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Design and Mechanism of Action of a New Prototype of Combi-Molecule “Programed” to Release Bioactive Species at a pH Range Akin to That of the Tumor Microenvironment
Published 2021-02-01“…We report a novel approach that seeks to design a “combi-molecule” to behave as an alkylating agent on its own and to undergo acid-catalyzed conversion to two bioactive species at a pH range akin to that of a tumor microenvironment: an AL530 prototype was synthesized and we studied its ability to release a chlorambucil analogue (CBL-A) plus a potent mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) inhibitor (PD98059) at different pHs in buffered solutions, plasma and tumors. …”
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lncRNA ELFN1-AS1 promotes proliferation, migration and invasion and suppresses apoptosis in colorectal cancer cells by enhancing G6PD activity
Published 2023-02-01Subjects: “…lncRNA <italic>ELFN1-AS1</italic>…”
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Bentuk dan Jenis Komunikasi Bernada Ujaran Kebencian (Studi Kasus Terhadap Postingan dan Komentar Pada Akun Instagram @Nyinyir_Update_Official)
Published 2023-06-01“…Data diperoleh dari komentar pada postingan akun instagram @nyinyir_update_official yang mengandung ujaran kebencian. …”
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Biomechanical Evaluation of 4th Generation Minimally Invasive Distal First Metatarsal Osteotomy-Akin Osteotomy Technique on First Ray Articular Contact Properties
Published 2023-12-01“…The Akin can lead to increased contact forces at the MTP joint with 100% translation of the capital fragment.…”
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11 EYLÜL SONRASINDA HOLLYWOOD'DA MİTOLOJİK YAKLAŞIMLAR VE ARKETİPLER
Published 2015-08-01“…Çalışmada, yukarıdaki gerçekliğin bir izdüşümü olarak 11 Eylül sonrasında Hollywood'da üretilen büyük bütçeli ve geniş kitlelere ulaşan çizgi roman uyarlamaları ve mitoloji kökenli filmler incelenecek ve bu filmlerdeki 11 Eylül yansımaları araştırılacaktır. …”
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Geomateryallerin Böhme aşındırma deney cihazı kullanılarak üç boyutlu görüntülenmesi
Published 2020-06-01Get full text
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Investor Reaction to Mandatory Offers on the Warsaw Stock Exchange
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GAİUS GRACCHUS’UN REFORM PROGRAMININ GENEL KARAKTERİ VE ROMA CUMHURİYETİ’NİN SOSYO-POLİTİK SINIRLARI
Published 2022-11-01Get full text
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The Relationship of Musculoskeletal System Disorders with Sleep Quality among Office Workers
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Beypazarı İlçesi’nde jeomorfolojik birimler ile arazi kullanım ilişkisi
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Atatürk'ün ekonomi politikası: Ulusal bağımsızlık ve ekonomik bağımsızlık
Published 1998-11-01Get full text
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