Showing 1 - 20 results of 224 for search 'The Great Mouse Detective', query time: 0.13s Refine Results
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    Ambulatory Electrocardiographic Monitoring and Ectopic Beat Detection in Conscious Mice by Felke Steijns, Máté I. Tóth, Anthony Demolder, Lars E. Larsen, Jana Desloovere, Marjolijn Renard, Robrecht Raedt, Patrick Segers, Julie De Backer, Patrick Sips

    Published 2020-07-01
    “…To study the pathophysiological mechanisms of arrhythmic disorders, mouse models are widely implemented. The use of a technique similar to AECG for mice is thus of great relevance. …”
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    Article
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    Functional ultrasound detects frequency-specific acute and delayed S-ketamine effects in the healthy mouse brain by Tudor M. Ionescu, Gillian Grohs-Metz, Bastian Hengerer

    Published 2023-05-01
    “…IntroductionS-ketamine has received great interest due to both its antidepressant effects and its potential to induce psychosis when administered subchronically. …”
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    Use of Monoclonal Antibodies in the Sensitive Detection and Neutralization of Botulinum Neurotoxin Serotype B by Luisa W. Cheng, Thomas D. Henderson, Tina I. Lam, Larry H. Stanker

    Published 2015-11-01
    “…Recently, we have developed a sensitive electrochemiluminescent (ECL) immunoassay for BoNT/B, using monoclonal antibodies (mAbs) MCS6-27 and anti-BoNT/B rabbit polyclonal antibodies as the capture and detector. The ECL assay detected as little as 1 pg/mL BoNT/B in the buffer matrix, surpassing the detection sensitivities of the gold standard mouse bioassays. …”
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    Smartphone-Assisted Colorimetric Detection of Glutathione and Glutathione Reductase Activity in Human Serum and Mouse Liver Using Hemin/G-Quadruplex DNAzyme by Yufen Lai, Mengyan Li, Xiaofei Liao, Li Zou

    Published 2021-08-01
    “…We herein develop a smartphone-assisted colorimetric biosensor for the detection of GSH and GR activity in human serum and mouse liver using hemin/G-quadruplex DNAzyme. …”
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    Article
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    Transgenic Mouse Models for the Study of Neurodegenerative Diseases by Alba Marín-Moreno, Sara Canoyra, Natalia Fernández-Borges, Juan Carlos Espinosa, Juan María Torres

    Published 2023-01-01
    “…However, a great deal of information about ND pathology and the search for possible therapies has been acquired using animal models and more precisely transgenic mouse models. …”
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    Article
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    Noninvasive Ultrasound Deep Brain Stimulation for the Treatment of Parkinson’s Disease Model Mouse by Hui Zhou, Lili Niu, Long Meng, Zhengrong Lin, Junjie Zou, Xiangxiang Xia, Xiaowei Huang, Wei Zhou, Tianyuan Bian, Hairong Zheng

    Published 2019-01-01
    “…Modulating basal ganglia circuitry is of great significance in the improvement of motor function in Parkinson’s disease (PD). …”
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    Article
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    Prenatal stress unmasks behavioral phenotypes in genetic mouse models of neurodevelopmental disorders by Kathryn M. Harper, Kathryn M. Harper, Samuel J. Harp, Samuel J. Harp, Sheryl S. Moy, Sheryl S. Moy

    Published 2023-09-01
    “…Identification of optimal stress protocols and critical windows for developmental effects would greatly improve the use of PNS in gene × environment mouse models of NDDs.…”
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    A MEN1 pancreatic neuroendocrine tumour mouse model, under temporal control by Lines, K, Nunes, R, Frost, M, Yates, C, Stevenson, M, Thakker, R

    Published 2017
    “…The availability of a temporally controlled conditional MEN1 mouse model would greatly facilitate the study of such early tumourigenic events, and overcome the limitations of other MEN1 knockout models, in which menin is lost from conception, or tumour development occurs asynchronously. …”
    Journal article
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    Mapping crossover events of mouse meiotic recombination by restriction fragment ligation-based Refresh-seq by Yan Wang, Yijun Chen, Junpeng Gao, Haoling Xie, Yuqing Guo, Jingwei Yang, Jun’e Liu, Zonggui Chen, Qingqing Li, Mengyao Li, Jie Ren, Lu Wen, Fuchou Tang

    Published 2024-03-01
    “…Abstract Single-cell whole-genome sequencing methods have undergone great improvements over the past decade. However, allele dropout, which means the inability to detect both alleles simultaneously in an individual diploid cell, largely restricts the application of these methods particularly for medical applications. …”
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    Article
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    Validation of a DNA methylation microarray for 285,000 CpG sites in the mouse genome by Carlos A. Garcia-Prieto, Damiana Álvarez-Errico, Eva Musulen, Alberto Bueno-Costa, Berta N. Vazquez, Alejandro Vaquero, Manel Esteller

    Published 2022-12-01
    “…Following the great acceptance of the human DNA methylation microarrays, we have herein validated a newly developed DNA methylation microarray (Infinium Mouse Methylation BeadChip) that interrogates 280,754 unique CpG sites within the mouse genome. …”
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    Near-Infrared Fluorescence Probe for Visualizing Fluctuations of Peroxynitrite in Living Cells and Inflammatory Mouse Models by Shuchun Qin, Yiming Ran, Yitian He, Xiaoyan Lu, Jiamin Wang, Weili Zhao, Jian Zhang

    Published 2023-05-01
    “…Therefore, the construction of a simple, rapid, and sensitive tool for detecting ONOO<sup>−</sup> is of great importance for the diagnosis of inflammation. …”
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    Article
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