Protein engineering of human properdin by Higgins, J

Type 2 and type 17 effector cells are increased in the duodenal mucosa but not peripheral blood of patients with functional dyspepsia by Grace L. Burns, Grace L. Burns, Grace L. Burns, Jessica K. Bruce, Jessica K. Bruce, Jessica K. Bruce, Kyra Minahan, Kyra Minahan, Kyra Minahan, Andrea Mathe, Andrea Mathe, Thomas Fairlie, Thomas Fairlie, Thomas Fairlie, Raquel Cameron, Raquel Cameron, Raquel Cameron, Crystal Naudin, Crystal Naudin, Prema M. Nair, Prema M. Nair, Prema M. Nair, Michael D. E. Potter, Michael D. E. Potter, Michael D. E. Potter, Mudar Zand Irani, Mudar Zand Irani, Mudar Zand Irani, Steven Bollipo, Steven Bollipo, Robert Foster, Lay T. Gan, Ayesha Shah, Ayesha Shah, Ayesha Shah, Natasha A. Koloski, Natasha A. Koloski, Natasha A. Koloski, Paul S. Foster, Paul S. Foster, Jay C. Horvat, Jay C. Horvat, Martin Veysey, Martin Veysey, Gerald Holtmann, Gerald Holtmann, Gerald Holtmann, Nick Powell, Marjorie M. Walker, Marjorie M. Walker, Marjorie M. Walker, Nicholas J. Talley, Nicholas J. Talley, Nicholas J. Talley, Simon Keely, Simon Keely, Simon Keely

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A Multicenter Evaluation of the Seraph 100 Microbind Affinity Blood Filter for the Treatment of Severe COVID-19 by Stephen A. Chitty, MD, Sarah Mobbs, FNP-BC, Brian S. Rifkin, MD, Steven W. Stogner, MD, Michael S. Lewis, MD, Jaime Betancourt, MD, Jeffrey DellaVolpe, MD, Fadi Abouzahr, MD, Andrew M. Wilhelm, DO, Harold M. Szerlip, MD, Amay Parikh, MD, Robert M. Gaeta, DO, Ian Rivera, MD, Caroline Park, MD, MPH, Benjamin Levi, MD, George L. Anesi, MD, MSCE, MBE, Karl C. Alcover, PhD, Thomas B. Arnold, BA, Jeffrey T. Howard, PhD, Kumar Sharma, MD, Kathleen P. Pratt, PhD, Ian J. Stewart, MD, Kevin K. Chung, MD, for the PURIFY Investigators, Amay Parikh, Sarah Guyler, Harold Szerlip, Giselle Carino, Tanqunisha Coleman, Robert J. Walter, Mai Nguyen, Robert Gaeta, Ian M. Rivera, Ferdinand Bacomo, Sean C. Reilly, Susan D. Rogers, Delia Marshall, Melba Francis, Sholanda Henderson, Bob Ward, Keith McCrea, Erdie de Peralta, Lakhmir S. Chawla, Andrea Worsham, Michael Benjamin, Brian Rifkin, Steven Stogner, Steve Farrell, Karen Brooks, Maria Voelkel, Sophie Haralson, Marianne Spevak, Daniell Clark, Laura Osgood, Qianru Wu, Kevin Grant, Rittal Mehta, Jeffrey Dellavolpe, Fadi Abouzahr, Mohammed Ahmed, Ginger Dowell, Stephen Amerson, Stephen Chitty, Srah Mobbs, Gwen Gratto-Cox, Christy Jordan, George Peoples, Dan Hargrove, Karen Arrington, Lauren Zahra, Jessica Raley, Katie Lyon, Rachel Macomber, Ashlee Richie, Tineka Brown, Laura Richie, Susan Hargrove, Emily Scribe, Steven White, Kevin Chung, Ian Stewart, Kathleen Pratt, Karl Alcover, Thomas B. Arnold, Lauren Walker, Amy Laczek, Breandan Sullivan, Nick Naughton, Sabrina Espinoza, Vikhyat Bebarta, Adit Ginde, Anip Bansal, Ilona Dewald, Isidro Susano Basilio, Andrew Wilhelm, Delia Owens, George L. Anesi, Kumar Sharma, Subrata Debnath, Sean P. Barnett, Nicholas S. Niazi, Jeffrey Howard, Benjamin Levi, Caroline Park, Tamim Hamdi, Peiman Lahsaei, Nilum Rajora, Christopher Choi, Andriy I Batchinsky, Michael Lewis, Jaime Betancourt, Nancy Mohler, Natalia Dudek, Jasmine Bagnas, James Oliver, Stephen Olson, Jenny Nguyen

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In Vitro Induction of Endothelial Apoptosis of the Post-Hypoxic Blood-Brain Barrier by Isoflurane but Not by Sevoflurane and Midazolam. by Michael S Dittmar, Walter Petermichl, Regina Lindner, Barbara Sinner, Bernhard M Graf, Felix Schlachetzki, Michael Gruber

“…Administration of high concentrations of isoflurane in experimental settings may have negative effects on the blood-brain barrier.…”
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Repeat controlled human malaria infection of healthy UK adults with blood-stage Plasmodium falciparum: Safety and parasite growth dynamics by Jo Salkeld, Jo Salkeld, Yrene Themistocleous, Jordan R. Barrett, Jordan R. Barrett, Celia H. Mitton, Thomas A. Rawlinson, Ruth O. Payne, Mimi M. Hou, Mimi M. Hou, Baktash Khozoee, Nick J. Edwards, Carolyn M. Nielsen, Carolyn M. Nielsen, Diana Muñoz Sandoval, Florian A. Bach, Wiebke Nahrendorf, Raquel Lopez Ramon, Megan Baker, Fernando Ramos-Lopez, Pedro M. Folegatti, Doris Quinkert, Doris Quinkert, Katherine J. Ellis, Ian D. Poulton, Alison M. Lawrie, Jee-Sun Cho, Jee-Sun Cho, Fay L. Nugent, Philip J. Spence, Philip J. Spence, Sarah E. Silk, Sarah E. Silk, Simon J. Draper, Simon J. Draper, Angela M. Minassian, Angela M. Minassian

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Juniperus Communis Extract Exerts Antitumor Effects in Human Glioblastomas Through Blood-Brain Barrier by Nu-Man Tsai, Kai-Fu Chang, Jun-Cheng Wang

“…Flow cytometry analysis, the terminal deoxynucleotidyl transferase-mediated nick end labeling (TUNEL) test, and western blotting were performed to identify the apoptotic pathway. …”
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Sources of pre-analytical variations in yield of DNA extracted from blood samples: analysis of 50,000 DNA samples in EPIC. by Elodie Caboux, Christophe Lallemand, Gilles Ferro, Bertrand Hémon, Maimuna Mendy, Carine Biessy, Matt Sims, Nick Wareham, Abigail Britten, Anne Boland, Amy Hutchinson, Afshan Siddiq, Paolo Vineis, Elio Riboli, Isabelle Romieu, Sabina Rinaldi, Marc J Gunter, Petra H M Peeters, Yvonne T van der Schouw, Ruth Travis, H Bas Bueno-de-Mesquita, Federico Canzian, Maria-José Sánchez, Guri Skeie, Karina Standahl Olsen, Eiliv Lund, Roberto Bilbao, Núria Sala, Aurelio Barricarte, Domenico Palli, Carmen Navarro, Salvatore Panico, Maria Luisa Redondo, Silvia Polidoro, Laure Dossus, Marie Christine Boutron-Ruault, Françoise Clavel-Chapelon, Antonia Trichopoulou, Dimitrios Trichopoulos, Pagona Lagiou, Heiner Boeing, Eva Fisher, Rosario Tumino, Claudia Agnoli, Pierre Hainaut

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Cluster randomised controlled trial of a theory-based multiple behaviour change intervention aimed at healthcare professionals to improve their management of type 2 diabetes in pri... by Justin Presseau, Joan Mackintosh, Gillian Hawthorne, Jill J. Francis, Marie Johnston, Jeremy M. Grimshaw, Nick Steen, Tom Coulthard, Heather Brown, Eileen Kaner, Marko Elovainio, Falko F. Sniehotta

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Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk by Warren, Helen R, Evangelou, Evangelos, Cabrera, Claudia P, Gao, He, Ren, Meixia, Mifsud, Borbala, Ntalla, Ioanna, Surendran, Praveen, Liu, Chunyu, Cook, James P, Kraja, Aldi T, Drenos, Fotios, Loh, Marie, Verweij, Niek, Marten, Jonathan, Karaman, Ibrahim, Lepe, Marcelo P Segura, O'Reilly, Paul F, Knight, Joanne, Snieder, Harold, Kato, Norihiro, He, Jiang, Tai, E Shyong, Said, M Abdullah, Porteous, David, Alver, Maris, Poulter, Neil, Farrall, Martin, Gansevoort, Ron T, Padmanabhan, Sandosh, Mägi, Reedik, Stanton, Alice, Connell, John, Bakker, Stephan J L, Metspalu, Andres, Shields, Denis C, Thom, Simon, Brown, Morris, Sever, Peter, Esko, Tõnu, Hayward, Caroline, van der Harst, Pim, Saleheen, Danish, Chowdhury, Rajiv, Chasman, Daniel I, Chakravarti, Aravinda, Newton-Cheh, Christopher, Lindgren, Cecilia M, Levy, Daniel, Kooner, Jaspal S, Keavney, Bernard, Tomaszewski, Maciej, Samani, Nilesh J, Howson, Joanna M M, Tobin, Martin D, Munroe, Patricia B, Ehret, Georg B, Wain, Louise V, Wain, Louise V, Vaez, Ahmad, Jansen, Rick, Joehanes, Roby, van der Most, Peter J, Erzurumluoglu, A Mesut, O'Reilly, Paul, Cabrera, Claudia P, Warren, Helen R, Rose, Lynda M, Verwoert, Germaine C, Hottenga, Jouke-Jan, Strawbridge, Rona J, Esko, Tonu, Arking, Dan E, Hwang, Shih-Jen, Guo, Xiuqing, Kutalik, Zoltan, Trompet, Stella, Shrine, Nick, Teumer, Alexander, Ried, Janina S, Bis, Joshua C, Smith, Albert V, Amin, Najaf, Nolte, Ilja M, Lyytikäinen, Leo-Pekka, Mahajan, Anubha, Wareham, Nicholas J, Hofer, Edith, Joshi, Peter K, Kristiansson, Kati, Traglia, Michela, Havulinna, Aki S, Goel, Anuj, Nalls, Mike A, Sõber, Siim, Vuckovic, Dragana, Luan, Jian'an, M, Fabiola Del Greco, Ayers, Kristin L, Marrugat, Jaume, Ruggiero, Daniela, Lopez, Lorna M, Niiranen, Teemu, Enroth, Stefan, Jackson, Anne U, Nelson, Christopher P, Huffman, Jennifer E, Zhang, Weihua, Marten, Jonathan, Gandin, Ilaria, Harris, Sarah E, Zemonik, Tatijana, Lu, Yingchang, Evangelou, Evangelos, Shah, Nabi, de Borst, Martin H, Mangino, Massimo, Prins, Bram P, Campbell, Archie, Li-Gao, Ruifang, Chauhan, Ganesh, Oldmeadow, Christopher, Abecasis, Gonçalo, Abedi, Maryam, Barbieri, Caterina M, Barnes, Michael R, Batini, Chiara, Blake, Tineka, Boehnke, Michael, Bottinger, Erwin P, Braund, Peter S, Brown, Morris, Brumat, Marco, Campbell, Harry, Chambers, John Campbell, Cocca, Massimiliano, Collins, Francis, Connell, John, Cordell, Heather J, Damman, Jeffrey J, Davies, Gail, de Geus, Eco J, de Mutsert, Renée, Deelen, Joris, Demirkale, Yusuf, Doney, Alex S F, Dörr, Marcus, Farrall, Martin, Ferreira, Teresa, Frånberg, Mattias, Giedraitis, Vilmantas, Gao, He, Gieger, Christian, Giulianini, Franco, Gow, Alan J, Hamsten, Anders, Harris, Tamara B, Hofman, Albert, Holliday, Elizabeth G, Jarvelin, Marjo-Riitta, Johansson, Åsa, Johnson, Andrew D, Jousilahti, Pekka, Jula, Antti, Kähönen, Mika, Kathiresan, Sekar, Khaw, Kay-Tee, Kolcic, Ivana, Koskinen, Seppo, Langenberg, Claudia, Larson, Marty, Launer, Lenore J, Lehne, Benjamin, Liewald, David C M, Lin, Li, Lind, Lars, Mach, François, Mamasoula, Chrysovalanto, Menni, Cristina, Mifsud, Borbala, Milaneschi, Yuri, Morgan, Anna, Morris, Andrew D, Morrison, Alanna C, Munson, Peter J, Nandakumar, Priyanka, Nguyen, Quang Tri, Nutile, Teresa, Oldehinkel, Albertine J, Oostra, Ben A, Org, Elin, Padmanabhan, Sandosh, Palotie, Aarno, Paré, Guillaume, Pattie, Alison, Penninx, Brenda W J H, Poulter, Neil, Pramstaller, Peter P, Raitakari, Olli T, Ren, Meixia, Rice, Kenneth, Ridker, Paul M, Riese, Harriëtte, Ripatti, Samuli, Robino, Antonietta, Rotter, Jerome I, Rudan, Igor, Saba, Yasaman, Pierre, Aude Saint, Sala, Cinzia F, Sarin, Antti-Pekka, Schmidt, Reinhold, Scott, Rodney, Seelen, Marc A, Shields, Denis C, Siscovick, David, Sorice, Rossella, Stanton, Alice, Stott, David J, Sundström, Johan, Swertz, Morris, Taylor, Kent D, Thom, Simon, Tzoulaki, Ioanna, Tzourio, Christophe, Uitterlinden, André G, Völker, Uwe, Vollenweider, Peter, Wild, Sarah, Willemsen, Gonneke, Hartman, Catharina A, Wright, Alan F, Yao, Jie, Thériault, Sébastien, Conen, David, John, Attia, Sever, Peter, Debette, Stéphanie, Mook-Kanamori, Dennis O, Zeggini, Eleftheria, Spector, Tim D, van der Harst, Pim, Palmer, Colin N A, Vergnaud, Anne-Claire, Loos, Ruth J F, Polasek, Ozren, Starr, John M, Girotto, Giorgia, Hayward, Caroline, Kooner, Jaspal S, Lindgren, Cecila M, Vitart, Veronique, Samani, Nilesh J, Tuomilehto, Jaakko, Watkins, Hugh, Gyllensten, Ulf, Knekt, Paul, Deary, Ian J, Ciullo, Marina, Elosua, Roberto, Keavney, Bernard D, Hicks, Andrew A, Scott, Robert A, Gasparini, Paolo, Laan, Maris, Liu, YongMei, Salomaa, Veikko, Toniolo, Daniela, Perola, Markus, Wilson, James F, Schmidt, Helena, Zhao, Jing Hua, Lehtimäki, Terho, van Duijn, Cornelia M, Gudnason, Vilmundur, Psaty, Bruce M, Peters, Annette, Rettig, Rainer, James, Alan, Jukema, J Wouter, Strachan, David P, Palmas, Walter, Metspalu, Andres, Ingelsson, Erik, Boomsma, Dorret I, Franco, Oscar H, Bochud, Murielle, Newton-Cheh, Christopher, Munroe, Patricia B, Elliott, Paul, Chasman, Daniel I, Chakravarti, Aravinda, Knight, Joanne, Morris, Andrew P, Levy, Daniel, Tobin, Martin D, Snieder, Harold, Caulfield, Mark J, Ehret, Georg B, Barnes, Michael R, Tzoulaki, Ioanna, Caulfield, Mark J, Elliott, Paul

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Transcutaneous electrical nerve stimulation regulates organ blood flow and apoptosis during controlled hypotension in dogs. by Lele Zhang, Xiaomei Shao, Chuanlong Zhou, Xiaoqing Guo, Ling Jin, Linli Lian, Xiaojing Yu, Zhenhua Dong, Yadi Mo, Jianqiao Fang

“…By the end of MAP restoration, gastric blood flow in the CH group was still low. At 72 h after applying CH, terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL)-positive cells in stomach and kidney tissue from the CH group were significantly increased compared with those in the GA group (P<0.05). …”
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Interleukin-10 attenuates impairment of the blood-brain barrier in a severe acute pancreatitis rat model by Ronggui Lin, Fei Chen, Shi Wen, Tianhong Teng, Yu Pan, Heguang Huang

“…Abstract Background Impairment of the blood-brain barrier (BBB) in severe acute pancreatitis (SAP) could result in life-threatening pancreatic encephalopathy. …”
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Study protocol: ASCRIBED: the impact of Acute SystematiC inflammation upon cerebRospinal fluId and blood BiomarkErs of brain inflammation and injury in dementia: a study in acute h... by Nick Leavey, Simon P. Hammond, Lee Shepstone, Jane Cross, Henrik Zetterberg, Colm Cunningham, Alasdair MacLullich, Leiv Otto Watne, Anne Marie Minihane, Clive Ballard, Anne-Brita Knapskog, Roanna Hall, Gregory Howard, Matt Hammond, Chris Fox

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A Three-Year Longitudinal Study Comparing Bone Mass, Density, and Geometry Measured by DXA, pQCT, and Bone Turnover Markers in Children with PKU Taking L-Amino Acid or Glycomacrope... by Anne Daly, Wolfgang Högler, Nicola Crabtree, Nick Shaw, Sharon Evans, Alex Pinto, Richard Jackson, Catherine Ashmore, Júlio C. Rocha, Boyd J. Strauss, Gisela Wilcox, William D. Fraser, Jonathan C. Y. Tang, Anita MacDonald

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Tolerogenic dendritic cells in type 1 diabetes: no longer a concept by Nick Giannoukakis, Nick Giannoukakis

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Methylene Blue Reduces Neuronal Apoptosis and Improves Blood-Brain Barrier Integrity After Traumatic Brain Injury by Jun Shen, Jun Shen, Jun Shen, Jun Shen, Wenqiang Xin, Wenqiang Xin, Wenqiang Xin, Qifeng Li, Qifeng Li, Qifeng Li, Yalong Gao, Yalong Gao, Yalong Gao, Lili Yuan, Jianning Zhang, Jianning Zhang, Jianning Zhang

“…The terminal deoxynucleotidyl transferase-dUTP nick end labeling (TUNEL) assay was used to assess neuronal apoptosis in vitro. …”
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Diathermy and bone sawing are high aerosol yield procedures: observations from a sterile laminar flow environment by Victoria Hamilton, Sadiyah Sheikh, Alicja Szczepanska, Nick Maskell, Fergus Hamilton, Jonathan P. Reid, Bryan R. Bzdek, James R. D. Murray

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Longitudinal measurement of serum neurofilament light in presymptomatic familial Alzheimer’s disease by Philip S. J. Weston, Teresa Poole, Antoinette O’Connor, Amanda Heslegrave, Natalie S. Ryan, Yuying Liang, Ronald Druyeh, Simon Mead, Kaj Blennow, Jonathan M. Schott, Chris Frost, Henrik Zetterberg, Nick C. Fox

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Therapeutic Effects of Umbilical Cord Blood Derived Mesenchymal Stem Cell-Conditioned Medium on Pulmonary Arterial Hypertension in Rats by Jae Chul Lee, Choong Ik Cha, Dong-Sik Kim, Soo Young Choe

“…Background: Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) may have multiple therapeutic applications for cell based therapy including the treatment of pulmonary artery hypertension (PAH). …”
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Analyses of human vaccine-specific circulating and bone marrow-resident B cell populations reveal benefit of delayed vaccine booster dosing with blood-stage malaria antigens by Jordan R. Barrett, Jordan R. Barrett, Sarah E. Silk, Sarah E. Silk, Catherine G. Mkindi, Karolina M. Kwiatkowska, Mimi M. Hou, Mimi M. Hou, Amelia M. Lias, Amelia M. Lias, Wilmina F. Kalinga, Ivanny M. Mtaka, Kirsty McHugh, Kirsty McHugh, Martino Bardelli, Martino Bardelli, Hannah Davies, Hannah Davies, Lloyd D. W. King, Lloyd D. W. King, Nick J. Edwards, Virander S. Chauhan, Paushali Mukherjee, Stella Rwezaula, Chetan E. Chitnis, Ally I. Olotu, Angela M. Minassian, Angela M. Minassian, Simon J. Draper, Simon J. Draper, Carolyn M. Nielsen, Carolyn M. Nielsen

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Hyperglycemia disrupted the integrity of the blood‐brain barrier following diffuse axonal injury through the sEH/NF‐κB pathway by Xing Wei, Zhiguo Xing, Tingqin Huang, Ming Zhang, Jinning Song, Yonglin Zhao

“…Cell apoptosis was examined by terminal deoxynucleotidyl transferase nick‐end labeling (TUNEL) assay. The permeability of blood‐brain barrier (BBB) was assessed by expression of tight junction proteins, leakage of Evans blue and brain water content. …”
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