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201
Cell adhesion to agrin presented as a nanopatterned substrate is consistent with an interaction with the extracellular matrix and not transmembrane adhesion molecules
Published 2008-12-01“…This has been demonstrated using nanopatterned RGD peptides, a canonical extracellular matrix ligand for integrin interactions. Cell adhesion was greatly reduced when the RGD-coated nanoparticles were separated by more than 60 nm, indicating a sharp spacing-dependent threshold for this form of cell adhesion.…”
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202
Immune responses in advanced colorectal cancer following repeated intradermal vaccination with the anti-CEA murine monoclonal antibody, PR1A3: results of a phase I study.
Published 2005“…In vitro PBMC proliferation with mitogens and recall antigens is greatly increased during the course of immunisation, with a shift in stimulated cytokine profile.…”
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203
Research on the anti-ageing mechanism of Prunella vulgaris L.
Published 2023-07-01“…These changes rarely present in young tissues, while greatly increasing in response to ageing. Firstly, the ageing model of the Institute of Cancer Research (ICR) mouse was established by d-galactose subcutaneous injection. …”
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204
ROS generation via NOX4 and its utility in the cytological diagnosis of urothelial carcinoma of the urinary bladder
Published 2011-10-01“…As a result, the sensitivity for detection of low grade, non-invasive UC was greatly increased (35% in conventional cytology (C-C) vs. 75% in ROS-C), and the specificity was 95%. …”
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205
Effect and Mechanism of Andrias davidianus Peptide Supplementation Combined with Treadmill Exercise on Body Mass Loss in Obese Rats
Published 2024-03-01“…Western blot was used to detect the expression of appetite-regulated proteins (NPY and proopiomelanocortin (POMC)) and energy metabolism-related proteins. …”
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206
Habitat Imaging of Tumors Enables High Confidence Sub-Regional Assessment of Response to Therapy
Published 2022-04-01“…Our data showed that LPM greatly increased the amount of information extracted from diffusion-weighted imaging, compared to cohort <i>t</i>-tests. …”
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207
Cellular environment of TTR deposits in an animal model of ATTR—Cardiomyopathy
Published 2023-03-01“…It is believed the number of cases to be greatly underestimated mostly due to misdiagnosis. …”
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208
Illuminating and Radiosensitizing Tumors with 2DG-Bound Gold-Based Nanomedicine for Targeted CT Imaging and Therapy
Published 2023-06-01“…Results from this work indicate that 2DG-PEG-AuD could greatly potentiate theranostic capabilities by providing high-resolution anatomical and functional images in a single CT scan and therapeutic capability.…”
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209
Electrospun sandwich mesh structures loaded with naringenin and vitamin K2 polycaprolactone/gelatin nanofibers synergistically promote bone regeneration
Published 2023-12-01“…The biocompatibility and osteogenic capacity of the membranes were assessed in vitro using mouse bone marrow mesenchymal stem cells (BMSCs). …”
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210
Mannose enhances intestinal immune barrier function and dextran sulfate sodium salt-induced colitis in mice by regulating intestinal microbiota
Published 2024-03-01“…BackgroundInflammatory bowel disease (IBD) greatly affects human quality of life. Mannose has been reported to be used to treat IBD, but the mechanism is currently unknown.MethodsC57/BL mice were used as research subjects, and the mouse acute colitis model was induced using dextran sulfate sodium salt (DSS). …”
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211
Gi- and Gq-coupled ADP (P2Y) receptors act in opposition to modulate nociceptive signaling and inflammatory pain behavior
Published 2010-04-01“…</p> <p>Results</p> <p>We detected mRNA and protein for ADP receptors P2Y12 and P2Y13 in mouse dorsal root ganglia (DRG). …”
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212
Highly efficacious and safe neutralizing DNA aptamer of SARS-CoV-2 as an emerging therapy for COVID-19 disease
Published 2022-12-01“…In addition, AYA2012004_L did not induce inflammatory response in the lungs of Th1 and Th2 mouse models as well as human PBMCs. AYA2012004_L was detectable in mice lungs and noticeable in insignificant amounts in other vital organs. …”
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213
miR‐29a‐3p promotes the regulatory role of eicosapentaenoic acid in the NLRP3 inflammasome and autophagy in microglial cells
Published 2023-06-01“…Methylated miR‐29a‐3p was detected via methylation‐specific polymerase chain reaction. …”
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214
Generalised deep learning model for semi-automated length measurement of fish in stereo-BRUVS
Published 2023-06-01“…The head-to-tail measurement method presented here builds on, and advances, previously published object detection for stereo-BRUVS. Furthermore, by replacing the manual process of four careful mouse clicks on the screen to precisely locate the head and tail of a fish in two images, with two fast clicks anywhere on that fish in those two images, a significant reduction in image processing and analysis time is expected. …”
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215
METTL3 regulates N6-methyladenosine modification of ANGPTL3 mRNA and potentiates malignant progression of stomach adenocarcinoma
Published 2023-06-01“…Abstract Background N6-methyladenosine (m6A) is associated with mammalian mRNA biogenesis, decay, translation and metabolism, and also contributes greatly to gastrointestinal tumor formation and development. …”
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216
Comparative transcriptomic analysis of Illumina and MGI next-generation sequencing platforms using RUNX3- and ZBTB46-instructed embryonic stem cells
Published 2024-01-01“…For example, we found that Gzmb, Gzmd, Gzme, Gdf6, and Ccr7 genes were robustly upregulated upon the forced expression of Runx3; on the other hand, Gpx2, Tdpoz4, and Arg2 were induced alongside the ectopic expression of Zbtb46.Discussion: Similar gene expression profile and greatly overlapping RUNX3- and ZBTB46-regulated gene sets were detected with both DNA sequencing platforms. …”
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217
Characterisation of AEBP2: a polycomb repressive complex 2 component
Published 2013“…Interestingly, I did not detect any peptides of the Polycomblike (PCL) family proteins. …”
Thesis -
218
Fusion Protein Vaccine Based on Ag85B and STEAP1 Induces a Protective Immune Response against Prostate Cancer
Published 2021-07-01“…The uptake of the fusion protein vaccine by DCs was evaluated by confocal microscopy, and DC markers were detected using flow cytometry after incubation with the fusion protein. …”
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219
Hyperactivation of mTORC1 in a double hit mutant zebrafish model of tuberous sclerosis complex causes increased seizure susceptibility and neurodevelopmental abnormalities
Published 2022-09-01“…Recently, second hit mutations have been detected frequently in mTORopathies. To investigate the pathophysiological effects of second hit mutations, several mouse models have been developed. …”
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220
Loss of Myostatin Alters Mitochondrial Oxidative Phosphorylation, TCA Cycle Activity, and ATP Production in Skeletal Muscle
Published 2022-12-01“…Expectedly, the MSTN null (<i>Mstn</i><sup>−/−</sup>) mouse has a hypermuscular phenotype. The muscle metabolism of the <i>Mstn<sup>−/−</sup></i> mice was detected by an enzyme-linked immunosorbent assay, indirect calorimetry, ChIP-qPCR, and RT-qPCR. …”
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