Relativism as a means to alleviate biology from genomic reductionism: But is the remedy effective? by Ehsani, Sepehr

“…For the past several decades, biomedical research has principally been centered on molecular biology and genomic science. Although many molecular pathways and players in different disease and normal biological processes have been elucidated over this period, the much hoped-for “true” understanding of cellular and organismic functions has arguably not been achieved. …”
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Epithelial-to-mesenchymal transition in cancer: complexity and opportunities by Zhang, Yun, Weinberg, Robert A

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Gene expression studies to investigate disease mechanisms in rheumatoid arthritis: Does angiogenesis play a role? by Larsen, H, Akhavani, M, Raatz, Y, Paleolog, E

“…Gene expression studies represent a new and challenging approach that allows molecular dissection of complex diseases such as rheumatoid arthritis (RA). …”

Inducing DNA damage through R-loops to kill cancer cells by Lam, Fred C, Kong, Yi Wen, Yaffe, Michael B

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Technical and implementation issues in using next-generation sequencing of cancers in clinical practice. by Ulahannan, D, Kovac, M, Mulholland, P, Cazier, J, Tomlinson, I

“…Next-generation sequencing (NGS) of cancer genomes promises to revolutionise oncology, with the ability to design and use targeted drugs, to predict outcome and response, and to classify tumours. …”

Signaling network state predicts Twist-mediated effects on breast cell migration across diverse growth factor contexts by Kim, Hyung-Do, Meyer, Aaron Samuel, Wagner, Joel Patrick, Wells, Alan, Gertler, Frank, Hughes-Alford, Shannon Kay, Lauffenburger, Douglas A

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Epithelial-to-mesenchymal transition in cancer: complexity and opportunities by Zhang, Yun, Weinberg, Robert A

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Epithelial-to-mesenchymal transition in cancer: complexity and opportunities by Zhang, Yun, Weinberg, Robert A

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Personalizing medicine: a systems biology perspective by Deisboeck, Thomas S.

“…Fueled by the comparably modest progress made so far in pursuing this expensive conventional route, there has been much interest lately in moving toward personalized or patient-specific medicine. For oncology, for instance, ‘specific’ refers to assessing not only tumor type, size, location, patient age and many other parameters that are already used and that result in the conventional grading and staging of the disease; rather, it argues for incorporating also the molecular fingerprint, or signature, and associated growth kinetics of the patient’s tumor when fine-tuning treatment regimen on a case-by-case basis (Roukos et al, 2007). …”
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Impact of variant reclassification in cancer predisposition genes on clinical care by Chiang, Jianbang, Chia, Tze Hao, Yuen, Jeanette, Shaw, Tarryn, Li, Shao-Tzu, Nur Diana Binte Ishak, Chew, Ee Ling, Chong, Siao Ting, Chan, Sock Hoai, Ngeow, Joanne

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Are redox changes a critical switch for mitotic progression? by Lim, Daniel Cham-Chin, Joukov, Vladimir, Yaffe, Michael B

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The Global Cancer Genomics Consortium's Second Annual Symposium: Genomics Medicine in Cancer Research by Kumar, R, Horvath, A, Mazumder, R, Toi, M, Sato, F, Pillai, MR, Costa, L, Carmo-Fonseca, M, Knapp, S, Dutt, A, Gupta, S, Badwe, R

“…The symposium featured 3 major themes: OMICS approaches toward the identification of cancer molecular drivers, single-cell analysis in cancer, and clinical and translational genomics. …”

A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis by Reticker-Flynn, Nathan E., Malta, David F. Braga, Underhill, Gregory H., Xu, Mary Jue, Winslow, Monte Meier, Hynes, Richard O, Jacks, Tyler E, Bhatia, Sangeeta N, Lamar, John

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Protein Kinase C α Is a Central Signaling Node and Therapeutic Target for Breast Cancer Stem Cells by Lu, Haihui, Buikhuisen, Joyce, Soh, Boon Seng, Lim, Elgene, Reinhardt, Ferenc, Wu, Zhenhua Jeremy, Krall, Jordan A., Bierie, Brian, Guo, Wenjun, Chen, Xi, Liu, Xiaole Shirley, Brown, Myles, Lim, Bing, Tam, Wai Leong, Weinberg, Robert A

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A DNA/HDAC dual-targeting drug CY190602 with significantly enhanced anticancer potency by Hemann, Michael, Liu, Chuan, Ding, Hongyu, Li, Xiaoxi, Pallasch, Christian, Hong, Liya, Guo, Dianwu, Chen, Yi, Wang, Difei, Wang, Wei, Wang, Yajie, Jiang, Hai, 1979-

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Synchronous endometrial and ovarian carcinoma (SEOC); case series and literature review by Lin, Shahzarul Fazril, Yahaya, Zainab, Ramli, Nuraini, Abdul Hamid, Habibah

Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State by Guo, Wenjun, Keckesova, Zuzana, Donaher, Joana Liu, Shibue, Tsukasa, Tischler, Verena, Reinhardt, Ferenc, Itzkovitz, Shaul Shalev, Noske, Aurelia, Zurrer-Hardi, Ursina, Bell, George, Tam, Wai Leong, Mani, Sendurai A., van Oudenaarden, Alexander, Weinberg, Robert A.

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Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment by Acharya, Nandini, Madi, Asaf, Zhang, Huiyuan, Klapholz, Max, Escobar, Giulia, Dulberg, Shai, Christian, Elena, Ferreira, Michelle, Dixon, Karen O, Fell, Geoffrey, Tooley, Katherine, Mangani, Davide, Xia, Junrong, Singer, Meromit, Bosenberg, Marcus, Neuberg, Donna, Rozenblatt-Rosen, Orit, Regev, Aviv, Kuchroo, Vijay K, Anderson, Ana C

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Genetic pathways in colorectal cancer. by Ilyas, M, Tomlinson, I

“…The model of colorectal tumorigenesis put forward by Fearon and Vogelstein has had great influence on molecular oncology. They proposed that a series of mutations occur in the progression from normal cells to colorectal cancer and that these mutations are associated with the histological features of such tumours. …”

Ruxolitinib versus best available therapy for polycythemia vera intolerant or resistant to hydroxycarbamide in a randomized trial by Harrison, CN, Nangalia, J, Boucher, R, Jackson, A, Yap, C, O'Sullivan, J, Fox, S, Ailts, I, Dueck, AC, Geyer, HL, Mesa, RA, Dunn, WG, Nadezhdin, E, Curto-Garcia, N, Green, A, Wilkins, B, Coppell, J, Laurie, J, Garg, M, Ewing, J, Knapper, S, Crowe, J, Chen, F, Koutsavlis, I, Godfrey, A, Arami, S, Drummond, M, Byrne, J, Clark, F, Mead-Harvey, C, Baxter, EJ, McMullin, MF, Mead, AJ