Commercializing Biomedical Research Through Securitization Techniques by Fernandez, Jose-Maria, Stein, Roger Mark, Lo, Andrew W.

“…In a simulation using historical data for new molecular entities in oncology from 1990 to 2011, we find that megafunds of $5–15 billion may yield average investment returns of 8.9–11.4% for equity holders and 5–8% for 'research-backed obligation' holders, which are lower than typical venture-capital hurdle rates but attractive to pension funds, insurance companies and other large institutional investors.…”
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Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase by DuPage, Michel J., Brauneis, Alison L., Jacks, Tyler E.

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Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data by Dekker, Job, Marti-Renom, Marc A., Mirny, Leonid A.

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Platelets guide the formation of early metastatic niches by Labelle, Myriam, Begum, Shahinoor, Hynes, Richard O

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DNA Damage-Mediated Induction of a Chemoresistant Niche by Gilbert, Luke Andrew, Hemann, Michael

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Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening by Jiang, Guozhi, Tao, Kai, Kuperwasser, Charlotte, Gupta, Piyush, Onder, Tamer T, Weinberg, Robert A, Lander, Eric Steven

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The Epithelial-Mesenchymal Transition Factor SNAIL Paradoxically Enhances Reprogramming by Unternaehrer, Juli J., Zhao, Rui, Kim, Kitai, Cesana, Marcella, Powers, John T., Ratanasirintrawoot, Sutheera, Onder, Tamer T., Shibue, Tsukasa, Weinberg, Robert A., Daley, George Q., Weinberg, Robert A

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Transcriptional profiling of cells sorted by transcript abundance by Klemm, Sandy Lee, Semrau, Stefan, Wiebrands, Kay, Mooijman, Dylan, Jaenisch, Rudolf, van Oudenaarden, Alexander, Faddah, Dina A.

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FDG-PET/CT(A) imaging in large vessel vasculitis and polymyalgia rheumatica: joint procedural recommendation of the EANM, SNMMI, and the PET Interest Group (PIG), and endorsed by t... by Slart, R, Glaudemans, A, Chareonthaitawee, P, Treglia, G, Besson, F, Bley, T, Blockmans, D, Boellaard, R, Bucerius, J, Carril, J, Chen, W, Cid, M, Dagupta, B, Dorbala, S, Gheysens, O, Hyafil, F, Jain, S, Klink, T, van der Laken, C, Lomeña, F, Massollo, M, Prieto-González, D, Luqmani, R, Roivanen, A, Salvarani, C, Saraste, A, Schirmer, M, Verberne, H, Versari, A, Voskuyl, A, Walter, M, Camellino, D, Brouwer, E, Cimmino, M, Slart, R

“…FDG-PET/CT is a functional imaging technique which is an established tool in oncology, and has also demonstrated a role in the field of inflammatory diseases. …”

Targeting Retinoblastoma tumour suppressor deficiency in Leiomyosarcoma by Sechi, I

“…</p> <p>Total proteome analysis was carried out to elucidate molecular pathways behind the cytotoxicity of alvespimycin (17-DMAG) in RB1-deficient LMS cells. …”

Prognostic implications of NOTCH1 and FBXW7 mutations in adults with T-cell acute lymphoblastic leukemia treated on the MRC UKALLXII/ECOG E2993 protocol. by Mansour, MR, Sulis, M, Duke, V, Foroni, L, Jenkinson, S, Koo, K, Allen, C, Gale, R, Buck, G, Richards, S, Paietta, E, Rowe, J, Tallman, MS, Goldstone, A, Ferrando, A, Linch, D

“…PURPOSE: Notch pathway activation by mutations in either NOTCH1 and/or FBXW7 is one of the most common molecular events in T-cell acute lymphoblastic leukemia (T-ALL) and, in pediatric disease, predicts for favorable outcome. …”

Minimal residual disease is a significant predictor of treatment failure in non T-lineage adult acute lymphoblastic leukaemia: final results of the international trial UKALL XII/EC... by Patel, B, Rai, L, Buck, G, Richards, S, Mortuza, Y, Mitchell, W, Gerrard, G, Moorman, A, Duke, V, Hoffbrand, A, Fielding, A, Goldstone, A, Foroni, L

“…The predictive value of molecular minimal residual disease (MRD) monitoring using polymerase chain reaction amplification of clone-specific immunoglobulin or T-cell Receptor rearrangements was analysed in 161 patients with non T-lineage Philadelphia-negative acute lymphoblastic leukaemia (ALL) participating in the UK arm of the international ALL trial UKALL XII/Eastern Cooperative Oncology Group (ECOG) 2993. …”

Soft tissue and visceral sarcomas: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up by Casali, P, Abecassis, N, Bauer, S, Biagini, R, Bielack, S, Bonvalot, S, Boukovinas, I, Bovee, J, Brodowicz, T, Broto, J, Buonadonna, A, De Álava, E, Dei Tos, A, Del Muro, X, Dileo, P, Eriksson, M, Fedenko, A, Ferraresi, V, Ferrari, A, Ferrari, S, Frezza, A, Gasperoni, S, Gelderblom, H, Gil, T, Grignani, G, Gronchi, A, Hannu, A, Hassan, B, Hohenberger, P, Issels, R, Joensuu, H, Jones, R, Judson, I, Jutte, P, Kaal, S, Kasper, B, Kopeckova, K, Krákorová, D, Le Cesne, A, Lugowska, I, Merimsky, O, Montemurro, M, Pantaleo, M, Piana, R, Picci, P, Piperno-Neumann, S, Pousa, A, Reichardt, P, Robinson, M, Rutkovski, P, Safwat, A, Schöffski, P, Sleijfer, S, Stacchiotti, S, Sundby Hall, K, Unk, M, Van Coevorden, F, Van der Graaf, W, Whelan, J, Wardelmann, E, Zaikova, O, Blay, J

“…Soft tissue sarcomas (STSs) gather over 80 histological entities, with even more molecular subsets, characterised by a low to very low incidence in all populations. …”

The breast cancer working group presentation was divided into three sections: the epidemiology, pathology and treatment of breast cancer by Toi, M., Ohashi, Y., Seow, A., Moriya, T., Tse, G., Sasano, H., Park, B.W., Chow, L.W.C., Laudico, A.V., Yip, C.H., Ueno, E., Ishiguro, H., Bando, H.

p53, stem cell biology and childhood blastomas by Oh, Lixian, Hafsi, Hind, Hainaut, Pierre, Ariffin, Hany

Overexpression of phospho-Akt correlates with phosphorylation of EGF receptor, FKHR and BAD in nasopharyngeal carcinoma by Yip , WK

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A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade by Jerby-Arnon, Livnat, Shah, Parin, Cuoco, Michael S., Rodman, Christopher, Su, Mei-Ju, Melms, Johannes C., Leeson, Rachel, Kanodia, Abhay, Mei, Shaolin, Lin, Jia-Ren, Wang, Shu, Rabasha, Bokang, Liu, David, Zhang, Gao, Margolais, Claire, Ashenberg, Orr, Ott, Patrick A., Buchbinder, Elizabeth I., Haq, Rizwan, Hodi, F. Stephen, Boland, Genevieve M., Sullivan, Ryan J., Frederick, Dennie T., Miao, Benchun, Moll, Tabea, Flaherty, Keith T., Herlyn, Meenhard, Jenkins, Russell W., Thummalapalli, Rohit, Kowalczyk, Monika S., Cañadas, Israel, Schilling, Bastian, Cartwright, Adam N.R., Luoma, Adrienne M., Malu, Shruti, Hwu, Patrick, Bernatchez, Chantale, Forget, Marie-Andrée, Barbie, David A., Shalek, Alex K., Tirosh, Itay, Sorger, Peter K., Wucherpfennig, Kai, Van Allen, Eliezer M., Schadendorf, Dirk, Johnson, Bruce E., Rotem, Asaf, Rozenblatt-Rosen, Orit, Garraway, Levi A., Yoon, Charles H., Izar, Benjamin, Regev, Aviv

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Single-molecule transcript counting of stem-cell markers in the mouse intestine by Itzkovitz, Shaul Shalev, Lyubimova, Anna, Blat, Irene C., Maynard, Mindy, van Es, Johan, Lees, Jacqueline, Jacks, Tyler E., Clevers, Hans, van Oudenaarden, Alexander

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Differential Tks5 isoform expression contributes to metastatic invasion of lung adenocarcinoma by Chen, Guoan, Dayton, Talya Lucia, Kim-Kiselak, Caroline, Hoersch, Sebastian, Whittaker, Charles A., Bronson, Roderick T., Beer, David G., Winslow, Monte M., Li, Carman Man-Chung, Jacks, Tyler E

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The extracellular matrix: Tools and insights for the “omics” era by Clauser, Karl R., Carr, Steven A., Naba, Alexandra, Ding, Huiming, Whittaker, Charles A., Hynes, Richard O.

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