Novel phylogenomic inference and ‘Out of Asia’ biogeography of cobras, coral snakes and their allies by Jeffrey L. Weinell, Frank T. Burbrink, Sunandan Das, Rafe M. Brown

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The Cobra Catheter: A Novel Concept and Device for the Thru-Septal Myocardium Approach by Min-Ku Chon, Dong-Hoon Shin, Su-Jin Jung, June-Hong Kim

“…These results showed that the novel Cobra catheter with a septal vein-independent trans-septal approach may be a safe and effective alternative for the treatment of structural heart diseases.…”
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Contrast optimization by region adaptation (COBRA) for grey scale images by Ahmed, Muhammad Mahmood

“…Based on this concept the proposed method named Contrast Optimization by Region Adaptation (COBRA) is developed by optimizing the contrast ratio of separated regions. …”
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Novel Three-Finger Neurotoxins from <i>Naja melanoleuca</i> Cobra Venom Interact with GABA_A and Nicotinic Acetylcholine Receptors by Lina Son, Elena Kryukova, Rustam Ziganshin, Tatyana Andreeva, Denis Kudryavtsev, Igor Kasheverov, Victor Tsetlin, Yuri Utkin

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Advax-SM™-Adjuvanted COBRA (H1/H3) Hemagglutinin Influenza Vaccines by Pedro L. Sanchez, Greiciely Andre, Anna Antipov, Nikolai Petrovsky, Ted M. Ross

“…In the present study, the adjuvant Advax-SM™ was combined with next generation, broadly reactive influenza hemagglutinin (HA) vaccines that were designed using a computationally optimized broadly reactive antigen (COBRA) methodology. Advax-SM™ is a novel adjuvant comprising inulin polysaccharide and CpG55.2, a TLR9 agonist. …”
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Design and Application of pH-Responsive Liposomes for Site-Specific Delivery of Cytotoxin from Cobra Venom by Lin Q, Jing Y, Yan C, Chen X, Zhang Q, Lin X, Xu Y, Chen B

“…By combining the advantages of CTX and stimuli-responsive nanotechnology, the novel CTX@PSL nanoformulation is a promising therapeutic candidate for cancer treatment.Keywords: cobra venom cytotoxin, tumor microenvironment, pH-responsive, targeted delivery, liposomes…”
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Cobra Venom Cytotoxins as a Tool for Probing Mechanisms of Mitochondrial Energetics and Understanding Mitochondrial Membrane Structure by Edward S. Gasanoff, Ruben K. Dagda

“…Importantly, we provide new insights on the molecular mechanisms through which cobra venom cytotoxins affect mitochondrial ATP synthesis, mitochondrial structure, and dynamics. …”
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Acute depletion of complement C3 with cobra venom factor attenuates memory deficits induced by status epilepticus by Nicole D. Schartz, Yibo Li, Alexandra L. Sommer, Amy L. Brewster

“…Results In the NOR test, rats in the C + V and C + CVF groups spent more time exploring the novel object. SE + V rats explored both objects equally, while SE + CVF rats spent significantly more on the novel object, suggesting a rescue of cognitive performance by CVF. …”
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Effect of Mucuna pruriens Seed Extract Pretreatment on the responses of spontaneously beating Rat Atria and Aortic Ring to Naja sputatrix (Javan Spitting Cobra) Venom by Fung, Shin Yee, Tan, Nget Hong, Sim, Si Mui, Aguiyi, John C.

“…The results also suggest that M. pruriens seed may contain novel cardioprotective agent with potential therapeutic value.…”
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Atrase A, a P-III class metalloproteinase purified from cobra venom, exhibits potent anticoagulant activity by inhibiting coagulation pathway and activating the fibrinolytic system by Xin-Jie Zhong, Cai-E Wang, Ya-Nan Li, Qi-Yun Zhang, Qian-Yun Sun

“…Furthermore, these findings underscore the potential of atrase A as a novel anticoagulant drug, offering insights into the functional evolutions of cobra venom metalloproteinases.…”
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Advanced two-dimensional liquid chromatography workflow for enhanced resolution of protein components in Indian Cobra (Naja naja) venom using hydrophobic interaction-reverse phase... by Sunil Kumar, Kunal Krishna, Anurag S. Rathore

“…In the current study, we introduced a novel, online two-dimensional liquid chromatography coupled with mass spectrometry for the separation of proteins within the venom of the Indian cobra snake (Naja naja). …”
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Paracapillaria (Ophidiocapillaria) siamensis sp. nov. (Nematoda: Trichuroidea): a new nematode in Naja kaouthia from Thailand by Vachirapong Charoennitiwat, Kittipong Chaisiri, Tapanee Kanjanapruthipong, Sumate Ampawong, Lawan Chanhome, Taksa Vasaruchapong, Urusa Thaenkham, Napat Ratnarathorn

“…These features serve to differentiate it from other species within the same subgenus, notably Paracapillaria (Ophidiocapillaria) najae De, 1998, a species coexisting P. siamensis sp. nov. in the monocled cobra from the same locality. This study addresses the co-infection of the novel species and P. najae within the same snake host, marking the second documented instance of a paracapillariid species in the monocled cobra within the family Elapidae. …”
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Supplementation of polyclonal antibodies, developed against epitope-string toxin-specific peptide immunogens, to commercial polyvalent antivenom, shows improved neutralization of I... by Abhishek Chanda, Nitin C. Salvi, Pravin V. Shelke, Bhargab Kalita, Aparup Patra, Upasana Puzari, Milind V. Khadilkar, Ashis K. Mukherjee

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Novel sACE2-Anti-CD16VHH Fusion Protein Surreptitiously Inhibits SARS-CoV-2 Variant Spike Proteins and Macrophage Cytokines, and Activates Natural Killer Cell Cytotoxicity by Abdolkarim Sheikhi, Leili Baghaie, Fatemeh Rahbarizadeh, Pooria Safarzadeh Kozani, Cobra Moradian, Mohammadreza Davidi, Narges Baharifar, Golnaz Kaboli, Mehdi Sheikhi, Yunfan Li, Mohammadamin Meghdadi, Abdulrahman M. Yaish, Aiden H. Yu, William W. Harless, Myron R. Szewczuk

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A Novel Hybrid Gray MCDM Model for Resilient Supplier Selection Problem by Alptekin Ulutaş, Mladen Krstić, Ayşe Topal, Leonardo Agnusdei, Snežana Tadić, Pier Paolo Miglietta

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Size matters: first-in-human study of a novel 4 French REBOA device by Neil Parry, Laura Moore, Adam Power, Asha Parekh, Oonagh Scallan, Shane Smith, Teresa Novick

“…Our objective was to evaluate the feasibility of a novel 4 French REBOA device called the COBRA-OS (Control of Bleeding, Resuscitation, Arterial Occlusion System).Methods This study is the first-in-human feasibility trial of the COBRA-OS. …”
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Complement C3 is a novel modulator of the anti-factor VIII immune response by Julie Rayes, Mathieu Ing, Sandrine Delignat, Ivan Peyron, Laurent Gilardin, Carl-Wilhelm Vogel, David C. Fritzinger, Véronique Frémeaux-Bacchi, Srinivas V. Kaveri, Lubka T. Roumenina, Sébastien Lacroix-Desmazes

“…Here, using in vitro assays for FVIII endocytosis by human monocyte-derived dendritic cells and presentation to T cells, as well as in vivo complement depletion in FVIII-deficient mice, we show a novel role for complement C3 in enhancing the immune response against therapeutic FVIII. …”
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Efficacy of DYRK1A inhibitors in novel models of Down syndrome acute lymphoblastic leukemia by Shannon L. Carey-Smith, Maryam H. Simad, Kunjal Panchal, Carlos Aya-Bonilla, Hannah Smolders, Sang Lin, Jesse D. Armitage, Vivien T. Nguyen, Kathryn Bentley, Jette Ford, Sajla Singh, Joyce Oommen, Anouchka P. Laurent, Thomas Mercher, John D. Crispino, Andrew P. Montgomery, Michael Kassiou, Thierry Besson, Emmanuel Deau, Laurent Meijer, Laurence C. Cheung, Rishi S. Kotecha, Sébastien Malinge

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Assessing Strategies to Overcome Barriers for Drone Usage in Last-Mile Logistics: A Novel Hybrid Fuzzy MCDM Model by Snežana Tadić, Mladen Krstić, Ljubica Radovanović

“…Therefore, the study employs a novel hybrid multi-criteria decision-making (MCDM) model that combines fuzzy Delphi-based fuzzy factor relationship (Fuzzy D-FARE) and fuzzy comprehensive distance-based ranking (Fuzzy COBRA) methods. …”
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Avulsion fracture of the posterior cruciate ligament in an uncommon location associated with distal injury to the patellar ligament by Rodrigo Pires e Albuquerque, Idemar Monteiro da Palma, Hugo Cobra, Alan de Paula Mozella, Victor Vaques

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