Necrotic Cells from Head and Neck Carcinomas Release Biomolecules That Are Activating Toll-like Receptor 3 by Tea Vasiljevic, Marko Tarle, Koraljka Hat, Ivica Luksic, Martina Mikulandra, Pierre Busson, Tanja Matijevic Glavan

“…TLR3-stimulating activity was detected in the fluids from all five patients and three mouse tumor grafts. …”
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Iron Oxide Nanoparticles for Visualization of Prostate Cancer in MRI by Avan Kader, Jan O. Kaufmann, Dilyana B. Mangarova, Jana Moeckel, Julia Brangsch, Lisa C. Adams, Jing Zhao, Carolin Reimann, Jessica Saatz, Heike Traub, Rebecca Buchholz, Uwe Karst, Bernd Hamm, Marcus R. Makowski

“…Prostate cancer (PCa) is one of the most common cancers in men. For detection and diagnosis of PCa, non-invasive methods, including magnetic resonance imaging (MRI), can reduce the risk potential of surgical intervention. …”
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Gallic acid mediates tumor-suppressive effects on osteosarcoma through the H19-Wnt/β-catenin regulatory axis by Fengxiang Pang, Shouchang Ding, Nan Li, Zhipeng Li, Nannan Tian, Chuanjian Shi, Fengwei Zhang, Yongxin Mai, Jinfang Zhang, Junyan Wang

“…Traditional Chinese medicines (TCM) have been used for thousands of years, which provide great insights into OS management. Gallic acid (GA) is a natural phenolic acid enriched in various foods and herbs. …”
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Advanced phosphocreatine-grafted chitosan hydrogel promote wound healing by macrophage modulation by Weibei Sheng, Haotian Qin, Tiehua Wang, Jin Zhao, Chongzhou Fang, Peng Zhang, Peng Liu, Anjaneyulu Udduttula, Hui Zeng, Yingqi Chen

“…Furthermore, when compared to the control group, the CSMP hydrogel promoted more skin area repair in the mouse wound defect area, and inflammatory factors such as IL-1β, IL-6, and TNF-α were lower in the repaired tissue for the CSMP group.Conclusion: This phosphate-grafted chitosan hydrogel showed great promise for wound healing through regulating the macrophage’s phenotype via the NF-κB signaling pathway.…”
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Role of beta-dystrobrevin in nonmuscle dystrophin-associated protein complex-like complexes in kidney and liver. by Loh, N, Nebenius-Oosthuizen, D, Blake, D, Smith, A, Davies, K

“…No beta-dystrobrevin was detected in these mice by Western blotting or immunocytochemistry. …”

Genome-wide analysis revealed the dysregulation of RNA binding protein-correlated alternative splicing events in myocardial ischemia reperfusion injury by Ning Ma, Hao Xu, Weihua Zhang, Xiaoke Sun, Ruiming Guo, Donghai Liu, Liang Zhang, Yang Liu, Jian Zhang, Chenhui Qiao, Dong Chen, Ailing Luo, Jingyun Bai

“…Abstract Background Myocardial ischemia reperfusion injury (MIRI), the tissue damage which is caused by the returning of blood supply to tissue after a period of ischemia, greatly reduces the therapeutic effect of treatment of myocardial infarction. …”
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Genetic mutation in Escherichia coli genome during adaptation to the murine intestine is optimized for the host diet by Tomoya Tsukimi, Nozomu Obana, Suguru Shigemori, Kazuharu Arakawa, Eiji Miyauchi, Jiayue Yang, Isaiah Song, Yujin Ashino, Masataka Wakayama, Tomoyoshi Soga, Masaru Tomita, Hiroshi Ohno, Hirotada Mori, Shinji Fukuda

“…Here, we show that notable mutations in sugar metabolism-related genes (gatC, araC, and malI) were detected in the E. coli K-12 genome just 2 weeks after colonization in the germ-free mouse intestine. …”
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Cyclic thrombocytopenia associated with estradiol: a case report by Ningbo Pang, Yingwei Li, Kangxi Zhou, Chunliang Liu, Rong Yan, Chenglin Sun, Weiling Xiao, Changgeng Ruan, Zhimin Zhai, Kesheng Dai

“…In addition, western blot detected the related protein expression. The corresponding assay kit measured the caspase-3 and PDE3A activity. …”
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Molecular characterization of hybrid virulence plasmids in ST11-KL64 KPC-2-producing multidrug-resistant hypervirulent Klebsiella pneumoniae from China by Fushan Zhang, Leyuan Li, Leyuan Li, Yuxin Zhao, Yuxin Zhao, Huiyue Dong, Huiyue Dong, Buhui Zhao, Buhui Zhao, Xiaoyu Zhao, Xiaoyu Zhao, Ziwei Xia, Ziwei Xia, Leizi Chi, Leizi Chi, Yan Wang, Yan Wang, Ruichao Li, Shangshang Qin, Shangshang Qin, Xiangjing Fu, Xiangjing Fu

“…IntroductionCarbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-HvKP) strains combining virulence and multidrug resistance (MDR) features pose a great public health concern. The aim of this study is to explore the evolutionary characteristics of virulence in CR-HvKP by investigating the genetic features of resistance and virulence hybrid plasmids.MethodsThe resistance and virulence phenotypes were determined by using antimicrobial susceptibility testing and the mouse bacteremia infection model, respectively. …”
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Towards Developing Novel Prostate Cancer Recurrence Suppressors: Acute Toxicity of Pseurotin A, an Orally Active PCSK9 Axis-Targeting Small-Molecule in Swiss Albino Mice by Oliver C. McGehee, Hassan Y. Ebrahim, Ashkan H. Rad, Khaldoun S. Abdelwahed, Ethar A. Mudhish, Judy A. King, Iman E. Helal, Sharon A. Meyer, Khalid A. El Sayed

“…Mice plasma samples were subjected to comprehensive hematological and biochemical analyses. Collected mouse organs were histopathologically examined. No morbidity was detected following the PsA oral dosing. …”
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OGT (O-GlcNAc Transferase) Selectively Modifies Multiple Residues Unique to Lamin A by Dan N. Simon, Amanda Wriston, Qiong Fan, Jeffrey Shabanowitz, Alyssa Florwick, Tejas Dharmaraj, Sherket B. Peterson, Yosef Gruenbaum, Cathrine R. Carlson, Line M. Grønning-Wang, Donald F. Hunt, Katherine L. Wilson

“…We report that lamin A is β-O-linked N-acetylglucosamine-(O-GlcNAc)-modified in human hepatoma (Huh7) cells and in mouse liver. In vitro assays with purified O-GlcNAc transferase (OGT) enzyme showed robust O-GlcNAcylation of recombinant mature lamin A tails (residues 385–646), with no detectable modification of lamin B1, lamin C, or ‘progerin’ (Δ50) tails. …”
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The critical role of pancreatic stone protein/regenerating protein in sepsis-related multiorgan failure by Ping Hu, Ping Hu, Yuan hua Lu, Wei Deng, Wei Deng, Qi Li, Ning Zhao, Qiang Shao, Ling Wu, Xu zhen Wang, Xu zhen Wang, Ke jian Qian, Fen Liu, Fen Liu

“…Survival analyses and disease severity scoring were performed to evaluate the survival status of the mice; enzyme-linked immunosorbent assays were performed to detect the levels of inflammatory factors and organ-damage markers in murine peripheral blood; terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining was performed to measure apoptosis levels in lung, heart, liver, and kidney tissue sections and to visualize the degree of organ damage in the mouse model; myeloperoxidase activity assay, immunofluorescence staining, and flow cytometry were performed to detect neutrophil infiltration levels in vital murine organs and the activation indexes of neutrophils.Results and discussionOur findings indicated that Circulating PSP/Reg levels were correlated with patient prognosis and sequential organ failure assessment scores. …”
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The power and promise of genetic mapping from Plasmodium falciparum crosses utilizing human liver-chimeric mice by Button-Simons, KA, Kumar, S, Carmago, N, Haile, MT, Jett, C, Checkley, LA, Kennedy, SY, Pinapati, RS, Shoue, DA, McDew-White, M, Li, X, Nosten, FH, Kappe, SH, Anderson, TJC, Romero-Severson, J, Ferdig, MT, Emrich, SJ, Vaughan, AM, Cheeseman, IH

“…The segregation distortion in the allopatric cross slightly erodes power to detect linkage in several genome regions. We greatly increase the power and the precision to map biomedically important traits with these new large progeny panels.…”

Transparent vertical nanotube electrode arrays on graphene for cellular recording and optical imaging by Jamin Lee, Keundong Lee, Kyumeen Kang, Asad Ali, Dong Wook Kim, Hyerim Ahn, Gwanho Ko, Myunghwan Choi, Youngbin Tchoe, Hye Yoon Park, Gyu-Chul Yi

“…Abstract Here, we report the fabrication of transparent multichannel vertical nanotube electrode arrays for detecting cellular activity and optically imaging neuronal networks. …”
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Sympathetic neurons secrete retrogradely transported TrkA on extracellular vesicles by Ashley J. Mason, Austin B. Keeler, Farah Kabir, Bettina Winckler, Christopher Deppmann

“…Furthermore, using a compartmentalized culture system, we find that TrkA derived from endosomes originating in the distal axon can be detected on EVs secreted from the somatodendritic domain. …”
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Effect of Hyaluronic Acid Oligosaccharides on Diabetic Cutaneous Ulcer Wound Healing by Activating Nrf2 Signaling Pathway by Zhongyuan HU, Xiuhua ZHANG, Shuaiguang LI, Huarong SHAO, Fei LIU, Bin GUO

“…With advantages of high safety and good stability, o-HA has great potential in clinical diabetic wound healing.…”
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Epidemiological Manifestation of Combined Natural Foci of Tularemia, Leptospirosis and Hemorrhagic Fever with Renal Syndrome: Mixed Infections by T. N. Demidova, N. E. Sharapova, V. V. Gorshenko, T. V. Mikhailova, A. S. Semihin, A. E. Ivanova

“…To assess the activity of natural foci and to identify epizootics in populations of mouse-like rodents, the materials of long-term epizootological studies in Russia were used. …”
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Molecular profiling of signalling proteins for effects induced by the anti-cancer compound GSAO with 400 antibodies by Cadd, V, Hogg, P, Harris, A, Feller, S

“…It inhibits angiogenesis and tumour growth in mouse models and may be evaluated in a phase I clinical trial in the near future. …”

Cry, Baby, Cry: Expression of Distress As a Biomarker and Modulator in Autism Spectrum Disorder by Esposito, Gianluca, Hiroi, Noboru, Scattoni, Maria Luisa

“…Background: Early diagnosis of autism spectrum disorder is critical, because early intensive treatment greatly improves its prognosis. Methods: We review studies that examined vocalizations of infants with autism spectrum disorder and mouse models of autism spectrum disorder as a potential means to identify autism spectrum disorder before the symptomatic elements of autism spectrum disorder emerge. …”
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Sparassis latifolia and exercise training as complementary medicine mitigated the 5-fluorouracil potent side effects in mice with colorectal cancer: bioinformatics approaches, nove... by Navid Abedpoor, Farzaneh Taghian, Khosro Jalali Dehkordi, Kamran Safavi

“…Identifying specific causal or sensitive components, such as coding RNA (cRNA) and non-coding RNAs (ncRNAs), may greatly aid in the early detection of colorectal cancer. …”
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