and the Potential use of Melatonin as an Anti-Obesity Agent by Sama Atta Gitti, Rayan Zaidan Khalaf, Abdulhadi Alrubaie

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Gut microbiota-derived melatonin from Puerariae Lobatae Radix-resistant starch supplementation attenuates ischemic stroke injury via a positive microbial co-occurrence pattern by Zhuoshi Lian, Ying Xu, Chan Wang, Ye Chen, Li Yuan, Zhongyu Liu, Yarui Liu, Peishi He, Zheng Cai, Jie Zhao

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