Experimental treatment of Ebola virus disease with TKM-130803: A single-arm phase 2 clinical trial. Yazar: Dunning, J, Sahr, F, Rojek, A, Gannon, F, Carson, G, Idriss, B, Massaquoi, T, Gandi, R, Joseph, S, Osman, H, Brooks, T, Simpson, A, Goodfellow, I, Thorne, L, Arias, A, Merson, L, Castle, L, Howell-Jones, R, Pardinaz-Solis, R, Hope-Gill, B, Ferri, M, Grove, J, Kowalski, M, Stepniewska, K, Lang, T, Whitehead, J, Olliaro, P, Samai, M, Horby, P

“… <h4>Background</h4> <p>TKM-130803, a small interfering RNA lipid nanoparticle product, has been developed for the treatment of Ebola virus disease (EVD), but its efficacy and safety in humans has not been evaluated.…”

Dynamics of conflict during the Ebola outbreak in the Democratic Republic of the Congo 2018-2019 Yazar: Kraemer, MUG, Pigott, DM, Hill, SC, Vanderslott, S, Reiner, RC, Stasse, S, Brownstein, JS, Gutierrez, B, Dennig, F, Hay, SI, Pybus, OG, Castro, MC, Vinck, P, Pham, PN, Nilles, EJ, Cauchemez, S

“…The outbreak emerged in a region of chronic conflict and insecurity, and directed attacks against health care workers may have interfered with disease response activities. Our study characterizes and quantifies the broader conflict dynamics over the course of the outbreak by pairing epidemiological and all available spatial conflict data. …”

Green-light autofluorescence versus combined blue-light autofluorescence and near-infrared reflectance imaging in geographic atrophy secondary to age-related macular degeneration Yazar: Pfau, M, Goerdt, L, Schmitz-Valckenberg, S, Mauschitz, MM, Mishra, DK, Holz, FG, Lindner, M, Fleckenstein, M

“…Post hoc review revealed that interreader differences were associated with media opacification interfering with lesion boundary demarcation to a larger extent in BAF than in GAF. …”

Functional genomic analysis of a RUNX3 polymorphism associated with ankylosing spondylitis Yazar: Vecellio, M, Chen, L, Cohen, CJ, Cortes, A, Li, Y, Bonham, S, Selmi, C, Brown, MA, Fischer, R, Knight, JC, Wordsworth, BP

“…Further functional effects were tested by small interfering RNA knockdown of the gene for interferon regulatory factor 5 (IRF5), followed by reverse transcription–qPCR (RT-qPCR) and enzyme-linked immunosorbent assay (ELISA) to measure the levels of IFNγ messenger RNA (mRNA) and protein, respectively. …”

Developing light-activated nucleic acids for gene knockdown in cell-free and living systems Yazar: Mazzotti, G

“…The two nucleic acids mainly used for gene knockdown are antisense oligonucleotides (ASOs), short single stranded DNA sequences, and small interfering RNAs (siRNAs), short double stranded RNA sequences. …”

Per-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion. Yazar: da Silva Xavier, G, Farhan, H, Kim, H, Caxaria, S, Johnson, P, Hughes, S, Bugliani, M, Marselli, L, Marchetti, P, Birzele, F, Sun, G, Scharfmann, R, Rutter, J, Siniakowicz, K, Weir, G, Parker, H, Reimann, F, Gribble, F, Rutter, G

“…Alpha-TC1-9 cells, human islets or cultured E13.5 rat pancreatic epithelia were transduced with anti-Pask or control small interfering RNAs, or with adenoviruses encoding enhanced green fluorescent protein or PASK. …”

RNA-based therapeutics for Alzheimer's disease Yazar: Woffindale, C

“…</p> <p>Recently, significant advances have occurred in the field of RNA interference (RNAi)-based therapeutics, allowing targeted silencing of disease-relevant genes through the use of short interfering RNAs (siRNAs) or microRNAs (miRNAs). However, development has been impeded by poor penetrance of the blood-brain-barrier (BBB) <em>in vivo</em>. …”

Neutrophil extracellular traps, local IL-8 expression, and cytotoxic T-lymphocyte absence in the lungs of fatal COVID-19: a retrospective histopathology cohort study Yazar: Melero, I, Villalba-Esparza, M, Recalde-Zamacona, B, Álvaro, T, Argueta, A, García-Tobar, L, Álvarez-Gigli, L, Sainz, C, Garcia-Ros, D, Toledo, E, Abengozar-Muela, M, Fernandez-Alonso, M, Rodriguez-Moreno, M, Reina, G, Carmona-Torre, F, Quiroga, JA, Pozo, JD, Cross, A, Echeveste, J, Lozano, M, Ho, L-P, Klenerman, P, Issa, F, Landecho, M, Andrea, CD

“…The function of cytotoxic T-lymphocytes in the immune responses against SARS-CoV-2 may be interfered with by the presence of NETs.</p>…”

Beta-oestradiol rescues DeltaF508CFTR functional expression in human cystic fibrosis airway CFBE41o- cells through the up-regulation of NHERF1. Yazar: Fanelli, T, Cardone, R, Favia, M, Guerra, L, Zaccolo, M, Monterisi, S, De Santis, T, Riccardi, S, Reshkin, S, Casavola, V

“…Importantly, knock-down of NHERF1 expression by transfection with siRNA (small interfering RNA) for NHERF1 inhibited the beta-oestradiol-dependent increase in DeltaF508CFTR protein expression levels and completely prevented the beta-oestradiol-dependent rescue of DeltaF508CFTR transport activity. …”

Neutrophil extracellular traps, local IL-8 expression, and cytotoxic T-lymphocyte response in the lungs of patients with fatal COVID-19 Yazar: Melero, I, Villalba-Esparza, M, Recalde-Zamacona, B, Jiménez-Sánchez, D, Teijeira, Á, Argueta, A, García-Tobar, L, Álvarez-Gigli, L, Sainz, C, Garcia-Ros, D, Toledo, E, Abengozar-Muela, M, Fernández-Alonso, M, Rodríguez-Mateos, M, Reina, G, Carmona-Torre, F, Quiroga, JA, Del Pozo, JL, Cross, A, López-Janeiro, Á, Hardisson, D, Echeveste, JI, Lozano, MD, Ho, L-P, Klenerman, P, Issa, F, Landecho, MF, de Andrea, CE

“…The function of cytotoxic T-lymphocytes in the immune responses against SARS-CoV-2 may be interfered with by the presence of NETs.…”

Developing novel approaches in understanding anxiety-related attentional biases to threat Yazar: Raeder, SM

“…Instead, the first study presented in Chapter 3 revealed that anxiety interfered with the recruitment of long-term memories when specifically threatening distracting information was presented. …”

Mapping the binding site of a cross-reactive Plasmodium falciparum PfEMP1 monoclonal antibody inhibitory of ICAM-1 binding Yazar: Lennartz, F, Bengtsson, A, Olsen, R, Joergensen, L, Brown, A, Remy, L, Man, P, Forest, E, Barfod, L, Adams, Y, Higgins, M, Jensen, A

“…The convex surface of DBLβ3_D4 has previously been shown to contain the ICAM-1 binding site of DBLβ domains, suggesting that the mAb acts by occluding the ICAM-1 binding surface. …”

Regulation of potassium currents in the sino-atrial node Yazar: Mattick, P

“…Upon cAMP elevation (via AC stimulation or isoprenaline) I_KS augmentation was greater than I_KR. Agents that interfered with the function of the sarcoplasmic reticulum (ryanodine and cyclopiazonic acid) also reduced I_KR and I_KS , but to a lesser extent than BAPTA-loading or KN-93, and these observations indicate that calcium from the SR contributed partially to (was not the sole source) the calcium regulating I_KR and I_KS . …”

β-Oestradiol rescues ΔF508CFTR functional expression in human cystic fibrosis airway CFBE41o- cells through the up-regulation of NHERF1 Yazar: Fanelli, T, Cardone, R, Favia, M, Guerra, L, Zaccolo, M, Monterisi, S, De Santis, T, Riccardi, S, Reshkin, S, Casavola, V

“…Importantly, knock-down of NHERF1 expression by transfection with siRNA (small interfering RNA) for NHERF1 inhibited the β-oestradiol-dependent increase in ΔF508CFTR protein expression levels and completely prevented the β-oestradiol-dependent rescue of ΔF508CFTR transport activity. …”

Duchenne muscular dystrophy: RNA-based therapeutics and microRNA biology Yazar: Roberts, T

“…This study describes a novel myostatin inhibition approach in which small interfering RNAs (siRNAs) complementary to a promoter-associated transcript induce transcriptional gene silencing (TGS) in cultured myotubes. …”

Surface modification of reduced graphene oxide film by Ti ion implantation technique for high dye-sensitized solar cells performance Yazar: Low, F.W., Lai, Chin Wei, Hamid, Sharifah Bee Abd

“…Further increase of the applied power to 200 W or 250 W led to the undesirable recombination of the Ti ions and rGO NS due to the exceptional photocatalytic activity among N719 dye/rGO/TiO2 interfaces which interfered the charge transportation at the KI electrolyte/N719 dye/rGO/TiO2 interfaces.…”

The role of miRNAs 34a, 146a, 320a and 542 in the synergistic anticancer effects of methyl 2-(5-fluoro-2-hydroxyphenyl)-1H- benzo[d]imidazole-5-carboxylate (MBIC) with doxorubicin... Yazar: Hasanpourghadi, Mohadeseh, Majid, Nazia Abdul, Mustafa, Mohd Rais

“…These miRNAs have the potential to alter the protein level of survivin, the anti-apoptotic protein and reduce the metastatic activity in human breast cancer cell lines by interfering with the nuclear accumulation of NF-KB. …”

Paeonol Attenuates LPS-Induced Endothelial Dysfunction and Apoptosis by Inhibiting BMP4 and TLR4 Signaling Simultaneously but Independently Yazar: Choy, Ker Woon, Lau, Yeh Siang, Murugan, Dharmani Devi, Vanhoutte, Paul M., Mustafa, Mohd Rais

“…Relaxation in response to the endothelium-dependent vasodilator acetylcholine were impaired in mouse aortae after exposure to LPSs; this endothelial dysfunction was reversed by cotreatment with paeonol, noggin (a BMP4 inhibitor), TAK242 (TLR4 antagonist), apocynin (an ROS scavenger), MAPK inhibitors, and AG (an iNOS inhibitor). BMP4 small interfering RNAs (siRNAs) abolished LPS-induced upregulation of BMP4 and cleaved caspase 3 protein, but not in cells treated with TLR4 siRNA and vice versa. …”

Surface plasmon resonance sensor based on gold-graphene quantum dots thin film as a sensing nanomatrix for phenol detection Yazar: Hashim, Hazwani Suhaila, Fen, Yap Wing, Omar, Nur Alia Sheh, Daniyal, Wan Mohd Ebtisyam Mustaqim Mohd, Fauzi, Nurul Illya Muhamad, Abdullah, Jaafar, Mahdi, Mohd Adzir

“…This gold-graphene quantum dots thin film-based SPR sensor also gave excellent selectivity towards phenol compared to other interfering substances. Additionally, atomic force microscopy proved the interaction between phenol and the thin film as a change in the RMS roughness can be observed.…”

Efficacy and Costs of Two Treatments for Diarrhoea in Calves Yazar: Che Yahya, Siti Nor

“…Another factor that interfered with the treatment was nursing of the diarrhoeic calves. …”
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