Pleiotropic associations of heterozygosity for the SERPINA1 Z allele in the UK Biobank by Katherine A. Fawcett, Kijoung Song, Guoqing Qian, Aliki-Eleni Farmaki, Richard Packer, Catherine John, Nick Shrine, Raquel Granell, Sue Ring, Nicholas J. Timpson, Laura M. Yerges-Armstrong, Richard Eastell, Louise V. Wain, Robert A. Scott, Martin D. Tobin, Ian P. Hall

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Anti-TNF therapy for inflammatory bowel disease in patients with neurodegenerative Niemann-Pick disease Type C [version 1; peer review: 2 approved] by David Smith, Nada Al Eisa, Isabelle Williams, Wolfram Haller, Sumeet Pandey, Alicia Chan, Hien Quoc Huynh, Holm H. Uhlig, Ruth Bettels, Gesche Düeker, Chinenye R. Dike, Laurent Peyrin-Biroulet, Thorsten Marquardt, Catherine DeGeeter, Frances M. Platt, Nick Platt, Tobias Schwerd

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Xenon ventilation MRI in difficult asthma: initial experience in a clinical setting by Grace T. Mussell, Helen Marshall, Laurie J. Smith, Alberto M. Biancardi, Paul J.C. Hughes, David J. Capener, Jody Bray, Andrew J. Swift, Smitha Rajaram, Alison M. Condliffe, Guilhem J. Collier, Chris S. Johns, Nick D. Weatherley, Jim M. Wild, Ian Sabroe

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The Effect of Inadequate Initial Empiric Antimicrobial Treatment on Mortality in Critically Ill Patients with Bloodstream Infections: A Multi-Centre Retrospective Cohort Study. by Rachel D Savage, Robert A Fowler, Asgar H Rishu, Sean M Bagshaw, Deborah Cook, Peter Dodek, Richard Hall, Anand Kumar, François Lamontagne, François Lauzier, John Marshall, Claudio M Martin, Lauralyn McIntyre, John Muscedere, Steven Reynolds, Henry T Stelfox, Nick Daneman

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Genomic characterization of sporadic isolates of the dominant clone of Mycobacterium abscessus subspecies massiliense by Rebecca M. Davidson, Jeanne B. Benoit, Sara M. Kammlade, Nabeeh A. Hasan, L. Elaine Epperson, Terry Smith, Sruthi Vasireddy, Barbara A. Brown-Elliott, Jerry A. Nick, Kenneth N. Olivier, Adrian M. Zelazny, Charles L. Daley, Michael Strong, Richard J. Wallace

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Management of Post-transplant Infections in Collaborating Hospitals (MATCH) Programme: a prospective cohort of all transplant recipients at Copenhagen University Hospital—Rigshospi... by Finn Gustafsson, Marie Helleberg, Frederik Viggo Lautrup Esmann, Sadaf Zahid, Kasper Sommerlund Moestrup, Nick Normand, Charlotte Matthews, Henrik Sengeløv, Michael Perch, Nicolai Aagaard Schultz, Søren Schwartz Sørensen, Jesper Melchior Hansen, Vibeke Brix Christensen, Daniel D Murray, J Lundgren, Cornelia Geisler Crone

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Experience of point-of-care HbA1c testing in the English National Health Service Diabetes Prevention Programme: an observational study by Kamlesh Khunti, Emma Barron, Jonathan Valabhji, Michael Sampson, Nicholas J Wareham, Susan Jebb, Shivani Misra, Emma English, W Garry John, Max O Bachmann, Julian Barth, Nick Oliver, K G M M Alberti, Chirag Bakhai, Simon O'Neill, Bob Young, Jenifer Smith

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Clinical covariates that improve the description of high dose methotrexate pharmacokinetics in a diverse population to inform MTXPK.org by Zachary L. Taylor, Tamara P. Miller, Ethan A. Poweleit, Nicholas P. DeGroote, Lauren Pommert, Oluwafunbi Awoniyi, Sarah G. Board, Ngozi Ugboh, Vivek Joshi, Nick Ambrosino, Ashley Chavana, Melanie B. Bernhardt, Eric S. Schafer, Maureen M. O'Brien, Sharon M. Castellino, Laura B. Ramsey

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A systematic analysis of the human immune response to Plasmodium vivax by Florian A. Bach, Diana Muñoz Sandoval, Michalina Mazurczyk, Yrene Themistocleous, Thomas A. Rawlinson, Adam C. Harding, Alison Kemp, Sarah E. Silk, Jordan R. Barrett, Nick J. Edwards, Alasdair Ivens, Julian C. Rayner, Angela M. Minassian, Giorgio Napolitani, Simon J. Draper, Philip J. Spence

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High prevalence of pulmonary tuberculosis among female sex workers, men who have sex with men, and transgender women in Papua New Guinea by Barne Willie, Avi J. Hakim, Steven G. Badman, Damian Weikum, Rebecca Narokobi, Kelsey Coy, Josephine Gabuzzi, Simon Pekon, Samson Gene, Angelyn Amos, Martha Kupul, Parker Hou, Nick M. Dala, David M. Whiley, Johanna Wapling, John M. Kaldor, Andrew J. Vallely, Angela Kelly-Hanku

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Single-dose BNT162b2 vaccine protects against asymptomatic SARS-CoV-2 infection by Nick K Jones, Lucy Rivett, Shaun Seaman, Richard J Samworth, Ben Warne, Chris Workman, Mark Ferris, Jo Wright, Natalie Quinnell, Ashley Shaw, Cambridge COVID-19 Collaboration, Ian G Goodfellow, Paul J Lehner, Rob Howes, Giles Wright, Nicholas J Matheson, Michael P Weekes

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Trypanosome spliced leader RNA for diagnosis of acoziborole treatment outcome in gambiense human African trypanosomiasis: A longitudinal follow-up studyResearch in context by Ipos Ngay Lukusa, Nick Van Reet, Dieudonné Mumba Ngoyi, Erick Mwamba Miaka, Justin Masumu, Pati Patient Pyana, Wilfried Mutombo, Digas Ngolo, Vincent Kobo, Felix Akwaso, Médard Ilunga, Lewis Kaninda, Sylvain Mutanda, Dieudonné Mpoyi Muamba, Olaf Valverde Mordt, Antoine Tarral, Sandra Rembry, Philippe Büscher, Veerle Lejon

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Prehospital recognition and antibiotics for 999 patients with sepsis: protocol for a feasibility study by Chris Moore, Jenna Bulger, Matt Morgan, Timothy Driscoll, Alison Porter, Saiful Islam, Mike Smyth, Gavin Perkins, Bernadette Sewell, Timothy Rainer, Prabath Nanayakkara, Chukwudi Okolie, Susan Allen, Greg Fegan, Jan Davies, Theresa Foster, Nick Francis, Fang Gao Smith, Gemma Ellis, Tracy Shanahan, Robin Howe, Helen Snooks

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Association of Brain Volumes and White Matter Injury With Race, Ethnicity, and Cardiovascular Risk Factors: The Multi‐Ethnic Study of Atherosclerosis by Thomas R. Austin, Ilya M. Nasrallah, Guray Erus, Lisa M. Desiderio, Lin Y. Chen, Philip Greenland, Barbara N. Harding, Timothy M. Hughes, Paul N. Jensen, WT Longstreth, Wendy S. Post, Steven J. Shea, Colleen M. Sitlani, Christos Davatzikos, Mohamad Habes, R. Nick Bryan, Susan R. Heckbert

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Association of High‐Density Lipoprotein‐Cholesterol Versus Apolipoprotein A‐I With Risk of Coronary Heart Disease: The European Prospective Investigation Into Cancer‐Norfolk Prospe... by Julian C. van Capelleveen, Andrea E. Bochem, S. Matthijs Boekholdt, Samia Mora, Ron C. Hoogeveen, Christie M. Ballantyne, Paul M Ridker, Wensheng Sun, Philip J. Barter, Alan R. Tall, Aeilko H. Zwinderman, John J. P. Kastelein, Nick J. Wareham, Kay‐Tee Khaw, G. Kees Hovingh

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Detection of tumor-derived extracellular vesicles in plasma from patients with solid cancer by Silvia R. Vitale, Jean A. Helmijr, Marjolein Gerritsen, Hicret Coban, Lisanne F. van Dessel, Nick Beije, Michelle van der Vlugt-Daane, Paolo Vigneri, Anieta M. Sieuwerts, Natasja Dits, Martin E. van Royen, Guido Jenster, Stefan Sleijfer, Martijn Lolkema, John W. M. Martens, Maurice P. H. M. Jansen

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Optimizing human α-galactosidase for treatment of Fabry disease by William C. Hallows, Kristen Skvorak, Nick Agard, Nikki Kruse, Xiyun Zhang, Yu Zhu, Rachel C. Botham, Chinping Chng, Charu Shukla, Jessica Lao, Mathew Miller, Antoinette Sero, Judy Viduya, Moulay Hicham Alaoui Ismaili, Kerryn McCluskie, Raphael Schiffmann, Adam P. Silverman, Jin-Song Shen, Gjalt W. Huisman

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Self-sampling kits to increase HIV testing among black Africans in the UK: the HAUS mixed-methods study by Maureen Seguin, Catherine Dodds, Esther Mugweni, Lisa McDaid, Paul Flowers, Sonali Wayal, Ella Zomer, Peter Weatherburn, Ibidun Fakoya, Thomas Hartney, Lorraine McDonagh, Rachael Hunter, Ingrid Young, Shabana Khan, Nick Freemantle, Jabulani Chwaula, Memory Sachikonye, Jane Anderson, Surinder Singh, Eleni Nastouli, Greta Rait, Fiona Burns

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Randomised feasibility study of prehospital recognition and antibiotics for emergency patients with sepsis (PhRASe) by Jenna Jones, Susan Allen, Jan Davies, Timothy Driscoll, Gemma Ellis, Greg Fegan, Theresa Foster, Nick Francis, Saiful Islam, Matt Morgan, Prabath W. B. Nanayakkara, Gavin D. Perkins, Alison Porter, Timothy Rainer, Samuel Ricketts, Bernadette Sewell, Tracy Shanahan, Fang Gao Smith, Michael A. Smyth, Helen Snooks, Chris Moore

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Cardiopulmonary, Functional, Cognitive and Mental Health Outcomes Post-COVID-19, Across the Range of Severity of Acute Illness, in a Physically Active, Working-Age Population by Oliver O’Sullivan, David A. Holdsworth, Peter Ladlow, Robert M. Barker-Davies, Rebecca Chamley, Andrew Houston, Samantha May, Dominic Dewson, Daniel Mills, Kayleigh Pierce, James Mitchell, Cheng Xie, Edward Sellon, Jon Naylor, Joseph Mulae, Mark Cranley, Nick P. Talbot, Oliver J. Rider, Edward D. Nicol, Alexander N. Bennett

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