An NKX2-1GFP and TP63tdTomato dual fluorescent reporter for the investigation of human lung basal cell biology by Goh, Kim Jee, Tan, Ee Kim, Lu, Hao, Roy, Sudipto, Dunn, Norris Ray

“…To address this outstanding question, in the last several years differentiation protocols incorporating human pluripotent stem cells (hPSC) have been developed to produce human basal cells in vitro with varying efficiencies. To facilitate this endeavour, we introduced tdTomato into the human TP63 gene, whose expression specifically labels basal cells, in the background of a previously described hPSC line harbouring an NKX2-1GFP reporter allele. …”
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Are choriocapillaris flow void features robust to diurnal variations? A swept-source optical coherence tomography angiography (OCTA) study by Lin, Emily, Ke, Mengyuan, Tan, Bingyao, Yao, Xinwen, Wong, Damon, Ong, Lirong, Schmetterer, Leopold, Chua, Jacqueline

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Risk prediction models to guide antibiotic prescribing : a study on adult patients with uncomplicated upper respiratory tract infections in an emergency department by Wong, Joshua Guoxian, Aung, Aung-Hein, Lian, Weixiang, Lye, David Chien, Ooi, Chee-Kheong, Chow, Angela

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Three essays on corporate finance by Zou, Kunru

“…The connections to top political leaders (i.e., Central Committee of the Communist Party of China) make local politicians engage more in rent-seeking by selling state-owned enterprises (SOEs) at substantial discounts. …”
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Persistent elevation of intrathecal pro-inflammatory cytokines leads to multiple sclerosis-like cortical demyelination and neurodegeneration by James, Rachel E., Schalks, Renee, Browne, Eleanor, Eleftheriadou, Ioanna, Munoz, Carmen Picon, Mazarakis, Nicholas D., Reynolds, Richard

“…Subpial demyelination was seen underlying these infiltrates, which was partly dependant on prior myelin oligodendrocyte glycoprotein (MOG) immunisation. …”
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Deregulated expression of a longevity gene, Klotho, in the C9orf72 deletion mice with impaired synaptic plasticity and adult hippocampal neurogenesis by Ho, Wan Yun, Navakkode, Sheeja, Liu, Fujia, Soong, Tuck Wah, Ling, Shuo-Chien

“…Taken together, our data suggest that C9ORF72 is required for synaptic plasticity and adult neurogenesis in the hippocampus and Klotho deregulations may be part of C9ORF72-mediated toxicity.…”
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Cyclin D1 integrates G9a-mediated histone methylation by Li, Zhiping, Jiao, Xuanmao, Di Sante, Gabriele, Ertel, Adam, Casimiro, Mathew C., Wang, Min, Katiyar, Sanjay, Ju, Xiaoming, Klopfenstein, D. V., Tozeren, Aydin, Dampier, William, Chepelev, Iouri, Jeltsch, Albert, Pestell, Richard George

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Experimental parameters defining ultra-low biomass bioaerosol analysis by Luhung, Irvan, Uchida, Akira, LiLim, Serene Boon Yuean, Gaultier, Nicolas Eugene, Kee, Carmon, Lau, Kenny Jia Xu, Gusareva, Elena S., Heinle, Cassie Elizabeth, Wong, Anthony, Premkrishnan, Balakrishnan N. V., Purbojati, Rikky Wenang, Acerbi, Enzo, Kim, Hie Lim, Junqueira, Ana Carolina M., Longford, Sharon Rae, Lohar, Sachin R., Yap, Zhei Hwee, Panicker, Deepa, Koh, Yanqing, Kushwaha, Kavita K., Ang, Poh Nee, Putra, Alexander, Drautz-Moses, Daniela Isabel, Schuster, Stephan Christoph

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The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice by Barretto, Sharon Ann, Lasserre, Frederic, Huillet, Marine, Régnier, Marion, Polizzi, Arnaud, Lippi, Yannick, Fougerat, Anne, Person, Elodie, Bruel, Sandrine, Bétoulières, Colette, Naylies, Claire, Lukowicz, Céline, Smati, Sarra, Guzylack, Laurence, Olier, Maïwenn, Théodorou, Vassilia, Mselli-Lakhal, Laila, Zalko, Daniel, Wahli, Walter, Loiseau, Nicolas, Gamet-Payrastre, Laurence, Guillou, Hervé, Ellero-Simatos, Sandrine

“…Pathway enrichment analysis suggested that microbiota–PXR interaction controlled fatty acid and xenobiotic metabolism. We confirmed that antibiotic treatment reduced liver triglyceride content and hampered xenobiotic metabolism in the liver from Pxr+/+ but not Pxr-/- male mice. …”
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Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood : an EWAS in multi-ethnic Asian individuals by Chen, Yuqing, Kassam, Irfahan, Lau, Suk Hiang, Kooner, Jaspal S., Wilson, Rory, Peters, Annette, Winkelmann, Juliane, Chambers, John C., Chow, Vincent T., Khor, Chiea Chuen, Van Dam, Rob M., Teo, Yik-Ying, Loh, Marie, Sim, Xueling

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Role of anterior segment optical coherence tomography angiography in the assessment of acute chemical ocular injury : a pilot animal model study by Tey, Kai Yuan, Gan, Jinyuan, Foo, Valencia, Tan, Bingyao, Ke, Meng Yuan, Schmetterer, Leopold, Mehta, Jodhbir S., Ang, Marcus

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Competitive ELISA for a serologic test to detect dengue serotype-specific anti-NS1 IgGs using high-affinity UB-DNA aptamers by Matsunaga, Ken-Ichiro, Kimoto, Michiko, Lim, Vanessa Weixun, Thein, Tun-Linn, Vasoo, Shawn, Leo, Yee Sin, Sun, William, Hirao, Ichiro

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Functional metagenomic analysis of quorum sensing signaling in a nitrifying community by Tan, Chuan Hao, Yeo, Yee Phan, Muhammad Hafiz Ismail, Ng, Noele Kai Jing, Subramoni, Sujatha, Taj, Shireen, Tay, Martin, Chao, Xie, Kjelleberg, Staffan, Rice, Scott A.

“…Of those genes, two represented a cognate pair of luxIR genes belonging to a Nitrospira spp. and those genes were demonstrated to be functionally active. …”
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Genome wide study of tardive dyskinesia in schizophrenia by Lim, Keane, Lam, Max, Zai, Clement, Tay, Jenny, Karlsson, Nina, Deshpande, Smita N., Thelma, B. K., Ozaki, Norio, Inada, Toshiya, Sim, Kang, Chong, Siow-Ann, Lencz, Todd, Liu, Jianjun, Lee, Jimmy

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Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy by Wu, Kan Xing, Yeo, Natalie Jia Ying, Ng, Chun Yi, Chioh, Florence Wen Jing, Fan, Qiao, Tian, Xianfeng, Yang, Binxia, Narayanan, Gunaseelan, Tay, Hui Min, Hou, Han Wei, Dunn, Norris Ray, Su, Xinyi, Cheung, Gemmy Chui Ming, Cheung, Christine

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A H₂O₂-activatable nanoprobe for diagnosing interstitial cystitis and liver ischemia-reperfusion injury via multispectral optoacoustic tomography and NIR-II fluorescent imaging by Chen, Junjie, Chen, Longqi, Wu, Yinglong, Fang, Yichang, Zeng, Fang, Wu, Shuizhu, Zhao, Yanli

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Promotion of knowledge transfer and retention in year 2 medical students using an online training exercise by Rosby, Lucy Victoria, Schmidt, Henk G., Tan, Gerald Jit Shen, Low-Beer, Naomi, Mamede, Silvia, Zwaan, Laura, Rotgans, Jerome Ingmar

“…Subsequently, they were shown the four trained-for cases again as well as different representations of the same conditions varying in the number of common elements and asked to provide a diagnosis, to test for near-transfer (four cases) and far-transfer (four cases) of knowledge. …”
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Opto-electrical bimodal recording of neural activity in awake head-restrained mice by Cobar, Luis Fernando, Kashef, Alireza, Bose, Krishnashish, Tashiro, Ayumu

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Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response by Zhu, Lei, van der Pluijm, Rob W., Kucharski, Michal, Nayak, Sourav, Tripathi, Jaishree, White, Nicholas J., Day, Nicholas P. J., Faiz, Abul, Phyo, Aung Pyae, Amaratunga, Chanaki, Lek, Dysoley, Ashley, Elizabeth A., Nosten, François, Smithuis, Frank, Ginsburg, Hagai, von Seidlein, Lorenz, Lin, Khin, Imwong, Mallika, Chotivanich, Kesinee, Mayxay, Mayfong, Dhorda, Mehul, Nguyen, Hoang Chau, Nguyen, Thuy Nhien Thanh, Miotto, Olivo, Newton, Paul N., Jittamala, Podjanee, Tripura, Rupam, Pukrittayakamee, Sasithon, Peto, Thomas J., Hien, Tran Tinh, Dondorp, Arjen M., Bozdech, Zbynek

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Structural and biochemical mechanisms of NLRP1 inhibition by DPP9 by Huang, Menghang, Zhang, Xiaoxiao, Toh, Gee Ann, Gong, Qin, Wang, Jia, Han, Zhifu, Wu, Bin, Zhong, Franklin, Chai, Jijie

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