ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters by Huang, Royston-Luke, Teo, Ziqiang, Chong, Han Chung, Zhu, Pengcheng, Tan, Ming Jie, Tan, Chek Kun, Lam, Ivan Chee Ren, Tan, Nguan Soon, Sng, Ming Keat, Leong, David Tai Wei, Tan, Suet Mien, Kersten, Sander, Ding, Jeak Ling, Li, Hoi-Yeung

“…We showed that cANGPTL4 binds and activates integrin α5β1-mediated Rac1/PAK signaling to weaken cell-cell contacts. cANGPTL4 subsequently associated with and declustered VE-cadherin and claudin-5, leading to endothelial disruption. Interfering with the formation of these cANGPTL4 complexes delayed vascular disruption. …”
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Optical reflectance contrast of micro- and nano-structures revealed with intravital micro-OCT by Chen, Si

“…We design a novel cost-effective interferometer-in-spectrometer scheme where the reference beam is spectrally shaped when passing through the zero-order diffraction channel of the grating prior to interfering with the sample light at the spectrometer input fiber tip. …”
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A role for the VPS retromer in Brucella intracellular replication revealed by genomewide siRNA screening by Casanova, Alain, Low, Shyan Huey, Québatte, Maxime, Sedzick, Jaroslaw, Tschon, Therese, Ketterer, Maren, Smith, Kevin, Emmenlauer, Mario, Ben-Tekaya, Houchaima, Dehio, Christoph

“…Here we used a systematic cell-based small interfering RNA (siRNA) knockdown screen in HeLa cells infected with Brucella abortus and identified 425 components of the human infectome for Brucella infection. …”
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Study of photodetector for the application of autonomous vehicles by Sun, Yue

“…The terahertz wave, like millimeter waves, is not easily interfered by weather and light; compared to optical cameras and LiDARs, terahertz automotive radars will not greatly degrade in performance even in severe weather; and the functions are similar to LiDARs. …”
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Destruction of endocrine disruptor compounds (EDCs) with ozone process by Low, Soo Min

“…(Primozone, 2017) Resorcinol is categorised as an endocrine disruptor because it can disrupt the human metabolism, triiodothyronine (T3) and thyroxine (T4), interfering with our thyroid activity. This will result in health risks for human and for the aquatic species in the water bodies. …”
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Crystal structure of the FK506 binding domain of plasmodium falciparum FKBP35 in complex with FK506 by Kotaka, Masayo, Ye, Hong, Alag, Reema, Hu, Guangan, Bozdech, Zbynek, Preiser, Peter Rainer, Yoon, Ho Sup, Lescar, Julien

“…A microarray analysis suggests that FK506 and cyclosporine A (CsA) might inhibit parasite development by interfering with the same signaling pathways.…”
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Up-regulation of Mcl-1 and Bak by coronavirus infection of human, avian and animal cells modulates apoptosis and viral replication by Zhong, Yanxin., Liao, Ying., Fang, Shouguo., Tam, James P., Liu, Ding Xiang.

“…Interestingly, the onset of apoptosis occurred earlier in IBV-infected mammalian cells silenced with short interfering RNA targeting Mcl-1 (siMcl-1), and was delayed in cells silenced with siBak. …”
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Genome-wide gene expression profiling of the Angelman syndrome mice with Ube3a mutation by Low, Daren., Chen, Ken-Shiung.

“…Consistent with this finding, expression of small interfering RNA that targets Ube3a in P19 cells caused down-regulation of Mc1r and Nr4a2, whereas overexpression of Ube3a results in the up-regulation of Mc1r and Nr4a2 when compared to mock transfected cells. …”
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Cytotoxicity evaluation of oxidized single-walled carbon nanotubes and graphene oxide on human Hepatoma HepG2 cells : an iTRAQ-coupled 2D LC-MS/MS proteome analysis by Yuan, Jifeng, Gao, Hongcai, Sui, Jianjun, Duan, Hongwei, Chen, William Wei Ning, Ching, Chi Bun

“…Based on the protein profile, we found oxidized SWCNTs induced oxidative stress and interfered with intracellular metabolic routes, protein synthesis, and cytoskeletal systems. …”
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Kinetically blocked stable heptazethrene and octazethrene : closed-shell or open-shell in the ground state? by Li, Yuan, Heng, Wee-Kuan, Lee, Byung Sun, Aratani, Naoki, Zafra, José L., Bao, Nina, Lee, Richmond, Sung, Young Mo, Sun, Zhe, Huang, Kuo-Wei, Webster, Richard David, López Navarrete, Juan T., Kim, Dongho, Osuka, Atsuhiro, Casado, Juan, Ding, Jun, Wu, Jishan

“…Their ground-state electronic structures were systematically investigated by a combination of different experimental methods, including steady-state and transient absorption spectroscopy, variable temperature NMR, electron spin resonance (ESR), superconducting quantum interfering device (SQUID), FT Raman, and X-ray crystallographic analysis, assisted by unrestricted symmetry-broken density functional theory (DFT) calculations. …”
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Silencing endogenous mutant P53 Using Sirna Induces P73-Mediated Apoptosis in Human Head And Neck Squamous Cell Carcinoma by Arief Ichwan, Solachuddin Jauhari, Taher, Muhammad, Masa-Aki, Ikeda

“…Here we show that treatment with small-interfering RNA(siRNA) specific to inhibit the expression of endogenous mutant p53R248Q protein induced apoptosis in HSC-4 cells. …”
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Time frequency analysis for wireless channel characterization / Zaiton Sharif by Sharif, Zaiton

“…This propagation environment affects the transmitted signal in terms of scattering, diffraction and reflection as it traveled towards the receiver causing the signals to be received distorted or interfered. Therefore, the central issue in this thesis is to determine appropriate techniques to characterize such a channel. …”
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Handling mixed numbers on a number line – a problem among lower secondary students / Noraini Noordin, Fadzilah Abdol Razak and Nooraini Ali by Noordin, Noraini, Abdol Razak, Fadzilah, Ali, Nooraini

“…It is hoped that these findings will shed some information on fraction confusion that interfered with their estimation and computation abilities.…”
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Realizing UWB antenna array with dual and wide rejection bands using metamaterial and electromagnetic bandgaps techniques by Althuwayb, Ayman Abdulhadi, Alibakhshikenari, Mohammad, Virdee, Bal Singh, Shukla, Pancham, Limiti, Ernesto

“…Compared to other dual notched band designs previously published the footprint of the proposed technique is smaller and its rejection notches completely cover the bandwidth of interfering signals.…”
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The effects of tocotrienolrich fraction on imiquimodinduced psoriatic lesion in mice / Awla Mohd Azraai by Mohd Azraai, Awla

“…It is a global health problem which results in localised or extensive development of erythematous scaly plaques, interfering with daily activities. Psoriasis has no cure however available treatment aims at controlling symptoms despite having many side effects. …”
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Ternary nanohybrid of reduced graphene oxide-nafion@silver nanoparticles for boosting the sensor performance in non-enzymatic amperometric detection of hydrogen peroxide by Yusoff, N., Rameshkumar, P., Mehmood, M.S., Pandikumar, A., Lee, H.W., Huang, N.M.

“…The coupling between rGO-Nf with silver nanoparticles (AgNPs) significantly boosted the electroanalytical performance by providing more active area for analyte interaction, thereby allowing more rapid interfacial electron transfer process. The interfering effect on the current response of H2O2 was studied and the results revealed that the sensor electrode exhibited an excellent immunity from most common interferents. …”

The development of a novel transforming growth factor-β (TGF-β) inhibitor that disrupts ligand-receptor interactions by Wu, Han, Sun, Yu, Wong, Wee Lin, Cui, Jiajia, Li, Jingyang, You, Xuefu, Yap, Lee Fah, Huang, Yu, Hong, Wei, Yang, Xinyi, Paterson, Ian Charles, Wang, Hao

“…The present study describes for the first time a designed molecule that can regulate TGF-β-induced signaling and EMT by interfering with the PPIs required for the formation of the TGF-β signaling complex. …”

Epigenetic silencing of CYP24 in tumor-derived endothelial cells contributes to selective growth inhibition by calcitriol by Chung, I., Karpf, A.R., Muindi, J.R., Conroy, J.M., Nowak, N.J., Johnson, C.S., Trump, D.L.

“…Furthermore, treatment of MDEC with a CYP24 small interfering RNA restored sensitivity to calcitriol. …”
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Designed mini protein 20 mimicking uricase encapsulated in ZIF-8 as nanozyme biosensor for uric acid detection by Abdul Aziz, Siti Fatimah Nur, Salleh, Abu Bakar, Ashari, Siti Efliza, Normi, Yahaya M., Yusof, Nor Azah, Ahmad, Shahrul Ainliah Alang

“…The developed nanozyme biosensor (mp20@ZIF-8/rGO/SPCE) exhibited high selectivity in the presence of the same fold concentration of interfering species with a detection limit of 0.27 μM, over a concentration range of 1 to 34 μM. …”

Inactivation kinetics of Salmonella enterica serovar Typhimurium NCTC 12023 in Chokanan mango Mangifera indica L. fruit juice by aqueous ozone treatment by Supian, N. A. M, Shah, N. N. A. K., Shamsudin, R., Sulaiman, A.

“…The results showed that the Bx values and mango pulp presence in the various MJ samples interfered with the S. enterica ser. Typhimurium disinfection activity by ozone. …”