A five-safes approach to a secure and scalable genomics data repository by Chih Chuan Shih, Jieqi Chen, Ai Shan Lee, Nicolas Bertin, Maxime Hebrard, Chiea Chuen Khor, Zheng Li, Joanna Hui Juan Tan, Wee Yang Meah, Su Qin Peh, Shi Qi Mok, Kar Seng Sim, Jianjun Liu, Ling Wang, Eleanor Wong, Jingmei Li, Aung Tin, Ching-Yu Cheng, Chew-Kiat Heng, Jian-Min Yuan, Woon-Puay Koh, Seang Mei Saw, Yechiel Friedlander, Xueling Sim, Jin Fang Chai, Yap Seng Chong, Sonia Davila, Liuh Ling Goh, Eng Sing Lee, Tien Yin Wong, Neerja Karnani, Khai Pang Leong, Khung Keong Yeo, John C. Chambers, Su Chi Lim, Rick Siow Mong Goh, Patrick Tan, Rajkumar Dorajoo

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Characterization of the human myelin oligodendrocyte glycoprotein antibody response in demyelination by Fiona Tea, Joseph A. Lopez, Sudarshini Ramanathan, Vera Merheb, Fiona X. Z. Lee, Alicia Zou, Deepti Pilli, Ellis Patrick, Anneke van der Walt, Mastura Monif, Esther M. Tantsis, Eppie M. Yiu, Steve Vucic, Andrew P. D. Henderson, Anthony Fok, Clare L. Fraser, Jeanette Lechner-Scott, Stephen W. Reddel, Simon Broadley, Michael H. Barnett, David A. Brown, Jan D. Lunemann, Russell C. Dale, Fabienne Brilot, the Australasian and New Zealand MOG Study Group

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Population genomic analyses reveal high diversity, recombination and nosocomial transmission among Candida glabrata (Nakaseomyces glabrata) isolates causing invasive infections by Wang, Yue, Xu, Jianping, Abid, Fatma Ben, Salah, Husam, Sundararaju, Sathyavathi, Al Ismail, Khalil, Wang, Kun, Matthew, Lisa Sara, Taj-Aldeen, Saad, Ibrahim, Emad B., Tang, Patrick, Perez-Lopez, Andres, Tsui, Clement K. M.

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Duration of carbapenemase-producing enterobacteriaceae carriage in hospital patients by Mo, Yin, Hernandez-Koutoucheva, Anastasia, Musicha, Patrick, Bertrand, Denis, Lye, David C., Ng, Oon Tek, Fenlon, Shannon N., Chen, Swaine L., Ling, Moi Lin, Tang, Wen Ying, Barkham, Timothy, Nagarajan, Niranjan, Cooper, Ben S., Marimuthu, Kalisvar

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Deep Learning Algorithm for Automated Cardiac Murmur Detection via a Digital Stethoscope Platform by John S. Chorba, Avi M. Shapiro, Le Le, John Maidens, John Prince, Steve Pham, Mia M. Kanzawa, Daniel N. Barbosa, Caroline Currie, Catherine Brooks, Brent E. White, Anna Huskin, Jason Paek, Jack Geocaris, Dinatu Elnathan, Ria Ronquillo, Roy Kim, Zenith H. Alam, Vaikom S. Mahadevan, Sophie G. Fuller, Grant W. Stalker, Sara A. Bravo, Dina Jean, John J. Lee, Medeona Gjergjindreaj, Christos G. Mihos, Steven T. Forman, Subramaniam Venkatraman, Patrick M. McCarthy, James D. Thomas

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The role of tyrosine hydroxylase-dopamine pathway in Parkinson's disease pathogenesis by Zhou, Zhi Dong, Saw, Wuan Ting, Ho, Patrick Ghim Hoe, Zhang, Zhi Wei, Zeng, Li, Chang, Ya Yin, Sun, Alfred Xu Yang, Ma, Dong Rui, Wang, Hong Yan, Zhou, Lei, Lim, Kah-Leong, Tan, Eng-King

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Updated efficacy of avelumab in patients with previously treated metastatic Merkel cell carcinoma after ≥1 year of follow-up: JAVELIN Merkel 200, a phase 2 clinical trial by Howard L. Kaufman, Jeffery S. Russell, Omid Hamid, Shailender Bhatia, Patrick Terheyden, Sandra P. D’Angelo, Kent C. Shih, Céleste Lebbé, Michele Milella, Isaac Brownell, Karl D. Lewis, Jochen H. Lorch, Anja von Heydebreck, Meliessa Hennessy, Paul Nghiem

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KCNQ2 R144 variants cause neurodevelopmental disability with language impairment and autistic features without neonatal seizures through a gain-of-function mechanism by Francesco Miceli, Charissa Millevert, Maria Virginia Soldovieri, Ilaria Mosca, Paolo Ambrosino, Lidia Carotenuto, Dewi Schrader, Hyun Kyung Lee, James Riviello, William Hong, Sarah Risen, Lisa Emrick, Hitha Amin, Dorothée Ville, Patrick Edery, Julitta de Bellescize, Vincent Michaud, Julien Van-Gils, Cyril Goizet, Marjolein H. Willemsen, Tjitske Kleefstra, Rikke S Møller, Allan Bayat, Orrin Devinsky, Tristan Sands, G. Christoph Korenke, Gerhard Kluger, Heather C. Mefford, Eva Brilstra, Gaetan Lesca, Mathieu Milh, Edward C. Cooper, Maurizio Taglialatela, Sarah Weckhuysen

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Targeted Gene Sanger Sequencing Should Remain the First-Tier Genetic Test for Children Suspected to Have the Five Common X-Linked Inborn Errors of Immunity by Koon-Wing Chan, Chung-Yin Wong, Daniel Leung, Xingtian Yang, Susanna F. S. Fok, Priscilla H. S. Mak, Lei Yao, Wen Ma, Huawei Mao, Xiaodong Zhao, Weiling Liang, Surjit Singh, Mohamed-Ridha Barbouche, Jian-Xin He, Li-Ping Jiang, Woei-Kang Liew, Minh Huong Thi Le, Dina Muktiarti, Fatima Johanna Santos-Ocampo, Reda Djidjik, Brahim Belaid, Intan Hakimah Ismail, Amir Hamzah Abdul Latiff, Way Seah Lee, Tong-Xin Chen, Jinrong Liu, Runming Jin, Xiaochuan Wang, Yin Hsiu Chien, Hsin-Hui Yu, Dinesh Raj, Revathi Raj, Jenifer Vaughan, Michael Urban, Sylvia van den Berg, Brian Eley, Anselm Chi-Wai Lee, Mas Suhaila Isa, Elizabeth Y. Ang, Bee Wah Lee, Bee Wah Lee, Allen Eng Juh Yeoh, Allen Eng Juh Yeoh, Lynette P. Shek, Lynette P. Shek, Nguyen Ngoc Quynh Le, Van Anh Thi Nguyen, Anh Phan Nguyen Lien, Regina D. Capulong, Joanne Michelle Mallillin, Jose Carlo Miguel M. Villanueva, Karol Anne B. Camonayan, Michelle De Vera, Roxanne J. Casis-Hao, Rommel Crisenio M. Lobo, Ruby Foronda, Vicky Wee Eng Binas, Soraya Boushaki, Soraya Boushaki, Nadia Kechout, Gun Phongsamart, Siriporn Wongwaree, Chamnanrua Jiratchaya, Mongkol Lao-Araya, Muthita Trakultivakorn, Narissara Suratannon, Orathai Jirapongsananuruk, Teerapol Chantveerawong, Wasu Kamchaisatian, Lee Lee Chan, Mia Tuang Koh, Ke Juin Wong, Siew Moy Fong, Meow-Keong Thong, Zarina Abdul Latiff, Lokman Mohd Noh, Lokman Mohd Noh, Rajiva de Silva, Zineb Jouhadi, Khulood Al-Saad, Pandiarajan Vignesh, Ankur Kumar Jindal, Amit Rawat, Anju Gupta, Deepti Suri, Jing Yang, Elaine Yuen-Ling Au, Janette Siu-Yin Kwok, Siu-Yuen Chan, Wayland Yuk-Fun Hui, Gilbert T. Chua, Jaime Rosa Duque, Kai-Ning Cheong, Patrick Chun Yin Chong, Marco Hok Kung Ho, Tsz-Leung Lee, Wilfred Hing-Sang Wong, Wanling Yang, Pamela P. Lee, Wenwei Tu, Xi-Qiang Yang, Yu Lung Lau

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Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming by Lei Xiong, Feng Wu, Qiong Wu, Liangliang Xu, Otto K. Cheung, Wei Kang, Myth T. Mok, Lemuel L. M. Szeto, Cheuk-Yin Lun, Raymond W. Lung, Jinglin Zhang, Ken H. Yu, Sau-Dan Lee, Guangcun Huang, Chiou-Miin Wang, Joseph Liu, Zhuo Yu, Dae-Yeul Yu, Jian-Liang Chou, Wan-Hong Huang, Bo Feng, Yue-Sun Cheung, Paul B. Lai, Patrick Tan, Nathalie Wong, Michael W. Chan, Tim H. Huang, Kevin Y. Yip, Alfred S. Cheng, Ka-Fai To

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Mako: A Graph-based Pattern Growth Approach to Detect Complex Structural Variants by Jiadong Lin, Xiaofei Yang, Walter Kosters, Tun Xu, Yanyan Jia, Songbo Wang, Qihui Zhu, Mallory Ryan, Li Guo, Chengsheng Zhang, Charles Lee, Scott E. Devine, Evan E. Eichler, Kai Ye, Mark B. Gerstein, Ashley D. Sanders, Micheal C. Zody, Michael E. Talkowski, Ryan E. Mills, Jan O. Korbel, Tobias Marschall, Peter Ebert, Peter A. Audano, Bernardo Rodriguez-Martin, David Porubsky, Marc Jan Bonder, Arvis Sulovari, Jana Ebler, Weichen Zhou, Rebecca Serra Mari, Feyza Yilmaz, Xuefang Zhao, PingHsun Hsieh, Joyce Lee, Sushant Kumar, Tobias Rausch, Yu Chen, Zechen Chong, Katherine M. Munson, Mark J.P. Chaisson, Junjie Chen, Xinghua Shi, Aaron M. Wenger, William T. Harvey, Patrick Hansenfeld, Allison Regier, Ira M. Hall, Paul Flicek, Alex R. Hastie, Susan Fairely

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The T Cell Immunoscore as a Reference for Biomarker Development Utilizing Real-World Data from Patients with Advanced Malignancies Treated with Immune Checkpoint Inhibitors by Islam Eljilany, Payman Ghasemi Saghand, James Chen, Aakrosh Ratan, Martin McCarter, John Carpten, Howard Colman, Alexandra P. Ikeguchi, Igor Puzanov, Susanne Arnold, Michelle Churchman, Patrick Hwu, Jose Conejo-Garcia, William S. Dalton, George J. Weiner, Issam M. El Naqa, Ahmad A. Tarhini

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Identifying high-impact variants and genes in exomes of Ashkenazi Jewish inflammatory bowel disease patients by Yiming Wu, Kyle Gettler, Meltem Ece Kars, Mamta Giri, Dalin Li, Cigdem Sevim Bayrak, Peng Zhang, Aayushee Jain, Patrick Maffucci, Ksenija Sabic, Tielman Van Vleck, Girish Nadkarni, Lee A. Denson, Harry Ostrer, Adam P. Levine, Elena R. Schiff, Anthony W. Segal, Subra Kugathasan, Peter D. Stenson, David N. Cooper, L. Philip Schumm, Scott Snapper, Mark J. Daly, Talin Haritunians, Richard H. Duerr, Mark S. Silverberg, John D. Rioux, Steven R. Brant, Dermot P. B. McGovern, Judy H. Cho, Yuval Itan

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Active involvement of nursing staff in reporting and grading complication‐intervention events—Protocol and results of the CAMUS Pilot Nurse Delphi Study by Christopher Soliman, Benjamin C. Thomas, Pasqualina Santaguida, Nathan Lawrentschuk, Evie Mertens, Gianluca Giannarini, Patrick Y. Wuethrich, Michael Wu, Muhammad S. Khan, Rajesh Nair, Ramesh Thurairaja, Benjamin Challacombe, Prokar Dasgupta, Sachin Malde, Niall M. Corcoran, Philippe E. Spiess, Philip Dundee, Marc A. Furrer

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Analysis of clinically relevant variants from ancestrally diverse Asian genomes by Chan, Sock Hoai, Bylstra, Yasmin, Teo, Jing Xian, Kuan, Jyn Ling, Bertin, Nicolas, Gonzalez-Porta, Mar, Hebrard, Maxime, Tirado-Magallanes, Roberto, Tan, Joanna Hui Juan, Jeyakani, Justin, Li, Zhihui, Chai, Jin Fang, Chong, Yap Seng, Davila, Sonia, Goh, Liuh Ling, Lee, Eng Sing, Wong, Eleanor, Wong, Tien Yin, Prabhakar, Shyam, Liu, Jianjun, Cheng, Ching-Yu, Eisenhaber, Birgit, Karnani, Neerja, Leong, Khai Pang, Sim, Xueling, Yeo, Khung Keong, Chambers, John Campbell, Tai, E-Shyong, Tan, Patrick, Jamuar, Saumya S., Ngeow, Joanne, Lim, Weng Khong

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Gender-Affirming Vaginoplasty: A Comparison of Algorithms, Surgical Techniques and Management Practices across 17 High-volume Centers in North America and Europe by Devin Coon, MD, MSE, Shane D. Morrison, MD, MS, Martin P. Morris, MD, MBE, Patrick Keller, MD, Rachel Bluebond-Langner, MD, Marci Bowers, MD, Pierre Brassard, MD, FRCSC, Marlon E. Buncamper, MD, PhD, Daniel Dugi, III, MD, FACS, Cecile Ferrando, MD, MPH, Katherine M. Gast, MD, Christine McGinn, DO, Toby Meltzer, MD, Stan Monstrey, MD, PhD, Müjde Özer, MD, Melissa Poh, MD, Thomas Satterwhite, MD, Jess Ting, MD, Lee Zhao, MD, William M. Kuzon, MD, PhD, Loren Schechter, MD

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COVID-19 in children across three Asian cosmopolitan regions by Gilbert T. Chua, Xiaoli Xiong, Eun Hwa Choi, Mi Seon Han, Sung Hee Chang, Byoung Lo Jin, Eun Joo Lee, Baek Nam Kim, Min Kyoung Kim, Kihyun Doo, Ju Hee Seo, Yae Jean Kim, Yeo Jin Kim, Ji Young Park, Sun Bok Suh, Hyunju Lee, Eun Young Cho, Dong Hyun Kim, Jong Min Kim, Hye Young Kim, Su Eun Park, Joon Kee Lee, Dae Sun Jo, Seung Man Cho, Jae Hong Choi, Kyo Jin Jo, Young June Choe, Ki Hwan Kim, Shuiqing Chi, Shao-tao Tang, Huan Qin, Li Shan Zhou, Peng Chen, Joshua Sung Chih Wong, Kate Ching Ching Chan, Felix Yat Sun Yau, Shu Yan Lam, Calvin Chit Kwong Chow, Tak Wai Wong, Victor Chi-man Chan, Grace Wing Kit Poon, Chun Bong Chow, Wilfred H. S. Wong, Yu Lung Lau, Godfrey Chi Fung Chan, Celine S. L. Chui, Xue Li, Marco Hok Kung Ho, Ian C. K. Wong, Paul Kwong Hang Tam, Kelvin K. W. To, Jong Hyun Kim, Patrick Ip, Mike Yat Wah Kwan

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Immunogenicity of COVID-19 vaccines and their effect on HIV reservoir in older people with HIV by Vitaliy A. Matveev, Erik Z. Mihelic, Erika Benko, Patrick Budylowski, Sebastian Grocott, Terry Lee, Chapin S. Korosec, Karen Colwill, Henry Stephenson, Ryan Law, Lesley A. Ward, Salma Sheikh-Mohamed, Geneviève Mailhot, Melanie Delgado-Brand, Adrian Pasculescu, Jenny H. Wang, Freda Qi, Tulunay Tursun, Lela Kardava, Serena Chau, Philip Samaan, Annam Imran, Dennis C. Copertino, Jr., Gary Chao, Yoojin Choi, Robert J. Reinhard, Rupert Kaul, Jane M. Heffernan, R. Brad Jones, Tae-Wook Chun, Susan Moir, Joel Singer, Jennifer Gommerman, Anne-Claude Gingras, Colin Kovacs, Mario Ostrowski

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Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased protective efficacy by Natasha KC, L. W. Preston Church, Pouria Riyahi, Sumana Chakravarty, Robert A. Seder, Judith E. Epstein, Kirsten E. Lyke, Benjamin Mordmüller, Benjamin Mordmüller, Peter G. Kremsner, Peter G. Kremsner, Mahamadou S. Sissoko, Sara Healy, Patrick E. Duffy, Said A. Jongo, Vicente Urbano Nsue Ndong Nchama, Salim Abdulla, Maxmillian Mpina, Maxmillian Mpina, Maxmillian Mpina, Sodiomon B. Sirima, Sodiomon B. Sirima, Matthew B. Laurens, Laura C. Steinhardt, Martina Oneko, MingLin Li, Tooba Murshedkar, Peter F. Billingsley, B. Kim Lee Sim, Thomas L. Richie, Stephen L. Hoffman

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Analysis of clinically relevant variants from ancestrally diverse Asian genomes by Sock Hoai Chan, Yasmin Bylstra, Jing Xian Teo, Jyn Ling Kuan, Nicolas Bertin, Mar Gonzalez-Porta, Maxime Hebrard, Roberto Tirado-Magallanes, Joanna Hui Juan Tan, Justin Jeyakani, Zhihui Li, Jin Fang Chai, Yap Seng Chong, Sonia Davila, Liuh Ling Goh, Eng Sing Lee, Eleanor Wong, Tien Yin Wong, SG10K_Health Consortium, Shyam Prabhakar, Jianjun Liu, Ching-Yu Cheng, Birgit Eisenhaber, Neerja Karnani, Khai Pang Leong, Xueling Sim, Khung Keong Yeo, John C. Chambers, E-Shyong Tai, Patrick Tan, Saumya S. Jamuar, Joanne Ngeow, Weng Khong Lim

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