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  1. 661

    Design and Mechanism of Action of a New Prototype of Combi-Molecule “Programed” to Release Bioactive Species at a pH Range Akin to That of the Tumor Microenvironment by Anne-Laure Larroque-Lombard, Etienne Chatelut, Jean-Pierre Delord, Diane-Charlotte Imbs, Philippe Rochaix, Bertrand Jean-Claude, Ben Allal

    Published 2021-02-01
    “…We report a novel approach that seeks to design a “combi-molecule” to behave as an alkylating agent on its own and to undergo acid-catalyzed conversion to two bioactive species at a pH range akin to that of a tumor microenvironment: an AL530 prototype was synthesized and we studied its ability to release a chlorambucil analogue (CBL-A) plus a potent mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) inhibitor (PD98059) at different pHs in buffered solutions, plasma and tumors. …”
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    Bentuk dan Jenis Komunikasi Bernada Ujaran Kebencian (Studi Kasus Terhadap Postingan dan Komentar Pada Akun Instagram @Nyinyir_Update_Official) by Agus Mulyanto, Aneu Nuraeni, Siska Mareti Maulani

    Published 2023-06-01
    “…Data diperoleh dari komentar pada postingan akun instagram @nyinyir_update_official yang mengandung ujaran kebencian. …”
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  5. 665

    Biomechanical Evaluation of 4th Generation Minimally Invasive Distal First Metatarsal Osteotomy-Akin Osteotomy Technique on First Ray Articular Contact Properties by Sudheer C. Reddy MD, Oliver Schipper MD, Jihui Li Ph.D

    Published 2023-12-01
    “…The Akin can lead to increased contact forces at the MTP joint with 100% translation of the capital fragment.…”
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    11 EYLÜL SONRASINDA HOLLYWOOD'DA MİTOLOJİK YAKLAŞIMLAR VE ARKETİPLER by Okan Ormanlı

    Published 2015-08-01
    “…Çalışmada, yukarıdaki gerçekliğin bir izdüşümü olarak 11 Eylül sonrasında Hollywood'da üretilen büyük bütçeli ve geniş kitlelere ulaşan çizgi roman uyarlamaları ve mitoloji kökenli filmler incelenecek ve bu filmlerdeki 11 Eylül yansımaları araştırılacaktır. …”
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