SDF-1/CXCL12 production by mature dendritic cells inhibits the propagation of X4-tropic HIV-1 isolates at the dendritic cell-T-cell infectious synapse. by González, N, Bermejo, M, Calonge, E, Jolly, C, Arenzana-Seisdedos, F, Pablos, J, Sattentau, Q, Alcamí, J

“…When CXCL12 activity was inhibited with specific neutralizing antibodies or small interfering RNAs (siRNAs), the block to mMDDC transfer of X4 viruses to lymphocytes was removed. …”

Flow-induced constriction in arterioles of hyperhomocysteinemic rats is due to impaired nitric oxide and enhanced thromboxane A(2) mediation. by Bagi, Z, Ungvari, Z, Szollár, L, Koller, A

“…Because flow-induced dilation is mediated by the endothelium, we hypothesized that HHcy alters this response by interfering with the synthesis/action of NO and prostaglandins. …”

High doses of TGF-β potently suppress type I collagen via the transcription factor CUX1. by Fragiadaki, M, Ikeda, T, Witherden, A, Mason, R, Abraham, D, Bou-Gharios, G

“…We demonstrate that the mechanism by which CUX1 suppresses type I collagen is through interfering with gene transcription. In addition, using an in vivo murine model of aristolochic acid (AA)-induced interstitial fibrosis and human AA nephropathy, we observe that CUX1 expression was significantly reduced in fibrotic tissue when compared to control samples. …”

Characterization of the RNA-interference pathway as a tool for reverse genetic analysis in the nascent phototrophic endosymbiosis, Paramecium bursaria by Jenkins, BH, Maguire, F, Leonard, G, Eaton, JD, West, S, Housden, BE, Milner, DS, Richards, TA

“…Using comparative genomics and transcriptomics supported by phylogenetics, we identify essential proteome components of the small interfering (si)RNA, scan (scn)RNA and internal eliminated sequence (ies)RNA pathways. …”

A missense mutation in connexin26, D66H, causes mutilating keratoderma with sensorineural deafness (Vohwinkel's syndrome) in three unrelated families. by Maestrini, E, Korge, B, Ocaña-Sierra, J, Calzolari, E, Cambiaghi, S, Scudder, P, Hovnanian, A, Monaco, A, Munro, C

“…This mutation occurs at a highly conserved residue in the first extracellular domain of the Cx26 molecule, and may exert its effects by interfering with assembly into connexons, docking with adjacent cells or gating properties of the gap junction. …”

Heat shock protein 27 functions in inflammatory gene expression and transforming growth factor-beta-activated kinase-1 (TAK1)-mediated signaling. by Alford, K, Glennie, S, Turrell, B, Rawlinson, L, Saklatvala, J, Dean, J

“…We have used small interfering RNAs to suppress HSP27 expression in HeLa cells and fibroblasts and found that it is required for pro-inflammatory cell signaling and the expression of pro-inflammatory genes. …”

O Canto Precário: Epopeia, derrogação heróica e desumanização em Caramuru (1781) by Martins, RE

“…To get here, I discuss through "Caramuru" the Brazilian literary neoclassicism, the epic design of its hero, the poetic representation of the figure of the Brazilian indigenous peoples according to the Portuguese colonial system, the subsequent canonical derogation from the lyric and epic modes, the 18th century conception of nature and the idea of natural goodness, and how the enlightenment thought contaminated the relationship with the Amerindian peoples, interfering with the Brazilian identity at the time of its independence.…”

Overt spatial attention modulates multisensory selection by Jensen, A, Frings, C, Spence, C, Merz, S

“…Fixating the distractor led to crossmodal congruency effects between the visual and auditory feature dimensions (e.g., a visually incongruent distractor interfered more if it was also auditorily incongruent with the target), while congruency effects were independent of each other when the distractor was not fixated (i.e., visual interference was not modulated by auditory interference in this case). …”

RNAi-mediated knockdown of HMG CoA reductase enhances gene expression from physiologically regulated low-density lipoprotein receptor therapeutic vectors in vivo. by Hibbitt, O, Agkatsev, S, Owen, C, Cioroch, M, Seymour, L, Channon, K, Wade-Martins, R

“…We demonstrated here that knockdown of HMG CoA reductase (HMGCR) by up to 70% using small interfering RNAs (siRNAs) led to a significant increase in binding and internalisation of LDL particles in vitro in mouse and human cells. …”

The role of PARPs and APLF in DNA interstrand crosslink repair by Zobel, F

“…The NHEJ repair factor APLF is recruited to chromatin in response to DNA ICLs and localizes to sites of laser induced damage in combination with the photreactive ICL inducing drug 4,5',8-trimethylpsoralen. …”

Mediator of DNA damage checkpoint 1 (MDC1) regulates mitotic progression. by Townsend, K, Mason, H, Blackford, A, Miller, E, Chapman, R, Sedgwick, G, Barone, G, Turnell, A, Stewart, G

“…In support of a role for hMDC1 in controlling mitotic progression, depletion of hMDC1 by small interfering RNA results in a metaphase arrest that appears to be independent of both BubR1-dependent signaling pathways and ATM/ATR activation. …”

Multifaceted mechanisms of HIV-1 entry inhibition by human α-defensin. by Demirkhanyan, L, Marin, M, Padilla-Parra, S, Zhan, C, Miyauchi, K, Jean-Baptiste, M, Novitskiy, G, Lu, W, Melikyan, G

“…The ability of HNP-1 to block HIV-1 uptake without interfering with constitutive endocytosis suggests a novel mechanism for broad activity against this and other viruses that enter cells through endocytic pathways.…”

On Principles of Least Change and Least Surprise for Bidirectional Transformations by Cheney, J, Gibbons, J, McKinna, J, Stevens, P

“…Naturally, they do not want their deliberate decisions disrupted, or their comprehension of their artefact interfered with, by a bx that makes changes to their artefact beyond the strictly necessary. …”

Negotiating power in sixteenth-century Italy: Ippolito II d'Este between Rome, France, and Ferrara by Vidori, G

“…Furthermore, the Cardinal’s strong involvement with French politics in Italy heavily interfered with his family’s policy and may be seen as the main reason for the Este’s long-term failure to establish themselves as a successful ecclesiastical dynasty.…”

Polarised single photons from a cavity-enhanced atom-light interface in photonic quantum networks by Barrett, T

“…No degradation of performance is observed when interfering these pairs through a 4x4 multimode interferometer integrated onto a photonic chip with non-classical correlations measured between photon detections orders of magnitude further separated in time than the propagation time through the chip. …”

Analysing the impact of far-out sidelobes on the imaging performance of the SKA-LOW telescope by Mort, B, Dulwich, F, Razavi-Ghods, N, de Lera Acedo, E, Grainge, K

“…To achieve the expected level of sensitivity for SKA-LOW, it is particularly important to understand how interfering sources in both near and far side-lobes of the station beam affect the imaging performance. …”

Effects of saliency, not global dominance, in patients with left parietal damage. by Mevorach, C, Humphreys, G, Shalev, L

“…In experiment 1 a group of left parietal patients were abnormally affected by a salient local stimulus that significantly interfered with their ability to identify global shapes. …”

Left posterior parietal theta burst stimulation affects gestural imitation regardless of semantic content. by Vanbellingen, T, Bertschi, M, Nyffeler, T, Cazzoli, D, Wiest, R, Bassetti, C, Kaelin-Lang, A, Müri, R, Bohlhalter, S

“…RESULTS: cTBS over both left IPL and SPL significantly interfered with gestural imitation. There was no differential effect of SPL and IPL cTBS on gesture type (meaningless versus meaningful). …”

A universal plug-and-display vaccine carrier based on HBsAg VLP to maximize effective antibody response by Marini, A, Zhou, Y, Li, Y, Taylor, I, Leneghan, D, Jin, J, Zaric, M, Mekhaiel, D, Long, C, Miura, K, Biswas, S

“…Importantly, using this carrier that is a vaccine antigen itself could be beneficial, as we show that anti-HBsAg IgG antibodies are induced without interfering with the Pfs25-specific immune response generated. …”

Altered eIF6 and Dicer expression is associated with clinicopathological features in ovarian serous carcinoma patients. by Flavin, R, Smyth, P, Finn, S, Laios, A, O'Toole, SA, Barrett, C, Ring, M, Denning, K, Li, J, Aherne, S, Aziz, N, Alhadi, A, Sheppard, B, Loda, M, Martin, C, Sheils, O, O'Leary, J

“…The status of eIF6 and proteins of the microRNA machinery may help predict toxicity and susceptibility to future interfering RNA-based therapy.…”